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Instruction for use: Citralgin

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Pharmacological group

Other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Nosological classification (ICD-10)

G43.9 Migraine, unspecified

Migraine, Acute migraine attack

M13.9 Arthritis, unspecified

Arthritis,Purulent arthritis (non-infectious), acute Arthritis,Pain in acute inflammatory diseases of the musculoskeletal system,Pain in chronic inflammatory diseases of the musculoskeletal system,The pain in osteoarthritis, Inflammation in osteoarthritis, Inflammatory arthropathy, Inflammatory and degenerative joint diseases, Inflammatory disease of the musculoskeletal system, Inflammatory joint disease, Inflammatory diseases of the musculoskeletal system, destructive arthritis, The disease of the musculoskeletal system, Diseases of the musculoskeletal system, Diseases of the musculoskeletal system and connective tissue, Infections musculoskeletal system, monoartrit, Non-infectious arthritis, rheumatic arthritis, Osteoarthritis, Acute inflammation of the musculoskeletal tissue, Acute inflammatory diseases of the musculoskeletal system, Acute inflammatory condition of the musculoskeletal system, Acute arthritis, Acute osteoarthritis, Post-traumatic osteoarthritis, Reactive arthritis, Chronic inflammatory diseases of the joints, Chronic arthritis, Chronic inflammatory arthritis, Chronic inflammation of the inner layer of the joint capsule, Chronic inflammation of the joint capsule,Chronic inflammatory disease of the joints, Exudative arthritis

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M42 Osteochondrosis

Pain in spinal osteochondrosis, Cervical osteochondrosis, Radicular syndrome in osteochondrosis, intervertebral osteochondrosis, osteochondrosis, Osteochondrosis with radicular syndrome, Osteocondritis of the spine

M54.1 Radiculopathy

Acute sciatica, Radiculopathy, Radiculitis, Radiculitis with radicular syndrome, Acute radiculopathy, Pain syndrome with radiculitis, Subacute radiculitis, Radiculitis, Chronic radiculitis, Diseases of the spinal column

T14.2 Fracture in unspecified area of body

Internal fixation of bone fracture, Acute period after fractures of bones, Edema after interventions for fractures, Fracture, Fractures of bones, Reposition of bone fragments in fractures, Traumatic bone injuries, Traumatic bone injury,Injuries of the osteoarticular system, Injuries to bone tissue

T14.9 Injury unspecified

Pain syndrome after trauma, Pain syndrome with injuries, Pain syndrome with trauma and after surgery, Pain in case of injury, Pain of a traumatic nature, Joint pain with injuries, Postoperative and post-traumatic pain, Pain in case of injury, Pain of a traumatic origin, Severe pain syndrome of traumatic origin, Deep tissue damage, Deep scratches on the trunk, Closed injury, Minor Household Injuries, Minor skin damage, Violations of the integrity of soft tissues, Uncomplicated trauma, Extensive traumatic injury, Acute pain syndrome of traumatic origin, Edema with trauma, Postponed sports injuries, Post-traumatic pain, Soft tissue injuries, Joint wounds, Sports injuries, Injury, Traumatic pain, Traumatic pains, Traumatic infiltrate,Injuries to sports


Cream for massage 1 jar

citrate complex (fruit acid salts), dimethicone, petrolatum, lanolin, emulsifiers, beeswax, methylparaben, propylparaben, perfume, purified water

Description of dosage form

Cream with a slight odor from white to light cream color.

Action on the body

Anti-inflammatory, analgesic.

Component properties

With inflammatory and metabolic-dystrophic diseases of the joints, myositis, osteochondrosis of the spine with secondary radicular syndrome (radiculitis) reduces swelling of the joint, morning stiffness, increases the volume of active and passive movements in the affected joints. In thrombophlebitis, postthrombophlebitic disease reduces edema, heaviness in the legs, cramps, pain and paresthesia. Reduces skin pigmentation at the site of trophic changes. Accelerates the resorption of hemorrhages and bruises. Enhances the effectiveness of massage.

One of the mechanisms of action of the Citralgin cream is the ability of the citrate ion entering into its composition to bind free calcium ions, which contributes to the normalization of the parameters of blood coagulation and microcirculation and is important for restoring blood flow in the periarticular tissues of the affected joint.

Components (citrate, pyruvate, malate, glutamate, lactate), which are part of Citralgin, release a considerable amount of energy and ATP molecules during their interconversion in the cycle of tricarboxylic acids (Krebs cycle). It is necessary for the normal functioning of enzyme systems of cells, incl. providing suppression of lipid peroxidation (one of the important factors supporting the inflammatory process) and for normalization of disturbed energy processes in the cartilaginous and periarticular tissues.

The binding of calcium and uric acid salts in tissues leads to a decrease and softening of the Geberden's nodules, gouty tophi, and prevents calcification of the periarticular tissues after the inflammatory process.

Reduces pain in joints, duration of morning stiffness, normalizes some laboratory parameters (ESR, CRP, rheumatoid factor, latex test).

In patients with rheumatoid arthritis, deforming osteoarthritis, reactive arthritis with periarticular changes (gangliolitis, tendopathy, rheumatoid nodules), a positive effect was observed during the application of Citralgin. In patients with rheumatoid arthritis, wrinkled formations on the rear of the wrist resorbed, rheumatoid nodules decreased in size; suffered significant regression of tendopathy in patients with reactive arthritis and rheumatoid arthritis. Inclusion in the complex therapy of "Citralgin" contributed to a significant decrease in the concentration of malonic dialdehyde and formation of peroxide, increased activity of superoxide dismutase and catalase. The use of the cream made it possible to reduce the dose of NSAIDs in more than half of patients, and in 20% of cases completely refuse to take NSAIDs.

From the parameters of blood coagulation, changes were detected from fibrinogen A, B, plasma tolerance to heparin (decrease). Significant changes in the level of platelet aggregation, PV, prothrombin index were not detected. Simultaneously, the acceleration of the normalization of microcirculation parameters was revealed in conjunctival biomicroscopy.


In the complex therapy of chronic joint diseases (arthrosis, arthritis), incl. spine (osteochondrosis, sciatica), trauma, thrombophlebitis and postthrombophlebitic conditions.


hypersensitivity to the components of the drug;

increased bleeding.

Side effects

Allergic reactions are possible. At the beginning of the application, pain or swelling may increase, which is associated with increased blood circulation in the tissues. In this case, the amount of the drug is temporarily reduced.


Strengthens the action of NSAIDs.

Dosing and Administration

Outwardly. For joint diseases: 3-4 times a day is applied to dry skin in the area of the affected joint, and also 10-15 cm above and below the joint and rubbed until completely absorbed. With rapid absorption, the application is repeated. The volume of the applied cream is not less than 0.5-1 ml per one joint. After the massage, a small amount is additionally applied to the skin, covered with wax paper and left until completely absorbed.

In the presence of Geberden's nodules with deforming osteoarthritis and gouty tophus, gout massage is used with these formulations using Citralgin.

In osteochondrosis of the spine with secondary radicular syndrome (radiculitis), the cream, massaged, is applied along the spine from the upper part of the neck to the sacrum for 5-10 minutes, simultaneously revealing the areas of greatest soreness. Another 3-5 minutes the cream is rubbed into these zones, achieving the maximum reduction of pain. On the area of maximum soreness the cream can be applied additionally and left to soak under the compress paper. It is recommended to combine with massage, manual therapy, physiotherapy, medicamental treatment.

In thrombophlebitis, postthrombophlebitis, "Citralgin" is applied a thin layer on the surface of the shin and thigh above the affected vein, without rubbing and covered with compress paper, leave until completely absorbed. The application is repeated 2-4 times a day. Duration of application - 2-3 weeks. Repeated courses every 3 months.

With trophic changes in the skin due to post-thrombotic disease, obliterating atherosclerosis, diabetes mellitus, etc., the cream is applied around ulcers, along the veins and arteries. The cream is not applied to the damaged skin. In the presence of pigmented spots, the cream is applied to the pigmented areas and along the course of the vessels. Reduction of pigmentation is possible after 2-3 weeks from the beginning of application.

Form of issue

Cream for massage. In the plastic jar 50 ml.

Storage conditions

In a cool place.

Keep out of the reach of children.

Shelf Life

24 months

Do not use after the expiry date printed on the package.

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