DR. DOPING

Instructions

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Instructions / Instruction for use: Alprox

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Dosage form: tablets

Active substance: Alprazolam*

ATX

N05BA12 Alprazolam

Pharmacological group:

Anxiolytics

The nosological classification (ICD-10)

F32 Depressive episode: Adynamic subdepression; Astheno-adynamic subdepressive states; Asthenodepressive disorder; Astheno-depressive disorder; Asthenodepressive state; Astheno-depressive state; Major Depressive Disorder; Vyaloapatichesky depression with retardation; Double depression; Depressive pseudodement; Depressive illness; Depressive mood disorder; Depressive disorder; Depressive mood disorder; Depressive state; Depressive disorders; Depressive syndrome; Depressive syndrome larviated; Depressive syndrome with psychoses; Depressed masks; Depression; Depression Depletion; Depression with the phenomena of inhibition within the framework of cyclothymia; Depression is smiling; Involutional depression; Involutionary melancholy; Involutional depression; Manic-depressive disorder; Masked Depression; Melancholic Attack; Neurotic depression; Neurotic depression; Shallow Depression; Organic depression; Organic depressive syndrome; Simple depression; Simple melancholic syndrome; Psychogenic depression; Reactive depression; Reactive depression with moderate psychopathological symptoms; Reactive depressive states; Reactive depression; Recurrent depression; Seasonal depressive syndrome; Severostatic depression; Senile Depression; Senile Depression; Symptomatic Depression; Somatogenic depression; Cyclotymic depression; Exogenous Depression; Endogenous depression; Endogenous Depressive Conditions; Endogenous Depression; Endogenous depressive syndrome

F41 Other anxiety disorders: Anxiety status; Anxiety; Chronic alarm; Sense of anxiety; Anxious-hypothetical states; Stopping an alarm; Nonpsychotic anxiety disorders

Composition and release form

1 tablet contains alprazolam 0.25, 0.5 or 1 mg; In a blister 10 pcs., In a box of 3 blisters or in plastic bottles of 100 pcs., In a box 1 bottle.

Pharmachologic effect

Mode of action - anticonvulsant, anxiolytic, myorelaxing, sleeping pills.

It potentiates the central effect of GABA, interacts with benzodiazepine receptors and increases the sensitivity of GABA receptors to the mediator.

Pharmacokinetics

Quickly absorbed, Cmax is determined after 1-2 hours. T1 / 2 - 12-15 hours. Frequent repeated application leads to cumulation.

Indications for the Alprox

Depression, panic disorder, withdrawal of anxiety and anxiety disorders (including depression).

Contraindications

Hypersensitivity (including other benzodiazepines), open-angle glaucoma, acute attack of glaucoma, severe respiratory failure, "nocturnal sleep apnea" syndrome, myasthenia gravis, pregnancy, child age.

Side effects

Headache, dizziness, drowsiness, inhibition, impaired attention, fatigue, confusion, dry mouth, diplopia, muscle weakness, ataxia, inadequate behavior, anxiety, agitation, irritability, hallucinations, psychoses.

Interaction

The effect is enhanced by drugs that depress the central nervous system, alcohol. Cimetidine prolongs excretion.

Dosing and Administration

Inside, the initial dose taken before bedtime. In panic disorders, 0.25-0.5 mg 3 times a day, with a gradual increase in the dose (no more than 1 mg in 3-4 days) to a maximum of 4-6 mg / day, during 4- 12 weeks. With depressive and anxiety disorders - 0.5 mg 3 times (up to 4 mg per day - maximum). Elderly patients - 0.25 mg twice a day with a gradual increase, up to 4 mg per day (in divided doses).

Overdose

Symptoms: drowsiness, confusion, impaired coordination, decreased reflexes, coma.

Treatment: there are no specific antidotes, gastric lavage and maintenance therapy are recommended.

Precautionary measures

Admission should be discontinued gradually, slowly lowering the dose: abrupt withdrawal can be accompanied by withdrawal symptoms (anxiety and fear). With caution appoint people working with mechanisms or drivers of vehicles (slowing the reaction speed and reducing concentration of attention). It is recommended to refrain from drinking alcohol. Breastfeeding mothers should stop breastfeeding for the duration of treatment.

Storage conditions of the drug Alprox

In a dry place, at room temperature.

Keep out of the reach of children.

Shelf life of the drug Alprox

3 years.

Do not use after the expiry date printed on the package.

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