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Afobazol (Afobazole) - selective non-benzodiazepine anxiolytic. Acting on the σ1-receptors in nerve cells of the brain, GABA Afobazol stabilizes / benzodiazepine receptors and restores their sensitivity to inhibition by endogenous mediators. Afobazol also increases the bioenergy potential of neurons and has a neuroprotective effect: restores and protects nerve cells.
The drugs are sold mainly in the form of a combination of anxiolytic (anti-anxiety) and a light stimulus (activating) effects. Afobazol reduces or eliminates anxiety (concern, foreboding, fear), irritability, tension (fearfulness, tearfulness, anxiety, inability to relax, insomnia, fear), depressed mood, somatic symptoms of anxiety (muscular, sensory, cardiovascular, respiratory , gastrointestinal symptoms), vegetative disorders (dry mouth, sweating, dizziness), cognitive disorders (difficulty concentrating, impaired memory), including arising from stress disorders (disorders of adaptation). Especially shows the use of the drug in patients with predominantly asthenic personality traits as alarming suspiciousness, insecurity, increased vulnerability and emotional lability, tendency to emotional and stress reactions.
The effect of the drug develops 5-7 days of treatment. The maximum effect is achieved by the end of the 4th week of treatment and persists after the end of treatment an average of 2.1 weeks. Afobazol causes muscular weakness, drowsiness and has no negative effects on concentration and memory. If its application is not formed addiction, drug dependency and does not develop "cancellation" syndrome.
Afobazol used in adults with anxiety:
Patients with various medical conditions:
In the treatment of:
Afobazol does not react with ethanol and does not affect the hypnotic effect of thiopental. It enhances the anticonvulsant effect of carbamazepine. It is strengthening the anxiolytic effect of diazepam.
Following oral administration Afobazol well and rapidly absorbed from the gastrointestinal tract.
Afobazol intensively distributed by well-vascularized organs, for it is characterized by a rapid transfer from the central pool (blood plasma) in the peripheral (highly vascularized organs and tissues).
Afobazol exposed to the effect of the first passage through the liver, the main directions of the metabolism is the hydroxylation of the aromatic ring of the benzimidazole cycle and oxidation by a morpholino moiety.
The drug has no negative influence on the driving of vehicles and the implementation of potentially hazardous activities that require high concentration and speed of psychomotor reactions.
After a meal.
The optimal single dose - 10 mg daily - 30 mg for 3 doses distributed over the day. The duration of a course of the drug is 2-4 weeks.
If necessary, on doctor's advice, the daily dose can be increased to 60 mg, and the duration of the treatment and 3 months.
Allergic reactions are possible. Rarely - headache, which usually resolves on its own and does not require the abolition of drug.
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