DR. DOPING

Instructions

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Instructions / Instruction for use: Tilcotil

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Active substance Tenoxicam

ņ“’ M01AC02Tenoxicam

Pharmacological group

Non-steroidal anti-inflammatory drug [NSAIDs - Oxicams]

Nosological classification (ICD-10)

G54.1 Disorders of lumbosacral plexus

Sciatica, Neurology radicular origin, spine Pathology, Sciatica lumbosacral, radiculoneuritis

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M10 Gout

Exacerbation of gout, Acute articular attack with gout, Acute gouty attack, Gouty attack, Recurrent gout attacks, Chronic gout

M15-M19 Osteoarthritis

M35.3 Rheumatic polymyalgia

Pseudoarthritis rhizomelic, Rheumatic polymyalgia, Pain syndrome in rheumatic diseases, Muscle pain with rheumatism, Extra-articular rheumatism, Extra-articular rheumatic syndrome, Extra-articular rheumatic diseases, Extra-articular rheumatic soft tissue injury, Extra-articular forms of rheumatism, Rheumatic soft tissue damage, Rheumatism of soft tissues, Rheumatic diseases of soft tissues, Rheumatic diseases of the periarticular soft tissues, Rheumatic affections of soft tissues, Rheumatic collagen diseases

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M54 Dorsalgia

Pain in the back area, Pain in the spine, Back pain, Pain in different parts of the spine, Backache, Painful pain syndrome in the spine, Pain in the musculoskeletal system

M54.3 Sciatica

Ishialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M54.4 Lumbago with sciatica

Pain in the lumbosacral spine, Lumbago, Sciatica, Lumbar syndrome

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

M79.0 Other unspecified rheumatism

Degenerative rheumatic disease, Degenerative and rheumatic diseases of the tendons, Degenerative rheumatic diseases, Localized forms of rheumatism of soft tissues, Rheumatism, Rheumatism with a pronounced allergic component, Rheumatism of the articular and extraarticular, Rheumatic attack, Rheumatic complaints, Rheumatic diseases, Rheumatic disease of the spine, Relapses of rheumatism, Articular and extra-articular rheumatism, Articular and muscular rheumatism, Articular rheumatism, Articular syndrome with rheumatism, Chronic rheumatic pain, Chronic articular rheumatism, Rheumatoid diseases, Rheumatic diseases of the intervertebral disc

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

M81.9 Other specified osteoporosis

Osteoporosis due to androgen deficiency, Primary osteoporosis, Osteoporosis in men, Parathyroid osteoporosis, Primary osteoporosis, Post-traumatic osteoporosis, Loss of calcium in bones and teeth, Presennial osteoporosis, Systemic osteoporosis

T08-T14 Injuries to unspecified part of trunk, limb or body region

Composition and form of release

1 tablet, coated, contains tenoxicam 20 mg; in the box 3 blisters for 10 pcs.

1 rectal suppository - 20 mg; in blistere 5 pcs., in the box 2 blisters.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Inhibits the synthesis of PG (prostaglandins) (inhibits the activity of cyclooxygenase 1 and cyclooxygenase 2), reduces the accumulation of leukocytes in the focus of inflammation.

Pharmacodynamics

Has a powerful and long-lasting painkiller (comes in 30 minutes) and anti-inflammatory effect with less pronounced antipyretic. With rheumatic diseases it weakens joint pain at rest and during movement, reduces morning stiffness and swelling, improves functions and increases the amount of joint movement.

Pharmacokinetics

Quickly and completely absorbed in the digestive tract. Bioavailability of 100%. Cmax is achieved after 2 hours. It binds to plasma proteins by 99%. The volume of distribution is 0.15 l / kg. T1 / 2 - 60-75 h. In the liver it is hydroxylated. Easily passes the histohematological barriers. The main part is excreted as inactive metabolites with urine, the rest - with bile.

Clinical Pharmacology

The anti-inflammatory effect develops by the end of the first week of treatment.

Indications

Inflammatory-degenerative diseases of the musculoskeletal system accompanied by pain syndrome: articular syndrome with gout, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, osteochondrosis, articular rheumatism (tendinitis, bursitis, myositis), pain in the spine, neuralgia, myalgia, trauma.

Contraindications

Hypersensitivity, active peptic ulcer, marked violations of the liver in the active stage, kidney failure, diabetes, arterial hypertension, heart failure, children's age.

pregnancy and lactation

Contraindicated.

Side effects

Nausea, heartburn, abdominal pain, diarrhea, flatulence, stomatitis, anorexia, erosive and ulcerative lesions, bleeding, headache, dizziness, insomnia, depression, increased excitability, edema in the eye, eye irritation, visual impairment, peripheral edema, increased plasma concentrations of creatinine, urea nitrogen, bilirubin and hepatic transaminase activity, allergic reactions (urticaria, pruritus); when using suppositories, there may be local irritation, painful defecation.

Interaction

Strengthens the effect of lithium preparations (including toxicity), indirect anticoagulants, oral hypoglycemic agents (sulfonylureas derivatives). Antacids reduce the rate of absorption. Simultaneous use of other NSAIDs increases the risk of side effects (especially from the gastrointestinal tract).

Dosing and Administration

Inside, rectally. According to 1 table. or 1 supp. 1 time per day (preferably at the same time).

In acute attacks of gout, 2 tablets. or 2 soups. 1 time per day for the first two days, then 1 table. or 1 supp. 1 time per day for 5 days.

Precautionary measures

With caution appoint elderly persons, against diuretics, nephrotoxic drugs, immediately after surgical interventions. A few days before surgery, the drug should be discontinued. In the course of long-term treatment, liver and kidney function control, prothrombin index (against indirect anticoagulants), glucose in the blood (if the patient receives oral hypoglycemic agents) is necessary.

Storage conditions

At a temperature of 15-25 į C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.