Instruction for use: Vero-Losartan

Dosage form: coated tablets

Active substance: Losartanum

ATX

C09CA01 Losartan

Pharmacological group

Angiotensin II receptor antagonists (AT1 subtype)

Nosological classification (ICD-10)

I10 Essential (primary) hypertension: hypertension; Arterial hypertension; Arterial hypertension crisis course; Essential Hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Primary hypertension; Arterial hypertension, complications of diabetes; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; arterial Hypertension; malignant Hypertension; Hypertonic disease; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; Isolated systolic hypertension

I15 Secondary hypertension: Arterial hypertension, complications of diabetes; hypertension; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; hypertension; arterial Hypertension; malignant Hypertension; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; hypertension; Arterial hypertension; Arterial hypertension crisis course; renovascular hypertension; Hypertension symptomatic; Renal hypertension; Renovascular hypertension; renovascular hypertension; Symptomatic hypertension

I50 Heart failure: Exacerbation of chronic heart failure; Shortness of breath with acute heart failure; Acute heart failure; Acute heart failure; Heart failure on the background of intoxication; Heart failure on the background of infections; Acute Heart Failure; Chronic myocardial insufficiency; Cardiac dyspnea

Composition and release form

1 tablet contains potassium losartan 50 mg; In a contour acheikova packing 10 pcs., In a cardboard bundle 1 packing.

Pharmachologic effect

Pharmacological action - hypotensive.

It blocks the receptors of angiotensin II (type ÀÒ1), reduces OPSS, postnagruzku, reduces systemic blood pressure and pressure in a small circle of blood circulation.

Pharmacokinetics

Well absorbed. It is distributed relatively evenly. Metabolizes with the formation of an active derivative.

Indications of the Vero-Losartan

Arterial hypertension, heart failure.

Contraindications

Hypersensitivity, pregnancy, breast-feeding, children's age.

Application of pregnancy and breastfeeding

If pregnancy occurs, you should stop taking it immediately (may cause developmental or fetal death, especially in the II-III trimester). For the duration of treatment, breastfeeding should be stopped.

Side effects

Dizziness, hypotension (dose-dependent), hyperkalemia.

Interaction

Compatible with other antihypertensive drugs. Against the background of diuretics (large doses) increases the risk of developing excessive hypotension in patients with dehydration..

Dosing and Administration

Inside, regardless of the intake of food (co-administration with other antihypertensive drugs is possible). With arterial hypertension - 50 mg once a day; If necessary, increase the dose to 100 mg. The maximum hypotensive effect is observed after 3-6 weeks after the beginning of the admission. For patients with heart failure, the initial dose is 12.5 mg once a day. The dose is titrated at weekly intervals (i.e. 12.5 mg / day, 25 mg / day, 50 mg / day) to an average maintenance dose of 50 mg once a day, depending on the tolerance of the drug. For patients receiving high doses of diuretics, the initial dose is reduced to 25 mg once a day. If the liver function is impaired, a dose reduction is necessary. Elderly patients, if renal dysfunction, including patients on dialysis, does not require correction of the initial dose.

Precautionary measures

If there is a violation of the liver (including in the anamnesis), it is necessary to prescribe smaller doses (the concentration of the drug in the plasma increases, especially with cirrhosis of the liver).

Conditions for storage of Vero-Losartan

In dry, the dark place at room temperature.

The shelf life of the drug Vero-Losartan

2 years.

Do not use beyond the expiration date printed on the package.