Instruction for use: Sodium deoxyribonucleate

Trade name of the drug – Desoxynatum, Derinat, Sodium desoxyribonucleate, Panagen

The Latin name of the substance Sodium deoxyribonucleate

Natrii deoxyribonucleas (genus. Natrii deoxyribonucleatis)

Pharmacological groups:

Regenerants and reparants

Stimulators of hematopoiesis

Other immunomodulators

The nosological classification (ICD-10)

A41.9 Septicemia, unspecified: Septic diseases; Septicemia / bacteremia; Toxico-infectious shock; Endotoxin shock; Bacterial septicemia; Bacterial infections of severe course; Generalized infections; Generalized systemic infections; Infections generalized; Wound sepsis; Septiccopymia; Septic-toxic complications; Septicemia; Septic conditions; Septic shock; Septic condition; Septic shock

B99 Other infectious diseases: Infections (opportunistic); Infections on the background of immunodeficiency; Opportunistic infections

I25 Chronic ischemic heart disease: Coronary heart disease on the background of hypercholesterolemia; Coronary heart disease is a chronic; Coronary heart disease; Stable coronary artery disease; Percutaneous transluminal angioplasty; Myocardial ischemia, arteriosclerosis; Recurrent myocardial ischemia

I73.1 thromboangiitis obliterans [Buerger's disease]: Berger's disease; thromboangiitis obliterans; trombangiit; thromboangiitis obliterans; Buerger's disease

I70.2 Atherosclerosis of arteries: arteriosclerosis obliterans; Arteriosclerosis peripheral arteries; Atherosclerosis of the arteries of the lower extremities; Atherosclerosis of peripheral arteries; Atherosclerosis limbs; Occlusive disease of the lower extremities; arteriosclerosis obliterans; Arteriosclerosis obliterans of lower limb arteries; Atherosclerosis obliterans of the upper limbs; Arteriosclerosis obliterans of lower extremities; Atherosclerosis of arteries; limb arteriopathy; Arteriosclerosis obliterans limbs; arteriosclerosis obliterans

I73.1 thromboangiitis obliterans [Buerger's disease]: Berger's disease; thromboangiitis obliterans; trombangiit; thromboangiitis obliterans; Buerger's disease

J00 Acute nasopharyngitis [rhinitis]: Viral rhinitis;Inflammation of the nasopharynx; Inflammatory Nose Disease; Purulent rhinitis; Nasal congestion; Nasal congestion due to cold and flu; Difficulty with nasal breathing; Difficulty with nasal breathing for colds; Difficult nasal breathing; Difficult nasal breathing for colds; Nasal hypersecretion; Coryza; ARI with phenomena of rhinitis; Acute rhinitis; Acute rhinitis of various origins; Acute rhinitis with thick purulent-mucous exudate; Acute rhinopharyngitis; Edema of the mucous membrane of the nasopharynx; Rhinitis; Rhinorrhea; Infectious-inflammatory disease of ENT organs;Severe cold; Rhinopharyngitis

J06 Acute upper respiratory tract infections of multiple and unspecified locations: Frequent colds of viral diseases; Infections of ENT organs; Acute respiratory illness of influenza nature; Pain for colds; Acute catarrhal disease; Cold; Colds; Colds; Respiratory infection; Seasonal catarrhal disease; Seasonal colds; Pain in infectious and inflammatory diseases of the upper respiratory tract; Bacterial infections of the upper respiratory tract; Bacterial infections of the respiratory system; Viral respiratory disease; Viral respiratory tract infections; Inflammatory disease of the upper respiratory tract; Inflammatory diseases of the upper respiratory tract; Inflammatory diseases of the upper respiratory tract with difficult to separate sputum; Inflammatory respiratory disease; Secondary infections for colds; Difficult sputum separation in acute and chronic respiratory diseases; Upper respiratory tract infections; Infections of the upper respiratory tract; Respiratory tract infections; Respiratory and lung infections; Infectious-inflammatory diseases of the upper respiratory tract; Infectious-inflammatory diseases of the upper respiratory tract and ENT organs; Infectious-inflammatory diseases of the upper respiratory tract in adults and children; Infectious-inflammatory diseases of the upper respiratory tract; Infectious inflammation of the respiratory tract; Respiratory tract infection; Qatar upper respiratory tract; Catarrh of the upper respiratory tract; Catarrh of the upper respiratory tract; Catarrhal phenomena from the upper respiratory tract; Cough in diseases of the upper respiratory tract; Cough for colds; ARVI; ARI; ARI with phenomena of rhinitis; Acute respiratory infection; Acute infectious-inflammatory disease of the upper respiratory tract; Acute respiratory disease; Persecution in the throat or nose; Respiratory and viral infections; Respiratory diseases; Respiratory infections; Recurrent respiratory tract infections; Secondary infections with influenza; Influenza states; Feverish conditions for influenza

J32 Chronic sinusitis: Allergic rhinosinusopathy; Purulent sinusitis; Catarrh of the nasopharyngeal region; Catarrhal inflammation of the paranasal sinuses; Exacerbation of sinusitis; Sinusitis chronic

J44 Other chronic obstructive pulmonary disease: Allergic bronchitis; Bronchitis allergic; Asthmatic bronchitis; Bronchitis obstructive; Disease of the bronchi; Difficult sputum separation in acute and chronic respiratory diseases; Cough with inflammatory diseases of the lungs and bronchi; Reversible bronchial obstruction; Reversible obstructive airway disease; Obstructive bronchial disease; Obstructive pulmonary disease; Obstructive bronchitis; Spastic bronchitis; Chronic lung diseases; Chronic nonspecific lung diseases; Chronic Obstructive Pulmonary Diseases; Chronic obstructive bronchitis; Chronic obstructive airways disease; Chronic obstructive pulmonary disease; Restrictive pathology of the lungs

K12 Stomatitis and Related Losses: Bacterial stomatitis; Inflammatory diseases of the oral cavity; Inflammatory diseases of tissues of the oral cavity; Inflammatory processes in the oral cavity; Fungal diseases of the mouth; Fungal infections of the oral cavity; Fungal infections and inflammatory diseases of the mouth; Diseases of the mouth; Infectious-inflammatory disease of the oral cavity; Exacerbation of inflammatory diseases of the pharynx and oral cavity; Stomatitis; Angular stomatitis; Chronic recurrent stomatitis; Ulcerative necrotic diseases of the oral mucosa; Ulcerative necrotic diseases of the oral mucosa; Ulcerative necrotic lesions of the oral mucosa; Ulcerative necrotic gingivostomatitis; Ulcerative stomatitis; Erosive-ulcerative lesion of the oral mucosa; Erosive-ulcerative lesions of the mucous membrane of the oral cavity; Erotic mucous membrane of the oral cavity; Recurrent ulcerative stomatitis

K25 Stomach ulcer: Helicobacter pylori; Pain syndrome with gastric ulcer; Pain syndrome with peptic ulcer of stomach and duodenum; Inflammation of the gastric mucosa; Inflammation of the mucosa of the gastrointestinal tract; Benign ulcer of the stomach; Disease of the stomach and duodenum, associated with Helicobacter pylori; Exacerbation of gastroduodenitis against ulcer disease; Exacerbation of peptic ulcer; Exacerbation of gastric ulcer; Organic GI disease; Peptic ulcer of the stomach and duodenum; Postoperative Stomach Ulcer; Recovering ulcers; Symptomatic Stomach Ulcers; Chronic inflammatory disease of the upper gastrointestinal tract associated with Helicobacter pylori; Helicobacter pylori eradication; Erosive-ulcerative lesions of the stomach; Erosive lesions of the stomach; Erosion of the gastric mucosa; Peptic Ulcer; Stomach ulcer; Stomach ulcer; Ulcerative lesions of the stomach; Symptomatic ulcers of the stomach and duodenum

K26 Ulcer of duodenum: Pain syndrome with duodenal ulcer; Pain syndrome with peptic ulcer of stomach and duodenum; Disease of the stomach and duodenum, associated with Helicobacter pylori; Exacerbation of peptic ulcer; Exacerbation of duodenal ulcer; Peptic ulcer of the stomach and duodenum; Recurrence of duodenal ulcer; Symptomatic ulcers of the stomach and duodenum; Helicobacter pylori eradication; Erosive-ulcerative lesions of the duodenum; Erosion-ulcerative duodenal lesions associated with Helicobacter pylori; Erosive lesions of the duodenum; Peptic ulcer disease of the duodenum; Ulcerative duodenal lesions

K29 Gastritis and duodenitis: Exacerbation of gastroduodenitis against ulcer disease; Duodenitis

L98.4 Chronic skin ulcer, not elsewhere classified: Secondarily infected trophic ulcers; Long-lasting non-healing skin ulcer; Ulceration of the skin; Cutaneous ulcer; Wetting ulcers; Chronic ulcers; Chronic skin ulcers; Chronic skin ulcer; Ulcers coughing; Septic ulcer

L98.4.2 * Trophic skin ulcer: Varicose ulcer; Varicose ulcers; Cutaneous ulcer; Non-healing ulcers; Trophic ulcer; Trophic ulcer of lower leg; Trophic skin lesions; Trophic after-burn ulcers; Trophic ulcers; Trophic skin ulcers; Ulcer of lower leg; Ulcer of skin; Ulcer of trophic skin; Ulcer on legs; Ulcerative necrosis of the skin; Ulcer of shin; Ulcer of the lower leg; Ulcers of lower extremities; Difficult healing ulcers

N41.9 Inflammatory disease of prostate, unspecified

N46 Male infertility: Azoospermia; Asthenospermia; Infertility; Infertility male; Marriage is infertile; Dispersion; Violation of spermatogenesis; Violations of spermatogenesis; Oligoastenozoospermia III-IV stage; Oligoastenospermia; Oligozoospermia; Oligospermia; Disorders of testicular functions; Spermatogenesis disorders; Inhibition of spermatogenesis; Yang syndrome

N71 Inflammatory diseases of the uterus other than the cervix: Intrauterine infections; Inflammatory diseases of female genitalia; Inflammatory diseases of female genital organs; Infection of the genitals; Chronic endometriometritis; Chronic inflammatory disease of the uterus; Endometritis; Endometriometry

N76 Other inflammatory diseases of the vagina and vulva: Vulvovaginitis atrophic; Vulvovaginitis bacterial; Vulvovaginitis estrogen-deficient; Bacterial vaginosis; Vaginitis; Vaginitis bacterial; Inflammatory diseases of the vagina and vulva; Inflammatory diseases of female genitalia; Inflammatory diseases of female genital organs; Vulvit; Vulvovaginitis; Vulvovaginitis; Gardnerella; Fungal vulvovaginitis in girls and virgins; Infection of the vagina; Infection of the genitals; Colpitis; Violation of purity of the vaginal secretion; Nonspecific cervicovaginitis; Nonspecific vulvitis; Nonspecific vulvovaginitis; Nonspecific colpitis; Recurrent nonspecific bacterial vaginosis; Senylic coverings; Mixed Colpus; Chronic vaginitis; Vulvovaginal infections; Bacterial vaginitis; Bacterial vaginosis; Bacterial vaginitis; Mixed vaginal infections

N97 Female infertility: Female infertility in anovulation; Hyperprolactinemic infertility; Hyperprolactinaemia with infertility; Endocrine infertility; Infertility due to hypothalamic-pituitary dysfunction; Infertility infertility; Infertility; Infertility on the background of hyperprolactinaemia; Functional infertility; Marriage is infertile; Infertility of ovarian genesis; Stimulation of the growth of a single follicle

T14.1 Open wound of unspecified body region: Secondary healing processes; Sluggishly granulating wounds; Sluggishly healing wounds; Sluggish wounds; Deep Wounds; Purulent wound; Granulating wounds; Prolonged non-healing wound; Long-lasting non-healing wound and ulcer; Long-lasting non-healing soft tissue wound; Healing of wounds; Wound healing; Capillary bleeding from superficial wounds; Bleeding wound; Radiation Wounds; Slowly epithelializing wounds; Minor cuts; Suppurated wounds; Violation of wound healing processes; Breach of skin integrity; Violations of the integrity of the skin; Violations of the integrity of the skin; Small cuts; Uninfected wounds; Uncomplicated wounds; Operating wound; Primary treatment of surface contaminated wounds; Primary wound treatment; Primary-delayed treatment of wounds; Poorly cicatrizing wound; Poor wound healing; Bad wound; Superficial injury; Superficial wound with mild exudation; Wound; The wound is large; Bite wound; Wound process; Wounds; Wound healing wounds; Stump Wounds; Wounds for gunshot; Wounds with deep cavities; Difficult healing wounds; Difficult wounds; Chronic Wounds

T30 Thermal and chemical burns of unspecified site: Pain syndrome with burns; Pain in burns; Pain with burns; Sluggishly healing post-burn wounds; Deep burns with a wet scab; Deep burns with abundant compartments; Deep burn; Laser burn; Burn; Burn of rectum and perineum; Burn with mild exudation; Burn disease; Burn injury; Superficial burn; Superficial burn of I and II degree; Superficial skin burns; After-burn trophic ulcer and wound; Post-burn complication; Loss of fluid in burns; Sepsis burn; Thermal burns; Thermal skin lesions; Thermal burn; Trophic after-burn ulcers; Chemical burn; Surgical burn

T33-T35 Frostbite

Characteristics of the substance Sodium deoxyribonucleate

Transparent colorless liquid (extract from milk of sturgeon fishes).

Pharmacology

Mode action - Anti-inflammatory, immunomodulating, reparative, regenerative.

Activates antiviral, antifungal and antimicrobial immunity at the cellular and humoral levels. It regulates hemopoiesis, normalizing the number of leukocytes, granulocytes, phagocytes, lymphocytes and platelets. Corrects the condition of tissues and organs in dystrophies of vascular origin, exhibits weak anticoagulant properties. In patients with chronic ischemic disease of the lower extremities (including against the background of diabetes mellitus), it increases tolerance to exercise when walking, reduces pain in the calf muscles, prevents the development of a feeling of cooling and chilliness of the feet. It improves blood circulation of the lower extremities, promotes the healing of gangrenous trophic ulcers, the appearance of a pulse on the peripheral arteries. Accelerates the rejection of necrotic masses (for example, on the phalanges of the fingers), which sometimes avoids surgical intervention. In patients with IHD improves myocardial contractility, improves microcirculation in the heart muscle, increases exercise tolerance and shortens the recovery period. Stimulates the reparative processes in peptic ulcer of the stomach and duodenum, restores the structure of the mucous membrane, suppresses the growth of Helicobacter pylori. It facilitates the engraftment of autografts in the transplantation of the skin and the tympanic membrane.

Application of the substance Sodium deoxyribonucleate

Solutions for external use and for injections: ARVI, trophic ulcers, burns, frostbite, long-term non-healing wounds, incl. With diabetes, purulent-septic processes, treatment of the surface of the graft before and after transplantation. Solution for external use: obliterating diseases of the lower extremities, defects of the mucous membrane of the oral cavity, nose, vagina. Solution for injection: myelodepression and cytostatic resistance in cancer patients, acute pharyngeal syndrome, peptic ulcer and duodenal ulcer, gastroduodenitis, ischemic heart disease, cardiovascular insufficiency, chronic ischemic disease of the lower extremities of the II and III stages, prostatitis, vaginitis, endometritis, infertility And impotence caused by chronic infections, chronic obstructive bronchitis.

Contraindications

Hypersensitivity.

Side effects of the substance Sodium deoxyribonucleate

Rarely - a short-term increase in body temperature (solution for injection).

Interaction

Strengthens the effect of antidiabetic drugs and anticoagulants.

Routes of administration

IM, adventitious.

Precautions for the substance Sodium deoxyribonucleate

To reduce soreness with IM injection should be administered slowly, within 1-2 minutes. Not allowed IV introduction.

At appointment to patients with a diabetes it is necessary to control the level of glucose in the blood (possible deep hypoglycemia).