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Instructions

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Instructions / Instruction for use: Prednisolon

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Active substance Prednisolon

ATX Code H02AB06 Prednisolon

Pharmacological group

Glucocorticosteroids

Nosological classification (ICD-10)

A48.3 Toxic shock syndrome

Bacteria-nomic shock, Infectious-toxic shock, intoxication syndrome, Toxic-infectious shock, Toxic shock, Chronic intoxication at diseases of the gastrointestinal tract, Chronic intoxication with gastrointestinal infections, endotoxin shock

B19 Viral hepatitis, unspecified

Anicteric hepatitis, viral hepatitis, Viral hepatitis in children, Infection of the liver, Acute liver infection

C71 Malignant neoplasm of brain

Astrocytoma, Glyoblastoma, Neuroblastoma, Tumors of the brain, Brain tumor, A brain tumor, Glioma sarcomatous, Metastatic brain tumors, Anaplastic astrocytoma, Metastases in the brain, Cancer of the brain, Malignant neoplasm of brain, Pinealoma, Primary brain tumor, Primary malignant brain tumor, Ependymoma, Malignant glioma, Neurilemoma, Schwannogloida, Schwannoma, Fibroblastoma perineural, Pineal adenoma, Oligodendroglioma, Tumors of the cerebral hemispheres, Oligodendrocytoma, Chemodectomy, Choroid papilloma, Granuloblastoma, Neuroglioma of the embryonic, Neurospangioblastoma, Neurospringioma, The spheroblastoma, Choroiditis, Tumors of the brain

E05.0 Thyrotoxicosis with diffuse goiter

Goiter toxic diffuse, Toxic goiter, Diffuse thyrotoxic goiter, Graves disease, Diffuse toxic goiter, Goiter diffuse toxic, Parry's disease, Flanyani disease, Von Bazedova's disease, Toxic diffuse goiter

E27.2 Addison's Crisis

Insufficiency of the adrenal cortex is acute, Adrenal crisis, Sympathic-adrenal crises, Acute adrenal insufficiency, Acute insufficiency of the adrenal cortex, Addisonism

G93.6 Edema of the brain

Intraoperative cerebral edema, Cerebral edema, Post-traumatic swelling of the brain, Brain edema associated with radiation therapy, Brain edema associated with head trauma, Post-traumatic cerebral edema, Edema of the brain in poisoning

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

J46 Status asthmaticus

Asthmatic attack, status asthmaticus, Bronchospasm in bronchial asthma

K72 Hepatic insufficiency, not elsewhere classified (including hepatic coma)

Insufficiency of the liver-cell, Pronounced hepatic encephalopathy, Coma hepatic, Latent hepatic encephalopathy, Insufficiency of the liver, Hepatic coma, Hepatic coma and precoma, Hepatic encephalopathy, Development of hepatic impairment, Encephalopathy of the liver, Inflammatory liver disease, Gepatargy, Encephalopathy portosystemic, Hepatocellular insufficiency, Hepatic precoma and coma, Portal-systemic encephalopathy

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M32 Systemic lupus erythematosus

Lupus erythematosus red disseminated, Disseminated lupus erythematosus, Chronic lupus erythematosus

R57.0 Cardiogenic shock

cardiogenic shock

R57.8.0 * Burn shock

Pain shock with burns, Burn shock

S06 Intracranial injury

Traumatic brain injury, Traumatic brain injury with a predominantly stem lesion level, Condition after traumatic brain injury,Brain Injury, skull Injuries, brain injury, Brain Contusion, Craniocerebral trauma, Traumatic brain injury,TBI, traumatic brain injury, The traumas of head injury, The consequence of traumatic brain injury, The consequence of TBI, Cranial trauma, Traumatic brain injury, Traumatic encephalasthenia, concussion

T50.9 Other and unspecified drugs, medicines and biological substances

Poisoning by cauterizing fluidsá Correction of side effects of drugs, Drug intoxication, Medication intoxication, Acute drug poisoning, Acute drug poisoning, Acute poisoning with potent and toxic substances, Poisoning with medicines, Oxalate poisoning, Poisoning by potent and poisonous substances, Poisoning with iodine preparations

T52.9 Toxic effect of organic solvents, unspecified

Poisoning by cauterizing fluids

T54.9 Other irritants

Poisoning by cauterizing fluids

T57.8 Toxic effect of other specified inorganic substances

Uranium poisoning, Poisoning with barium, Poisoning with silver nitrate, Endemic selenosis

T78.2 Anaphylactic shock, unspecified

Anaphylactic shock, Anaphylactoid reaction, Anaphylactic shock, Anaphylactic reactions, Anaphylactic shock to drugs

T78.4 Allergy, unspecified

Allergic reactions to insulin, Allergic reactions to insect stings, Allergic reactions similar to systemic lupus erythematosus, Allergic diseases, Allergic diseases of mucous membranes, Allergic diseases and conditions resulting from increased release of histamine, Allergic diseases of mucous membranes, Allergic symptoms, Allergic symptoms in the mucous membranes, Allergic reactions, Allergic reactions caused by insect bites, Allergic reactions, Allergic conditions, Allergic laryngeal edema, allergopathy, allergic conditions, Allergy, House dust allergy, Anaphylaxis, Cutaneous reactions to medications, Skin reaction to insect stings, Cosmetic allergy, Drug allergy, Acute allergic reaction, Laryngeal edema allergic genesis and background radiation, Food and drug allergy

T79.4 Traumatic shock

Hemorrhagic shock, Crush syndrome, hemorrhagic shock, postoperative shock, post-traumatic shock, traumatic shock, hemorrhagic shock and encephalopathy syndrome

T81.1 Shock during or after the procedure, not elsewhere classified

Operating shock, Postoperative shock, Operational shock

Z51.0 Course of Radiotherapy

Supplement to external radiation therapy, Local X-ray irradiation, Radiation therapy, Brain edema associated with radiation therapy, Lesion in radiation therapy, Radiotherapy

Composition

Solution for injection 1 ml

active substance:

Prednisolon sodium phosphate (in terms of Prednisolon) 30 mg

Auxiliary substances: nicotinamide; Sodium metabisulfite; Disodium edetate; Sodium hydroxide; water for injections

pharmachologic effect

Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive.

Dosing and Administration

In / in (intravenously) (struino, then drip) or in / m (intramuscularly). The dose of Prednisolon and the duration of treatment are set by the doctor individually, depending on the indications and severity of the disease.

In acute adrenal insufficiency, a single dose of the drug is 100-200 mg, daily 300-400 mg.

In severe allergic reactions Prednisolon is administered in a daily dose of 100-200 mg for 3-16 days.

In bronchial asthma, the drug is administered depending on the severity of the disease and the effectiveness of complex treatment from 75 to 675 mg for a course of treatment of 3 to 16 days; In severe cases, the dose may be increased to 1400 mg per treatment course and more with a gradual dose reduction.

With asthmatic status Prednisolon is administered at a dose of 500-1200 mg / day, followed by a decrease to 300 mg / day and transition to maintenance doses.

In thyrotoxic crisis, 100 mg of the drug are administered at a daily dose of 200-300 mg; If necessary, the daily dose can be increased to 1000 mg. The duration of administration depends on the therapeutic effect, usually up to 6 days.

In the case of shock resistant to standard therapy, Prednisolon is usually injected at the start of the therapy, after which it is switched to a drop introduction. If the BP does not increase within 10-20 min, repeat the fluid administration of the drug. After excretion from the shock state, drip administration is continued until BP stabilizes. A single dose is 50-150 mg (in severe cases - up to 400 mg). Repeated drug is administered after 3-4 hours. The daily dose can be 300-1200 mg (with a subsequent dose reduction).

In acute hepatic renal failure (acute poisoning, postoperative and postpartum periods), Prednisolon is administered at 25-75 mg / day; In the presence of indications, the daily dose can be increased to 300-1500 mg / day and above.

In rheumatoid arthritis and systemic lupus erythematosus Prednisolon is administered in addition to the systemic administration of the drug at a dose of 75-125 mg / day not more than 7-10 days.

In acute hepatitis Prednisolon is administered at 75-100 mg / day for 7-10 days.

When poisoning with cauterizing liquids with burns of the digestive tract and upper respiratory tract Prednisolon is prescribed in a dose of 75-400 mg / day for 3-18 days.

If it is impossible to / in the introduction of Prednisolon is administered in / m in the same doses. After arresting the acute condition, prescribe inside Prednisolon in tablets, followed by a gradual decrease in the dose.

With prolonged use of the drug, the daily dose should be reduced gradually. Long-term therapy can not be stopped suddenly!

Form of issue

Solution for injection, 30 mg / ml. In ampoules of 1 ml. At 3, 5, 10 amp. In a plastic pallet. 1, 2 pallets are placed in a cardboard box.

Conditions of leave from pharmacies

On prescription.

StorageConditions

At temperatures below 25 ° C.

Keep out of the reach of children.

Shelf life of Prednisolon

2 years.

Do not use after the expiry date printed on the package.