Instruction for use: Radomin

Dosage form: pill

Active substance: Pentoxyphyllinum

ATX

C04AD03 Pentoxifylline

Pharmacological group

Antiaggregants

Adenosinergic agents

Angioprotectors and microcirculation correctors

The nosological classification (ICD-10)

H34 Vascular occlusion of retina: Arterial thrombosis of the vessels of the eye; Venous thrombosis of the vessels of the eye; Violation of retinal circulation; Disturbances of intraocular circulation; Insufficient blood supply to the mesh and choroid; Occlusion of central retinal vessels; Acute obstruction of retinal arteries; Subacute and chronic circulatory insufficiency in the retina or in the choroid of the eye; Vascular diseases of the retina; Vascular disorders in the retina of the eye; Vascular thrombosis of the retina; Central retinal vein thrombosis; Thrombosis of the central vein of the retina and its branches; Thrombosis of the central vein of the retina of the eye and its branches

H83 Other internal ear disorders: Disturbance of inner ear function; Violation of the inner ear function of vascular genesis; Disturbances of blood supply to the inner ear; Functional disorder of the inner ear

I63 Cerebral infarction: ischemic Stroke; Ischemic brain disease; Ischemic stroke; Ischemic stroke and its consequences; Ischemic cerebral stroke; Ischemic cerebrovascular accident; Ischemic brain damage; Ischemic brain damage; ischemic conditions; Cerebral ischemia; Acute hypoxia brain; Acute cerebral ischemia; Acute ischemic cerebrovascular accident; Acute cerebral infarction; Acute ischemic stroke; Acute period of ischemic stroke; Focal cerebral ischemia; Ischemic stroke; recurrent stroke; The syndrome of Morgagni-Adams-Stokes; Chronic cerebral ischemia; cerebrovascular stroke; embolic stroke; Ischemic brain damage

I73.0 Raynaud's Syndrome: Raynaud's syndrome Leriche; Raynaud's disease; Raynaud's phenomenon; RaynaudLeriche syndrome; Raynaud's disease; Raynaud's syndrome with trophic disorders; Peripheral angiopathy

I79.2 Peripheral angiopathy in diseases classified elsewhere: diabetic angiopathy; Angiopathy in diabetes; arteriosclerosis diabetic; Pain in lesions of peripheral nerves; Diabetic angiopathy; Diabetic microangiopathy; Diabetic vascular disease; Intermittent angioneurotic disbaziya; Macroangiopathy in diabetes; microangiopathy; Microangiopathy in diabetes mellitus; Tingling sensations in the hands and feet; Coldness in the extremities; Peripheral angiopathy; Peripheral arterial disease; Sclerosis Menkeberga; Chronic obliterating diseases of arteries

I87.0 Postphlebitic syndrome: post-thrombotic venous insufficiency; Postthrombotic disease; Post thrombophlebitic syndrome; Post-thrombophlebitis; Post-thrombophlebitic syndrome; Postphlebitic syndrome; Post thrombotic syndrome; Postphlebitic syndrome (stasis syndrome)

I99 Other and unspecified disorders of the circulatory system: angiopathy; Arterial angiopathy; Atherosclerotic angiopathy; Hemodynamic right heart defects; Hemodynamic defect of the right heart; coronary angiopathy; Infringement of blood circulation; Violation of circulation; Violation microcirculation in organs and tissues; Peripheral circulatory disorders; Disorders of the peripheral circulation in the extremities; circulatory failure; Hemodynamic instability occlusion of arteriovenous origin; Acute circulatory failure; Psevdostenokardicheskie state; Psevdostenokardicheskoe disorder; circulatory disorder; Cardiovascular diseases; Vascular insufficiency; Thrombosis arteriovenous shunt; Thrombosis with prosthetic heart valves; Deterioration of blood circulation in the pelvic organs; Functional failure of the cardiovascular system; Functional disorders of the cardiovascular system; Chronic arterial insufficiency; Chronic heart failure; Age-related vascular disease; The risk of thrombosis

L98.4.2 * Trophic skin ulcer: Varicose ulcer; Varicose ulcers; Cutaneous ulcer; Non-healing ulcers; Trophic ulcer; Trophic ulcer of lower leg; Trophic skin lesions; Trophic after-burn ulcers; Trophic ulcers; Trophic skin ulcers; Ulcer of lower leg; Ulcer of skin; Ulcer of trophic skin; Ulcer on legs; Ulcerative necrosis of the skin; Ulcer of shin; Ulcer of the lower leg; Ulcers of lower extremities; Difficult healing ulcers

T33-T35 Frostbite

Composition and release form

1 pills contains pentoxifylline 400 mg; In blistere 10 pcs., In a cardboard box 2 blisters.

Pharmacology

Mode of action - Vasodilator, antiaggregational, angioprotective, improving microcirculation.

It blocks phosphodiesterase and increases the content of cAMP in the cells.

Pharmacodynamics

Increases the elasticity of red blood cells, reduces their aggregation, reduces the concentration of fibrinogen and the viscosity of blood, inhibits platelet aggregation, increases fibrinolysis, improves peripheral circulation, normalizes the rheology of blood and supplies tissues with oxygen.

Pharmacokinetics

Well and fully absorbed. Cmax is achieved in 2-4 hours and remains stable for 12 hours.

Indications of Radomin

Post-thrombophlebitic syndrome, trophic ulcers of the lower leg, gangrene, frostbite, Raynaud's disease, vascular disorders of the eye and hearing organs, cerebral circulation disorders, diabetic angiopathy.

Pregnancy and breast-feeding

Contraindicated in the first months of pregnancy.

Side effects

Dyspeptic disorders, skin allergic reactions.

Interaction

Strengthens the antithrombotic effect of heparin and fibrinolytic drugs, the effect of certain hypotensive and hypoglycemic drugs.

Dosage and Administration

Inside, after eating, not chewing, drinking water, 1 tablet 2-3 times a day.

Overdose

Symptoms: hyperemia (face), hypotension, clonic-tonic convulsions, loss of consciousness, vomiting (sometimes "coffee grounds"), fever. Treatment is symptomatic.

Precautionary measures

With a simultaneous appointment with antidiabetic and hypotensive drugs, the dose should be reduced.

Storage conditions of Radomin

In a place protected from light and moisture, at room temperature.

Keep out of the reach of children.

Shelf life

3 years

Do not use beyond the expiration date printed on the package.