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DR. DOPING

Instructions

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Instruction for use: Oxoralen ultra

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Active substance Methoxsalen

ATX code D05BA02 Methoxsalen

Pharmacological group

dermotropic means

Nosological classification (ICD-10)

L40 Psoriasis

Chronic psoriasis with diffuse plaques, Generalized psoriasis, Psoriasis of the scalp, Psoriasis of the scalp, Generalized form of psoriasis, Psoriasis dermatitis, Psoriasis complicated by erythroderma, Invalidative psoriasis, Isolated psoriatic plaque, Exfoliative psoriasis, Psoriatic Erythroderma, Psoriasis with eczematosis, Hyperkeratosis in psoriasis,Inverse psoriasis,Psoriasis eczematous, Dermatosis of psoriasis, Psoriasis of the genitals, Psoriasis with lesions of hairy areas of skin, Erythrodermal psoriasis, Chronic psoriasis of the scalp, Chronic psoriasis, Ordinary psoriasis, Refractory psoriasis, Kebner phenomenon, Scaly lichen

Composition and form of release

1 soft gelatin capsule contains methoxalene 10 mg; in bottles of dark glass for 50 pcs., in a cardboard bundle 1 bottle.

pharmachologic effect

Pharmacological action - antipsoriatic, photosensitizing.

In the cells of the epithelium it forms covalent bonds with DNA and increases its sensitivity to the damaging effect of the long-wave UV spectrum A (320-400 nm). The maximum photosensitivity of the skin is observed after 1.5-2.1 hours. As a result of massive damage to epithelial cells, an inflammatory reaction occurs, manifested in delayed erythema, reaching a peak after 48-72 hours. After a period of time (from several days to several weeks) after inflammation followed by healing, which manifests itself in the form of enhanced production of melanin and the formation of a normal stratum corneum.

Indication

Invalidative psoriasis (in combination with UV irradiation).

Contraindications

Hypersensitivity to therapy with UV radiation, aphakia (due to an increased risk of retinal damage), severe violations of the liver and kidneys, hematoporphyria, malignant melanoma, scaly skin carcinoma.

pregnancy and lactation

Carefully.

Side effects

From the nervous system and sensory organs: dizziness, nervousness, insomnia, depression.

On the part of the intestine: nausea, vomiting.

From the skin: erythema, itching, burns (with excessive exposure to UV radiation).

Dosing and Administration

Inside, with milk or low-fat food, 1.5-2 hours before UVA-irradiation (ultraviolet A high intensity). The dose depends on the body weight of the patient (an average of 20-40 mg per 1 reception) and is taken every other day (not more often). Course - 1-3 months.

Precautionary measures

With caution appoint children under 12 years. At the beginning of therapy exposure exposure to UV radiation should be limited to five minutes, gradually increasing to 30 minutes. It is not recommended to use with drugs that cause photosensitive reactions.

Storage conditions

At a temperature of 15-30 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.

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