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Noophen (Noofen, Acidum aminophenylbutyricum, Acidum aminophenylbutyric) - nootropic drug, a derivative of gamma-aminobutyric acid, and phenylethylamine. It has tranquilizing properties, it stimulates memory and learning ability, increases physical working capacity, eliminates mental and emotional stress, anxiety, fear, and improves sleep. No effect on choline and adrenergic receptors.
The drug prolongs the latency period and shortens the duration and severity of nystagmus. Visibly reduces the appearance of fatigue and vasovegetative symptoms, including headache, a feeling of heaviness in the head, sleep disturbances, irritability, emotional lability, increases mental performance, improves mood, increases the interest and initiative, motivation to be active without sedation or excitation.
Unlike tranquilizers influenced Noophen (Noofen) improved psychological indicators (attention, memory, speed and accuracy of the sensory-motor responses). There was no formation of addiction and dependency to the drug, withdrawal syndrome.
After oral administration, the drug is well absorbed and penetrates into all tissues of the body. In brain tissue gets about 0.1% γ-amino-β-phenylbutyric acid hydrochloride of the dose of the drug, in patients younger and older age may increase the penetration through the BBB. After 3 hours, γ-amino-β-phenylbutyric acid hydrochloride in urine is detected, at the same time, the concentration in the brain tissue is not reduced, it is still detected in the brain at 6 hours.
Repeated use of the drug does not accumulate in the body.
Most binding γ-amino-β-phenylbutyric acid hydrochloride in the liver (80%), it is not
Precautions should be prescribed to patients with erosive and ulcerative diseases of the digestive tract (due to the irritating effect of the drug is recommended to be prescribed the drug in smaller doses).
With prolonged use is necessary to control the cellular composition of the blood, liver function.
Effects on ability to drive vehicles and management mechanisms
During treatment, patients must be careful when driving and busy with other potentially hazardous activities that require high concentration and psychomotor speed reactions, as some patients may experience CNS side effects, such as drowsiness and dizziness.
Inside, after eating, squeezed water. The capsule should not be chewed.
Asthenic and anxious-neurotic states: adults - 250-500 mg 3 times a day. The maximum single dose for adults - 750 mg for patients older than 60 years - 500 mg. If necessary, the daily dose was increased to 2.5, the course of treatment is 4-6 weeks.
Stuttering, tics, and enuresis in children aged 8 to 14 years - 250 mg 2-3 times a day; in children older than 14 years - adult dose.
Insomnia and night anxiety in elderly patients - 250-500 mg 3 times a day.
To eliminate dizziness dysfunction of the vestibular analyzer infectious origin (otogenny labyrinthitis) and Meniere's disease: in acute appoint 750 mg 3 times a day for 5-7 days, with a decrease in the severity of vestibular disorders - 250-500 mg 3 times a day for 5-7 days, then - 250 mg 1 time per day for 5 days. At relatively mild disease - 250 mg 2 times a day for 5-7 days, followed by 250 mg 1 time per day for 7-10 days.
To eliminate dizziness dysfunction of the vestibular analyzer vascular and traumatic genesis appoint 250 mg 3 times daily for 12 days.
To prevent motion sickness when kinetoses: 250-500 mg dose 1 hour before the intended journey or when the first symptoms of motion sickness. Antiseasick Noophen (Noofen) effect increases with increasing dose. When the expressed seasickness manifestations (including the "indomitable" vomiting) taking the drug orally is ineffective even at a dose of 750-1000 mg.
In the combined therapy of alcohol withdrawal syndrome for relief of psychopathological disorders and somatovegetativnyh in the first days of treatment appoint 250-500 mg 3 times a day and 750 mg at bedtime, with a gradual decrease in the daily dose to normal adult.
Do not take a double dose to replace the missed dose.
In patients with kidney and / or liver failure after prolonged use is necessary to monitor renal function and / or liver.
If abnormal liver function, high doses can cause liver toxicity. Such patients the drug is prescribed in smaller doses.
For the purposes of mutual potentiation Noophen (Noofen) can be combined with other nootropic drugs, reducing the dose Noofen (Noophen) and combination drug.
It extends and enhances the effect of hypnotics, neuroleptics and antiparkinsonian drugs.
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