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DR. DOPING

Instructions

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Instruction for use: Terridecase

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Dosage form

Liofilizate for the preparation of solution for intracavitary administration and external application.

Composition

Active substance:

Modified enzyme terrylitin, the product of covalent attachment of the proteolytic enzyme terrylitin to oxidized polyglucin.

Description of dosage form

The porous mass or powder is white or white with a yellowish tint of color.

Pharmacological group

Proteolytic agent.

Pharmacodynamics

TERRIDECASE® is a proteolytic enzyme obtained by the covalent attachment of terrylitin to oxidized polyglucin.

Terrilitina - microbial proteolytic enzyme obtained from the culture solution of native Aspergillus terricola strain H - 20, with a wide range of specific hydrolytic action on various protein substrates used as necrolytic and wound healing for external application.

The addition of polyglukine to terrylitin significantly reduced the allergic and locally irritating effect of the drug.

The main mechanism of action is due to the proteolytic activity of terrylitin and its ability to hydrolyze various protein substrates, including mucins, and also to exert fibrinolytic action.

Pharmacokinetics

Pharmacokinetics for this drug has not been studied.

Indications

Sores, decubitus ulcers, trophic ulcers, abscesses subcutaneous tissue of various localization (after dissection, removing nonviable tissues thorough drainage abscess cavity), empyema, coagulated gematoraks, purulent tracheobronchitis, bronchiectasis, sputum stasis after lung resection.

Contraindications

Individual intolerance, bleeding wounds, bleeding ulcers, ulcerated surfaces malignancies simultaneous reception of thrombolytic drugs to avoid hemorrhagic complications are not administered in inflammation foci (before autopsy). Contraindicated in pregnancy and during breastfeeding.

Due to the lack of data on the use of the drug in children under 18 years of age (efficacy and safety of the drug is not established), do not prescribe the drug without consulting a doctor.

pregnancy and lactation

The safety of taking the drug during pregnancy and during lactation with external and intracavitary application has not been studied.

Dosing and Administration

TERRIDECASE® applied as a solution, for which the contents of the vial (ampoule) 100 PE (Proteolytic Units) dissolved in 2 - 5 ml of distilled water or 0.9% sodium chloride solution, or 0.25% solution of procaine.

Apply externally, intrapleural, intratracheal, intrabronchial.

On purulent wounds, bedsores, trophic ulcers impose napkins moistened with a solution of TERRIDECASE®, a waterproof bandage is applied from above; the dressing is changed once a day or every other day.

With open sanation of the empyema of the pleura in the pleural cavity, injections of turuns with the drug are introduced.

With closed puncture sanation, a solution of TERRIDECASE® at a dose of 100 PU is administered intrapleural both in the preoperative and postoperative periods 1 time per day. The course of treatment - 2 - 7 procedures.

In the closed puncture treating postoperative gematoraksa solution TERRIDEKAZY® injected intrapleurally in a dose of 100 - 200 PU per day courses of 3 - 7 administrations with aspirated exudate liquefied (after 2 - 3 hours after the administration of the enzyme).

With purulent tracheobronchitis, 3 to 5 ml of TERRIDECASE® (100 PU) solution is injected through the intubation tube (or intra-tracheal) 5 to 6 times a day for 3 to 4 days.

At a delay of a sputum in the postoperative period after a resection of lungs intrabronchially enter 2 - 3 ml of a solution of TERRIDECASE® (10-15 PU)

For this purpose, 100 PU of the drug is dissolved in 20 ml of 0.9% sodium chloride solution. The course of treatment 1 - 3 procedures.

Side effects

The rise in body temperature is due to the absorption of products of proteolysis of viable tissues with insufficient drainage of the wound, allergic reactions.

Overdose

Cases of an overdose have not been revealed.

Interaction

TERRIDECASE® promotes better penetration into the focus of inflammation of other drugs (hydroxymethylquinoxaline dioxide, ampicillin + oxacillin, lincomycin). The drug is compatible with antimicrobial and chemotherapeutic agents.

special instructions

Do not use intravenously.

In case of complications, it is necessary to create conditions for a good outflow of pus from the wound, or to cancel the drug.

Influence on the ability to drive vehicles and control mechanisms:

On the adverse impact on the ability to drive vehicles and management mechanisms have not been reported.

Form of issue

Lyophilizate for the preparation of a solution for intracavitary administration and external application in ampoules (bottles) of 100 PU.

For 10 ampoules (bottles) in a box or pack of cardboard box with instructions for use of the drug, a knife for opening ampoules or a scarifier ampoule.

Storage conditions

At a temperature of 0 to 10 ° C.

In a dry place protected from light.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiration date.

Conditions of leave from pharmacies

Let go on prescription.

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