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Instruction for use: Selank

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Dosage form: Nasal drops; Substance-powder

Dosage form

The drops are nasal.


Selank in terms of 100% substance (threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline diacetate) - 1.5 mg.

Methylparahydroxybenzoate (nipagin) - 1 mg.

Purified water - up to 1ml.

Description of dosage form

Colorless transparent liquid.

Pharmacological group

A nksioliticheskoe means (tranquilizer).


SelankŪ is a synthetic analogue of the endogenous peptide taftcin, has an original mechanism of neurospecific action on the central nervous system, binds to specific receptors on the membranes of nerve cells.

Affects the exchange of monoamines in the emotionogenic structures of the brain (hypothalamus, diencephalon, cortex) and the activity of brain enzymes tyrosine and tryptophan hydroxylase. It shows tropicity to the serotonergic system, normalizing the serotonin level of the brain under conditions of experimentally caused its decrease. SelankŪ stabilizes the processes of excitation and inhibition in the brain and increases the stability of neurons of the cerebral cortex to functional loads of high intensity.

In the spectrum of the pharmacological action of the drug, an anxiolytic (anti-anxiety) effect with a stimulating (activating) component predominates. The drug does not possess hypnotic and muscle relaxant properties. Positively affects the mnestic and cognitive functions of the brain, including their violation. Activates the learning, memory, analysis and playback of information, improves attention and short-term memory. Increases the motivational stability and adequacy of adaptive behavior. SelankŪ has a vegetotrophic effect, it improves the vegetative maintenance of activity in conditions of emotional stress, it has an optimizing effect on the adaptive reserve of the organism. Selang does not reveal undesirable side effects and toxic effects at a 200-300-fold dose increase compared to ED 50. It does not have embryotoxic, teratogenic, allergic, local irritant effect, does not show mutagenic properties. The drug has no undesirable long-term effects.

Selang does not cause drug dependence.


Absolute bioavailability of Selang with intranasal administration is 92.8%. The drug is rapidly absorbed from the nasal mucosa and after 30 seconds is detected in the blood plasma. Concentration in the blood plasma progressively decreases within 5 - 5.5 minutes. Metabolites with intranasal route of administration are not detected. Penetrates into the brain tissue. The drug is quickly distributed to organs and tissues, is found unchanged in well-vascularized organs (liver, kidneys, heart). In daily urine, neither unchanged drug nor metabolites are determined, which is due to the rapid degradation of SelangŪ under the influence of tissue peptidases.


It is used in adults with anxiety and anxiety-asthenic disorders, corresponding to the diagnostic criteria of generalized anxiety disorders, neurasthenia, adaptation disorders.


Pregnancy, lactation. Individual intolerance of the drug.

Dosing and Administration

Selanc is administered intranasally using a vial of a dropper.

Carefully cut off the tip of the pipette.

The cap should close the pipette

Turn the bottle and, tapping lightly on the bottom, wait for the liquid to fill the entire space of the pipette.

Remove the cap and lightly press on the wide part of the pipette, squeeze the required number of drops of the drug into the nasal passage (on the mucous membrane).

Instillation of the drug in the nasal passages is carried out in the sitting position of the patient with a slightly tossed head, then for a short while a finger is clamped on each nostril. The effectiveness of absorption can be reduced in the presence of increased secretions of the nasal mucosa. At a time, no more than 2-3 drops are injected into each nostril, which is 300 μg (4 drops - 0.2 ml) - 450 μg (6 drops - 0.3 ml). To increase the dose of a single dose, repeated administration of the drug is carried out after 15 minutes. The optimal single doses are 300 to 900 μg (4 to 12 drops), daily doses 900 to 2,700 μg (12 to 36 drops), distributed over 3 doses during the day. The duration of the course use of the drug is 10 - 14 days. If necessary, the course of treatment can be repeated after 1 - 3 weeks.

Side effects

With increased sensitivity to the perception of odor and taste, if the preparation gets from the nasal cavity to the mucous membrane of the pharynx, unpleasant gustatory sensations may appear. Possible the development of allergic reactions with individual intolerance.


With the use of SelangŪ due to the rapid degradation of the drug, overdose and intoxication are not observed.


SelangŪ does not affect the effects of drugs that depress and stimulate the central nervous system - haloperidol, pentobarbital, hexobarbital, analeptics.

Special instructions

The lack of hypnose-sedative and muscle relaxant properties and the presence of positive influence on cognitive functions make it possible to apply SelangŪ to people of various professions, including those requiring increased attention and coordination of movements (drivers of vehicles, operators, etc.).

Release form

Nasal drops of 0.15%.

3 ml in a glass bottle, sealed with a plastic stopper - a pipette, or in a glass bottle sealed with a plastic screw cap with an attached pipette with a lid. Each vial with instructions for use is packaged in a pack of cardboard.

Storage conditions

List B.

In the dark place at a temperature of no higher than +10 ° C, do not allow freezing.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the time specified on the package.

Terms of leave from pharmacies

According to the doctor's prescription.

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