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DR. DOPING

Instructions

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Instruction for use: Coxib

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Active substance Celecoxib

ņ“’ M01AH01 Celecoxib

Pharmacological group

NSAIDs - Coxiba

Nosological classification (ICD-10)

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M15-M19 Osteoarthritis

Composition and form of release

1 capsule contains celecoxib 100 or 200 mg; in a contour acheive box 10 pcs., in a cardboard bundle 3 packs.

pharmachologic effect

Pharmacological action - anti-inflammatory, analgesic.

Selectively inhibits cyclooxygenase-2 and blocks the formation of pro-inflammatory PG (in particular, prostaglandin E2). In therapeutic doses does not affect the activity of human cyclooxygenase-1 and thus does not disrupt normal physiological processes involving prostaglandins, particularly in the mucous membrane of the stomach, intestines and platelets.

Pharmacodynamics

In controlled clinical trials, it was noted that the incidence of gastrointestinal complications did not differ from placebo and was significantly lower than with non-specific cyclooxygenase inhibitors.

Indication

Deforming osteoarthritis, rheumatoid arthritis (symptomatic treatment of pain and inflammatory syndrome).

Contraindications

Hypersensitivity (including sulfanilamides), allergic reactions associated with taking acetylsalicylic acid and other NSAIDs, gastric ulcer and duodenal ulcer in the acute stage, I and III trimester of pregnancy, breastfeeding.

Side effects

Abdominal pain, diarrhea, dyspepsia, flatulence, nausea, headache, dizziness, insomnia, pharyngitis, rhinitis, sinusitis, anemia, peripheral edema, leg cramps, allergic reactions in the form of skin rashes, itching.

Interaction

Antacids reduce absorption from the gastrointestinal tract, fluconazole - the concentration of the drug in the plasma.

Simultaneous use with warfarin increases the risk of hemorrhagic complications.

Dosing and Administration

Inside. With deforming osteoarthritis, 200 mg once a day or 100 mg twice a day; if necessary, up to 400 mg / day in 2 divided doses; with rheumatoid arthritis - 200-400 mg / day in 2 divided doses.

special instructions

Clinical data on the use of the drug in patients with severe impairment of liver and kidney function, as well as in people under 18 years of age are absent.

A comment

The drug is in the process of registration.

storage Conditions

In a dry, the dark place at a temperature of no higher than 25 į C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.

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