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Heptral (Adamethioninum, Adamethionine, Geptral) - gepatoprotektor has antidepressant activity. It has choleretic and holekineticheskoe action. It has a detoxifying, regenerating, antioxidant, antifibroziruyuschimi and neuroprotective properties.

It fills ademetionine deficiency and stimulates its production in the body, primarily in the liver and brain. Participates in biological transmethylation reactions (donator of methyl groups). The molecule of S-adenosyl-L-methionine (ademethionine) donates a methyl group in the reactions of methylation of cell membrane phospholipids, proteins, hormones, neurotransmitters; transsulfatirovaniya - a precursor of cysteine, taurine, glutathione (provides redox mechanism of cellular detoxification), acetylation of coenzyme. Increases of hepatic glutamine, cysteine and taurine in plasma; reduces the serum methionine, normalizing the metabolic reactions in the liver. Also involved in the processes of decarboxylation aminopropilirovaniya as a precursor of polyamines - putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine and spermine, included in the structure of ribosomes.

It has choleretic effect due to increased mobility and the polarization of the membrane of hepatocytes, as a result of stimulating the synthesis of phosphatidylcholine in them. This improves the function associated with the membranes of hepatocytes bile acid transport systems and facilitates passage of bile acids in the biliary system. Effective with Lobular embodiment cholestasis (a violation of the synthesis and bile flow). Promotes detoxification of bile acids, increases the content in hepatocytes and conjugated sulfated bile acids. Conjugation with taurine increases the solubility of bile acids and removing them from the hepatocyte. The process of sulfation of bile acids helps to eliminate the possibility of their kidneys, facilitates the passage through the membrane of hepatocytes and excretion of bile. In addition, the sulfated bile acids protect membranes of liver cells from the toxic action of non-sulfated bile acids (present in high concentration in the hepatocytes in intrahepatic cholestasis). In patients with diffuse liver disease (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome reduces the severity of itching and changes in biochemical parameters, including the level of direct bilirubin, alkaline phosphatase activity of aminotransferases. Choleretic and hepatoprotective effect lasts up to 3 months after stopping treatment.

The efficiency ademetionina at hepatopathies caused by hepatotoxic drugs.

Appointment of the drug to patients with opioid addiction, accompanied by lesions of the liver, resulting in regression of clinical manifestations of abstinence, improving the functional state of the liver and microsomal oxidation processes.

Antidepressant Activity ademetionina manifested gradually, starting with the end of the first week of therapy and stabilized for 2 weeks of treatment. The drug is effective in recurrent endogenous and neurotic depression resistant to amitriptyline. It has the ability to interrupt the relapse of depression.

Appointment of the drug in osteoarthritis reduces the severity of pain, increases the synthesis of proteoglycans and leads to partial regeneration of cartilage tissue.


  • intrahepatic cholestasis during pretsirroticheskih and cirrhotic conditions, which may occur in the following diseases: fatty degeneration of the liver; chronic hepatitis; Toxic liver disease of various etiologies, including alcohol, virus, medicines (antibiotics, anti-cancer, anti-tuberculosis and anti-viral drugs, tricyclic antidepressants, oral contraceptives); chronic cholecystitis without stones; cholangitis; cirrhosis of the liver; encephalopathy, including associated with hepatic insufficiency (alcohol, etc.);
  • intrahepatic cholestasis in pregnancy;
  • depression symptoms.


  • Hypersensitivity to the drug
  • genetic disorders affecting the methionine cycle and / or cause homocystinuria and / or hyperhomocysteinemia (deficit cystathionine beta-synthase, a violation of metabolism of vitamin B12);
  • hypersensitivity to any component of the drug;
  • age 18 years.

Precautions: bipolar disorder; pregnancy (I trimester), lactation.

Special instructions:

Given the invigorating effect of the drug is not recommended to take it at bedtime. In appointing the drug Heptral (Geptral) patients with cirrhosis of the liver on the background hyperasotemia requires systematic monitoring of residual nitrogen. During long-term therapy is necessary to determine the content of urea and creatinine in the blood serum.

Do not appoint ademetionine patients with bipolar disorder. There are reports about the transition depression hypomania or mania in patients taking ademetionine.

There are also reports of the sudden appearance or growth of concern in patients taking ademetionine. In most cases, the abolition of therapy is not required, in some cases concern was resolved after dose reduction or discontinuation of the drug.

Since a deficiency of vitamin B12 and folic acid can reduce the level of ademetionina at-risk patients (anemia, liver disease, pregnancy or the probability of vitamin deficiency, due to other diseases or diet, eg vegetarians), should monitor the level of vitamins. If a failure is detected, the recommended simultaneous reception ademetionina with vitamin B12 and folic acid. Ademethionine affects homocysteine immunoassay results, which may cause false high level of homocysteine in the plasma. For patients taking ademetionine, it is recommended to use non-immunological methods of analysis for determining the level of homocysteine.

Effects on ability to drive and use machines. Some patients may experience dizziness Geptral (Heptral) when taking the drug. Do not drive a car and operate machinery while taking the drug for as long as patients are confident that the therapy does not affect the ability to engage in this type of activity.

Suggested Use:

Inside. Tablets should be taken whole, not chewed, preferably in the morning, between meals.

Tablets Heptral (Geptral) drug should be removed from the blister immediately before ingestion. The dose is from 800 to 1600 mg / day.

The duration of therapy is determined by the doctor.

Side effects:

Among the most frequent adverse reactions observed nausea, abdominal pain and diarrhea. Following are summary data on adverse reactions that were observed during treatment with ademetionina.

Immune system: laryngeal edema, allergic reactions.

Infections and infestations; urinary tract infections.

From the nervous system: dizziness, headache, paresthesia, confusion, and insomnia.

On the part of the cardiovascular system, "tides", phlebitis of superficial veins, cardiovascular disorders.

From the digestive system: abdominal distension, abdominal pain, diarrhea, dry mouth, dyspepsia, esophagitis, flatulence, gastrointestinal disorder, gastrointestinal bleeding, nausea, vomiting, hepatic colic, hepatic cirrhosis.

Skin: Sweating, pruritus, rash, angioedema, skin reactions.

From the musculoskeletal system: arthralgia, muscle cramps.

Other: asthenia, chills, flu-like symptoms, malaise, peripheral edema, fever.


  • Comes in original packaging. Item is brand new and unopened.


  • Keep away from direct sunlight.
  • Keep locked and away from children.
  • Store in dry place at room temperature.
  • Do not exceed storage temperature higher than 25 C

Important notice- the outer box design may vary before prior notice!


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