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Instruction for use: Vasocardin

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Trade name of the drug Vasocardin

Dosage Form: tablets

Active substance:Metoprololum

ATX

C07AB02 Metoprolol

Pharmacotherapeutic group: Beta-blockers

The nosological classification (ICD-10)

E05 Thyrotoxicosis [hyperthyroidism]: Von Basedow's disease; Basedow's disease; hyperthyroidism; Goitre diffuse toxic; Increased thyroid function; tireotoksicski reaction; Toxic diffuse goiter; goiter; Enlargement of the thyroid gland with symptoms of hyperthyroidism; The phenomenon of iodine Basedow

G43 Migraine: The pain of migraine; Migraine; hemiplegic migraine; Migraine headache; A migraine attack; Continuous headache; hemicrania

I10 Essential (primary) hypertension: hypertension; Arterial hypertension; Arterial hypertension crisis course; Essential Hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Primary hypertension; Arterial hypertension, complications of diabetes; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; arterial Hypertension; malignant Hypertension; Hypertonic disease; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; Isolated systolic hypertension

I15 Secondary hypertension: Arterial hypertension, complications of diabetes; hypertension; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; hypertension; arterial Hypertension; malignant Hypertension; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; hypertension; Arterial hypertension; Arterial hypertension crisis course; renovascular hypertension; Hypertension symptomatic; Renal hypertension; Renovascular hypertension; renovascular hypertension; Symptomatic hypertension

I20 Angina [angina]: Heberden disease; Angina pectoris; The attack of angina pectoris; recurrent angina; Spontaneous angina; Stable angina pectoris; Angina rest; Angina progressing; Angina mixed; Angina spontaneous; stable angina; Chronic stable angina; Angina Syndrome X

I21 Acute myocardial infarction: Myocardial infarction in the acute phase; Acute Myocardial Infarction; Myocardial infarction with pathologic Q wave and without; Myocardial infarction complicated by cardiogenic shock; Infarction left ventricular; Transmural myocardial infarction; Myocardial infarction netransmuralny (subendocardial); Netransmuralny myocardial infarction; Subendocardial myocardial infarction; The acute phase of myocardial infarction; Acute myocardial infarction;Sub-acute phase of myocardial infarction; Subacute phase of myocardial infarction; Thrombosis of the coronary arteries (the arteries); Threatened myocardial infarction; Myocardial infarction without Q wave

I22 Subsequent myocardial infarction: Atherosclerosis and the likelihood of reinfarction; Myocardial infarction re; Relapses myocardial infarction

I25 Chronic ischemic heart disease: Coronary heart disease on the background of hypercholesterolemia; Coronary heart disease is a chronic; Coronary heart disease; Stable coronary artery disease; Percutaneous transluminal angioplasty; Myocardial ischemia, arteriosclerosis; Recurrent myocardial ischemia

I49.9 Irregular heartbeat, unspecified: Paroxysmal supraventricular tachycardia; extrasystole arrhythmia; Atrial fibrillation tachysystolic; supraventricular tachyarrhythmia; supraventricular arrhythmias; AV reciprocating tachycardia; AV-nodal reciprocating tachycardia; ventricular fibrillation; Irregular heartbeat; Antidromic reciprocating tachycardia; Cardiac arrhythmias; Arrhythmias; Arrhythmia; Heart arythmy; Arrhythmia due to hypokalemia; ventricular tachyarrhythmias; The high frequency of ventricular contraction; Cardiac arrhythmias; Paroxysmal supraventricular arrhythmia; Paroxysmal supraventricular arrhythmia; Paroxysmal dysrhythmia; Paroxysmal atrial-ventricular rhythm; cardiac arrhythmias; supraventricular tachycardia; tachyarrhythmia; Precordial abnormal pulsation

Composition (per tablet): 1 tablet contains 100 mg of metoprolol tartrate; in blister 10 pcs., in box 5 blisters.

Pharmacological Properties of Vasocardin

Pharmachologic effect - antianginal, antihypertensive, anti-arrhythmic.

Selectively blocking beta1-adrenergic receptors

Pharmacodynamics

It reduces myocardial oxygen consumption, lengthens refractory phase, lowers systolic (arterial hypertension) and diastolic (after a few weeks of therapy), blood pressure, reduces plasma renin activity.

Suppress automaticity of sinus node, slows heart rate slows AV conduction, reduces the excitability of myocardial contractility and cardiac output.

Pharmacokinetics

When ingestion absorbed 95%. Bioavailability is 50%. Binding to plasma proteins - 10%. The volume of distribution - 5.5 l / kg. Penetrates into breast milk. T1 / 2 -. 3.5 hours excreted by the kidneys (95%), mainly as metabolites (only 10% - unchanged).

Indications for Vasocardin

Hypertension, cardiac hyperkinetic syndrome, myocardial infarction, hyperthyroidism, arrhythmia. Prevention of angina attacks, migraine.

Contraindications for Vasocardin

Hypersensitivity. AV block, cardiogenic shock, decompensated heart failure, peripheral vascular disease, sinus bradycardia, chronic obstructive pulmonary disease, labile insulin-dependent diabetes mellitus, metabolic acidosis.

Side effect of Vasocardin

Diarrhoeal phenomenon, headache, dizziness, fatigue, insomnia, depression, shortness of breath, bradycardia, hypotension, cardiac insufficiency, Raynaud's syndrome, blurred vision, allergic reactions.

Interaction

It enhances the effect of antihypertensive and hypoglycemic drugs. Antiarrhythmic agents deepen hypotension and bradycardia, tricyclic antidepressants, barbiturates, nitroglycerin, diuretics, oral contraceptives - only anti-hypertensive effect. Rifampicin reduces, cimetidine increases the concentration in the blood. Increases in blood alcohol concentration and prolongs its action.

Dosage and Administration

Inside (after eating the same time), 100 mg (200 mg) per day in 2 divided doses.

Myocardial infarction: a maintenance dose of 200 mg / day (morning and evening).

In hyperthyroidism: 150-200 mg / day in 3-4 divided doses.

The maximum daily dose of 400 mg.

Overdose

Symptoms: hypotension, congestive heart failure, cardiogenic shock, bradycardia, difficulty breathing, bronchospasm, vomiting, loss of consciousness, generalized convulsions.

Treatment: symptomatic. If bradycardia and conduction disturbances shown in / bolus administration of atropine at a dose of 0.5-2 mg; reducing myocardial contractility - in / glucagon at an initial dose of 1-10 mg, then - 2-2.5 mg / h infusion; seizures - slow in / diazepam.

Precautionary measures

It should be remembered that vasocardin adversely affect the ability to drive and perform work that requires a high rate of mental and physical reactions.

Storage conditions of Vasocardin

In a dry, dark place at a temperature of 15-21 C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use beyond the expiration date printed on the package.

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