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Instruction for use: Azaleptin

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Dosage form: substance powder

Active substance: Clozapine*


N05AH02 Clozapine

Pharmacological group:


The nosological classification (ICD-10)

F20 Schizophrenia: Schizophrenic conditions; Exacerbation of schizophrenia; Schizophrenia; Chronic schizophrenia; Dementia praecox; Bleuler's disease; Psychotic discordant; Dementia early; The febrile form of schizophrenia; Chronic schizophrenic disorder; Psychosis of the schizophrenic type; Acute form of schizophrenia; Acute schizophrenic disorder; Cerebral Organic Insufficiency in Schizophrenia; Acute attack of schizophrenia; Schizophrenic psychosis; Acute schizophrenia; Sluggish schizophrenia; Sluggish schizophrenia with apathoabulic disorders; Acute stage of schizophrenia with excitation

F23.9 Acute and transient psychotic disorder, unspecified: Psychotic disorder; Somatized Mental Disorder; Acute psychotic disorder; Reactive psychosis

F25 Schizoaffective disorders: Schizoaffective disorders; Schizoaffective psychosis; Schizoaffective disorder

G20 Parkinson's disease: A trembling paralysis; Idiopathic Parkinsonism; Parkinson's disease; Symptomatic Parkinsonism

Z91.5 In a personal anamnesis of self-harm: Suicidal thoughts


Tablets 1 table.

active substance:

Clozapine (azaleptin) 25/100 mg

auxiliary substances: MCC - 101/110 mg; potato starch - 20.25 / 33.6 mg; povidone (polyvinylpyrrolidone high molecular weight medical) - 2,25 / 3,9 mg; calcium stearate - 1,5 / 2,5 mg

Pharmachologic effect

The pharmacological action is neuroleptic.

Dosing and Administration

Inside, after eating, squeezed a small amount of liquid, 2-3 times a day. A single dose for adults - 50-200 mg, the initial daily - 150-300 mg, the average daily - 200-400 mg, the highest daily dose - 600 mg. The dose is selected individually, starting with the appointment of small doses (25 mg) and gradually increasing them by 25-50 mg per day until the therapeutic effect is obtained. For mild forms of the disease for maintenance therapy, as well as in patients with hepatic or renal insufficiency, CHF, with cerebrovascular disorders are prescribed at lower daily doses (20-200 mg). It is necessary to take into account the stage-by-stage manifestation of the therapeutic effect: the rapid onset of hypnotic and sedative action; relief of anxiety, psychomotor agitation and aggressiveness (after 3-6 days); antipsychopathic effect (after 1-2 weeks); effect on the symptoms of negativity (after 20-40 days). After reaching a therapeutic effect, they switch to a supportive course.

Release form

Tablets 25 mg and 100 mg. 5 contour cell packs of 10 tab. is placed in a cardboard box.

Conditions of leave from pharmacies

On prescription.

Storage conditions of the drug Azaleptin

In the dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life of the drug Azaleptin

5 years.

Do not use after the expiry date printed on the package.

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