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Instruction for use: Pentalginum-N

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Active substance Codeine + Caffeine + Metamizole sodium + Naproxen + Phenobarbital

ATX Code N02BB72 Metamizole sodium in combination with psycholeptics

Pharmacological groups

NSAIDs - Propionic acid derivatives in combinations

NSAIDs - Pyrazolones in combinations

Nosological classification (ICD-10)

G43 Migraine

The pain of migraine, Migraine, hemiplegic migraine, Migraine headache, A migraine attack, Continuous headache, hemicranias

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

R50 Fever of unknown origin

Malignant hyperthermia, Hyperthermia malignant

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

Composition and form of release

1 tablet contains metamizole sodium 0.3 g, naproxen 0.1 g, caffeine 0.05 g, codeine (base) 0.008 g and phenobarbital 0.01 g; in a contour acheive box 10 pcs., in a box 1 or 2 packs.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic, spasmolytic, sedative.

Has the properties of sedatives (phenobarbital), non-narcotic analgesics and NSAIDs (metamizole, naproxen), strengthened codeine (blocks opiate receptors) and caffeine (increases the permeability of histohematological barriers).


Moderately expressed pain syndrome: toothache and headache, myalgia, arthralgia, radiculitis, neuralgia, algodismenorea, etc .; febrile conditions, colds and other diseases, accompanied by pain and inflammation.


Hypersensitivity, gastric ulcer and duodenal ulcer (at the stage of exacerbation), blood diseases, conditions accompanied by respiratory depression, increased intracranial pressure, craniocerebral trauma, acute myocardial infarction, cardiac rhythm disturbance, hypertension, alcohol intoxication, acute attack of bronchial asthma, glaucoma, marked violation of liver and / or kidney function, pregnancy, breast-feeding, children under 12 years.

pregnancy and lactation

Contraindicated in pregnancy. For the duration of treatment, breastfeeding should be discontinued.

Side effects

From the nervous system and sensory organs: dizziness, drowsiness.

From the cardiovascular system and blood (hematopoiesis, hemostasis): granulocyte or leukopenia, agranulocytosis.

On the part of the intestine: nausea, vomiting, constipation, erosive and ulcerative lesions of the gastrointestinal tract.

Allergic reactions: skin rash, itching, urticaria.

Other: renal dysfunction (with prolonged use).


Increases the toxic effect of non-opioid analgesics, reduces the level of cyclosporin concentration in the plasma. Tricyclic antidepressants, oral contraceptives, allopurinol increases the toxic effect of metamizole sodium; Barbiturates, phenylbutazone - weaken. Sedative drugs and tranquilizers increase the analgesic effect of Pentalgina-H.

Dosing and Administration

Inside, 1 table 1-3 times a day. The maximum daily dose is 4 tablets. The course of treatment is no more than 5 days.


Symptoms: nausea, vomiting, pain in the stomach, tachycardia, arrhythmia, respiratory depression.

Treatment: gastric lavage, the appointment of absorbents; symptomatic therapy.

Precautionary measures

With caution should be appointed for violations of the liver and kidneys, peptic ulcer of the stomach and duodenal ulcer (in remission), elderly patients. With prolonged use, it is necessary to control the composition of peripheral blood. During therapy, alcohol should be avoided and care should be taken during the work of drivers of vehicles and people whose profession is associated with increased concentration of attention.

Storage conditions

In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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