Cipramil (Citalopram) tablets - Instructions for Use, Dosage, Side Effects, Reviews

Synonyms: Acelopam, Alcytam, Apo-Citalopram, Arpolax, Aurex, Celepra, Celica, Celopram, Cilonast, Cimal, Cipram, Cipramil, Ciral, Citalanorm Genericon, Citalex, Citalomine, Citalon, Citalop, Citalopram Actavis, Citalopram Alpharma, Citalopram BMM Pharma, Citalopram Cipla, Citalopram EG, Citalopram HEXAL, Citalopram Orion, Citalopram ratiopharm, Citalopram, Citalopram-CT, Citaloran, Citapram, Citara, Citomax, Citopam, Città, C-Pram, C-Talo, Cytop, Dalsan, Humorap, Hydertan, Kylipram, Lecital, Linisan, Lupram, Madam, Mooylec, Oropram, Pisconor, Pram, Procimax, Seropram, Starcitin, Timopram, Zalopram, Zetalo, Zyloram, Abgenix, Actipram, A-Depress-Therapy, Akarin, Alepram, Alopra, Antidepressa, Apo-Cital, Apo-Citalopram, Arrow Citalopram, Bellcital, Bestilo, Bivien, Calton, Celapram, Celexa, Celica, Celius, Cerotor, Ciazil, Cilate, Cilift, Cilopa, Cinapen, Cinavol, Ciprager, Cipralam, Cipram, Cipramil D.A.C., Cipramil, Cipraned, Ciprapine, Ciprotan, Ciral, Cita, Citagen, CitaHexal, Cital, Citalanorm Genericon, Citalec Zentiva, Citalec, CitaLich, Citalobell, Citalodep, Citalogamma, Citalogen, Citalohexal, Citalon, Citalopram - 1 A Pharma, Citalopram +pharma, Citalopram 1A Farma, Citalopram 1A Pharma, Citalopram A, Citalopram ABC, Citalopram AbZ, Citalopram Acost, Citalopram Actavis, Citalopram AL, Citalopram Almus, Citalopram Alter, Citalopram Alternova, Citalopram Aphar, Citalopram Apotex, Citalopram Arcana, Citalopram Aristo, Citalopram Arrow, Citalopram Asol, Citalopram Atid, Citalopram beta, Citalopram Bexal, Citalopram Biogaran, Citalopram Bluefish, Citalopram BMM Pharma, Citalopram CF, Citalopram Cinfa, Citalopram CNSpharma, Citalopram CristerS, Citalopram CT, Citalopram Cuve, Citalopram Davur, Citalopram Decrox, Citalopram DOC, Citalopram dura, Citalopram ecosol, Citalopram Edigen, Citalopram EG, Citalopram esparma, Citalopram Eurogenus, Citalopram Evolugen, Citalopram G.L., Citalopram Genericon, Citalopram Germed, Citalopram Helvepharm, Citalopram Hennig, Citalopram HEXAL, Citalopram Holsten, Citalopram Hydrobromide, Citalopram Interpharm, Citalopram Isomed, Citalopram Kern Pharma, Citalopram Korhispana, Citalopram Lareq, Citalopram Mabo, Citalopram Molteni, Citalopram Mylan, Citalopram Normon, Citalopram Orifarm, Citalopram Orion, Citalopram Ortodrol, Citalopram PCH, Citalopram Pensa, Citalopram Pfizer, Citalopram Pharmagenus, Citalopram Pliva, Citalopram Qualigen, Citalopram Qualimed, Citalopram Ranbaxy, Citalopram Ranbaxygen, Citalopram ratiopharm, Citalopram Rex, Citalopram Rimafar, Citalopram RPG, Citalopram Sandoz, Citalopram Sigma Tau, Citalopram Stada, Citalopram STADA, Citalopram Streuli, Citalopram TAD, Citalopram Teva, Citalopram Torrex, Citalopram Ur, Citalopram Uxa, Citalopram Vitabalans, Citalopram Winthrop, Citalopram Zydus, Citalopram, citalopram-biomo, Citalopram-CT, Citalopram-Hexal, Citalopram-Hormosan, Citalopram-Mepha, Citalopram-neuraxpharm, Citalopram-Odan, Citalopram-ratiopharm, Citalopram-Teva, Citalopram-Winthrop, Citalo-Q, Citalostad, Citalowin, Citalox, Citalvir, Citao, Citapram, Citara, Citaratio, Citaxin, Citexam, Citol, Citolap, Citolixin, Citom, Citopam, Citox, Citrex, Citrol, Claropram, CO Citalopram, Cortran, CTP, Dalsan, Decilop, Depramil, Depretal, Doc Citalopram, DRL Citalopram, Ecloram, Elopram, Eslopram, Etapiam, Exenadil, Felipram, Feliximir, Feliz 20, Frimaind, Galopran, Gen-Citalopram, GenRX Citalopram, Goldamit, Humorap, Kitapram, Laira, Lodeprem, Lopracil, Lopram, Lopraxer, Mai Ke Wei, Malicon, Maxapran, Opra, Oropram, Pasilopram, Pharmacor Citalopram, PMS-Citalopram, Pralotam, Pram, Pramcil, Pramexyl, Pramital, Prepram, Pricital, Prisdal, Prisma, RAN-Citalo, ratio-Citalopram, Recital, Relapaz, Relaxol, Remicital, Renevil, Return, Ropramin, Sandoz Citalopram, Selon, Sepram, Seproc, Seregra, Seretover, Seropram, Seror, Serotor, Setronil, Siloam, Sitalo, Starcitin, Talam, Talohexal, Talopram, Taloram, Talosin, Te Lin Na, Temperax, Teva-Citalopram, Ultidep, Varom, Vesema, Vivipram, Vodelax, Wang You, Xadorek, Yi Tai Na, YiTeAn, Zanipram, Zeclicid, Zentius, Zoxipan, Zyloram, Adeprenal, Atinorm, Belmazol, Celius, Cilopress, Cipramil, Citalgert, Citalopram ABC, Citalopram Alitti, Citalopram Almus, Citalopram DOC, Citalopram Dr. Reddy’s, Citalopram Eurogenerici, Citalopram Germed, Citalopram HEXAL, Citalopram L.CH., Citalopram Mylan, Citalopram Pensa, Citalopram Ranbaxy, Citalopram ratiopharm, Citalopram Royal Pharma, Citalopram Sandoz, Citalopram Teva, Citalopram Winthrop, Citalopram, Citaloprol, Citepamix, Citesint, Depran, Depretal, Erlicon, Etapiam, Kaidor, Lopracil, Lopraxer, Loptar, Marpram, Oropram, Percitale, Prefucet, Ricap, Selon, Seropram, Sintopram, Sitaleu, Sotovon, Talopram, Talopron, Taloram, Taprocil, Tasonade, Unstress, Verisan, Verus, Xadorek, Zanipram, Zeclicid.

Active substance: Citalopram.

What is citalopram?

Citalopram is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs).

Citalopram is used to treat depression. You can buy Cipramil.

What is the most important information I should know about citalopram?

You should not use citalopram if you also take pimozide, or if you are being treated with methylene blue injection.

Do not use citalopram if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using citalopram. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not give citalopram to anyone younger than 18 years old without the advice of a doctor. Citalopram is not approved for use in children.

ATC - N06AB04 Citalopram.

Pharmacological group - Antidepressants.

Nosological classification (ICD–10)

F32 Depressive episode;

Composition, structure and packing

Tablets, film-coated white, oval, with Valium, marked “C” and “N” is symmetric about the risks.

Other ingredients: corn starch, lactose monohydrate, Copovidone, glycerol 85%, microcrystalline cellulose, croscarmellose sodium, magnesium stearate.

Cover structure: Valium 5, macrogol 400, titanium dioxide (E171).

Tablets, film-coated white, oval, with Valium, marked “C” and “N” is symmetric about the risks.

Other ingredients: corn starch, lactose monohydrate, Copovidone, glycerol 85%, microcrystalline cellulose, croscarmellose sodium, magnesium stearate.

Cover structure: Valium 5, macrogol 400, titanium dioxide (E171).

Pharmacological action

Antidepressant. The mechanism of action is associated with selective blockade of reverse neuronal uptake of serotonin in the synapses of neurons of the central nervous system with minimal effect in the reuptake of norepinephrine and dopamine. Have no or little ability to bind to a variety of receptors, including serotonin HT 1A -, 5HT 2A -, dopamine D 1 - and D 2 -, α 1 -, α 2 - and β-adrenergic receptors, histamine H 1 receptors, GABA-receptor-m holninoretseptory and benzodiazepine receptors.

Helps to improve mood, relieves anxiety, reduces fear and stress, eliminates dysphoria, reduces obsessive-compulsive disorder, practically does not cause sedation.

Stable clinical effect develops after 7–10 days of regular admission.

Pharmacokinetics

After oral administration, C max of citalopram in plasma is reached after 2–4 hours. Oral bioavailability is about 80%.

Changes in the concentration of citalopram in plasma are linear. C ss is installed in the plasma after 1–2 weeks of therapy.

Binding to plasma proteins - less than 80%.

In blood plasma citalopram is present mainly in unchanged form. Metabolized by demethylation, deamination and oxidation.

T 1/2 is 1.5 days.

Excreted by the kidneys and through the intestine.

Citalopram Dosage

Taken orally 1 time/day.

For adults, depending on the evidence, the initial dose is 10–20 mg/day, if necessary, may increase to 60 mg/day. In patients older than 65 years - 20 mg/day, if necessary, may increase to 40 mg/day.

Duration of therapy (for relapse prevention) is 6 months or more.

Drug Interactions

With the simultaneous use with MAO inhibitors may develop a hypertensive crisis (serotonin syndrome). Therefore contraindicated simultaneous use of citalopram and MAO inhibitors within 14 days after the termination of their admission

In very small extent inhibits isozyme CYP2D6, therefore does not interact with drugs metabolized by this isoenzyme.

However, we can not exclude the decrease of concentration of citalopram in plasma by enhancing its metabolism due to induction of carbamazepine microsomal liver enzymes in their simultaneous application.

With the simultaneous use of cimetidine may moderate increase in C ss of citalopram in plasma.

The effects of sumatriptan and other serotonergic agents may increase citalopram in their simultaneous application.

Pregnancy and lactation

Safety of citalopram during pregnancy and lactation has not been established. Application is justified only in cases where the potential benefits of therapy for the mother outweighs the potential risk to the fetus and child.

In experimental studies have not revealed teratogenic effects and any effect of citalopram on reproduction and perinatal development of the fetus.

Citalopram Side effects

The nervous system: dizziness, headache, tremor, somnolence, insomnia, agitation, nervousness, headache, paresthesia; sleep disturbance, impaired concentration, amnesia, anxiety, decreased libido, increased appetite, anorexia, apathy, suicidal attempts, confusion, fatigue, mood swings, aggressive behavior, emotional lability, agitation, mania, hypomania, panic behavior, paranoid reaction, psychosis, extreme tiredness, anxiety, extrapyramidal disorders, convulsions, euphoria, serotonin syndrome (agitation, confusion, diarrhea, hyperthermia, hyperreflexia, ataxia, sweating, uncontrolled behavior), hallucinations, depersonalization; in exceptional cases, when used in high dozah- seizures.

Cardio-vascular system: atrial flutter, tachycardia, bradycardia, orthostatic hypotension, increased or decreased blood pressure, supraventricular and ventricular arrhythmias.

From the digestive system: nausea, dry mouth, constipation, diarrhea, dyspepsia, vomiting, abdominal pain, flatulence, anorexia, increased salivation, increased liver enzymes.

From the urinary system: frequent urination, polyuria.

Metabolic disorders: decrease or increase in body weight, hyponatremia, hyperthermia.

The respiratory system: rhinitis, sinusitis, cough, shortness of breath.

Reproductive system: abnormal ejaculation, increased or decreased libido, female anorgasmia, dysmenorrhea, impotence, menstrual disorders, galactorrhea.

Skin: sweating, rash, itching, sensitivity to light, epidermal necrolysis, angioedema.

From the senses: disturbance of accommodation, blurred vision, mydriasis, taste disturbance, ringing in the ears.

On the part of the musculoskeletal system: myalgia, arthralgia.

With the blood coagulation system: rarely - the development of bleeding (eg, bleeding, caused by gynecological causes gastrointestinal bleeding, ecchymosis), thrombocytopenia.

Other: asthenia, fatigue, allergic reactions, syncope, malaise, mammalgia, yawning, teeth grinding, anaphylactoid reaction.

Indications

Depression of various origins (endogenous and exogenous); affective (depression, bipolar, dysthymic) disorder; mixed anxiety and depressive disorders; anxiety and phobic disorders (phobic, panic, obsessive-compulsive, generalized anxiety, post-traumatic stress disorder); somatization disorder; psychosomatic disorders with autonomic dysfunction (including autonomic dysfunction of the cardiovascular system, respiratory system, gastrointestinal tract, urogenital system); vascular dementia with depressive symptoms; depressive disorders in women (premenstrual dysphoria, depression during pregnancy, postpartum depression, depression in premenopausal); eating disorders (anorexia, bulimia); depression in alcoholism; Depression in the elderly. Contraindications

Hypersensitivity to citalopram.

Cautions

Patients with liver failure citalopram should be used in minimal doses.

At weak and moderate renal insufficiency does not require correction dosing regimen of citalopram information on the application in severe renal failure is absent.

In the application of citalopram may be a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate citalopram may cause a more pronounced bradycardia.

Citalopram should not be used concurrently with MAO inhibitors.

It should be used with caution citalopram maximum dose in patients receiving cimetidine in high doses.

Use in Pediatrics

Efficacy and safety of citalopram in children has not been established.

Effects on ability to drive vehicles and management mechanisms

It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.

Cipramil (Citalopram)Reviews
When you read reviews about citalopram (Cipramil) , it becomes clear that this drug is quite "serious". His reception lasts for months. Patients are warned that the effect should be expected no earlier than two months after starting treatment. A standard course lasts on average - six months. During this time, the majority of patients come some improvement (someone says, that health is fully restored, while others are not so sure of the results).

But for the final course in virtually all cases there are concerns how easily they can refuse Cipramil? - And this is not an idle question. Cancel the drug should be gradual. Almost all patients feel worse. This condition is described by some as a lack of confidence in the state of stress. Others have reported this suffering brittle. There are patients whose symptoms returned fully, after a while, after the end of therapy Cipramil.

- I drink Cipramil already two years and did not know if you can drink it all your life? I work, but to abolish it scary! - So he wrote one patient with anxiety disorders on the background of vegetative-vascular dystonia.

Starting the use of such drugs can only be prescribed by a doctor. In no case do not resort to Cipramil simply due to "depression occurred." After all, his influence and complexity of the system of selection of the dose can aggravate your condition.