Cirrhosis of the liver

21 Aug 2018

Cirrhosis of the liver is a chronic polyethological progressive disease that occurs with the defeat of the parenchymal and interstitial tissue of the organ with necrosis and dystrophy of the hepatic cells, nodal regeneration and diffuse proliferation of connective tissue, a violation of the architectonics of the organ and the development of some degree of liver function insufficiency. In economically developed countries cirrhosis of the liver is one of the six main causes of death in the age group of 35-60 years and is up to 30 cases per 100 thousand of the population. In the world, 40 million people die each year from viral cirrhosis and hepatocellular carcinoma, which develops against the background of the carrier of the hepatitis B virus.

Cirrhosis of the liver is more common in men, of the 4 patients with cirrhosis, three are men. The disease is noted in all age groups, but more often after 40 years.

The main causes of cirrhosis:

• intoxication with alcohol;
• viral and autoimmune hepatitis;
• chemical toxic substances;
• alcohol abuse;
• metabolic disorders;
• hepatotoxic drugs;
• heart failure;
• diseases of the biliary tract.

There is a cryptogenic cirrhosis, the causes of which are still unknown.

According to statistics, 80% of cirrhoses go unnoticed, without attracting the attention of either the patient or the doctor. Among the most common clinical manifestations of liver cirrhosis are general symptoms such as weakness, reduced ability to work, abdominal discomfort, dyspeptic disorders, fever, joint pain. Often there are flatulence, pain and a feeling of heaviness in the upper half of the abdomen, weight loss, asthenia.

The most frequent complaints are:

• weakness;
• fast fatiguability;
• decreased ability to work (bloating, poor tolerance of fatty foods and alcohol, nausea, vomiting, diarrhea);
• sleep disturbance, irritability;
• feeling of heaviness or pain in the abdomen (mainly in the right hypochondrium);
• impotence;
• itching of the skin;
• menstrual cycle disorders in women.

General medicines

Anabolics: Riboxin and others.

Beta-adrenoblockers: Anaprilin, propranolol, etc.

Hepatoprotectors: Hepatosan, Hepatofalk of the plant, Sirep, Erbisol, Heptor, Heptral, Methionine, Hepa-Merz, Ornitsetil, Karsil, Karsil Forte, Legalon 140, Legalon 70, Silageon, Silimar, Lipamida tablets, coated, 0.025 g, Lipoic acid, Brentzialle forte, Essentiale N, Essentiale forte N, Hepafor, Dipan, Liv.52, Liv.52 K, Tykveol, Phosphogliv Fort, Essley forte and others.

Diuretics: Aldactone-saltucine, Bufenox, Bufenoxa injection 0.025%, Aldactone, Vero-Spironolactone, Spirix, Spironaxan, Spironol, Urakton, Fursemid, Oxodolin, Moderetik, etc.

Metabolics: Lactulose Poli et al.

Inhibitors of fibrinolysis: Gumbix and others.

Interferons: Pegasys and others.

Coagulants (including coagulation factors), hemostatics: Vikasola injection 1%, etc.

Antiviral drugs: Viferon et al.

Enzymes: Creon 10000, Creon 25000, pancreatin, Hermitage and others.

Additional medicines

Supplements: Vazoton (L-arginine), Tykvelon, Hepagard Active, Hepagard, Neovitel - bioactive complex with milk thistle, Bifidum-Multi-1, Bifidum-Multi-2, Bifidum-Multi-3, Polibacterin, Hepatamin, Betusil and others.

Proteins and amino acids: Hepasol A and others.

Vitamins and vitamin-like agents: Pyridoxalphosphate, Ribovital, Retinol acetate acetate coated tablets 0.01135 g (Vitamin A 33000 IU), Retinol palmitate, cyanocobalamin, Ricavit, Livolin Forte and others.

Detoxifying agents, including antidotes: Carbactin, etc.

Immunosuppressants: Artamina et al.

Macro and trace elements: Oksirich et al.

Means that normalize the intestinal microflora: Probiophore, etc.