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Instruction for use: Timoptic

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Active substance Timolol

ATX Code S01ED01 Timolol

Pharmacotherapeutic group:


Ophthalmic agents

The nosological classification (ICD-10)

H40.0 Suspected glaucoma

Marked rise in intraocular pressure, Hypertension eyes, ocular hypertension, Measurement of intraocular pressure, ophthalmohypertension, Elevated IOP, Elevated intraocular pressure, Elevated intraocular pressure in infectious diseases of the eye, Povyshennore intraocular pressure, Increased ophthalmotonus, Spontaneous blockade angle opposite eye, Narrow chamber angle, Iatrogenic, blockade angle opposite eye

H40.1 Primary open-angle glaucoma

open-angle glaucoma, Open-angle glaucoma, Primary glaucoma, pseudoexfoliation glaucoma, Elevated IOP

H40.5 Glaucoma secondary to other eye diseases

The secondary open-angle glaucoma, Glaucoma afakicheskaya, Secondary glaucoma

Structure and Composition

1 ml of a solution containing 2.5 or 5 mg of timolol maleate; in bottles of 5 ml, in the box one bottle.

pharmachologic effect


Beta-adrenoceptor blocking.


The action develops quickly, within 20 minutes after the application, the maximum reduction of intraocular pressure occurs in 1-2 hours, persists for 24 hours. It has a predominantly local effect, but after absorption may cause systemic effects typical of beta-blockers. The decrease is attributable to lower intraocular pressure of aqueous humor formation and a moderate increase in the drainage function.

Clinical pharmacology

Long-term use of the drug may be associated with decreased sensitivity to its action. However, the three-year observation of patients during treatment revealed no significant differences in intraocular pressure after the initial stabilization.


Elevated intraocular pressure: ocular hypertension, glaucoma (chronic open, secondary, combined with aphakia in children - the ineffectiveness of other antiglaucoma agents) and narrow chamber angle, spontaneous or iatrogenic blockade angle opposite eye in history.


Hypersensitivity, bronchial asthma (including in history), and others. Chronic obstructive pulmonary disease, sinus bradycardia, AV block II-III degree cardiac failure, cardiogenic shock.

Pregnancy and breast-feeding

When pregnancy is possible only when the probable hazard and expected effect. During lactation the drug is recommended cancellation or termination of breastfeeding.

Side effects

Conjunctivitis, blepharitis, keratitis, decreased corneal sensitivity; visual disturbances (refraction changes, diplopia, ptosis); bradycardia, arrhythmia, hypotension, collapse, heart block, cardiac arrest, congestive heart failure, chest pain, palpitations, stroke, cerebral ischemia, dizziness, headache, nausea, fatigue, depression, fatigue, bronchospasm, respiratory distress, shortness of breath , allergic skin reactions: local and generalized rash, urticaria, alopecia, death (bronchospasm, heart failure).


When combined with the appointment of noradrenaline possible mydriasis. Compatible (additive effect) with calcium antagonists, beta and alpha-blockers (reduction of intraocular pressure, hypotension, bradycardia).

Dosing and Administration

Kongungualno, adults: 1 drop 0.25% solution, 2 times a day (0.5% solution is used, if necessary increase dose); after stabilization of reduced intraocular pressure (mean 4 weeks) available instillation of 1 drop of 1 per day. In appointing timoptika after the other. Funds (excluding beta-blockers) necessary to the simultaneous use of the combination for 1 day, the second day of the previously used drug completely cancel and continue treatment timoptikom. Children: 1 drop every 12 hours (compared to other drugs.).

Precautionary measures

Cardiac failure should be adequately compensated before starting treatment, and these patients should be continuously monitored cardiovascular system. In angle-closure glaucoma drug may be used only in conjunction with miotics (for opening camera angle). Be wary appointed to wearing soft contact lenses (they may be delayed a preservative, which is part of the preparation): instillation produced without lenses, and lenses can be worn in just 15 minutes (it is better to use timoptik without benzalkonium chloride). With the utmost care given to patients who had a history of severe anaphylactic reactions, as against the background of beta-blockers (by repeated contact with the allergen) can develop even more pronounced reaction.

Storage conditions

In the dark place at a temperature no higher than 30 C.

Keep out of the reach of children.

shelf life

3 years.

Do not use beyond the expiration date printed on the package.

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