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Instruction for use: Semprex

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Dosage form: capsules

Active substance: Acrivastinum


R06AX18 Acrivastine

Pharmacological group:


The nosological classification (ICD-10)

J30 Vasomotor and allergic rhinitis: Allergic rhinopathy; Allergic rhinosinusopathy; Allergic diseases of the upper respiratory tract; Allergic rhinitis; Allergic rhinitis seasonal; Vasomotor runny nose; Prolonged allergic rhinitis; All-year-round allergic rhinitis; All-year allergic rhinitis; Year-round or seasonal allergic rhinitis; All-the-year-round rhinitis of an allergic nature; Rhinitis vasomotor allergic; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic rhinitis; Edema of the nasal mucosa; Edema of the nasal mucosa; Edema of the mucous membrane of the nasal cavity; Swelling of the nasal mucosa; Swelling of the nasal mucosa; Pollinosis; Permanent allergic rhinitis; Rhinoconjunctivitis; Rhinosinusitis; Rhinosinusopathy; Seasonal allergic rhinitis; Seasonal allergic rhinitis; Hay rhinitis; Chronic allergic rhinitis; Allergic diseases of the respiratory tract

L20 Atopic dermatitis: Allergic diseases of the skin; Allergic skin disease noninfectious etiology; Allergic skin disease etiology nemikrobnoy; Allergic skin diseases; Allergic skin lesions; Allergic reactions on the skin; atopic dermatitis; Allergic dermatosis; Allergic diathesis; Allergic itching dermatosis; Allergic skin disease; Allergic skin irritation; allergic Dermatitis; atopic Dermatitis; allergic dermatoses; exudative diathesis; Itchy atopic eczema Itchy allergic dermatosis; Allergic skin disease; Cutaneous allergic reaction to drugs and chemicals; Cutaneous reactions to medications; Skin and allergic disease; Acute eczema; common neurodermatitis; Chronic atopic dermatitis; Exudative diathesis

L30.9 Unspecified Dermatitis: Allergic dermatoses complicated by a secondary bacterial infection; Anal eczema; Bacterial maturation; Varicose Eczema; Venous dermatitis; Inflammation of the skin; Inflammation of the skin upon contact with plants; Inflammatory Skin Disease; Inflammatory Skin Diseases; Inflammatory Skin Diseases; Inflammatory skin reactions; Inflammatory processes of the skin; Hypostatic dermatitis; Fungal Eczema; Fungal dermatosis; Dermatitis; Dermatitis is stagnant; Dermatitis and eczema in the anal area; Dermatitis acute contact; Perianal dermatitis; Dermatosis; Dermatosis of the scalp; Dermatosis of psoriasis; Dermatosis with persistent itching; Dermatoses; Dermatoses itchy; Other itching dermatoses; Significant eczematous manifestations; Itching with dermatoses; Itching eczema; Itching dermatoses; Itching dermatitis; Itching dermatosis; True eczema; Skin reaction to insect bites; Skin itching with dermatosis; Constitutional eczema; Weeping eczema; Drowsing inflammatory skin disease; Dying Infectious-Inflammatory Skin Disease; Non-allergic dermatitis; Nummular eczema; Acute contact eczema; Acute inflammatory skin disease; Acute dermatosis; Acute severe dermatosis; Perianal dermatitis; Superficial dermatosis; Subacute Contact Eczema; Simple dermatitis; Occupational dermatitis; Psychogenic dermatosis; Bubble dermatitis of newborns; Pustular eruptions; Irritation and redness of the skin; Low-flammable eczema; Dry atrophic eczema; Dry eczema; Toxic dermatitis; Ear eczema like dermatitis; Chronic eczema; Chronic dermatosis; Chronic dermatosis; Chronic common dermatosis; Scaly papular dermatosis; Eczema; Eczema anal region; Eczema of the hands; Eczema Contact; Eczema lichenized; Eczema Nummular; Eczema acute; Eczema acute contact; Eczema subacute; Eczematous dermatitis; Eczema-like rashes; Ecome exogenous; Endogenous eczema; Gluteal dermatitis; Limited itching dermatitis


Capsules - 1 caps.

Acrivastine 8 mg

Auxiliary substances: lactose monohydrate; Sodium starch glycolate; Magnesium stearate; Titanium dioxide; gelatin; Iron oxide black E172; Iron oxide red E172

12 pieces in the blister; In the box 1 blister.

Description of dosage form

White capsules in a hard gelatin shell, opaque, with the company logo and the inscriptions Wellcome and SEMPREX.

Pharmachologic effect

Pharmacological action - antiallergic, antiexudative.

It blocks histamine H1 receptors.


Well absorbed, relatively evenly distributed in the body. Cmax after taking 8 mg of acrivastine is achieved after 1.5 hours. Poor penetration through the BBB. T1 / 2 is approximately 1.5 hours. It is excreted mainly by the kidneys (mostly unchanged).

Clinical Pharmacology

Significant antiallergic and antiexudative effects last up to 12 hours. It has weakly expressed anticholinergic and sedative properties.

Indications for Semprex

Allergic rhinitis (including hay fever), allergic itching dermatoses (including atopic eczema), acute and chronic urticaria (including idiopathic, cholinergic, cold), symptomatic dermographism.


Hypersensitivity (including triprolidine), marked renal failure (Cl creatinine less than 50 ml / min or creatinine in the blood above 150 μmol / l), children under 12 years.

Application in pregnancy and breastfeeding

Perhaps, if the expected effect of therapy exceeds the potential risk to the fetus.

Side effects

Rash, allergic reactions, drowsiness, anaphylaxis (rarely).

Dosing and Administration

Inside, regardless of meals, squeezed water. Adults and children over 12 years of age - 8 mg (1 caps.) 3 times a day.


Symptoms: gastrointestinal disorders, headache, drowsiness.

Treatment: symptomatic and supportive, if necessary - gastric lavage.

Precautionary measures

Given the possibility of an individual reaction to the drug, care must be taken when driving vehicles and mechanisms. At simultaneous reception with alcohol or the means oppressing the central nervous system, it is possible to increase the decrease in the reaction speed.

With caution should be used in elderly patients (monitoring of kidney function is necessary).

Storage conditions of the drug Semprex

In a dry, the dark place at a temperature of no higher than 30 C.

Keep out of the reach of children.

Shelf life of the drug Semprex

5 years.

Do not use after the expiry date printed on the package.

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