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DR. DOPING

Instructions

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Instruction for use: Bilem

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Active substance Tamoxifen

ATX code L02BA01 Tamoxifen

Pharmacological groups

Estrogens, gestagens; Their homologues and antagonists

Antineoplastic hormonal agents and hormone antagonists

Nosological classification (ICD-10)

C50 Malignant neoplasm of breast

Cancer of the nipple and areola of the breast, Breast carcinoma, The hormone-dependent form of recurrent breast cancer in women in menopause, Hormone-dependent breast cancer, Disseminated breast carcinoma, Disseminated Breast Cancer, Malignant breast cancer, Malignant neoplasm of breast, Contralateral breast cancer, Locally advanced or metastatic breast cancer,Locally-distributed breast cancer, Locally-recurring breast cancer, Metastatic breast carcinoma, Metastasis of breast tumors, Metastatic breast carcinoma, Inoperable breast carcinoma, Incompatible breast cancer, Breast cancer in women with metastases, Breast cancer in men with metastases, Breast Cancer, Breast cancer in men, Mammary cancer, Breast cancer with distant metastases, Breast cancer in postmenopausal women, Breast cancer hormone-dependent, Breast cancer with local metastases, Breast cancer with metastases, Breast cancer with regional metastases,Breast cancer with metastases, Common hormone-dependent forms of breast cancer, Common Breast Cancer, Recurrent Breast Cancer, Recurrence of breast tumors, Breast cancer, Estrogen-dependent breast cancer, Estrogen-Dependent Breast Cancer, Disseminated breast cancer with overexpression of HER2, Tumors of the mammary glands

C54 Malignant neoplasm of uterus

Uterine cancer, Cancer of the body of the uterus, Sarcoma of the uterus

N97 Female infertility

Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle

Composition and form of release

1 tablet contains tamoxifen citrate 10 or 20 mg; In a blister 10 pcs., In a cardboard box 10 blisters.

pharmachologic effect

Pharmacological action - antitumor, antiestrogenic.

It competes with estradiol for binding to cytoplasmic estrogen receptors in the target organs and prevents the formation of estrogenretseptornogo complex with the endogenous ligand - 17-beta-estradiol.

Indications

Breast cancer (in the postmenopausal period), cancer of the uterus (neglected forms), anovulatory infertility.

Contraindications

Pregnancy, lactation (lactating women should refuse breastfeeding).

Side effects

Loss of appetite, nausea, vomiting and other gastrointestinal disorders, flushing with hot flashes, vaginal bleeding or discharge, menstrual disorders, thrombosis, hypercalcemia, peripheral edema, genital itching, depression, headaches, dizziness, pain swelling, decreased visual acuity, Corneal opacity and retinitis, temporary thrombocytopenia, skin rash.

Dosing and Administration

Inside. In cancer, endometrial: 20-30 mg 1-2 times a day, in breast cancer: 20-40 mg 1-2 times a day, with anovulatory infertility: 10 mg 2 times a day for 4 consecutive days, starting with 2 Th day of menstruation. For subsequent 4-day cycles, you can increase the dose to 20-40 mg 2 times a day.

Overdose

Treatment is symptomatic.

storage Conditions

In the dark place at a temperature below 25 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.

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