Alprazolam - Interactions with other Active Compounds

Alprazolam + azelastine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + acrivastine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + amisulpride

In a joint application with amisulpride alprazolam notes expressed increased inhibitory action on CNS.

Alprazolam + amprenavir

Against the background of amprenavir blocked biotransformation increased alprazolam concentration in plasma, increasing the activity and the risk of toxicity.

Alprazolam + aprepitant

The potential effect of alprazolam increase in the plasma concentration (whose metabolism through CYP3A4) should be taken into account with concomitant administration of alprazolam with aprepitant.

Alprazolam + astemizole

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + boceprevir

It must be carried out careful clinical monitoring of cases of respiratory depression and / or prolonged sedation state during simultaneous use of boceprevir with / in the introduction of alprazolam. Needed correction doses of alprazolam.

Alprazolam + Buprenorphine

(Mutually) oppression CNS.

Alprazolam + Buspirone

(Mutually) oppression CNS.

Alprazolam + sodium valproate

(Mutually) oppression CNS.

Alprazolam + Valproic acid

(Mutually) oppression CNS.

Alprazolam + Valproic acid

Against the background of valproic acid is enhanced CNS depression.

Alprazolam + voriconazole

Voriconazole may cause increased plasma concentrations of alprazolam, which is metabolized by the action of CYP3A4 isoenzyme, and the development of prolonged sedation. With simultaneous use of voriconazole and alprazolam is recommended to evaluate the feasibility of correction dose of alprazolam.

Alprazolam + Haloperidol

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + hydroxyzine

(Mutually) oppression CNS; against the background of the / m dose of alprazolam should be to reduce by 50% (subject to cardiac arrest and death).

Alprazolam + hydroxyzine

(Mutually) oppression CNS; against the background of the / m of hydroxyzine dose of alprazolam should be reduced by 50% - a high probability of severe, even fatal, complications.

Alprazolam + guanfacine

(Mutually) sedation.

Alprazolam + Diazepam

(Mutually) oppression CNS, increases the risk of apnea (with on / in the introduction).

Alprazolam + Diazepam

Alprazolam (mutually) oppression CNS; in the background in risk / apnea increases in administration of diazepam.

Alprazolam + Digoxin

Against the backdrop of increased alprazolam concentration in plasma, reduced clearance and / or Vss digoxin, increasing the risk of toxicity.

Alprazolam + Digoxin

Alprazolam digoxin concentration increases due to a decrease in serum clearance and / or Vd digoxin, which can lead to glycoside intoxication.

Alprazolam + Dipotassium clorazepate

(Mutually) effect.

Alprazolam + Diltiazem

Perhaps strengthening effect; combined with the appointment of caution.

Alprazolam + diphenhydramine

(Mutually) deprimatsiyu (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + diphenhydramine

(Mutually) oppression CNS.

Alprazolam + droperidol

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Zolpidem

(Mutually) oppression CNS.

Alprazolam + imipramine

Against the background of alprazolam increased (by a third) plasma Css imipramine.

Alprazolam + indinavir

Indinavir should not be simultaneously combined with alprazolam.

Alprazolam + Itraconazole

Itraconazole as an inhibitor of CYP3A4 biotransformation slows considerably reduces the clearance increases in the plasma concentration of alprazolam, enhances the effects, including side; concomitant use is contraindicated.

Alprazolam + carbamazepine

(Mutually) oppression CNS.

Alprazolam + Quetiapine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Ketamine

(Mutually) oppression CNS.

Alprazolam + ketoconazole

Ketoconazole as an inhibitor of CYP3A may significantly reduce the clearance of alprazolam; concomitant use is contraindicated.

Alprazolam + Ketorolac

It reported the development of hallucinations while taking ketorolac in the form of tablets in patients taking alprazolam.

Alprazolam + Clarithromycin + Amoxicillin + lansoprazole

Concomitant use of clarithromycin (as part of a set of tablets and capsules, clarithromycin + amoxicillin lansoprazole +) with alprazolam (metabolized isoenzyme of CYP3A) is contraindicated.

Alprazolam + clemastine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + Clozapine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Clonazepam

(Mutually) oppression CNS.

Alprazolam + Codeine

(Mutually) oppression CNS.

Alprazolam + lamotrigine

(Mutually) oppression CNS.

Alprazolam + levetiracetam

(Mutually) oppression CNS.

Alprazolam + lorazepam

(Mutually) oppression CNS.

Alprazolam + Methohexital

(Mutually) oppression CNS.

Alprazolam + Metoclopramide

(Mutually) sedation.

Alprazolam + midazolam

(Mutually) oppression CNS.

Alprazolam + Morphine

(Mutually) oppression CNS.

Alprazolam + oxazepam

(Mutually) oppression CNS.

Alprazolam + Olanzapine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Omeprazole

Against the background of omeprazole (inhibitor of microsomal oxidation) slows the biotransformation and prolonged effect.

Alprazolam + Paroxetine

(Mutually) oppression CNS; the combined use caution.

Alprazolam + perphenazine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + pramipexole

(Mutually) sedation; the sharing of caution.

Alprazolam + primidone

(Mutually) oppression CNS.

Alprazolam + promethazine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + promethazine

Alprazolam enhances and prolongs the (mutually) sedation; with a joint appointment must be to reduce the dose.

Alprazolam + Propofol

(Mutually) oppression CNS.

Alprazolam + Propofol

Alprazolam enhances anesthetic and sedation (mutually) effects; combined with the appointment of possible distinct reduction in systolic, diastolic, and mean arterial pressure and cardiac output.

Milk thistle fruit extract

The combined application of milk thistle fruit extract that inhibits the cytochrome P450 system, can enhance the effect of alprazolam.

Alprazolam + remiphentanil

(Mutually) oppression CNS.

Alprazolam + Risperidone

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Risperidone

When used together, care is needed.

Alprazolam + Sertraline

Sertraline 50 mg daily does not inhibit the metabolism of alprazolam, carried out by isoenzyme CYP3A3 / 4. Concomitant use of sertraline and alprazolam should be undertaken with caution.

Alprazolam + Temazepam

(Mutually) oppression CNS.

Alprazolam + Terfenadine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + tiagabine

(Mutually) oppression CNS.

Alprazolam + thioridazine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Topiramate

(Mutually) oppression CNS.

Alprazolam + Tramadol

(Mutually) effect; the combined appointment increases the risk of seizures.

Alprazolam + trifluoperazine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Phexofenadine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + phenytoin

(Mutually) oppression CNS.

Alprazolam + Phenobarbital

(Mutually) oppression CNS.

Alprazolam + Phentanyl

(Mutually) oppression CNS.

Alprazolam + fluvoxamine

Against the background of reduced excretion of fluvoxamine (a danger of cumulation) alprazolam.

Alprazolam + Phluconazole

Phluconazole CYP3A inhibitor slows the biotransformation and clearance decreases; co-administration is not recommended.

Alprazolam + Fluoxetine

The combined use of alprazolam and fluoxetine resulted in an increase in the plasma level of alprazolam and reduction of psychomotor activity.

Alprazolam + Phlurazepam

(Mutually) oppression CNS.

Alprazolam + fluphenazine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + fosamprenavir

When combined with the use of alprazolam fosamprenavir may increase serum concentrations that can lead to an increase in its activity.

Alprazolam + chlordiazepoxide

(Mutually) oppression CNS.

Alprazolam + chlorpromazine

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Chlorprothixenum

(Mutually) oppression CNS; combined with the appointment of caution.

Alprazolam + Cetirizine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + Cyclosporine

Perhaps strengthening effect, including side; combined with the appointment of caution.

Alprazolam + cimetidine

Cimetidine increases Cmax (almost 2 times) and T1 / 2 (slightly) reduces Cl (42%) of alprazolam.

Alprazolam + cyproheptadine

(Mutually) deprimation (worsens the functioning of the CNS and reducing the speed of psychomotor reactions).

Alprazolam + cyproheptadine

If concomitant use of alprazolam and cyproheptadine is synergistic effect on the central nervous system, deepens deprimation and decreases the speed of psychomotor reactions.

Alprazolam + enflurane

(Mutually) oppression CNS.

Alprazolam + Erythromycin

Slows elimination; combined with the appointment of caution.

Alprazolam + estazolam

(Mutually) oppression CNS.

Alprazolam + ethanol

Against the background of enhanced alprazolam effect on the CNS.

Alprazolam + ethosuximide

(Mutually) oppression CNS.