Tablets Afobazol really good

Advantages: really helped

Tablets Afobazol really good, helped to deal with severe depression, surviving divorce.

While not start taking them consistently was nervous, I could not soothe himself absolutely nothing more than common sense in my head, just missing ...

When I started taking them, I was able to control his emotions, was able to think straight and do not cheat yourself by creating a problem from scratch.

My girlfriend they are also very helpful to go through the hardest parting with the young man and betrayal ... She says: I do not know how to do without it afobazole handled ...

In general I advise !!!

Afobazol - Soothing effect begins about a week

Attention! Before application of drugs, consult with a specialist!

Advantages: effective

I itself is very nervous and impressionable man, I start very nervous, and very sharp all worried. Begins to reduce the stomach, starting almost run back and forth as a result of a nervous breakdown, and so on.

Where that four years ago I had the same problem and the doctor advised Afobazol. I started taking it, but he had no effect. But somewhere in a week I suddenly caught a very pleasant state - a state of self-confidence and that everything is in your hands as they say. And I've never been that way. I still love to dig into myself and began to think about what is the reason. And then I realized that the reason - these pills.

And then I started to feel the effect after each reception of a tablet. That is, they have a cumulative effect which manifested through time.

I recommend these pills over the same nerve and moving as I did. Because otherwise I feel sorry for you and myself. And these pills help not so much nervous. So I advise this drug.

Afobazol Led nerves in order

Advantages: not feel sleepy

I am a teacher at the Department of Linguistics of the linguistic faculty. I was afraid when asked again, confused in terms. Once completely forgotten definition. And so on and so forth. I tried to take the usual sedatives such as valerian, but they only make things worse, a third pair was generally not himself, would take off his jacket and lay down, hiding them.

So I tried four means, until finally he caught me Afobazol. Well, that had the patience to spend on drink a course manual. I took it exactly one month, and the results were excellent. The head is clear, no drowsiness and anxiety.

Afobazol tranquilizer

Advantages: It calms without causing drowsiness.

Disadvantages: price

I met with the drug in a difficult period of my life. Who experienced a divorce, he will understand that the state in which I was. It was found that expressions such as "the soul hurts", "the heart is torn from the breast" is not a beautiful expression, and the very real physical condition.

My colleague, observing my condition, advised Afobazol.

The drug is a tranquilizer, but unlike other means of this group does not cause drowsiness, muscle weakness.

While taking the drug can drive a car! Used for anxiety, fear, sleeplessness ... and protects nerve cells.

Take 1 tablet should be. 3 times a day.

The action comes on the 5th day of reception.

I have taken two times per day. In the morning and in the evening. I took 2 packs. About a month receiving repeated. I can not say that stress "vanished", but the drug has helped me to survive it. Emotions go by the wayside, allowing look at the other side of the problem.

But anxiety, bad feeling really good fights. Recently I had to take again. Slowly fear and anxiety are gone.

Before using best to consult with a specialist, as there are contraindications. Be healthy!

Duration of use: 2 Month

Afobazol - It gave me peace of mind and have helped to change the lives

Advantages: quick effect, are not addictive

Some time ago my life was in this period that annoyed me literally everything! The difficult situation on the job, working with people, all this affected me negatively. I was a clot of negative energy. I read that you can take Afobazol. The key choice is that it is not addictive. Get used to antidepressants, and then even more bogged down I did not want.

I started taking. I try not to miss, and to act according to instructions. To be honest, I do not really believe that the tablet will be able to solve my problem. Yes, the problems are not solved, but my attitude toward them changed! I became calm, I have ceased to annoy the little things, for me the world has changed. Addiction is not caused, it's been 2 months since I have been taking them. Having ceased to be irritated over trifles, I reviewed his life, resigned from the hated work, and now me more of these pills are not necessary. I hope that will not be necessary, but I'm glad that they exist.

Duration of use: 1 month

Afobazol - The effect is at once

Advantages: quick effect, helps, does not violate the brain

Afobazol helped me always, even for the first time in 18 years, when I was taking my first session. Before, I used it properly - that is, one-time fee, on some tablets, but their effect was manifested at once, all the emotions as the hand is removed, the complete indifference.

Now, I accept it for a week, I can say that it is desirable to take it as instructed - 3 times a day after meals. And in such a case would be a good effect. When taking a little longer than it should "Afobazol", start side effects - drowsiness, change of state of excitement to apathy (in my personal experience).

However, I can say that it is a means of uniquely valid. I recommend to use in accordance with the instructions, and then the effect would be appropriate!

Duration of use: 2 weeks

Afobazol - Soft action-stable effect!

Advantages: good price, it does not cause drowsiness and addiction

One tablet Afobazol not solve all your problems like insomnia and depression. The drug has constantly enhances the action. Peak action, somewhere in the fifth day.

Many people write to Afobazol extremely negative reviews. Probably, everything is the fact that since the drug does not make you instantly happy, it begins to seem a sharp deterioration in his psyche. That is, we ourselves begin to harass, and the situation is many times worse than it was.

Therefore, I recommend acceptance Afobazol with careful assessment of their sensations, with a discount that does not express eto- means. It works great, but the admission rates!

Pros of Afobazol - non-toxic, harmless practical and good compatibility with other drugs. Behavior is almost does not change, it does not decrease the reaction. Deleted only unnecessary mistrust and anxiety!

Afobazol - Good drug

Advantages: no side effects!

I am a very nervous man, prone to depression, suffer from migraine, tinnitus, hypotension, insomnia. I have a hyperactive child, he was very nervous and excitable. I am no one helps with him. I became nervous and decided to take Afobazol tablets.

I became much calmer and at the same time actively. I took half of the course is already feel the result, the head almost no pain and increased strength.

I give my child for half a tablet, so as not so much nervous and sleep was calmer.

FAQ: Membrane - Antibiotics

6 facts about bacterial resistance to drugs and how to solve this problem.

One of the pressing biomedical problems currently the problem of resistance of pathogenic bacteria to the drugs with which they are trying to deal with, i.e. is resistant to antibiotics. The problem has long been known, since antibiotics were first, and so far it has not been solved. People are trying to find and develop new, more effective drugs that will fight bacterial infections, but the bacteria are not far behind: they have learned to adapt and do quite well even in relation to the newly created drug compounds.

• 1.Solutions to this problem

How can help here the methods of computer simulation? Why, in fact, we are talking about a computer simulation? The fact that there was an understanding that fight bacterial infections can not simply interfering with the functioning of the bacterial processes on the genome level by adjusting, for example, the work of enzyme systems, which are often used in recent years. We know that there is an entire large group of so-called antimicrobial peptides, which affect the membrane forming bacteria therein defects, pores, and thus the membrane by osmotic shock die, due to the fact that the fading difference in the concentration of various ions in bacterial and outside cells. This is all the traditional approaches, and academic labs, and pharmaceutical companies are working to improve such drugs. (For example Meldonium).

But because of resistance remains a problem, you need to look for new ways. And one of them is to see how the bacteria themselves cope with this task, because their bacterial life, they are forced to fight for survival, and they are not isolated and live, and surrounded by other strains, often aggressive and hostile to them . And to combat these undesirable neighbors bacteria in the course of evolution, we have developed a number of interesting techniques and synthesized a number of interesting molecules, which, in fact, need to look carefully. These molecules are very effective and are very strong antibiotics. For a long time it was known that many bacteria produce these compounds, but the mechanisms of action of these compounds is still unclear in many respects. That is, here it is necessary to understand at the molecular level, why these connections are very good, and many of the emerging synthetic drug compounds to fight the bacteria are either not very effective or bacteria find an opportunity to adapt to them.

• 2.About lantibiotics

One of the projects just our laboratory and is connected by the computer to try to model the process behavior of molecules produced by bacteria which are able to cause bacterial cell death. As an object of research, we chose the so-called lantibiotics. This is a rather unusual peptide compounds, because they consist not only of the canonical amino acid residues, which, as we know, there are twenty types, but also contain quite modified amino acid residues are chemically modified, that is, non-standard chemical structure. Often this ring structure, that is such a lantibiotic molecule is a sequence of several macrocycles, unlike conventional linear antibacterial peptides. The most famous of the lantibiotic is nisin. This peptide lantibiotic which has long been used, for example, in the food industry as an antibacterial additive. It is completely harmless to humans, but some species of bacteria kill very effectively. The compound is used for a long time, but the mechanism of action of nisin at the molecular level is still not clear. It is known that the action target lantibiotic Nisin molecule is the so-called lipid-II in the composition of the bacterial membrane. That is, it is not simply accumulate on the bacterial membrane and forms therein some pores and defects, and it specifically recognizes very effectively on the surface of bacterial membranes he desired compound, which is called the target. Lipid-II molecules are precisely such a specific target. Lantibiotic molecule associated with the lipid-II and blocks its operation.

• 3.On the functioning of lipid-II and causes of death of the bacteria

The fact that the lipid-II - a molecule that contains the polar part consisting of two carbohydrate residues: small peptide fragment and a long hydrophobic tail, which "anchors" for the molecule in the membrane. That is, its molecule interacts with the polar head groups of lipids, and its hydrophobic tail is thicker in the membrane. This molecule is involved in the synthesis of the so-called cell wall (glycocalyx), transferring it to the internal components of the bacterial cytoplasmic membrane surface to the outer surface. And if disrupt lipid-II, the bacterium dies, because it can not synthesize their cell walls and becomes defenseless.

In our studies, we tried to understand how the lantibiotic molecule recognizes its target lipid-II, in the bacterial membrane. The problem is that the lipid-II molecule surrounded by a large number of other lipid molecules, and which are also charged and polar groups in their properties and would seem to be close to have a molecule of the lipid-II. Consequently, it was necessary to find out an experiment in the computer, if different than a membrane, which is present in the composition of the target, the lipid-II, from the diaphragm, in which no such a target. Experiments do not yet possible. The most that is possible - by means of atomic force microscopy to obtain images of a membrane looks in general, that is not at the molecular level. Here, apparently, it is a question that lantibiotic molecule recognizes some features that have a molecular scale. As mentioned above, even the most modern experimental approaches can not clarify the situation, so to help researchers come methods of computer modeling.

• 4.How lipid-II affects membrane

In our laboratory, we have made great efforts to study the structure and dynamics of membranes that mimic bacterial membranes. These model membranes were embedded target molecule being studied - lipid molecules-II. And it turned out amazing thing: the lipid-II molecule is really much changes the properties of the surrounding membrane, changes locally. This is what we are designed for your computer. It took, of course, a supercomputer, because the system contains hundreds of thousands of particles, and the necessary time dynamics modeling (hundreds of nanoseconds and microseconds). Besides the membrane must be hydrated, because the water molecule also strongly influence the properties of the membrane and in the membrane of the target behavior. Thus, very complex supramolecular system was used in the calculations. The result is: a membrane which is composed of lipid-II, behaves in an unusual manner. Near lipid-II molecules there is an interesting feature: it creates around itself an area which by its physical and chemical properties different from what is in the undisturbed membrane, that is no target. In addition, the dynamics of the behavior of this lipid-II in the bacterial membrane is very unusual, that is, there are areas, hills and valleys, if figuratively say, near the molecule lipid-II. And they're on their hydrophobic and dynamic properties differ greatly from the free membrane.

• 5.Features of behavior of the antibiotic and membrane

When we saw that in the membrane creates a disturbance here, and with quite specific characteristics in terms of amphiphilic, and in terms of structure and dynamic behavior, we have decided that it is this feature of the membrane near the location of the lipid-II is a key. Lantibiotic molecule, which themselves too are amphiphilic (i.e., they polar and nonpolar portions are separated in space) recognize lipid-II - a target with which they have to be bred, it is on the basis of this pattern occurring in the membrane. We have simply tried to understand, but what, in fact, unusual in the behavior of lipid-II molecules, and the difference between the membrane, which has a target from the one in which this target is not. In addition, we had to figure out how to target induced lantibiotic molecule.

• 6.Research Perspective

The next challenge is this: take a large set of compounds, such lantibiotic (but simpler in chemical synthesis and smaller than natural lantibiotic that they then could efficiently produce), and see how the so-called "molecular trap" - prototypes of the future antibiotics - bind with its target in the membrane.

Further goes the optimization process (improvement) of these traps in order to achieve maximum efficiency, that is, the binding constant (affinity) and the highest selectivity. It is also desirable that these molecules trap or future medication, antibiotics, were selective for the action that they kill only certain strains of pathogenic bacteria, but do not touch the other strains, which may be useful.

But it is all to come. At least now it is clear that we are on the right track, and the first part of the problem, that defines the primary target recognition act lantibiotic in the membrane clear. I believe that the result is very interesting and the future also looks promising. Of course, we are not talking about that in a year or two will be a new antimicrobial compound market. But, at least, we will deal with the molecular mechanisms of action of new molecules.

Anaprilin: what makes this drug? Instructions for use. How does it act on the heart and on the human body?

Before starting the doctor's advice, you should find out what Anaprilin (Propranolol) from what helps and when this drug is administered. Skilled of course to trust, but it is necessary to know the principle of action of the drug and possible complications. In the future, this information will help.

What controls the human body?

Our body is regulated by the interaction of the two systems:

Nervous system:

• "Quick Response", changes occur in a split second.
• The basic structural unit is the nerve cell, the transmission of information provides an electric current.
• Based on the conditioned and unconditioned reflexes.
• From an evolutionary perspective – later one.

Humoral system:

• The reactions proceed more slowly, within minutes or even hours.
• Effects on the body is due to the hormones that are produced by glands.
• It has a lasting impact on the internal environment.
• It is inherent in the first complex organisms.

Pathologies of the nervous system appear almost instantly, the person violated the sensitivity of the extremities, decreased motor activity, impaired learning things and perception of the world.

And here endocrine disorders are usually chronic, the first manifestations of the disease may appear after weeks or even months from the date of violation of the hormonal balance.

Violations related to the nervous system

Many violations are developed according to the scheme of interaction between these two systems. Here, for example, is produced by the adrenal glands adrenaline had an effect on beta-adrenergic receptors. As a result, the person:

• Participation pulse.
• Increased heart's need for oxygen.
• Increased blood pressure.
• Decreased tone of the bronchi.

And this is only the most serious consequences, not counting the "stuff" in the form of:

• Panic attacks.
• Increased sweating.
• Violations of bowel motility.
• Relaxation of sphincters.

But if the "petty" points will only lead to unpleasant sensations and "loosening" of nerves, the acceleration of the heartbeat can lead to serious heart problems. (one can buy Meldonium).

In old age, this condition can result in a myocardial infarction. Regenerative capabilities of the body at times almost limitless, but pensioners rarely return to normal life after such heart attacks. It is therefore important to minimize stress, get rid of unnecessary worries and enjoy life. And do not be in a constant state of emotional tension. Elevated blood pressure figures - is not worse than can "get" in this case.

For why use Anaprilin (Propranolol)?

If the recommendations are not to stick or they for some reason do not help, you need to pass to the treatment of developing the disease. To do this, use β-blockers, special drugs, which reduce the sensitivity of receptors for adrenaline. Most often assigned Anaprilin (Propranolol), because of its availability, relatively low cost and effective influence on the body.

The drug is given by the cardiologist, after examination and treatment plan. This usually occurs if there is a suspicion:

• Angina pectoris.
• Hypertension.
• Tachycardia.
• Arrhythmia.
• VVD.
• Pathology of the adrenal glands.
• Attacks of panic attacks.

As seen in the last paragraphs, sometimes the medicine is used and neurologists with endocrinologists, but mostly we are talking about heart problems. In terms of a panic attack - the drug has no effect on the brain and does not eliminate the cause of this condition, it just minimizes the manifestations on the level of the internal organs.

It does not help to cope with the attack and "pull yourself together," but deliver us from the small unpleasant symptoms that accompany each panic attack.

How to take Anaprilin (Inderal)?

The drug is dosed strictly doctor, start a course is only necessary on the basis of its recommendations. Self-medication, especially when it comes to vehicles such, it is impossible to deal with.

Depending on the disease, the daily dose ranges from 160-320 mg:

• Tablets can drink twice a day - in the morning and evening, for 80 mg.
• It is recommended to start treatment with the triple use of 40 mg.
• Before or after the meal - little it does not matter.
• Wash down Inderal (Anaprilin, Propranolol) should only cool boiled water, no teas, juices and especially alcohol.
• At the time of dosing is recommended to avoid alcohol and tobacco use.
• During the course of treatment is necessary to see your doctor regularly and adjust the dose of medication.

The final effect is achieved through the combined therapy and long-term use of the drug. If you have already decided to take pills, you need to drink the whole course without stopping halfway.

And one more thing, the drug may slightly reduce the concentration and reaction speed, so that the wheel after use is better not to sit down. If duties require rapid decision-making and involve a risk of injury - from receiving Propranolol probably have to give up.

Status panic attack

Our bodies are not always adequately respond to environmental stimuli, sometimes it flows into fits of panic attacks. This disease affected a small percentage of the population, but it does not mean that the problem does not exist and it does not have to fight:

• Seizures occur during stressful situations - the examinations, heavy conversations, problems at work.
• Duration strictly individual, from several minutes to hours.
• In addition to anxiety and panic attacks, a person experiences unpleasant sensations in the internal organs.
• Most notably rapid breathing and feeling your own heartbeat.
• It echoing heartbeat may exacerbate the panic, it is simple "cheat" themselves and start thinking about a heart attack.

Such patients are not assigned pills course, because this may lead to changes in the body, and the amount of change produced by adrenaline. By and large, the adrenal glands and heart healthy, just sometimes the whole system fails because of the peculiarities of the nervous regulation. As soon as another bout of "loom" on the horizon, you should drink 1-2 pills and already after a quarter of an hour you can feel the effect.

It is not a sedative, with nerves still have to do something and somehow convince your brain that you need to calm down. But in this process if the heart, lungs and gastrointestinal tract will not disturb - not bad.

When you need to drink Anaprilin (Inderal, Propranolol)?

Anaprilin’s main problem is that it is non-selective drug. Those. it acts on all the β-adrenergic receptors located in the body. Not only in the heart, but in lung, intestine, uterus. And this, in turn, may result in a not very pleasant side effects. Pharmacology has solved this problem by developing a selective blockers, Inderal but continue to appoint:

• In the case of angina attacks.
• When hypertension.
• After identifying adrenal disease.
• For the treatment of coronary heart disease.
• When thyrotoxicosis.
• In case of ESP is detected.
• For investment status during a panic attack.

You can ask the doctor what exactly it is guided by assigning it a non-selective drug. Most likely, you will hear an adequate explanation, and get another assignment.

If the home medicine cabinet has Anaprilin (Inderal) from what helps agent needs to know the whole family. Attacks of angina is always unpleasant, and may be accompanied by panic, the patient will not have time out to explain exactly what a tablet should be given to him.