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Cymbalta - instructions, dosage, side effects, analogs

23 Oct 2019

Antidepressant: Cymbalta 

Active ingredient: duloxetine (Duloxetine)

Analogs: Azaphen, Remeron, Mirazep, Phenazepam, Zoloft, Velaksor.

Cymbalta (duloxetine) - an antidepressant, is an inhibitor of the reuptake of serotonin and norepinephrine, while it has a weak inhibitory effect on the reuptake of dopamine. Thus, the principle of his work is based on the increase of noradrenergic and serotonergic neurotransmission in the central nervous system.

This is a modern drug whose dual mechanism of action has proved effective in treating depression of varying severity. In addition to its high effectiveness, this antidepressant can boast a considerable speed of action. A distinct antidepressant effect is observed already in the first week of application of duloxetine. In addition, the drug is characterized by persistence and uniformity of action, which allows to observe continuous improvements throughout the treatment period. In addition, the Cymbalta has a strong analgesic effect, occurring already during the first two weeks of taking the drug.


The study of the effectiveness of duloxetine in the fight against chronic migraine proves that the drug can successfully cope with pain and increases the pain threshold. Of the 46 patients with chronic migraine, serious improvements have occurred in more than half. At the end of the three-month course of treatment, the average number of days without a headache (within one month) increased by approximately 60%, and the frequency of migraine attacks decreased by 40%.

Indications for use: Treatment of depression; Treatment of diabetic neuropathy in painful form.

Contraindications: Cymbalta (duloxetine) should not be taken concurrently with MAO inhibitors (wait at least 2 weeks); people who are hypersensitive to the drug and its components; patients with closed-angle uncompensated glaucoma; women in the period of breastfeeding. In addition, there is no fixed experience in the use of the drug for patients under 18 years of age.

Dosage and administration: The drug " Cymbalta" should be taken orally, swallowing whole capsules, regardless of food intake. Do not crush / chew capsules, as well as mixing them with liquids and adding to food (this will destroy the enteric shell of the capsule).

The initial dose is 60 mg / day and, if necessary, can be increased up to a maximum of 120 mg / day. In this case, the dose should be divided into two doses. For patients suffering from severe renal failure (with a QC less than 30 ml / min), the initial dosage is 30 mg / day. People suffering from violations of the functioning of the liver should reduce the initial dose of duloxetine or reduce the frequency of admission.

Side effects: Most often, the following effects are observed: sleep disturbance (both drowsiness and insomnia), dizziness (excluding vertigo), headache, nausea, dry mouth, constipation.

Storage conditions: The drug should be stored in a place inaccessible to children, at a temperature of 15-30 C.

Terms of selling from pharmacies: Cymbalta (duloxetine) is released on prescription.

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