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Alternative antimicrobials

23 Oct 2016

The biologist Dr. Doping talks about security levels of bacteria, E. coli and potential antibiotics. What is the role of microorganisms in environmental antibiotics? What do the microbes produced bacteriocins? And is it possible introduction of alternative antimicrobial agents in medical practice?

Antibiotics - it is a kind of "marking territory", that is, is that the microorganism produces (scientifically speaking - secreted) into the environment, and that not even such a killing, how much deters foreign body. Both concentrations of antibiotics that are commonly used in medicine, by orders of magnitude higher than that amount in which they exist in nature. This is precisely the root of the fact that when the microbes live permanently under this pressure, they naturally try to adapt quickly.

Over the last 20-25 years there has been a very serious breakthrough in biotechnology that can be produced in very large quantities of proteins of very different nature, with any changes that people want, that is, to introduce some mutations that allow this protein to acquire any necessary properties . Assume infra-red tag to the protein to sew that it will be possible to observe the motion of the protein molecule in the body, that is, under the infrared laser beam to a depth of up to a few centimeters inside the human body can be observed some fluorescence can be understood, where moving the molecule, then have thus control the pharmacokinetics - which moves the medication the way it exists in the human, for example, the bloodstream.

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The potential is there, and conventional antibiotics, again from that modern combinatorial organic chemistry is highly developed, that is, now it is possible to calculate the computer, computer to simulate what we want - this, however, is that more used to some medicines from the field of immunological or antiviral - I, frankly, have not heard about antibiotic developed in this way, but, nevertheless, it is possible. Antimicrobial peptides have certain common properties, ie, they can be again changed at the behest or on the calculation of scientists, respectively, in order to make them more stable, better able to penetrate into the enemy microbe specialized in relation to some one microbes, or, on the contrary, a common action - that is, there are very broad prospects.

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