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Instruction for use: Ventax

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Dosage form: Capsules retard

Active substance: Theophyllinum


R03DA04 Theophylline

Pharmacological group

Adenosinergic agents

The nosological classification (ICD-10)

I27 Other forms of cardiopulmonary diseases: Chronic pulmonary heart disease; Hypertension pulmonary circulation; Pulmonary hypertension; Pulmonary heart disease; pulmonary heart disease; Cardio-pulmonary insufficiency; Secondary pulmonary hypertension; Chronic pulmonary heart; Eisenmenger syndrome

J45 Asthma: Asthma of physical effort; Asthmatic conditions; Bronchial asthma; Bronchial asthma of light course; Bronchial asthma with difficulty in sputum discharge; Bronchial asthma of severe course; Bronchial asthma physical effort; Hypersecretory asthma; The hormone-dependent form of bronchial asthma; Curbing asthma attacks with bronchial asthma; Non-allergic bronchial asthma; Night Asthma; Exacerbation of bronchial asthma; Attack of bronchial asthma; Endogenous forms of asthma; Night attacks of asthma; Cough with bronchial asthma J98.8.0 * Bronchospasm: Bronchospasm with bronchial asthma; Bronchospasm when exposed to an allergen; Bronchospastic reactions; Bronchospastic conditions; Bronchospastic syndrome; Diseases accompanied by bronchospastic syndrome; Reversible bronchospasm; Spasmodic cough

R06 Abnormal breathing: Kussmaul breath; Respiratory disorders of central origin; Tachypnea

Composition and release form

1 capsule retard contains theophylline anhydrous 100, 200 or 300 mg; In the blister 10 pcs., In the package 2 blisters.


Mode of action - diuretic, bronchodilator.

Inhibits phosphodiesterase and increases the intracellular concentration of cAMP; Blocks the release of inflammatory mediators and the action of adenosine, stimulates the respiratory center, normalizes perfusion processes in the lungs, increases the release of adrenaline and noradrenaline by the adrenal glands, the frequency and strength of the heartbeats, stimulates the secretion of gastric juice. Increases renal blood flow and glomerular filtration, increases diuresis.


Quickly and completely absorbed from the digestive tract. Bioavailability is 88-100%. The bronchodilating effect appears at a concentration of theophylline 5 mkg / ml and increases in proportion to the increase in the logarithm of concentration. Binding to plasma proteins is about 60%. Penetrates through the placental barrier, is found in breast milk. Metabolised in the liver. T1 / 2 for non-smokers - 5-10 h, for smokers - 4-5 h, lengthened with pulmonary and cardiac insufficiency, liver damage, viral infections, fever. About 10% is excreted by the kidneys unchanged.

Indications of Ventax

Bronchospasm (treatment and prevention) in chronic obstructive pulmonary diseases, bronchial asthma, respiratory disorders of the central genesis, nocturnal apnea, pulmonary hypertension, pulmonary heart failure.


Hypersensitivity to components, epilepsy, stomach and duodenal ulcer (exacerbation phase), children's age (up to 6 years).

Application of pregnancy and breastfeeding

During pregnancy (especially in the first trimester), use is possible if the intended benefit to the mother exceeds the potential risk to the fetus. With caution appoint lactating women (since theophylline excreted in breast milk, it is desirable to suspend breastfeeding).

Side effects

Rarely - nausea, vomiting, diarrhea, headache, anxiety, agitation, sleep disorders, tremor, palpitation, arrhythmia.


Reduces the activity of beta-blockers, lithium salts. The effect is enhanced by furosemide, beta 2-adrenomimetics, methylxanthines, ephedrine and ephedrine-containing drugs; The latter, in addition, increase the risk of side effects. Phenobarbital, rifampicin, phenytoin, carbamazepine, sulfinpyrazone, smoking increase Cl theophylline, and macrolides, lincomycin, allopurinol, beta-adrenoblockers, cimetidine, oral contraceptives - reduce excretion.

Dosage and Administration

Inside, not liquid, squeezed with enough liquid. Adults - 300 mg after meals 2 times a day (morning and evening).

At the first appointment to patients with a body weight of 60 kg and above begin with an evening intake of 200 mg, then - 200 mg twice a day; At a weight of less than 60 kg - with an evening intake of 100 mg, then - 100 mg twice a day; The dose is gradually increased by 100-200 mg per day, with an interval of 1-2 days.

The maintenance dose for patients with a mass above 60 kg is 600 mg per day, below 60 kg is 400 mg. In patients with heart and liver lesions and body weight greater than 60 kg, the maintenance dose is 400 mg per day (possibly up to 720 mg per day), less than 60 kg - 200 mg per day (possibly up to 480 mg per day) in 2 divided doses (morning And in the evening).

Patients with accelerated metabolism (smokers) and a body weight of more than 60 kg are prescribed 600 mg in the evening and 300 mg in the morning; With a mass of less than 60 kg - 400 mg in the evening and 200 mg in the morning. Children 6-8 years - 400-600 mg per day, 8-12 years - 600-800 mg per day, 12-18 years - 720-1080 mg per day (in 2 divided doses).

Storage conditions of Ventax

At a temperature of 15-25 C.

Keep out of the reach of children.

Shelf life of the drug Ventax

3 years.

Do not use after the expiry date printed on the package.

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Taxorest 60 capsules