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Instruction for use: Clomifene (Clomiphenum)

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Pharmacological group

Estrogens, gestagens; Their homologues and antagonists

Nosological classification (ICD-10)

E28.2 Polycystic ovary syndrome

Stein-Levental Syndrome, Polycystic ovary, Polycystic ovary syndrome, Stein-Levental Syndrome, Sclerokrostoznaya disease of the ovaries, Stein-Leventhal syndrome, Polycystic ovary syndrome

N46 Male infertility

Azoospermia, Asthenospermia, Infertility, Infertility male, Marriage is infertile, Dispersion, Violations of spermatogenesis, Oligoastenozoospermia III-IV stage, Oligoastenospermia, Oligozoospermia, Oligospermia, Disorders of testicular functions, Spermatogenesis disorders, Inhibition of spermatogenesis, Yang syndrome

N91 Lack of menstruation, meager and rare menstruation

Amenorrhea, Amenorrhea hypogonadotropic, Amenorrhea is prolactin-dependent, Oligomenorrhoea, Shortening of the secretory phase of the menstrual cycle, Menstrual disorders, Menstruation disorders, Prolactin-dependent amenorrhea without galactorrhea

N93 Other abnormal bleeding from the uterus and vagina

Atonic uterine bleeding, Prolonged menstruation, Blood loss during menstruation, Bleeding from the genitourinary system, Bleeding uterine dysfunctional, Bleeding from the genital tract of organic etiology, Uterine bleeding, Menorrhagia with fibroids, Functional uterine bleeding, Abnormal bleeding from the genitals in women

N97 Female infertility

Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle

O92.6 Galactorrhea

Chiari-Frommyl Syndrome, Idiopathic galactorrhea

Code CAS911-45-5


White or white with cream-colored crystalline powder. Slightly soluble in water, sparingly soluble in alcohol.


The pharmacological action is antiestrogenic.

It binds the estrogen receptors in the hypothalamus and ovaries. When ingestion is well absorbed from the digestive tract (gastrointestinal tract). Metabolised in the liver. Excreted with bile, subjected to enterohepatic recirculation. It is excreted from the body with faeces. T1 / 2 is 5-7 days. In small doses, it increases the secretion of gonadotropins (prolactin, FSH (follicle stimulating hormone) and LH (luteinizing hormone)), stimulates ovulation. With a low content of endogenous estrogens in the body has a moderate estrogenic effect, with a high level - antiestrogenic. Reducing the level of circulating estrogens, promotes the secretion of gonadotropins. In large doses inhibits the secretion of gonadotropins. Has no genetic and androgenic activity.

Application of Clomifene

Anovulatory infertility (ovulation induction), dysfunctional uterine bleeding, amenorrhea (disgonadotropnaya form secondary, postkontratseptivnaya), galactorrhea (compared to pituitary tumors), polycystic ovaries (Stein syndrome - Leventhal), Chiari-Frommelya syndrome, androgen deficiency, oligospermia, for the diagnosis of Violations of the gonadotropic function of the pituitary gland.


Hypersensitivity, severe hepatic and / or renal insufficiency, uterine bleeding of unknown etiology, ovarian cyst, tumor or pituitary failure, pregnancy (including suspected it).

pregnancy and lactation

Contraindicated in pregnancy.

The action category for fetus by FDA is X.

Side effects

From the nervous system and sensory organs: headache, dizziness, depression, fatigue, anxiety, insomnia, slowing of mental and motor responses, impaired vision.

On the part of the intestine: nausea, vomiting, gastralgia, flatulence, diarrhea.

On the part of the genitourinary system: cystic enlargement of the ovaries, dysmenorrhea, pollakiuria, polyuria, multiple pregnancies.

Other: hot flashes, weight gain, pain in the abdomen, the chest, the testes (in men), hyperthermia, reversible hair loss, allergic skin reactions.


Compatible with preparations of gonadotropic hormones.


Symptoms: nausea, vomiting, hot flashes, visual disturbances, abdominal pain.

Treatment: symptomatic therapy.

Routes of administration



Before and during treatment must be continued monitoring gynecologist should check ovarian function, carry out vaginal examination, to observe the phenomenon of "pupil" and others. With an increase in ovarian cystic transformation or treatment with clomifene to suspend the normalization of ovarian size. Therapy is continued with the use of minimal doses or shorten the period of treatment. Against the background of treatment it is recommended to monitor liver function. It is impossible to appoint persons without the exemption from work whose professional activity requires quick physical and mental reactions.

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