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Instruction for use: Histimet

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Dosage form: Eye drops; Nasal spray

Actibe substance: Levocabastinum


S01GX02 Levocabastine

Pharmacological groups:


An anticongestants

Ophthalmic products

The nosological classification (ICD-10)

H10.1 Acute atopic conjunctivitis: Allergic conjunctivitis; Allergic eye diseases; Allergic conjunctivitis; Allergic conjunctivitis caused by chemical and physical factors; Allergic rhinoconjunctivitis; Allergic inflammation of the eyes; Spring Qatar; Spring keratitis; Spring conjunctivitis; Conjunctivitis allergic; Year-round allergic conjunctivitis; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic keratoconjunctivitis; Acute allergic conjunctivitis; Superficial bacterial infection of the eyes; Rhinoconjunctivitis; Seasonal allergic conjunctivitis; Seasonal conjunctivitis; SENSORY; Chronic allergic keratoconjunctivitis; Chronic allergic conjunctivitis

J30 Vasomotor and allergic rhinitis: Allergic rhinopathy; Allergic rhinosinusopathy; Allergic diseases of the upper respiratory tract; Allergic rhinitis; Allergic rhinitis seasonal; Vasomotor runny nose; Prolonged allergic rhinitis; All-year-round allergic rhinitis; All-year allergic rhinitis; Year-round or seasonal allergic rhinitis; All-the-year-round rhinitis of an allergic nature; Rhinitis vasomotor allergic; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic rhinitis; Edema of the nasal mucosa; Edema of the nasal mucosa; Edema of the mucous membrane of the nasal cavity; Swelling of the nasal mucosa; Swelling of the nasal mucosa; Pollinosis; Permanent allergic rhinitis; Rhinoconjunctivitis; Rhinosinusitis; Rhinosinusopathy; Seasonal allergic rhinitis; Seasonal allergic rhinitis; Hay rhinitis; Chronic allergic rhinitis; Allergic diseases of the respiratory tract

J31 Chronic rhinitis, nasopharyngitis and pharyngitis: Allergic rhinosinusopathy; Inflammation of the nasal mucosa; Infectious and inflammatory diseases of ENT organs; Catarrh of the nasopharyngeal region; Year-round rhinitis; Ozena; Persecution in the throat or nose; Rhinitis hyperplastic; Rhinitis chronic; Pharyngoesophagitis; Chronic Bacterial Rhinitis

Composition and release form

1 ml eye drops or nasal spray contains levocabastine 0.5 mg; In bottles-droppers of 4 ml or in bottles with a sprayer of 10 ml, respectively, in a cardboard bundle 1 bottle.

Pharmachologic effect

Mode of action - anti-allergic, antihistamine.

Selectively blocks histamine H1 receptors.


After instillation in the eye, Levocabastine is absorbed slowly and not completely. The concentration in the plasma is too small to have a systemic effect. With a single intranasal injection, 30-40 μg of levocabastine is absorbed, 70% of this amount is excreted mostly unchanged in urine. T1 / 2 35-40 hours.

Indication for the Histimet

Allergic rhinitis and conjunctivitis.



Application in pregnancy and breastfeeding

During pregnancy, it is prescribed only in those cases when the expected positive effect of treatment exceeds the potential risk to the fetus.

Side effects

Irritation of the conjunctiva or nasal mucosa.

Dosing and Administration

Conjunctival (eye drops) 1 drop in each eye or intranasally (nasal spray) - 2 injections into each nasal passage (it should be cleaned first). Apply usually 2 times a day, if necessary - 3-4 times a day.

Precautionary measures

With caution use the spray for violations of kidney function. Burying in the eyes eliminates the wearing of soft (hydrophilic) contact lenses.

Storage conditions of the drug Histimet

At a temperature of 15-30 ° C.

Keep out of the reach of children.

Shelf life of the drug Histimet

Eye drops 0.5 mg / ml - 2 years.

Eye drops 0.05% - 2 years.

Spray nasal 0.5 mg / ml - 3 years.

Do not use after the expiry date printed on the package.

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