DR. DOPING

Instructions

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Instructions / Instruction for use: Salozinal

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Active substance Mesalazine

ATX Code A07EC02 Mesalazine

Pharmacological group

NSAIDs - Salicylic acid derivatives

Nosological classification (ICD-10)

K50 Crohn's disease [regional enteritis]

Crohn's disease, Crohn's disease with fistula, Granuloma of the intestine, Granulomatous enteritis, Crohn's disease, Regional ileitis, Terminal Ileitis, Enteritis regional

K51 Ulcerative colitis

Colitis acute ulcerative, Colitis ulcerative, Ulcerative-necrotic colitis, Colitis ulcerative-hemorrhagic nonspecific, Colitis ulcerative and trophic, Colitis ulcerative idiopathic, Colitis ulcerative nonspecific, Nonspecific ulcerative colitis, Proctocolitis ulcers, Hemorrhagic purulent rectoxitis, Rectoccolitis ulcerative-hemorrhagic

Composition and form of release

1 tablet contains mesalazine 250 mg, in a package of 50 pcs.

pharmachologic effect

Pharmacological action - anti-inflammatory, antibacterial.

Pharmacokinetics

Salosinal, thanks to a special tablet coating, releases mesalazine, the active metabolite of sulfasalazine, mainly in the large intestine (60-79%). In the jejunum, 15-30% of the active substance is released, with only about 10% entering the systemic circulation.

Indications

Nonspecific ulcerative colitis; Crohn's disease (prevention and treatment of exacerbations).

Contraindications

Hypersensitivity, severe hepatic-renal failure, gastric and duodenal ulcer, hemorrhagic diathesis.

pregnancy and lactation

It is not recommended to use the drug during pregnancy and during lactation.

Side effects

Weakness, headache, bronchospasm, pseudo erythritis, methemoglobinemia, allergic reactions.

Interaction

Increases the toxicity of methotrexate, sulfonamides, furosemide and rifampicin. It increases the hypoglycemic effect of sulfonylurea derivatives and the ulcerogenic effect of glucocorticosteroids.

Dosing and Administration

Inside, after eating, with plenty of water; with exacerbation of colitis - 2-3 tablets 3 times a day. For the prevention of relapse - 1-2 tablets 3 times a day.

Overdose

Symptoms: nausea, vomiting, epigastric pain, weakness, drowsiness. Treatment: gastric lavage, laxative, symptomatic therapy.

Precautionary measures

It is recommended to conduct a regular blood and urine test with prolonged therapy.

Storage conditions

In a dry place, at room temperature.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.