Chinese Erotology and Healing

Dr. Doping tells about Chinese meditation practice, an ancient treatise on sexuality and the division into male and female beginning.

To paraphrase a famous saying: if there was a Chinese Bible, it would be written that in the beginning was not the Word, and in the beginning there was the sexual energy. And if we look at the first treatises related to the recovery and meditative practices, all of them devoted to the regulation of sexual energy. This tradition has existed in various guises for nearly 2,500 years, and in the twentieth century, it began to change significantly and has gone through several important stages. First of all, for a long time in the historiography of the present text - they are widely translated - which did not come from China, and it was the meeting of Chinese texts, preserved in Japan. They were called Ishinpo and kept in the Imperial Library of Tokyo. These texts are widely translated since the 30s of the twentieth century known Sinologists - first Frenchman Maspero, then into many languages Dutch researcher Robert van Gulik, who, in fact, coined the term "Chinese sexual yoga", although, of course, such a concept in the Chinese practice never existed.

In many texts considered a forgery, because that in itself corpus was compiled, probably in the IX century and expanded in the XIII century to the great composition a variety of texts, from small, just two pages, to large tracts of 30-40 pages several Juan, there are several scrolls. This situation persisted until the years 1972-1974 was not opened the tomb of Mawangdui in Hunan in China, where there was, in fact, found a giant library of ancient texts, including, for example, one of the early lists of text "Tao Te Ching "Lao Tzu, and at the same time it was discovered about a dozen texts on sexual practices. The texts were without names, many of them are poorly preserved, and these were mainly texts on bamboo tablets. Some of them were in the form of silk books, that is, the texts written on silk, but the composition was repeated inscriptions on bamboo tablets. In the main text, which we attribute to the ancient sexology, - a text silk books, many of them are preserved in part and not amenable to interpretation and translation, other preserved quite well. Then they were given the name, and today we do not use those titles that were originally given - they did not have titles, and the names given to investigators. And, perhaps, the very first text, which is known for stories of human self-regulation is called "On the union of yin and yang" ( "Ho Yin Yang"), and it offers the first concept of energy regulation in the human body. In fact, this is the first treatise on ancient sexuality.

Immediately evident that since the text refers at least to the II century BC - and, most likely, some of his pieces belong to the III and, possibly, to the V-VI centuries BC, in fact, to the time of Confucius - we We need to understand that even then there were some schools. Mavanduya of texts - and there are about ten of sexual regulation - put a big question before us whether the school existed specifically or only methods? Accordingly, whether the teachers and their followers, or it was just some kind of household records, which were then brought together, as had once been kept records Lao Tzu? By repeated passages in different texts, we understand that, most likely, we are talking about the existence of schools, teachers, traditions and transmissions. We meet a number of stable phrases, which are then repeated almost throughout Chinese history, it can not be transferred outside, that is "out of school". Accordingly, we understand that the school existed. It can be studied only from teacher to student, so we can assume that already at least during the Han there were schools that were based entirely on sexual practices.

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What was the basis of these sexual practices? The man really was considered as a microcosm, which repeats all the energy and all the forces present in the macrocosm, that is, man is the point of copulation of yin and yang. Man must properly regulate it, and the concept of "fear of sexual energy loss" for the first time there. In the ancient texts it is referred to as yin - jing or yin - qi, that is, the seed - the yin and initially regarded as dark energy, female. This is related to the Taoist concept - tao as the all generating beginning. Here we must recall that in the "Tao Te Ching" present the concept of Tao as the feminine, because there is the phrase "of the dao womb all out," Dao is likened to a general female from which the womb leaves the whole world, and as a result, mating with female general is a product of this world. Sexual beginning supple, due to the yin, and, as a consequence, it is dangerous, because it is associated with a loss of energy, with energy streaming. And starting from the II century BC to the Middle Ages and practically develops the concept of retention of sexual energy in the human body.

Initially, there is no division in the feminine and masculine, male and female practice. However Mavandian texts say that the partners must imbue each other. It is expressed in terms such as, for example, "drinking the moisture of each other", "absorb qi each other", "exchange of qi." Then this concept (in this case it seems to be equitable between the two partners) in the Middle Ages formed in the masculine concept. Man saturate the woman, and consequently, most of the texts and practices related to the male practice. And from here there are texts that describe in everyday life, as a man must choose the right partner. There are just instructions on how a woman should look like, how it should be selected, for example, the hair shine, hair growth on the arms, on her walk, in spots on her body, that is, the woman is seen solely as a tool for man power.

Since the XII and almost to the XVII century there is a special women's literature. The most famous text - a "Manual of the goddess Queen Mother of the West", which is designed exclusively for women's practice. Here, the practice of female repeats men, only in reverse. The basis of the concept of man's practice was bi-ching, that is, locking seed, seed retention in the human body, because the rejection, the release of the seed is a loss of energy, as a consequence - loss of vitality. Therefore, retention is the basis. And there were many interpretations of what the hold. It's not all emissions and that abstinence from sexual activity for some time. And different schools offering different interpretations of the original concept. The principle was simple: the joy is delivered not release the seed, but simply through intercourse with a partner, but without release, a man and rejoices, and imbues himself, seeds itself. In Taoism masculine concept comes, perhaps, to such an absurdity, when blood men should be replaced entirely his seed. And, for example, one of the Taoist story tells: some peasant woman tried to seduce Taoist could not, and when he fell asleep, she was angry, stuck a knife into his body, and out instead of blood poured the seed; She was upset that I lost such a man. This, of course, was very widespread at the level of the Chinese myths.

The woman should hold a sho, ie blood. In this case, the blood is like menstrual blood, and an analogue of the energy that is associated with the concept of the male seed. In this case, women's blood is particularly energy substance. Texts already XVII century mock this concept, and the texts of medieval, IX-X centuries, still support the idea that a woman should be at the expense of certain exercises to stop menstrual cycles, that is to keep the blood inside, and only due to this it can be the immortal. In Taoism, this concept comes to its logical absurdity: refers to the immortal celestial beings-women, that 15 years after the onset of menstruation were able to master certain exercises and hold the blood inside. Thus, it turned out that the absence of any emission of energy is the basis of sexual practices.

This paradox of the rest of the Chinese culture. Of course, Confucian culture provides mass childbirth, many children in the family, that is the cult of the family is very important. The ethical dimension of these sexual practices is opposite the main concept of the state. Of course, on that mocked and condemned serious Buddhists. In Buddhism, there is the concept of celibacy while living in the monastery, but Buddhism itself does not deny procreation. Buddhism, which had a great influence in China after the III-V centuries AD, provided the concept is just the integration into the state, including the state ideology. And only one direction - Chinese Taoism, and the partially - supported the concept of energy retention. Therefore, the energy confinement concept, or, as in China called, Shuang-shyu (a joint nurturing, pair feeding people), goes to the background is the Chinese culture and is divided clearly into two lines.

This is clearly seen already in literature IX-X centuries. One line - it's actually a mockery of his body, but due to this - the melting of the body inside the pill of immortality, holding a seed and blood and, as a consequence, a very fine adjustment of the body on the selection of partners for mutual feeding, the exchange of energy. It was a mystical school, which, according to tradition, will be maintained until the XIX century. For example, the preserved interesting records of the British, the British, who came to China in the XIX century and were surprised to find in the south of the country the whole school, not mystical, where young girls were taught to keep themselves in the blood, that is, in fact, to become immortal.

The second tradition was degeneration, desacralization mystical tradition. This is a subtle mockery, mockery of the primary mystical concept. It's all sorts of erotic, very vulgar Chinese novels, short stories, where mock those Taoists who are trying to achieve immortality and, in fact, destroying themselves. In the XVII century there are such novels as "prayer rug from the flesh," Li Yu, appear everyday urban novels, where mock these practices. But these stories are commonplace. In this case, the sexual practices came to more subtle aesthetics and erotology. A special type of patterns, novels like "Jin Ping Mei" ( "Jin Ping Mei"), which is considered erotic and still will not be published in China in its entirety.

But at the same time in China is not a very important part erotology that we see in other cultures - fun. Fun as it was in Russian culture, sexy fun, fertility. Just sexual culture of China is not associated with fertility, but only with a mystical rebirth of man. And the main point, which is stored, starting with texts Mavanduya II century BC up to the XVII century texts - is enlightenment through regulation of sexual energy. And, in fact, the sexual practice in China can be viewed in the same way as, for example, for Buddhism, Taoism, and other mystical schools, enlightenment system due to certain exercises.

How does the placebo effect?

Cardiologist Dr. Doping tells about drugs without proven benefit, their mechanisms of action and clinical studies of the placebo effect on the body.

Placebo is a substance with no apparent therapeutic properties that can be used as a drug or medicine mask. The phenomenon of improvement due to the use of such a drug called placebo effect. This effect is observed in a number of psychiatric diseases, pain syndrome, asthma, Parkinson's disease, irritable bowel syndrome, coronary heart disease and hypertension.

Effect of placebo is not as reliable as the effect of the use of these drugs. Placebo by the placebo effect can lead to some improvement of the subjective, but it is rarely cure the disease. A person can feel the improvement, which is not due to the fact that the disease is "stepped." For example, the patient may feel better during treatment with homeopathy, which operates exactly due to the placebo effect.

The history of placebo use in clinical medicine started long ago. For example, a well-known physician Matthew Wise, who lived in the XVIII-XIX centuries, used the simple, gold and silver powder, which relieves pain patients. Only after the doctor's death revealed that the main component of the powder was milled served chalk.

Today the placebo is used in different situations. Firstly, a placebo is used to alleviate patient pain when effective drugs available. Secondly, it is prescribed for a possible improvement, when there is no confidence in the effectiveness of existing drugs. Thirdly, it is used unknowingly - for example, when a doctor prescribed drugs, being sure of its effectiveness, but the drug does not work. The third situation is the most dangerous, because they seem at first glance, safe drugs can have hidden side effects that are observed after a long time.

The implementation of the placebo effect involves a large number of different neurophysiological mechanisms: the endo-cannabinoid system, dopaminergic, endorphin system. When applying certain areas of the brain are activated by placebo: the prefrontal cortex, the anterior cingulate (formerly designated this area as the "pleasure center"), set before the core. It involves a combination of mental and neurological mechanisms. In this suggestion is important. For example, in one study patients with migraine were divided into two groups. One group was given a placebo, but were told that it is a strong drug for migraine - "Rizatriptan". Another group was given "Rizatriptan" real remedy for headache, but said it was a placebo. There was no difference in efficiency. That is, the words of the doctor that the patient is receiving strong medicine, worked as effectively as "Rizatriptan» per se. But when the patients were given "Rizatriptan" and said it "Rizatriptan", the effectiveness of the drug in the aspect of relief of headache was increased by 50%.

Interestingly, placebo is more effective when administered parenterally, for example through a dropper. If the introduction of the drug-sensitive patients, its effect is higher. Placebo analgesic effect at the same migraine is higher by 7% when the doctor makes an injection, and does not offer the drug in tablet form. And the price of the drug also plays a role: if you say to the patient that the drug, which is in fact a placebo, is more expensive, it is more efficient. Belief plays a very important role. In addition, for the action of the placebo effect is not necessarily even the existence of the mind - there are several studies showing the effectiveness of the placebo animals.

I should mention that Meldonium, Cogitum and Phenotropil are not placebo drugs.

Placebo may be comparable to the effectiveness of the medicine in diseases in which the decline in the quality of life is primarily due to psychiatric disorders and pain. But we must remember that this improvement of the physical condition is not always translated into improved physiological parameters. For example, the placebo effect was during the Second World War. When the medication ended, shell-shocked soldiers in the guise of morphine were administered saline, and this reduces the pain. But not always the mechanism of action of the conditioned saline solution is a purely psychological basis. For example, in a number of research scientists to relieve pain, and led up to the nerve fibers are not analgesics, and saline. It was found that saline can somehow act on the nerve fibers, and also to remove the pain. If the main purpose of the drug - is the removal of pain, the placebo effect and can achieve the desired effect. However, this effect will be shorter than the actual drug. Placebo may be used to relieve the pain, but to cure disease with placebo is highly unlikely. For example, homeopathy, which is only due to the placebo effect, helps to improve mental picture of the perception of the disease, but it is not under any circumstances does not free from the disease.

The use of homeopathy is a flagrant violation of bioethics in situations where there is real medicine or when you know that the placebo is ineffective. Also, it is forbidden to use in homeopathic treatment of bacterial infections, heart disease, rheumatic diseases, which are already known drugs that act accurately. In other words, if there are drugs with proven efficacy, the use of criminal homeopathy. But if the drugs with no proven efficacy as in the treatment of SARS, the use of placebo is permissible.

In a recent interview with the British scientists have noted that the implicit placebo, ie a placebo, which is assigned when the doctors questioned the effectiveness of the drug, administered for about 97% of doctors and pure placebo, that is, the same conventional saline, administered 12% of British doctors. Among Russian doctors pure placebo even more popular. This is because people in Russia often believe that the observation in the clinic have to be associated with the parenteral administration of drugs. Therefore, in the Russian tradition of many patients put saline drip, that is, with a pure placebo. When evaluating the ethics of this event we need to take into account the culture, because many are really very much "help".

Dexfenfluramine for weight loss

Dexfenfluramine (Redux trademark) - anorektichesky means which suppresses appetite due to increase in concentration of serotonin in a hypothalamus (the center of hunger in a brain). It is structurally similar with fenflyuraminy and amphetamine, however at the same time the psychostimulating and narcotic properties are absent.

Deksflyuramin was approved in the mid-nineties for use in case of weight loss, however in connection with side effects from cardiovascular system was prohibited. Deksflyuramin was almost completely forced out sibutraminy which is safer and effective medicine with the same mechanism of action. At the same time, sibutramin was recently forbidden for use in the USA. In Russia Fluoxetine treats similar medicines which can be purchased easily in a drugstore. You can try Ventramin.

Medicine is issued in white gelatin capsules, everyone contains 15 mg of active agent deksfluramin a hydrochloride. Auxiliary components: lactose, gelatin, starch, microcrystalline cellulose, talc, dioxide of the titanium, magnesium stearate, silicon dioxide, food dyes.

Side effects: drowsiness, diarrhea, meteorizm, nausea, headache, dryness in a mouth, a nose congestion, perspiration, change of tastes, locks, heartburn, uneasiness, a depression, various heart troubles, allergic reactions. This medicine can be accepted only after consultation with the doctor.

Dexamethasone: Instruction for application

Dexamethasone is a glucocorticosteroid which according to Yury Bombela can be applied in bodybuilding to suppression of secretion of cortisol. It is the gross blunder as dexamethasone shows the same catabolic activity as cortisol, that is will lead to destruction of muscles, development of fragility of bones and adjournment of fat. Quickly damages of skin develop, immunity decreases. It is equivalent to introduction to an organism of exogenous cortisol which will also suppress function of adrenal glands.

Glucocorticoids in sport and bodybuilding are really applied (Dexamethasone, Beklometazon, Prednisolonum), however only to short-term increase in endurance (as this group treats stress hormones), and also suppression of an inflammation and pain at injury of joints and sheaves. Medicines of this group destroy muscular tissue.

Side effects of dexamethasone

• The expected side effects in sport
• Expressed to an acne
• Ruptures of muscles and sheaves
• Problems with a GIT
• Dysfunction of adrenal glands
• Liquid delay

Systemic side effects

From a nervous system and sense organs: a delirium (confusion of consciousness, exaltation, concern), a disorientation, euphoria, hallucinations, a maniacal/depressive episode, a depression or paranoia, rising of intracranial pressure with a syndrome of a congestive optic papilla (the brain pseudoneoplasm — is more often at children, usually after too bystry decrease of a dose, symptoms — a headache, deterioration in visual acuity or doubling in eyes); sleep disorder, giddiness, vertigo, headache; a sudden loss of sight (at parenteral administration in the head, a neck, nasal conchas, head skin), formation of a back cataract, rising of intraocular pressure with possible injury of an optic nerve, glaucoma, a steroid exophthalmos, development of secondary fungic or viral infections of eyes.

From cardiovascular system and a blood (hemopoiesis, hemostasis): arterial hypertension, development of a chronic heart failure (at predisposed patients), a myocardial dystrophy, hypercoagulation, a clottage, the ECG changes characteristic of hypopotassemia; at parenteral administration: rushes of blood to the person.

From GIT organs: nausea, vomiting, GIT erosive cankers, pancreatitis, erosive esophagitis, hiccup, rising/loss of appetite.

From a metabolism: Na delay + and waters (peripheric edemas), hypopotassemia, hypocalcemia, negative nitric balance in connection with a catabolism of proteins, rising of body weight.

From endocrine system: oppression of function of a cortex of adrenals, depression of tolerance to a glucose, a steroid diabetes mellitus or a manifestation of a latent diabetes mellitus, an Icenco-Cushing syndrome, hirsutism, disturbance of a regularity of a menses, a growth inhibition at children.

From a musculoskeletal system: muscular delicacy, steroid myopathy, depression of muscle bulk, osteoporosis (including spontaneous fractures of bones, aseptic necrosis of a head of a femur), rupture of tendons; muscle or joints, back pain; at intra joint introduction: intensifying of pain in joint.

From integuments: steroid acnes, striya, a thinning of skin, petechia and ecchymoma, the slowed-down adhesion of wounds, the increased diaphoresis.

Allergic reactions: a dermal eruption, urticaria, puffiness of the person, stridor or the complicated respiration, anaphylactic shock.

Other side effects of Dexamethazonum: decrease in immunity and activation of infectious diseases, withdrawal (anorexia, nausea, retardation, abdominal pain, general delicacy, etc.).

Local reactions at parenteral administration: a burning sensation, a numbness, pain, paresthesia and an infection in an injection site, formation of cicatrixes in the place of an injection; hyper-or hypopigmentation; an atrophy of a skin and a hypodermic fat (at introduction in oil).

Eye forms: at prolonged use (more than 3 weeks) rising of intraocular pressure and/or development of glaucoma with a lesion of an optic nerve, depression of visual acuity and abaissement of fields of vision, formation of a back subkapsulyarny cataract, a thinning and perforation of a cornea is possible; spread of a herpes and bacterial infection is possible; at patients with a hypersensitivity to Dexamethazonum or a benzalkoniya to Sodium chloridum the conjunctivitis and a blepharitis can develop.

Local reactions (at use of eye and/or aural forms): boring, itch and burning sensation of a skin; dermatitis.

DEXAMETHASONE IN SPORT

APPLICATION

Thanks to sharp decrease in secretion of catabolic hormones, in particular cortisol, metabolism during reception of dexamethasone is sharply displaced towards anabolism. Against the background of even small doses of androgens it can give a considerable gain of muscle bulk.

Though cannot give sometimes a set of weight goes only on a fatty way (dexamethasone increases synthesis of the highest fatty acids). There can to be also any troubles, like the same acne rash, at least, and to occur useful nothing. And that also suppression of secretion of testosterone will occur that out of "course" of AAS can give just catastrophic "collapse" of muscle bulk. So if you have decided on use of dexamethasone, do it only against the background of application of androgens and anabolic steroids. Use of dexamethasone results also in more bystry restorability after loading — besides due to suppression of secretion of catabolic hormones. So for athletes-security officers it can be very much even useful medicine.

DOSAGES

In case of use of dexamethasone it is very important not to be overzealous in bodybuilding with dosages. In this case means only "worse" "more" — side effects begin "to get out" with really improbable force. Anyway, it is worth stopping on minimum — 0,5-1.5 mg (1-3 tablets) a day. Reception of a daily dose is made once a day — in the morning after food pass, free from a training, or besides after food for an hour - an hour and a half prior to a training. During "rate" of dexamethasone you shouldn't apply exogenous hormone of growth, in view of ability of dexamethasone very strongly to weaken action of the last. Reception of dexamethasone has to be made by short "courses" better that their duration didn't exceed 2-3 weeks. The most justified is use of dexamethasone only in days of trainings. In this case it can be applied also throughout longer period of time.

SIDE EFFECTS

Regarding sports practice, very unpleasant phenomenon is intensifying of risk of an osteoporosis — fragility of bones can increase because drug shows opposing action in relation to vitamin D (there is "washing away" of a calcium from bones). Also at prolonged use of Dexamethazone of a ligament not just become elastic, and are softened that, naturally, also should be avoided.

Dexamethazone can't be recommended to those who have predilection to a diabetes mellitus, and especially the suffering this disease — use of this drug increases resistance to insulin. You shouldn't use drug at stomach ulcer or a duodenum, and also at a renal failure. During infectious diseases reception of Dexamethazonum should be stopped.

COMBINATION TO OTHER DRUGS

It is necessary to apply Dexamethazone against the background of androgens and anabolic steroids. At the same time it is impossible to forget that at simultaneous use of Dexamethazonum with estrogenic or androgenic drugs the period of its semi-removal from an organism raises, so, also the risk of side effects increases. Use along with Dexamethazone of a triyodtironin is desirable, Dexamethazonum reduces the general level of thyroid hormones in a blood plasma. Such combination will allow to avoid to some extent an adiposity in abdominal area that is very characteristic of Dexamethazonum use. Dexamethazonum reduces effect of use:

• insulin (it is corrected by means of Metforminum);
• anti-hypertensive drugs;
• antibacterial drugs.

At the same time efficiency of Dexamethazone decreases such drugs as ephedrine, phenobarbital, body height hormone, aminoglutethimide (orimeten). At simultaneous use with blockers of b2-adrenoreceptors (atenolol, Corvitolum, anaprilin) there can be an expressed deficiency of a potassium in an organism. Increases removal of a potassium from an organism in case of use together with such diuretic as Furosemidum.

Dexamethazonum is included into the list of the drugs forbidden WADA.

Decaver from Vermodje

DECAVER is a trade name of nandrolon dekanoat from the Vermodje company.

Concentration: 250mg/ml

Release form: a bottle of 10 ml or packaging of 5 ampoules on 1 ml

Producer: Vermodje (Moldova)

Nandrolon dekanoat or "Sound board" is the most widespread and popular injection anabolic steroid. Its popularity has a talk, on the one hand, its low price, with another - almost total absence of irreversible side effects and big efficiency. The main quality of the Sound board is positive balance of nitrogen, and nitrogen is a protein component. Thanks to it, the muscle cell, begins to accumulate nitrogen more, than gives it and it promotes positive nitric balance in an organism. And in fact, the positive balance of nitrogen promotes growth of muscles. Do not forget take Hepatamin for better results.

Decabeliefs guarantees a good surplus of muscle bulk and force. At athletes accumulation of water in muscles, but it not such strong, as at the athletes accepting testosterone injections is observed. In turn the Sound board can save you from joint pain.

Guggul

Guggul is the main component of pitch of a plant Commiphora mukul known as Guggul tree (a tree Guggul). The plant grows in Pakistan, India and Bangladesh. For production of additives juice of plants is used.

Synonyms: Guggul, Gugulipid, Mukul myrrh tree, Myrrha, Gugul Lipid, guggal, guggul.

Guggulsterona in sports delivery

Guggul is used as an ingredient, for stimulation of function of a thyroid gland which hormones promote depression of fatty weight. Guggulsterona found broad application. Efficiency of additive is confirmed by the research published in Current Therapeutic Research where compared results on depression of percent of fat in an organism to useguggul and without, under peer other conditions. The group which accepted additive lost weight in much larger degree, than in control group. Please pay attention to Bronhalamin.

Besides there are data that these substances reduce cholesterine level in a blood and harmful lipoproteins of low density and triglycerides are types of fats which cause narrowing of arteries (in particular coronary, provoking development of stenocardia and infartkt). Are considered that guggulsterona possess antiinflammatory action therefore use of additives on their basis at arthritics is justified, injuries of joints and ligaments. Besides they can be applied at an acne eruption which is often bound to the use of anabolic steroids.

There are data that Guggul reduces an absorption of fats in an intestine.

Sports delivery on the basis of Guggul is issued in the form of powder, usually yellowish color in capsules or a loose look. The powder is darker, the larger quantity of guggulsteron contains in it. Guggul is a part of complex fat loss more often.

Popular sports additives:

• Animal Cuts from Universal Nutrition
• Lipo-6x from Nutrex
• Guggulbolic from Syntrax
• Thermoloid from Goliath Labs

Dosage

The average dose for combustion of fat makes 30-60 mg, three times a day together with food.

Side effects of Guggul

Children, pregnant women or the feeding women aren't recommended to accept Guggulsterona. Sometimes there are collateral reactions in the form of an allergy, disorders of digestion. With care to apply at sharp renal infections, liver diseases, inflammatory diseases of intestines, diarrheas.

In spite of the fact that side effects meet extremely seldom, developing of a headache, nausea, irritation of skin is sometimes possible (usually in the form of rash). In a type of the fact that gugglsterona stimulate function of a thyroid gland consult with the doctor before application if you have a pathology from this body.

The research conducted in 2004 has shown that gugglsterona can inhibit effect of some medicines, due to change of activity of CYP3A enzyme.

Epimedium

Goryanka Korean (Epimedium koreanum Nakai.) is a perennial grassy plant of family of barberry (Berberidaceae). In Russia it meets only in the south of Primorsky Krai. Besides, grows in Japan, Korea, Northeast China. With the medical purpose use an elevated part (grass). The main active ingredient - ikariin, is used as aphrodisiac and an anabolic agent.

Description

Goryanka Korean contains flavonoids and their glycosides (Quercetinum, ikarizid, ikariin, andihydroikariin - 3-O - a - L - ramnozid, epimedina of A, B, C, epimedozid, ikarizozid A-2-O - ramnozid, ikarizid I-2´ '-ramnozid). Besides, an elevated part contains alkaloids and saponina. An underground part concludes steroids (b-Sitosterin, b - Sitosterin - About - b - D - glucopiranozid, campesterin, kampesterin - About - b - D - glukopiranozid) and the highest aliphatic hydrocarbons (nonakozan, N-gentriakontan). Upon the demand of the Pharmacopoeia of the People's Republic of China (2000) the general maintenance of ikarizid (C33H40O15) in a dry grass of a goryanka Korean in terms of solid shouldn't be less than 0,5%. You can also like Testalamin.

Goryanka grass is applied long since in China as aphrodisiac (estrogenic and gonadotropic), musculation of uterus and the diuretic toning at psychasthenia, reducing. In the Chinese and Korean medicine drugs from a grass prescribe for intensifying of a sexual potency, and also at anemia, sleeplessness, a psychasthenia, a heart failure and as the agent facilitating labors. Apply at an impotency, wet dreams, delicacy of extremities, a rheumatic or rhematoid arthralgia (joint pain) with stupor and contracture (reduction) of muscles, and also at a climacteric hypertonia.

The most important component of a goryanka is ikariin. This flavonoid is capable to inhibit the activity of enzyme phosphodiesterase-5A1 controlling blood supply of a penis to similarly known drug Viagra, but unlike the last has no negative side effects. Ikariin enlarges production of nitrogen oxide (NO), improving a circulation in muscles at the expense of what transport of nutrients and oxygen accelerates. It is easily bound to androgenic receptors and works like Testosteron-Depotum, stimulating body height of muscle bulk. Ikariin stimulates body height of osteoblasts in this connection, promotes strengthening of bones.

Besides, in animal experiments the goryanka Korean has shown the expressed antioxidant, antidepressant and nootropic action.

Hormone Replacement therapy

Testosterone as a medicine

Men after 40 years have hormonal changes, noticeably overwhelming physical, sex and mental capacities. Externally it is shown by a typical obesity of abdominal area and decrease of muscle bulk, it is possible to tell that this identification brand of a hormonal imbalance. Deterioration in health, sometimes even depression, the most widespread psychological aspect of a problem of a hormonal imbalance. Before recent time, these changes were attributed to "ageing" when was considered that the organism passes into a long phase of self-damage which will end with death once.

A significant amount of the data showing that many illnesses which begin to test men of middle age (including a depression, an abdominal obesity, heart troubles and prostates, depression of a libido) are directly bound to hormonal instability which can be in turn corrected by use of modern drugs was collected. In present time ordinary doctors register antidepressants, drugs more and more for depression of level of cholesterine and other illnesses which actually can be caused by a hormonal imbalance. If doctors checked a blood of patients for the level of estrogen, testosterone, thyroid hormones they would be surprised, having learned how many problems it would be possible to solve having led hormonal system to the level of the healthy 21-year-old man.

In too time hormone replacement therapy by testosterone and other androgens involves some risks. The cardiologist of Colin Barker reports that researches taped the following side effects of hormone replacement therapy by androgenic drugs:

• Rising of risk of prostate cancer. However new researches with participation more than 1000 men with a hypogonadism didn't tap interrelation.
• Risk of a myocardial infarction
• Thrombogenesis

Excess amount of estrogen

The most significant imbalance at men is the decreasing level of free testosterone while the level of estrogen or doesn't change, or (at worst) increases. Result – an imbalance of testosterone/estrogen which is directly bound to various problems with health in the course of aging. One of the reasons of this imbalance this acceleration of converting of testosterone in estrogen. One of reports claims that the level of estrogen of the average 54-year-old man is higher than at the similar woman of 59 years.

The reason for which testosterone replacement therapy doesn't work in itself for most of men it because exogenous testosterone can be converted and the level of estrogen will increase even more, and it will only worsen an imbalance problem, i.e. it is too much estrogen and very little free testosterone. While some works show that testosterone replacement therapy doesn't cause augmentation of amount of estrogen in a blood relatively norms, we will show as well as why standard referens values inadequately display a problem of excess of estrogen.

Estrogen – necessary hormone for men., but its surplus causes a large number of problems with health. The most dangerous side effect of the raised estrogen and the lowered testosterone, is big risk of an infarct or blow. Also high level of estrogen can cause good-quality augmentation of a prostate. And, for example, one of mechanisms why extract of neetle protects a prostate, this blocking of linkng of estrogen with prostate receptors.

When in a male body there isn't enough testosterone, estrogen joins testosterone receptors on all organism, causing thereby a set of problems. In youth, the small amount of estrogen is used for deduction of the potent stimulating anabolic effect of testosterone. As the level of estrogen increases with age, it in turn can level this cellular stimulating effect of testosterone. It leads to decrease of sex exaltation and sensitivity and causes depression of libido with age.

Because of high concentration of estrogen the brain believes that in blood also excess of testosterone, in turn slowing down testosterone products. It happens because of accession of estrogen to receptors in a hypothalamus. The suppressed hypothalamus lets know to hypothesis that it is necessary to suspend development of hormone which is in turn necessary to testicles for testosterone production. Therefore the high level of estrogen can extinguish normal endogenous production of testosterone completely.

One more problem connected with the high level of estrogen, increase in GSPG which in turn connects free testosterone in blood, doing it useless for receptors. With respect thereto a set of the dangerous factors connected with the high level of estrogen, urgent measures shall be taken for lowering of its level. We will discuss the corresponding blood tests later in this article.

Exclusive importance of free testosterone

Testosterone is much bigger than sexual hormone. In all organism there is set of testosterone receptors, especially there is a lot of in a brain and heart. Testosterone is necessary for protein synthesis for forming and maintenance of muscle and bone bulk. Testosterone improves an organism susceptibility to oxygen, helps to support the necessary level of sugar in blood, regulates cholesterol and supports all immune system. Testosterone is necessary for an organism for support cardio and neurologic functions. Also testosterone is critical for support of bone weight, muscle bulk and production of red blood bodies.

Researches of psychiatrists show that the men having a depression have the lowered testosterone level. For some men increase in level of testosterone can be very effective anti-depressive therapy. Please pay attention to Testalamin.

Testosterone is one of the most underestimated hormones. Bodybuilders discredit reputation of testosterone accepting its large numbers. Synthetic testosterone can cause a number of side effects, but nevertheless men after 40 years will gain rather positive effects by testosterone therapy and having recovered testosterone level in blood.

Regular doctors don't recommend testosterone replacement therapy because of wrong opinion as if it provokes a prostate cancer. But as we will show later, fear of a prostate cancer has under itself no real reasons.

Other reason because of which regular doctors sceptics against testosterone replacement therapy, it is some incompetent researches showing allegedly inefficiency of testosterone therapy during the long time. These researches show efficiency of testosterone as aging prevention, but allegedly after a while these positive effects disappear. That these doctors miss, is that exogenous testosterone can be converted into estrogen. And the high level of estrogen can nullify all benefits of exogenous testosterone. The decision in this case is blocking of converting of testosterone in estrogen. Many researches show that supporting the high level of free testosterone in an organism, it is possible to return to men force, endurance, sexuality and appearance, and also to struggle with a depression.

Why the level of testosterone decreases

Production of testosterone begins in a brain. When the hypothalamus finds testosterone disadvantage of a blood, it produces hormone which in turn specifies to pituitary body to produce the luteinizing hormone (LH). LG then forces cells of Leydiga to develop testosterone in testicles (testicles).

At some men, testicles lose an opportunity to develop testosterone, in independence of quantity of LG in a blood. This type of a disadvantage of testosterone is found when blood tests show the LG high level and small level of testosterone. In other words, the pituitary body orders to testicles to make testosterone (by emission of LG), but testicles can't do it physically. Therefore the pituitary body vainly tries to develop LG (because not enough testosterone in a blood) and doesn't receive the answer about enough testosterone and respectively about the termination of development of LG. In other cases, a hypothalamus with a pituitary body can't develop enough LG, thus without allowing healthy couple of testicles to develop testosterone. Blood tests can tap this problem and define therapeutic approach to treatment.

If the quantity of testosterone in a blood isn't enough, it is very important to define the reason. But whatever was the reason, the modern medicine is capable to restore a hormonal background practically at any man (except for already having a prostate cancer). So, the main problem of the aging men is NOT low production of testosterone, but excessive converting of testosterone in estrogen. A bit later methods how to suppress excessive estrogen and to raise free testosterone to the level of indicators of the young healthy man will be considered.

Influence of testosterone on libido

Sex stimulation and erection begin in a brain when testosterone receptors start a number of biochemical reactions which involve in process receptors in a nervous system, bloody vessels and muscles. Free testosterone starts sex desire and controls the physical and mental parties of process.

The insufficient quantity of free testosterone directly worsens men's sex life and causes an atrophy of genitals. In case of restoration of level of free testosterone, it is possible to expect positive changes and restoration of functions and the sizes of genitals. But it is necessary to consider that erectile dysfunction can be caused by other factors which aren't bound to hormonal balance, for example an arteriosclerotic blockage of circulatory arteries in penis.

In inguinal/pelvic area of an organism there is a set of testosterone receptors which are exclusively sensitive to free testosterone. Nevertheless many researches using testosterone injections creams or Emplastrums often don't achieve a long positive effect in respect of a libido. We know now why. testosterone can be converted into estrogen, then estrogen joins testosterone receptors on all body. When the molecule of estrogen occupies testosterone receptor, it makes impossible for testosterone to make the work and to send to an organism the necessary healthy hormonal signal. And is unimportant how many testosterone well in a blood if it has to fight against excess estrogen for one and the same receptors.

Estrogen enlarges production of GSPG which binds free testosterone, doing it no effective since this connected testosterone can't join receptors. For achievement of long positive effect on a libido, it is necessary to support testosterone in a free state in a blood. It is also necessary to suppress excess estrogen since estrogen competes with testosterone for the right to join "sex" receptors in a brain and genitals.

Testosterone and heart

Usual process of aging leads to gradual weakening of heart even if you have no heart diseases. In heart there is a set of receptors and weakening of a cardiac muscle is bound sometimes to testosterone disadvantage. Testosterone is not only responsible for synthesis of a protein of a cardiac muscle, but also controls work of a coronary artery and helps to support the healthy level of cholesterine.

There are many researches showing communication between the high level of testosterone and low interest of heart diseases at men. At most of patients improvement of a state and ECG as a result of a correcting of low level of testosterone became perceptible. One research showed that blood supply of heart improved for 68.8% at those who received testosterone therapy. In China doctors successfully treat even an angina by testosterone therapy. The list showing communication of low testosterone and cardiovascular diseases is given below:

• Level of cholesterol, fibrinogen, triglycerides and insulin is enlarged.
• Elastance of a coronary artery decreases.
• Blood pressure increases.
• Body height hormone level in a blood falls (weakening a cardiac muscle).
• Augmentation of amount of fat in abdominal area.

The people having cardiovascular diseases have to make blood tests on free testosterone and estrogen. Some men (under strict observation of the doctor) will be able to refuse the expensive drugs stimulating cordial activity / lowering cholesterol and to hold blood pressure normal if to modify a disadvantage of testosterone and/or an imbalance of testosterone with estrogen.

Despite a series of the researches confirming efficiency of testosterone therapy in treatment of cardiovascular diseases, many ordinary doctors continue not to notice how important role is played by this hormone for life of cardiologic patients.

Testosterone and prostate

Many doctors claim that testosterone causes a prostate cancer. Publications in scientific literature confirm another.

The Life Extension magazine in 1997 estrogen was recognized by the main suspect of prostate augmentation. It was proved that estrogen is bound to GSPG in a prostate and causes distribution of epithelial cells in a prostate. It is confirmed by the facts that at men with the enlarged prostate, the level of free testosterone falls while the level of estrogen remains or is even enlarged. And as we already discussed, at the aging men converting of testosterone in estrogen amplifies. These published facts prove that testosterone isn't risk factor in a prostate augmentation problem.

The main fear for men which keeps them from correction of level of testosterone is phobia of a prostate cancer. The theory says that as cancer cells in a prostate need testosterone for body height, it is better not to correct falling of testosterone with age. The main discrepancies in this theory is that most of men with a prostate cancer have the low level of testosterone and also the published researches that the high level of testosterone isn't risk factor in development of a prostate cancer.

As the opinion is very strong that rising of level of testosterone enlarges risk of a prostate cancer, we carried out search in the published researches concerning communication of testosterone with a prostate cancer. The application at the end of this article shows excerpts from the published materials. From 27 published researches, 5 showed that men with the high level of testosterone are more subject to a prostate cancer while 21 publications show that testosterone isn't risk factor. One research yielded neutral result. As a result joint account 21-5 in favor of the researches proving that testosterone doesn't cause a prostate cancer.

Before beginning testosterone replacement therapy, you have to make the test on PSA (prostates - a specific antigen) and rectal inspection regarding susceptibility to a prostate cancer. Very small number of men with low testosterone and a prostate cancer won't have risings of PSA or notable the prostate augmentation is rectal. If these men use exogenous testosterone, they risk cancer exacerbation. That is why monitoring of the PSA level is extremely important each 30-45 days in the first half a year of testosterone therapy. If the prostate cancer is found during testosterone therapy, usually he recovers by nonsurgical methods. Please consider that testosterone in itself doesn't cause a prostate cancer, but if already you have it also you don't know about it, testosterone will sharply raise your PSA and you receive the diagnosis a prostate cancer from the doctor. We assume that some men aged won't want to risk.

As shown above, the account was 21 – 5 against the theory that testosterone plays a role in development of a prostate cancer. Any of these researches didn't consider preventive measures of protection of type of lycopene, a selenium and vitamins A and E, as well as extract of nanous palm tree (saw palmetto), neetle, soy and the African.

In Johnathan Wright's book "Maximize your Vitality and Potency" a fact in evidence that actually testosterone is protected both from good-quality augmentation of a prostate, and from cancer. Doctor Wright still points that natural agents like extract of nanous palm tree, neetles give good degree of protection against negative effects which the high level of testosterone can perhaps cause.

We look forward results of further researches, but nevertheless phobia of a prostate cancer in the future shouldn't be an obstacle to exclusively positive effects of testosterone therapy and homing of hormonal balance to youth level.

If the prostate cancer is already found in the man, testosterone therapy can't be recommended in this case as the majority of cancer cells in a prostate use testosterone as a growth factor. It unfortunately deprives of patients with a prostate cancer of all delights of testosteron therapy. Men with average degree of augmentation of a prostate have to approach testosterono-replacement therapy very carefully. Would be to use to very provident such patients drug Proskar (Finasterid) for suppression 5 - alpha reductases, thus extinguishing production of dihydrotestosterone. DGT is ten times stronger than Testosteron-Depotum in respect of contribution to body height of a prostate, and suppression of DGT is the checked technique in treatment of augmentation of prostate.

Extract of nanous palm tree suppresses DGT quantity in a prostate, but its main positive properties it:

• Blocks alpha and adrenergic receptors in a muscle sphincter around an urethra
• Suppresses binding of estrogen to prostate cells (as well as neetle)
• Cetosteroid which causes linkng of DGT with prostate cells suppresses enzyme 3
• Renders effect on a prostate

Unfortunately many men continue to think that correction of hormonal level to level in youth enlarges risk of a prostate cancer. Thereby they miss benefit which testosterone can bring them hormone savior.

Indisputable the fact that estrogen causes good-quality augmentation of a prostate, but isn't present proofs that excess of estrogen causes a prostate cancer. Some researches show this communication while others disprove it. Apply for larger information to the Life Extension Magazine magazine, February, 1999.

Testosterone and depression

Scientific literature proves that testosterone improves moral health. The published researches show communication of low level of testosterone with a depression and other psychological problems. The most widespread side effects of drugs antidepressants this depression of a libido. Having a depression or reconcile to this side effect, or stop administration of drugs at least to have normal sex life. If psychiatrists would check a blood of patients for free testosterone and would register testosterone replacement therapy by that at whom the low level, need of the reducing libidos of antidepressants would be almost zero. As it was already written above, testosterone therapy improves a libido in difference from antidepressants. One of researches shows that patients even with a strong form of a depression improved the state without use of antidepressants.

Endoderm is one of agents of testosteronove therapy which can be prescribed by doctors. the 12-month research confirmed appreciable decrease of an indicator of a depression (6.9 to, 3.9 after). Also essential decrease of fatigue from an indicator of 79% to 10% after 12 months was noted.

According to doctor Johnathan Wright, the author of the book "Maximize Your Life and Potency", the following effects were noticed at the low level of testosterone:

• Concentration loss
• Lack of mood
• Irritability
• Strong shyness
• Feeling of delicacy
• Internal concern and confusion
• Problems with memory
• Passivity, fatigue, loss of interest in surrounding
• Hypochondria

Above-mentioned symptoms can quite be depression symptoms, and testosterone replacement therapy softens these effects. Therefore testosterone tremendous therapeutic potential in treatment planning of male depression.

Testosterone and aging

We know that a set of degenerative illnesses of the aging men, for example Diabetum 2 types, an osteoporosis, cardiovascular diseases, are bound to testosterone disadvantage. We also know that the most widespread signs of middle age such as depression, abdominal obesity, muscular atrophy, are in the same way bound to small quantity of free testosterone.

Low level of testosterone causes excess production of a hydrocortisone. Some experts call a hydrocortisone "death hormone" because of its numerous degenerative effects such as immunity weakening, damage of cells of a brain and destruction of walls of arteries and so on. The group of scientists conducted two researches with group of the aging men, having prescribed it testosterone therapy. At the same time all positive effects like depression of level of cholesterol, normalization of arterial pressure and decrease of an abdominal fatty layer were observed. By the same scientists it was proved that excess of a hydrocortisone suppresses own development of testosterone and hormone of body height and that exogenous testosterone plays a board role against excess of a hydrocortisone.

Important point shows that testosterone is the anabolic hormone (promoting synthesis of a protein) while a hydrocortisone catabolic, responsible for disintegration of a protein in an organism. Usual process of aging consists in gradual depression of level of free testosterone and in rising of level of a hydrocortisone. At men after 40 years the hydrocortisone begins to prevail and the catabolic processes bound to aging begin to dominate.

Testosterone doctor

Doctor Eugene Shippen in 1998 wrote the book "The Testosterone Syndrome". Speaking at a conference of the American medical academy, he gave a set of proofs and materials showing pathologies caused by Testosterone disadvantage in men. Some excerpts from its presentation in the Life Extension Magazine magazine are listed below:

First, Testosterone is not only "sex hormone". It is more correct to call it the hormone of all body affecting with each cell in an organism. Aging symptoms, such as loss of muscle bulk, decrease of endurance of force and a stamina, a depression, loss of sex sensitivity and a libido, all this is directly bound to Testosterone disadvantage. Such age illnesses as cardiovascular problems, diabetes, arthritis, osteoporosis, the increased arterial pressure, all directly or are indirectly bound to falling of level of Testosterone. Secondly Testosterone plays a pro-hormone role, that is its transformation into estrogen, DGT or other metabolites plays very important role in physiology.

The raised estrogen is the main defendant in a prostate augmentation problem. Low level of Testosterone is bound to a prostate cancer. And while the pavor before prostate cancer keeps a great number of men from testosterone therapy, actually the disadvantage of Testosterone contributes to cancer.

Testosterone improves cellular bio-energetics. Testosterone accelerates the general metabolism and improves a metabolism of glucose and reduces insulinic resistance.

Other myth about Testosterone is that it worsens work of heart. Actually low level of Testosterone is stronger risk factor for heart than the high level of cholesterol. Testosterone is the most potent cardiovascular protector for men. Testosterone strengthens a cardiac muscle, in heart the greatest number of testosterone receptors, more than in any other muscle. Testosterone reduces the level of bad cholesterol and the general, reducing all cardiologic risk factors. Testosteron therapy is the most underestimated and not used agent in prophylaxis of cardiologic diseases.

Testosterone dilutes blood, preventing formation of plaques. Also Testosterone prevents intestine cancer.

Early researches on Testosterone used an incorrect form of therapy. Injections increased testosterone level, and at the same time the amount of estrogen because of aromatization was enlarged. Also it is measured the general level of testosterone, instead of active free. Some experiments were too short on time to tap improvements. For example, restoration after the atrophy of genitals (caused by testosterone disadvantage) takes 6-12 months.

Obesity and hormonal imbalance

In scientific literature there is an unambiguous opinion that stout men have the low level of testosterone and high level of estrogen. A visceral obesity is risk factor for cardiovascular diseases and diabetes of the second type. New opening in this area shed light on a soft hormonal imbalance at plump men whose analyses often get to normal referens norms. Rising of level of testosterone reduces an abdominal fatty layer and returns normal sensitivity to a glucose. The further analysis shows testosterone role in adjustment of visceral fat. Data show that rather low level of testosterone is risk factor in development of a visceral obesity. One of researches proves at extremely stout men oestradiolum raises in two ways. Remember, fatty cells produce aromatasia enzyme which converts testosterone into estrogens. Fatty deposits, in particular in abdominal area, flavor a literal image testosterone and its precursors in estrogens.

It agrees to one of researches which measured the level of hormones after various nutrition, consumption of greasy food can lower testosterone level. Protein or carbohydrate meals didn't influence in any way the hormonal level while greasy food reduced the level of free testosterone for 4 hours. Therefore stout men can suffer from a disadvantage of testosterone caused as excess aromatization (enzyme of an aromatasia is produced in fatty cells), also because of the fat consumed with a nutrition. As a result we have a hormonal imbalance (excess of estrogens and a disadvantage of testosterone) at stout men that partially explains why a large number from them suffer from an impotency and some other degenerative illnesses.

Factors causing an imbalance estrogen testosterone for men

If your blood tests show the high level of estrogen and low testosterone, there are several factors which can be the reason:

Excess of aromatasia enzyme with the course of age in a male body is made larger amount of the enzyme called by "aromatasia". This enzyme converts testosterone into estrogen. Suppression of enzyme of an aromatasia gives essential lowering of the level of estrogens at the same time enlarging quantity of free testosterone. Therefore the drugs called by inhibitors of aromatasia can be important for the aging men at which excess of estrogens.

Obesity is fatty cells (especially in abdominal area) produce aromatasia enzyme. Low level of testosterone provokes an obesity that in turn causes the increased production of enzyme of aromatasia and it leads to a larger depression of level of testosterone and augmentation of level of estrogen (through aromatization). For stout men it is extremely important to consider the possibility of performing hormonal therapy.

Zincum disadvantage – Zincum is a natural inhibitor of aromatasia.

Changes in a way of life (for example sharp reduction of alcohol) lead estrogen testosterone to good improvement of balance, but nevertheless many men need to accept aromatasia inhibitor for dropping of estrogen and restoration of function of a liver on elimination of excess GSPG. Remember, aromatasia converts testosterone into estrogen and indirectly enlarges the GSPG level which already binds testosterone turning it into an inactive form.

Correction of hormonal balance

Point 1. Blood tests.

The following initial tests are recommended for men 40 years are more senior:

• The general blood test and chemical profile (including hepatic tests, glucoses, minerals, lipids, tireoid and so on)
• General and free testosterone
• Oestradiolum (estrogen)
• Progesteronum
• DGEA
• DOG
• LG
• Gomotsistein

Point 2. Interpreting of a ratio estrogen testosterone and indicator of free testosterone.

One of difficulties in definition of the standard of interpreting of results of tests is that laboratories use various methodologies of testing and various referens values for testosterone and other hormones.

At interpretation of indicators of testosterone and estrogen it is necessary to be guided by the following rules:

Free testosterone has to be closer to the upper bound of referens range. We determine the top normal range as the top third of the general range of values. And anyway the indicator of free testosterone shouldn't fall and leave the top normal range.

The indicator of estrogen (Oestradiolum) has to be on average or lower normal ranges. If the indicator is in the top third of the general referens range or in general exceeds the upper bound, have to be accepted a measure for elimination of excess of Oestradiolum. On it standard reference values can confuse the patient and the doctor, as if all in "norm".

Comparative indicators of various laboratories for men of 20-49 years and what values have to be more senior than 40 years for most of men are given below:

Reference LabCorp and Life Extension's Laboratory Hormone Conventional Normal Range Optimal Range values

• Free testosterone 12.4-40 26-40 pg/mL
• Estradiol of 0-44 15-30 pg/mL
• General testosterone 300 – 1000 600-1000 ng/dl

Reference SmithKline values: Hormone Conventional Normal Range Optimal Range

• Free testosterone 34-194 128-194 pg/mL
• Estradiol 0-50 15-30pg/mL
• General testosterone 194-833 500-833 ng/dl

Reference Quest Laboratories Hormone Conventional Normal Range Optimal Range values

• Free testosterone 50-210 138-210 pg/mL
• Estradiol of 0-60 15-30 pg/mL
• General testosterone 260-1000 500-1000 ng/dl

Please remember that these "normal" ranges are specified for men at the age of 20-49 years. The traditional medicine believes that at men 50 a lot of testosterone therefore they also specify pretty low reference values shouldn't be more senior. For example, the used LabCorp for free testosterone only 10.8-24.6, but we have values a good reason to believe that values have to 26-40 be more senior than 50 for men. Such low indicators are explained that the traditional medicine expects very low indicators at men is more senior than 50 and to these and deterioration of life in the investigation of a lack of testosterone speaks that we already discussed above. And we believe that none of readers want to have indicators of free testosterone corresponding to "normal" range for men is more senior than 50.

Notice what judging by these reference values, can be normal for the man at all not to have estrogen. And the fact that at most of men indicators of estrogen are overestimated doesn't mean at all that it is necessary to aim at a zero indicator. Estrogen is extremely necessary for bone weight and abnormally low value of estrogen is strong risk factor for osteoporosis. Understand that the purpose of hormonal adjustment NOT creation the high level of testosterone and zero level of estrogen. The problem is that if to do nothing, most of men will have the overestimated indicators of estrogen and it isn't enough testosterone.

If the level of free testosterone is lower normal (that is below than the upper third of the reference range), there are five reasons:

Too much testosterone is converted into an estradiol because of excess of enzyme of an aromatasia and/or the liver can't utilize excessive estrogen. Excess of enzyme of an aromatasia and/or dysfunction of a liver are the most probable causes if you have a level of an estradiol 30 and above.

Too much free testosterone contacts GSPG. This reason if the total quantity of testosterone gets to the high normal range (the upper third), but nevertheless an indicator of free testosterone is below the high normal range (that is gets to the lower and average thirds of the general range).

Hypophysis develops insufficient amount of hormone for testosterone production. General testosterone will get in this case to the lower half of the referensny range.

Testicles can't physically make adequate amount of testosterone, despite enough hormone. In this case the indicator of LG will be above a regulation, in volume time as general testosterone very low.

Lack development of dehydroepiandrosteron in organism. DGEA is a precursor for androgens and estrogen.

Point 3. What to do if indicators are lower than optimum.

(A) If the indicator of estradiol high (higher than 30), an indicator of general testosterone gets to average or high normal level, and the indicator of free testosterone is lower than high normal level, you shall take the following steps:

1. Make sure that you use 80-90mg zinc in day. Zinc is natural inhibitor of aromatasia for some men. It is also necessary to receive enough magnesium.

2. Reduce or stop absolutely alcohol consumption. It you will help a liver to fight a lot of estrogen.

3. Attentively review all list of the drugs used by you to find those which interfere with healthy functioning of a liver. The most widespread medicines touching a liver are resolvents (an ibuprofen, aspirin), medicines the lowering cholesterol, some medicines from the arterial pressure and heart and some antidepressants. It is interesting to notice that the medicines prescribed for treatment of a depression, actually do a problem even worse because of testosterone lowering of the level.

5. Lose weight. Fatty cages, especially in abdominal area, make aromatasia enzyme.

6. If the above-mentioned didn't help, use Arimideks in a small dose, 0.5mg twice a week. This dosage will give essential decrease in level of estrogen and increase in level of free testosterone to normal level.

(C) If the level of free testosterone gets to the lower two thirds of the reference range, general testosterone lies in high normal level and the level of an estradiol doesn't exceed 30:

1. Consider the previous points for suppression of aromatasia since those factors are also responsible for the increased GSPG level.

2. Accept anabolic complexes and testosteron boosters.

(C) If the level of general testosterone gets to the lower two thirds of the range and the level of free testosterone is low:

1. Check the LG level. If the LG level is lower normal, the doctor can prescribe you individual doses of HGCh. HGCh imitates LG and can/shall recover normal testicular production of testosterone.

2. After a month of use of HGCh blood test shall show essential increase in testosterone. Still you can notice visual increase in ovaries. Having recovered testosterone level, monitor levels of an estradiol and free testosterone each 30-45 days the first 5 months to be convinced that exogenous testosterone increases your level of free testosterone, without raising at the same time an estradiol

(D) If the level of general testosterone is still low, despite HGCh therapy, it means that your testicles lost a capability to make testosterone. In this case begin therapy by means of testosterone plaster or cream, don't use an injection and a tablet. Before therapy make the test on the DOG and undergo manual testing of a prostate. Having recovered testosterone level to normal, monitor levels of an estradiol, the DOG and free testosterone of each 30-45 days the first 6 months to be convinced that exogenous testosterone is metabolized correctly. Your purpose to raise the level of free testosterone to the upper third of the reference range, without increasing and controlling at the same time the level of estradiol.

You remember, the excessive level of estrogen (estradiol) blocks testosterone products, suppresses a libido and sexual opportunities and is risk factor in development of a prostate cancer and cardiovascular diseases. Having settled the healthy level of testosterone (the upper third of values of the range) and an estradiol (no more than 30), continue to monitor blood on key indicators a la free/general testosterone, the DOG, estradiol, etc. For men of 40-50 years correction of level of estradiol often everything that is necessary and shall be made

Hormone Replacement therapy for women

Quite recently very big clinical trial comparing at women which carried out switching off of function of ovaries (purpose of zoladeks) efficiency of inhibitors of aromatasia and tamoxifen was complete. Unfortunately, benefits of purpose of inhibitors of aromatasia in such situation it wasn't revealed. Certainly, there is a chance that some subgroup (patients with HER2 with positive tumors nevertheless benefited from news agency or in case of a large number of the affected lymph nodes) within the research, but the effect "was dissolved" in general population of patients to whom it didn't bring benefit, however if it and so, then won't call a prize huge. Anyway, according to the international recommendations at women before a natural menopause tamoxifen (+/-switching off of function of ovaries) is standard approach. Question of whether it will be necessary in your situation (an artificial menopause) after 2-3 years of acceptance of tamoxifen to pass to acceptance of inhibitors of aromatasia (as it is done in case of approach of a natural menopause) or it is necessary to continue acceptance of tamoxifen up to 5 years without answer since there are no unambiguous researches in this respect. It is possible when time to solve comes (i.e. 2-3 years later from the beginning of acceptance of tamoxifen) the answer will come by itself (if, for example, there are side effects of tamoxifen that will demand replacement). But now to transition to news agency you have no unambiguous indications.

According to the international recommendations women in post menopause have several options (which efficiency and safety doesn't differ so to recommend any specific). 1. Inhibitors of aromatasia of 5 years, 2. tamoxifen 2-3 years, then aromatasia inhibitors to the total duration of endocrine therapy of 5 years, 3. tamoxifen of 5 years, then inhibitors of aromatasia of 5 years. Choose any... Certainly, after the conversation with the doctor. Concerning horror of side effects and a low performance of tamoxifen, I will repeat once again, rumors about it are strongly exaggerated from an easy hand of the pharmaceutical firms making aromatasia inhibitors. Here the simple example - so endometrial cancer frightening you, really, met more often in group of the patients receiving tamoxifen within the big randomized researches (in comparison with aromatasia inhibitors). However, we will look at absolute figures. From 4000 patients accepting tamoxifen, an endometrium giperplasia (good-quality which treatment requires only a scraping and replacement of tamoxifen by news agency) or endometrial cancer (its frequency isn't even specified separately, and there was it much less than giperplasia) developed at 62 (2%), and among 4000 accepting news agencies at 10 (0,3%). At the same time, news agencies aren't deprived too a certain toxicity of which it is less at tamoxifen (for example, risk of osteoporosis and fractures of bones, joint pains, etc.). Therefore, from my point of view, the tamoxifen use mode 2-3 years, and then news agency up to 5 years is most profitable (efficiency is comparable, and side effects of each of medicines the patient is influenced by only a half of "term")

Eternal course or GZT

Speaking on "an eternal rate" of anabolic steroids much, and people, actually, break into two camps. The first are blind haters who just condemn, and splash saliva, at the same time without having the slightest concept about the positive moments of replacement therapy. The second are enthusiastic little fools who shout "give, prick oil - guzzle tablets, the good fellow, the handsome man", and don't realize a negative.

Personally to me - all the same, I for health. At me no places neither concerning natural athletes, nor concerning people on synthetic hormones burn slightly. Yes, I always am interested in motives of the beginning of therapy, but I don't undertake to condemn. I will try to share the reasonings as much as possible concisely. But nevertheless I apologize for "a lot of text" In "decent society" an eternal rate call hormone replacement therapy (GZT). In classical understanding if it is about testosterone replacement, this ensuring normal levels of androgens by entering of their exogenous analogs.

In developed countries, to men somewhere for 30 which complain of health very often recommend to make the test on Testosterone general and if the indicator is lower the 12th nmol/l, then suggest to begin with it replacement therapy. This decision involves a number of the positive moments. The structure of a body changes to the best: it is more than meat, it is less than fat, sexual function endures the second youth, there is a certain anti aging effect, in whole - the organism wins back all negative which he received for the time spent in a condition of deficit of androgens.

There is also a reverse of the medal, less cheerful. GZT is a heavy responsibility for a condition of the organism. It is necessary to control constantly lipidic profile, all-clinical indicators of blood, Estradiol and Prolaktin's levels. Doctors who vigorously describe all pleasures of life on exogenous Testosterone not really like to tell about it, but there are good chances that in a couple of years GZT of people faces need of application: anticoagulants, aromatasia inhibitors, and fight against high GSPG. And it is already rather strong such set of the medicines "for comfortable life".

At least important also the fact that on GZT development of natural gonadotropin steadily approaches zero. Therefore if it is necessary to get posterity, then any vitamin and grasses you won't manage. Here horionic and menopausal gonadotropin of the person are already necessary, as a rule. As it is told - you like to ride - like to carry also. Nevertheless, I perfectly understand people who go on this way. Such therapy saves from many problems which disturb men in process of aging and it is impossible to deny at least such banal fact that it at the fixed levels of Testosterone of people in general feels differently.

Professional sport

It is no secret that constantly to progress, or to hold gathered at a high index of body weight, it is necessary the most part of time to carry out with the raised hormonal background. It is reality. If the usual "recreational body builder" to be happy with life has enough couple of courses a year, then at the competitive level such approach doesn't roll any more.

Athletes apply GZT in a bit different look. Dosages of testosterone have to provide not health and health, but body height of sports indicators and to improve physical shape, respectively they are much higher. Besides, if the person is on GZT, silly not to use drugs with mainly anabolic activity, here in a ligament it is possible to use anything, from Nandrolonum of decanoat and Boldenon to Trenbolonov, just regularly carrying out replacements of drugs. I will repeat, such scheme is necessary if the person sees himself in sport. And it doesn't exempt from control of all indicators of an organism, as well as in a case with GZT on medical indications, on the contrary it is necessary to be even more attentive to a condition of an organism.

There is also the third option of succession of events. It is simply boring for some people to live with usual levels of hormones. And life on steroids, certainly, other. As if and that didn't write, it is necessary, creatine with a protein, and will be a handsome man" - all this nonsense, of course. Yes, the person who is constantly on exogenous hormones if he isn't a full moon, will be always stronger, is more hardy also in the best visual form than the natural colleague. It is possible to tear on itself shirts and to shout that it not so, but is the truth. If at someone bombs about it, that is a good occasion to look to the truth in eyes or to descend to the psychologist.

Conclusion

GZT is most often expensive. It is very heavy to get down after 2-3 years of a course, and at the same time not to have high chances to face need all life to carry out on replacement therapy, other words - to return to her. There are many examples when people can't reach normal physiological values of hormones after cancellation of long therapy by androgens. It is possible to argue long on this subject and to say that "a fig, all got down, and all was abruptly", but isn't present, not everything, and can not always normally "get down". All the matter is that even if we support work of testicles as regular introduction of HGCh and MGCh, stimulating cages of Leydiga and Sertoli, respectively, that we all the same can't ensure normal functioning of a hypothalamus hypophysis. Their function is suppressed, and the longer they don't work in a section of development of gonadotropins, behind their uselessness, there is more problematic than them work to start. Well, sorry, misters, all of us in life make the choice. Someone wants to be not such as everything, at least physically, and he chooses a way of "hormonal improvement", and someone wants to achieve the high sports objectives, and without them to it not to live normally, soul there now demands.

Anyway, it is better when the person makes the similar decision consciously. Also it isn't necessary to condemn blindly him or to encourage, it is necessary approaching objectively, trying to inform on what consequences can be expected.  

Medicines hormones of hypothalamus

Medicines hypothalamus, hypophysis, epifiz, thyroid, parathyroid and pancreatic glands carry to peptide hormones.

Sermorelin is a synthetic analog of natural rileasing-hormone of human height; use for diagnostics.

Rifatironin, and also protirelin is synthetic analogs of tirotropinrileasing-hormone, release tireotropin hormone; apply to diagnostics.

The medicines stimulating release of gonadotropin hormones depending on concentration can stimulate and oppress secretion of hormones of hypophysis.

Ganirelics is medicine with high antagonistic activity concerning natural gonadotropin hormone; apply in case of premature puberty.

Tsetirelics is the antagonist of rileasing-hormone.

Gonadorelin entered intermittent raises products of gonadotropin hormones of hypophysis, it is applied to diagnostics and treatment of gipogonadism.

Somatostatin is a synthetic tetrapeptide analog of somatostatin, and octeokgreotid is an octapeptide analog of somatostatin.

Indications to application: a stop of bleedings from expanded veins of gullet.

Medicines hormones of adenogipofiz

Hormones of adenogipofiz possess an important role in regulation function of endocrine glands. Some of them in the form of pharmaceutical medicines are used in the medical purposes.

Tirotropin is medicine of tireotropin hormone (TTG) is vidospetsific glycoprotein with a molecular weight of 24 000 — 30 Ltd companies.

Pharmacodinamica: stimulates education and differentiation of interfollicul epithelium of a thyroid gland, and also development and receipt in blood of its hormones — the iodated tironin. You can try Cerebramin.

Indications to application: in case of an acute inflammation and hypofunction of a thyroid gland with the diagnostic purpose.

Medicines hormones of neurohypophysis

Neurohypophysis hormones is antidiuretic hormone and oxytocin are synthesized in supraoptic and the paraventricul kernels of area and on axons of supraopticogipofiz nervous way arrive in back share of hypophysis where are deposited. Both hormones are octapeptides which structure contains cyclic kernel and side chain.

Oxytocinum

Pharm cinetics: effect of drug at introduction to a vein develops in 1 — 2 min. and 15 — 20 min. proceed.

Pharm dynamics: enlarges permeability of membranes for K+ ions, and also the intracellular maintenance of Na + and Sa ++ therefore potential goes down and cellular excitability increases, system is stimulated. It leads to stimulation of reduction of a body of the womb, especially at the end of pregnancy, to dropping of a tonus of a neck of uterus.

Indications to use: patrimonial delicacy, a uterus atony, hypotonic uterine bleedings, for excision of an afterbirth at Cesarean section.

Contraindications: disharmony of the size of a head of a fetus to the basin sizes, the transversal and slanting provision of a fetus, the menacing hysterorrhesis. At over dosage there is a risk of hysterorrhesis and puerperal bleedings.

Vasopressin (in Ukraine it isn't registered)

Pharm cinetics: effect of drug develops in 30 — 45 min. after introduction.

Pharm dynamics: stimulates education ts-AMF, fosforilirut albuminous molecules, raises water reabsorption through an apical membrane, has the regulating effect on a water reabsorption a distal canaliculus of kidneys; detains ions of Na+, SG, narrows vessels and capillaries, raises the ABP.

Indications to use: bed wetting, not diabetes mellitus.

Side effects: delay of sodium and water, rising of ABP.

Dezmopressin

Dezmopressin is synthetic polypeptide, antidiuretic hormone analog.

Pituitrin is the medicine containing oxytocin and antidiuretic hormone (in Ukraine it isn't registered).

Pharmacokinetics: the beginning of action in 2 — 3 min., duration — 15 — 20 min.

Indications to application: excitement and strengthening of activity of a uterus in case of primary and its secondary weakness, hypotonic bleedings, normalization of involution of a uterus during the postnatal and post abortion period, bed wetting, not diabetes.

Side effects: a sodium delay in an organism, hypostases, increase HELL.

Adiurekrin represents dry pituitrin, contains mainly anti-diuretic hormone (ADG).

Pharmacokinetics: the beginning of action in 15 — 20 min., duration — 6 — 8 h.

Indications to application: as anti-diuretic means in case of not sugar, bed wetting.

Side effects: chronic allergic rhinitis, resistance to medicine.

Medicines of epifiz gormonon

Epifiz plays an important role in mechanisms of biorhythms.

Hormone of an epifiz is melatonin which is formed of serotonin by acetylation and O-methylation. Melatonin normalizes circadian rhythms, accelerates adaptation to bystry change of time zones, normalizes the psychoemotional status, regulates neuroendocrine functions, shows the immune stimulating and antioxidant properties, neurotyre-tread properties are noted.

Indications to application: as the means regulating a dream (falling asleep processes) for normalization of a biological rhythm when changing time zones.

Side effects: hypostases, drowsiness.

Forms of production of medicines

• Oxytocinum — ampoules on 1 and 2 ml (5 and 10 PIECES)
• Pituitrinum — ampoules on 1 ml (5 PIECES)
• Desmopressin — bottles on 1 ml (1 ml — 0,1 mg)
• Adiuretinum SD — bottles on 5 ml of 0,01% - γξ solution
• Triiodthyronini hydrochloridum — tablets on 0,00002 and 0,00005 g (20 and 50 mkg)
• Mercazolilum — tablets on 0,005 g
• Glibenclamidum — tablets on 0,005 g
• Metforminum — tablets on 0,25 g

Growth hormone: all results

Published in the USA and considered very authoritative in the scientific world of Journal of Clinical Endocrinology and Metabolism last year published very interesting article in which brought together results of the researches concerning body height hormone, over the last 10 years. Such researches collected 27, and, after processing of their results by means of statistical methods, the following turned out.

Body height hormone:

REDUCES FATTY WEIGHT ON AVERAGE BY 0.9 KG

REDUCES AMOUNT OF FAT IN THE ORGANISM ON AVERAGE BY 1%

REDUCES VISCERAL FAT ON AVERAGE BY 23 CM REDUCES THE LEVEL OF LIPOPROTEINS

LOW DENSITY (BAD CHOLESTEROL) ON 9 MG/DL REDUCES THE GENERAL LEVEL OF CHOLESTEROL BY 7 MG/DL

ENLARGES "DRY" MUSCLE BULK ON AVERAGE BY 1.8 KG

From 5 to 7 percent of those who used body height hormone tested the following side effects: pains in ligaments and joints, puffiness, a numbness of arms and legs. Also small rising of level of Saccharum in a blood and insulin level was noted, but these values quickly enough came back to norm limits. You can try Hepatamin.

By the way

This cutting is intended for those who consider an indicator of effectiveness of hormone of growth the sleep of hands and legs accompanying its injections, and also ligament and joints pain. As we see, those who use this hormone of growth face such problems not so much. I will emphasize: PRESENT. And here "happy" owners to "Bl Topsov" and his numerous derivatives have the listed problems practically in hundred cases from hundred.

While POSITIVE EFFECTS AT THEM are EXPRESSED IN MUCH SMALLER DEGREE, IF AT ALL EXPRESSED. No, of course, if all you wait from growth hormone for, is the various unpleasant moments, like pains, a sleep and puffiness then your choice shall be unambiguous - to "Bl Tope" and others.

IF YOU WANT TO RECEIVE THE MEDICINE WORKING IN RESPECT OF A SET OF WEIGHT AND DISPOSAL OF FATTY DEPOSITS, IMPROVEMENT OF QUALITY OF LIFE, THEN I ADVISE TO PAY ATTENTION TO THOSE MEDICINES WHICH UNDERWENT THE MOST STRICT TESTING ARE LICENSED AND CERTIFIED FOR SALE IN PHARMACY CHAIN.