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Instruction for use: Spophyllin retard 250

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Dosage form: tablets retard

Active substance: Theophyllinum


R03DA04 Theophylline

Pharmacological group

Adenosinergic agents

The nosological classification (ICD-10)

J45 Asthma: Asthma of physical effort; Asthmatic conditions; Bronchial asthma; Bronchial asthma of light course; Bronchial asthma with difficulty in sputum discharge; Bronchial asthma of severe course; Bronchial asthma physical effort; Hypersecretory asthma; The hormone-dependent form of bronchial asthma; Curbing asthma attacks with bronchial asthma; Non-allergic bronchial asthma; Night Asthma; Exacerbation of bronchial asthma; Attack of bronchial asthma; Endogenous forms of asthma; Night attacks of asthma; Cough with bronchial asthma

J45.0 Asthma with predominance of the allergic component: Asthma of bakers; Allergic lung diseases; Bronchial asthma, professional; Aspirin Asthma; Asthma atopic; Asthma bronchial atopic; Atopic asthma; Atopic bronchial asthma; Persistent atopic bronchial asthma; Allergic diseases of the respiratory tract

J45.1 Non-allergic asthma: Bronchial asthma physical exertion; Asthma of physical effort

J45.8 Mixed asthma: Asthma, bronchial, infectious-allergic; Infectious-allergic bronchial asthma; Infectious-allergic asthma

R06 Abnormal breathing: Kussmaul breath; Respiratory disorders of central origin; Tachypnea

Composition and release form

1 tablet retard (prolonged action) contains theophylline 100 or 250 mg; In a cardboard box 5 blisters for 10 pcs.


Mode of action - bronchodilating, diuretic, vasodilating, cardiotonic.

Inhibits phosphodiesterase and increases the level of cAMP in cells, competitively blocks adenosine receptors. Affects the intracellular distribution of calcium, reduces the release of histamine and leukotrienes, reduces the synthesis and effects of PG, increases the release of endogenous catecholamines.


As a result of increased motor activity of the ciliary epithelium of the trachea and bronchi, stimulation of the respiratory center and bronchodilation, it increases and improves alveolar ventilation. Strengthens the contractility of the heart muscle, stimulates the secretory activity of the stomach, increases the tone of the central nervous system, moderately expands pulmonary, renal and coronary vessels. Relaxes the smooth muscles of the digestive tract and biliary tract.


Well absorbed in the digestive tract. Binding to plasma proteins - 60% (in children and patients with cirrhosis of the liver - 35%). It penetrates the placental barrier into breast milk. Cmax - after 6 hours (in children - 4 hours), T1 / 2 - 10-15 hours. The therapeutic concentration in plasma is 10-20 μg / ml. Metabolised in the liver. It is excreted in the urine (unchanged - about 10%).

Indications of Spophyllin retard 250

Bronchial asthma, bronchoobstructive syndrome, chronic respiratory failure with hypoventilation, bronchiolitis in children.


Hypersensitivity, peptic ulcer of stomach and duodenum, bleeding in the digestive tract, hepatic insufficiency, myocardial infarction, arrhythmia, hypertrophic obstructive cardiomyopathy, thyrotoxicosis, epilepsy, glaucoma.

Side effects

Nausea, vomiting, gastroesophageal reflux, gastrointestinal bleeding, headache, insomnia, anxiety, seizures, tachyarrhythmia, allergic reactions.


Cimetidine, allopurinol, cyclosporine, macrolides, oral contraceptives, influenza vaccine - increase the concentration in the plasma; Phenobarbital, phenytoin, xanthine preparations, other inducers of microsomal oxidation - reduce. Strengthens the effect of diuretics, reduces - propranolol, pyrazolone derivatives, probenecid, coumarin anticoagulants.

Dosage and Administration

Inside, without chewing, 30 minutes before meals - 250 mg 2 times a day (with night choking attacks, the evening dose is increased by 1.5-2 times and taken at 22-24 h). Children (weighing up to 30 kg) - 10-20 mg / kg / day for 2 admission.

Storage conditions of Spophyllin retard 250

In dry, the dark place at a temperature of 5-25 C.

Keep out of the reach of children.

Shelf life of the drug Spophyllin retard 250

2 years.

Do not use after the expiry date printed on the package.

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