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DR. DOPING

Instructions

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Instruction for use: Profasi

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Active substance: Chorionic gonadotropin

ATX code G03GA01 Chorionic gonadotropin

Pharmacological group

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Nosological classification (ICD-10)

E23.0 Hypopituitarism

Kalmann's syndrome, Infantilism pituitary, Dwarfism is cerebral-pituitary, Cachexia pituitary, Cachexia diencephalo-pituitary, Anovulatory disorders, Symmonds disease, Secondary hypogonadism in men, Secondary hypogonadotropic hypogonadism, Hypogenitalism, Hypogonadism, Hypogonadism hypogonadotropic, Hypogonadism of the pituitary, Hypogonadism in men, Hypogonadotropic hypogonadism, Hypopituitarism, Pituitary insufficiency, Lack of growth in children with hypopituitarism, Pangypopituitarism, Primary hypogonadism, Primary hypogonadotropic hypogonadism, Shihan Syndrome, Shihina's Syndrome, Symmonds-Glinsky disease, Laron's dwarfism, Sheena's Syndrome, Syndrome of a fertile eunuch

E23.6.0 * Adiposogenital Syndrome

Adiposogenital Syndrome

E25 Adrenogenital disorders

Macroghenytozomy in boys, Adrenogenital syndrome, Decreased function of the sex glands, Congenital dysfunction of the adrenal cortex, Apera-Halle Syndrome, Crook-Apera-Halle Syndrome

E29 Testicular dysfunction

Hypofunction of gonads in men, Androgenic dysfunction, Dysfunction of the sex glands, Dysfunction of gonads in men, Underdevelopment of the genitals in men, Primary hypogonadism in men

N46 Male infertility

Azoospermia, Asthenospermia, Infertility, Infertility male, Marriage is infertile, Dispersion, Violations of spermatogenesis, Oligoastenozoospermia III-IV stage, Oligoastenospermia, Oligozoospermia, Oligospermia, Disorders of testicular functions, Spermatogenesis disorders, Inhibition of spermatogenesis, Yang syndrome

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

N97 Female infertility

Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle

O00-O08 Pregnancy with abortive outcome

O20.0 Threatened abortion

Abortion threatening, threatening miscarriage, Spastic conditions with the risk of abortion, Threatened miscarriage in the first trimester of pregnancy, The threat of miscarriage, threatened abortion, The threat of miscarriage, Threatened spontaneous miscarriage

Composition and form of release

1 ampoule with powder for the preparation of the injection solution contains human chorionic gonadotropin 2000 or 5000 IU; Complete with a solvent in ampoules of 1 ml, in the package 3 sets.

pharmachologic effect

Pharmacological action - luteinizing, stimulating spermatogenesis.

In women - mainly luteinizing, in men - mainly steroidogenic, initiates and supports spermatogenesis.

indications

In women, infertility associated with anovulation, "superovulation" (in the implementation of various auxiliary methods of reproduction for the onset of conception), malnutrition of the yellow body and maintenance of the luteal phase, habitual miscarriage of pregnancy, threatening spontaneous miscarriage. In men - hypogonadotropic hypogonadism, cryptorchidism, oligoasthenospermia and azoospermia.

Contraindications

Hypersensitivity, swelling of the ovaries, pituitary gland, carcinoma or hormone-dependent prostate cancer; Dysgenesis of the gonads, absence of the uterus, early onset of menopause, obstruction of the fallopian tubes; Thrombophlebitis; lactation.

Side effects

Headaches, weakness, irritability, anxiety, depression; Occasionally allergic reactions; Pain in the area of injection; In women - the syndrome of ovarian hyperstimulation, in men - fluid retention, edema, hypersensitivity of nipples and gynecomastia, premature puberty.

Dosing and Administration

 / ì, ï / ê (the powder is dissolved immediately before use).

For women: with anovulatory infertility - up to 10,000 IU (in the middle of the cycle), for "superovulation" - up to 10,000 IU, once, with a deficiency of the yellow body - 5000 IU IM (on the fifth day after ovulation), habitual miscarriage, threat of spontaneous miscarriage - 10000 IU in / m, then - 5000 IU twice a week.

Men: to normalize serum testosterone levels - up to 4000 IU weekly, for induction of spermatogenesis - up to 12000 IU weekly for 6-9 months or 4000 IU three times a week for 6-9 months, followed by a dose reduction of up to 2000 IU three times a week 3 more months. With prepubertal cryptorchidism three different schemes of drug administration are used: 4000 IU 3 times a week for 3 weeks; 5000 IU in a day, only 4 injections; 500-1000 IU of the drug for 6 weeks, only 25 injections. With idiopathic normogonadotropic oligospermia, 5000 IU weekly for 3 months (together with pergonal), with oligospermia and asthenospermia, 2500 IU every 5 days or 10,000 IU every 2 weeks for 3 months.

storage conditions

At a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf Life

3 years.

Do not use after the expiry date printed on the package.

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