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Instruction for use: Yohimbine hydrochloride

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Trade name of the drug Yohimbine hydrochloride, Yohimbin Spiegel

The Latin name of the substance Yohimbine hydrochloride

Yohimbini hydrochloridum (genus. Yohimbini hydrochloridi)

Chemical rational name: Methyl (16alfa, 17alpha) -17-gidroksiyohimban-16-carboxylate (as hydrochloride)

Gross formula C21H26N2O3.HCl

Pharmacotherapeutic group: Alpha-blockers

Regulators potency

The nosological classification (ICD-10)

F52.2 Lack of genital response: Secondary impotence; hyposexuality; Impotence; Impotence on the basis of neurasthenia; Impotence against the background of functional nervous disorders; Impotence of different origin; Violation potency; erectile Dysfunction; potency Disorders; erectile dysfunction; Erectile dysfunction of various origins; Lack of erection; The weakening of potency; The weakening of sexual activity; The weakening of erection; Lowering the male potency; Sexual disorders in men; Sexual dysfunction; Weak potency; Reduced potency; Reduced potency; erectile disfunction; Erectile dysfunction, neurogenic

CAS code 65-19-0

Description of Yohimbine hydrochloride

The alkaloid from the bark of a West African tree Corynanthe yohimbe and roots of Rauwolfia serpentina. The crystalline powder odorless.

Pharmacological Properties of Yohimbine hydrochloride

Pharmachologic effect - Mode of action - improves erectile function, stimulating potency.

Selectively blocking the central and peripheral presynaptic alpha2-adrenergic receptors. In high doses, it has the ability to block postsynaptic alpha-adrenoceptors. It improves erectile function (presumably due to increased blood flow to the penis and decreasing of outflow). Improves mood, may exacerbate anxiety.

It has antidiuretic action (possibly due to stimulation of the hypothalamic centers and the release of posterior pituitary hormone).

Indications for Yohimbine hydrochloride

Psychogenic and functional impotence.

Contraindications for Yohimbine hydrochloride

Hypersensitivity expressed by the human kidney / liver function, labile blood pressure, uncontrolled hypo- / hypertension, concomitant use of agonists.

Restrictions to application

Impaired function of the cardiovascular system, stomach ulcer and duodenal ulcer history, the presence of mental illness.

Side effect of Yohimbine hydrochloride

Agitation, tremors, headache, dizziness, anxiety, irritability, increased blood pressure, tachycardia, orthostatic collapse (in high doses), increased motor activity, nausea, abdominal pain, vomiting, diarrhea, priapism, a decrease in urine output.


It should not be combined with drugs that affect mood, including antidepressants.

Precautions for substance Yohimbine hydrochloride

Do not use in cases involving the risk of a sudden drop in blood pressure and the development of tachycardia.

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