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Instructions

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Instruction for use: Zyprexa

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Dosage form: tablets

Active substance: Olanzapine*

ATX

N05AH03 Olanzapine

Pharmacological group:

Neuroleptics

The nosological classification (ICD-10)

F20 Schizophrenia: Schizophrenic conditions; Exacerbation of schizophrenia; Schizophrenia; Chronic schizophrenia; Dementia praecox; Bleuler's disease; Psychotic discordant; Dementia early; The febrile form of schizophrenia; Chronic schizophrenic disorder; Psychosis of the schizophrenic type; Acute form of schizophrenia; Acute schizophrenic disorder; Cerebral Organic Insufficiency in Schizophrenia; Acute attack of schizophrenia; Schizophrenic psychosis; Acute schizophrenia; Sluggish schizophrenia; Sluggish schizophrenia with apathoabulic disorders; Acute stage of schizophrenia with excitation

F22 Chronic Delusional Disorders: Delusional Chronic Disorder; Delusional Disorders; Delusional syndrome; Paranoia; Chronic affective-delirious states

F25 Schizoaffective disorders: Schizoaffective disorders; Schizoaffective psychosis; Schizoaffective disorder

Composition and release form

1 tablet, coated with a shell, contains olanzapine 5; 7.5 or 10 mg; in the blistere 7 pcs., in the box 4 blisters.

Pharmachologic effect

Pharmacological action - antipsychotic.

As a ligand of serotonin (2A / 2C, 3, 6), dopamine (D1-D5), m-cholino (m1-m5), histamine H1 and alpha1-adrenergic receptors, it has a selective effect on the limbic system.

Pharmacokinetics

Well absorbed, Cmax in plasma - after 5-8 hours Metabolised in the liver (along the conjugation and oxidative pathways) to inactive metabolites. The main metabolite, 10-N-glucuronide, does not pass through the BBB. The average T1 / 2 varies (depending on age and sex) within 21-54 hours.

Indiation for the Zyprexa

The acute form of schizophrenia and other psychoses, accompanied by pronounced positive (delusions, hallucinations, thinking disorders, hostility, suspicion) and / or negative symptoms (blunted affect, emotional and social isolation, poverty of speech activity) symptoms. Secondary affective symptoms on the background of schizophrenia and concomitant disorders.

Contraindications

Hypersensitivity.

Application in pregnancy and lactation

If it is necessary to prescribe during pregnancy, the expected benefit for the mother and the risk for the fetus should be carefully correlated. During lactation, nursing mothers should stop breastfeeding.

Side effects

Frequent (more than 10%) - drowsiness, weight gain; rare (less than 10%) - dizziness, dry mouth, constipation, peripheral edema, orthostatic hypotension, akathisia, dystonia, eosinophilia (asymptomatic), a small and temporary increase in prolactin (gynecomastia, lactorrhea), hepatic transaminase activity.

Interaction

Weaken the effects of levodopa and dopamine agonists. Activated carbon lowers bioavailability by 50-60% when taken orally. Smoking and carbamazepine accelerate metabolism. There was no obvious interaction with antacids, cimetidine, imipramine, warfarin, diazepam, lithium, theophylline, biperidenum.

Dosing and Administration

Inside, regardless of food intake. The initial dose is from 10 mg / day, once. Then the daily dose can vary - from 5 to 20 mg / day, depending on the clinical condition.

Storage conditions of the drug Zyprexa

In dry, the dark place at a temperature of 15-30 ° C.

Keep out of the reach of children.

Shelf life of the drug Zyprexa

3 years.

Do not use after the expiry date printed on the package.

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