Instruction for use: Prednisolone (Methylprednisolonum)

Pharmacological group

Glucocorticosteroids

Nosological classification (ICD-10)

A09 Diarrhea and gastroenteritis of allegedly infectious origin (dysentery, bacterial diarrhea)

Bacterial diarrhea, Bacterial dysentery, Bacterial infections of the digestive tract, Bacterial gastroenteritis, Diarrhea bacterial, Diarrhea or dysentery of amoebic or mixed etiology, Diarrhea of infectious genesis, Diarrhea on the background of antibiotic therapy, Traveler's Diarrhea, Travelers diarrhea due to changes in diet and habitual diet, Diarrhea due to antibiotic therapy, Dysenteric bacteriocarrier, Dysenteric enteritis, Dysentery, Dysentery bacterial, Dysentery mixed, Gastrointestinal infection, GI tract infections, Infectious diarrhea, Infectious Disease of the GI tract, Infection of the gastrointestinal tract, Infection of the biliary tract and gastrointestinal tract, GI tract infection, Summer diarrhea, Nonspecific acute diarrhea of infectious nature, Nonspecific chronic diarrhea of infectious nature, Acute bacterial diarrhea, Acute diarrhea in food poisoning, Acute dysentery, Acute bacterial gastroenteritis, Acute gastroenterocolitis, Acute Enterocolitis, Subacute dysentery, Diarrhea chronic, Refractory diarrhea in AIDS patients, Staphylococcal enteritis in children, Staphylococcal enterocolitis, Toxic diarrhea, Chronic dysentery, Enteritis, Enteritis infectious, Enterocolitis

A16 Tuberculosis of respiratory organs, not confirmed bacteriologically or histologically

A17.0 Tuberculous meningitis (G01 *)

Tuberculosis of serous membranes, Tuberculous meningitis, Meningitis tuberculosis

C34 Malignant neoplasm of bronchi and lung

Small cell anaplastic lung tumors, Small cell and non-small cell lung cancer, Small cell lung cancer, Locally-distributed small cell lung cancer, Locally advanced non-small cell lung cancer, Undifferentiated lung cancer, Non-small cell lung cancer, Bronchogenic Cancer, Non-small cell lung cancer, Inoperable locally advanced non-small cell lung cancer, Cancer of the bronchi, Lungs' cancer, Small cell lung cancer, Lung cancer, Small cell lung cancer, Non-small cell lung cancer, Lung cancer of squamous cell, Recurrent non-small cell non-small cell lung cancer, Small cell lung carcinoma, Inoperable metastatic non-small cell lung cancer, Lung carcinoma, Ovsyocellular carcinoma of the lung, Disseminated lung cancer, Tumors of the lungs

C81 Hodgkin's disease [lymphogranulomatosis]

Paltauf-Sternberg disease, The generalized form of Hodgkin's disease, Lymphogranulomatosis, Hodgkin's disease, Hodgkin's lymphoma, Hodgkin's malignant lymphoma, Hodgkin's lymphoma, Lymphoproliferative diseases, Reticulosis fibromyaloid, Pelya-Ebstein fever

C91 Lymphoid leukemia [lymphatic leukemia]

Lymphocytic leukemia, Lymphoproliferative diseases, Neuroleukemia, Refractory acute lymphoblastic leukemia, Refractory lymphoblastic leukemia, Transformation of preleukemias, Chronic lymphatic leukemia, Lymphoproliferative disorders

C92 Myeloid leukemia [myeloid leukemia]

Ph-positive chronic myelogenous leukemia, Granulocytic leukemia, Myeloid leukemia, Myeloid leukemia, Myeloma disease, Neuroleukemia, Acute myeloblastic leukemia, Acute non-lymphoblastic leukemia, Acute non-lymphoblastic leukemia in adults, Refractory acute non-lymphoblastic leukemia, Induction of remission in PMLL, Transformation of preleukemias, Subleukemic myelosis, Myeloblastic leukemia, Myeloid leukemia

D59.1 Other autoimmune hemolytic anemia

Autoimmune hemolytic anemia, Immune hemolytic anemia, Autoimmune hemolytic anemia

D60.9 Acquired pure red cell aplasia, unspecified

Hematopoietic disorders, Partial red cell aplasia of hematopoiesis, Erythroid anemia

D61.0 Constitutional aplastic anemia

Anemia hypoplastic

D69.3 Idiopathic thrombocytopenic purpura

Werlhof's disease, Idiopathic autoimmune thrombocytopenia, Idiopathic thrombocytopenic purpura of adults, Idiopathic thrombocytopenic purpura in adults, Immune idiopathic thrombocytopenic purpura, Immune thrombocytopenia, Bleeding in patients with thrombocytopenic purpura, Evans Syndrome, Thrombocytopenic purpura, Thrombocytopenia of immune origin, Chronic idiopathic thrombocytopenic purpura, Essential thrombocytopenia, Autoimmune thrombocytopenic purpura in pregnancy, Posttransfusion purpura

D69.5 Secondary thrombocytopenia

Secondary cytopenia

D70 Agranulocytosis

Agranulocytosis is hereditary, Aleicia, Aleykocytosis, Agranulocytic angina, Angina agranulocytic, Primary cytopenia

D86.0 Lung sarcoidosis

E05 Thyrotoxicosis [hyperthyroidism]

Von Bazedova's disease, Basedova's disease, Hyperthyroidism, Goiter toxic diffuse, Increased function of the thyroid gland, Thyrotoxic reaction, Toxic diffuse goiter, Toxic goiter, Thyroid enlargement with hyperthyroidism, The phenomenon of iodine-Bashedov

E05.0 Thyrotoxicosis with diffuse goiter

Goiter toxic diffuse, Toxic goiter, Diffuse thyrotoxic goiter, Graves disease, Diffuse toxic goiter, Goiter diffuse toxic, Parry's disease, Flanyani disease, Von Bazedova's disease, Toxic diffuse goiter

E06.1 Subacute thyroiditis

De Cherven's disease, De Kervena granulomatous goiter, Thyroiditis granulomatous giant cell

E27.1 Primary insufficiency of the adrenal cortex

Addison's Disease, Addisonism, Adrenocortical insufficiency, Hypofunction of the adrenal cortex, Collapse with Addison's Disease, Insufficiency of the adrenal cortex primary, Primary adrenocortical insufficiency, Primary adrenal insufficiency

E27.4 Other and unspecified adrenocortical insufficiency

Hypocorticism, Hypoaldosteronism, Adrenal insufficiency, Insufficiency of the adrenal cortex, Insufficiency of the adrenal cortex, Secondary adrenocortical insufficiency, Secondary adrenal insufficiency, Secondary insufficiency of the adrenal cortex, Temporary decrease in the function of the adrenal cortex, Dysfunction of the adrenal cortex

E27.8 Other specified disorders of the adrenal gland

E83.5.0 * Hypercalcemia

Hypercalcemic crisis, Idiopathic hypercalcemia of newborns, Milk-alkaline syndrome

G35 Multiple sclerosis

Disseminated sclerosis, multiple sclerosis, Relapsing Multiple Sclerosis, Secondary progressive multiple sclerosis, Exacerbation of multiple sclerosis, Mixed forms of multiple sclerosis

G93.6 Edema of the brain

Intraoperative cerebral edema, Cerebral edema, Post-traumatic swelling of the brain, Brain edema associated with radiation therapy, Brain edema associated with head trauma, Post-traumatic cerebral edema, Edema of the brain in poisoning

H10.1 Acute atopic conjunctivitis

Allergic conjunctivitis, Allergic eye disease, Allergic conjunctivitis, Allergic conjunctivitis is caused by chemical and physical factors, Allergic rhinoconjunctivitis,Allergic inflammation of the eye, Spring catarrh, Spring keratitis, Spring conjunctivitis, allergic Conjunctivitis, Perennial allergic conjunctivitis,Exacerbation of pollen allergy in the form of Syndrome rinokonyunktivalnogo, Acute allergic keratoconjunctivitis, Acute allergic conjunctivitis,Superficial bacterial eye infections,rhinoconjunctivitis, Seasonal allergic conjunctivitis, Seasonal conjunctivitis, Sennoz, Chronic allergic keratoconjunctivitis, Chronic allergic conjunctivitis

H10.5 Blepharoconjunctivitis

Chronic Blepharoconjunctivitis, Blepharoconjunctivitis, Staphylococcal blepharoconjunctivitis

H10.9 Conjunctivitis, unspecified

Trahomny conjunctivitis, catarrhal conjunctivitis, Giperpapillyarny conjunctivitis, Non-infectious conjunctivitis, purulent conjunctivitis, Purulent conjunctivitis form, Year-round conjunctivitis, purulent conjunctivitis, Subacute conjunctivitis, Secondarily infected with conjunctivitis

H15.0 Sclerite

Acute scleritis, Chronic scleritis, Diffuse scleritis, Sclerite

H15.1 Episcleritis

Acute episcleritis, Chronic episcleritis

H16.0 Corneal ulcer

Allergic corneal ulcer, Erosion of the cornea, Regional ulcer, Purulent corneal ulcer,Corneal ulcer, Trophic ulcers of the cornea, Traumatic erosion of the cornea, Ulceration of the cornea, Keratitis with corneal ulceration, Ulcerative keratitis, Purulent corneal ulcers, Epithelial point keratitis, Ulceration of superficial corneal layers, Keratomalacia, Corneal ulcer, Recurrent erosions of the cornea, Recurrent ulcers of the cornea, Bacterial corneal ulcer, Septic ulcer of the cornea, Corneal edge ulcer

H20 Iridocyclitis

recurrent iritis, sympathetic iridocyclitis, Sluggish posterior uveitis, Sluggish posterior uveitis, Posterior uveitis, the posterior segment of the eye Iridocyclitis, Iridocyclitis and other uveitis, Irit, Keratoiridotsiklit, Acute iritis, uveitis, cycle of Acute iridocyclitis, Acute non-infectious uveitis

H30 Chorioretinal inflammation

Retinitis, Chorioretinitis, Central and peripheral chorioretinal dystrophy

H44.1 Other endophthalmitis

Ophthalmic sympathetic, Egyptian ophthalmia,Endophthalmitis

H46 Optic neuritis

Leber Retinitis, Inflammatory optic neuritis of the optic nerve, Strona syndrome, Inflammation of the optic nerve, Papillitis

I00 Rheumatic fever without mention of cardiac involvement

Acute rheumatism, Rheumatic arthritis acute, Rheumatism is active, Rheumatic fever, Acute attack of rheumatic joint disease

I01 Rheumatic fever with involvement of the heart

Rheumatic carditis acute

I25.2 Myocardial infarction in the past

Cardiac syndrome, Postponed myocardial infarction, Post-infarction period, Rehabilitation after myocardial infarction, Reocclusion of the vessels, Angina postinfarction, Condition after myocardial infarction, Condition after myocardial infarction, Postinfarction cardiosclerosis

J18.9 Pneumonia, unspecified

Pneumonia in immunodeficiency states, Pneumonia with Legionnaires' Disease, Community-acquired pneumonia, Hospital-acquired pneumonia, Hospital pneumonia, Hospital pneumonia, Interstitial pneumonia, Respiratory infections, Non-pneumococcal pneumonia, Pneumonia

J30 Vasomotor and allergic rhinitis

Allergic rinopatiya, Allergic rhinosinusopathy, Allergic respiratory diseases, Allergic rhinitis, nasal allergy, Seasonal Allergic Rhinitis, Vasomotor rhinitis, Long-allergic rhinitis, Perennial allergic rhinitis, Perennial allergic rhinitis, Year-round or seasonal allergic rhinitis, Year-round allergic rhinitis nature, Rhinitis allergic vasomotor, Exacerbation of pollen allergy in the form of Syndrome rinokonyunktivalnogo, Acute allergic rhinitis, Edema of the nasal mucosa, Edema of the nasal mucosa, Swelling of the mucosa of the nasal cavity, Swelling of the nasal mucosa, Swelling of the nasal mucosa, pollen disease, Permanent allergic rhinitis, rhinoconjunctivitis, rhinosinusitis,rhinosinusopathy, Seasonal allergic rhinitis, Seasonal Allergic Rhinitis, Haymarket rhinitis, Chronic allergic rhinitis, Allergic respiratory diseases

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

J46 Status asthmaticus

Asthmatic attack, status asthmaticus, Bronchospasm in bronchial asthma

J63.2 Berylliosis

J69.0 Pneumonitis caused by food and vomit

Aspiration pneumonia, Pneumonia aspiration, Postoperative aspiration pneumonia in neurosurgical and thoracic operations

J82 Pulmonary eosinophilia, not elsewhere classified

Pulmonary infiltrate, Eosinophilic pulmonary infiltrate, Leffler's syndrome, Leffler's disease

J84.1 Other interstitial lung diseases with mention of fibrosis

Pneumonia fibrous, Pneumonia chronic, Fibrosis of the lung, Diffuse pulmonary fibrosis, Idiopathic pulmonary fibrosis, Fibrosis of the lungs, Pneumosclerosis, Pleurofibrotic fibrosis, Fibrosis of the lungs idiopathic, Fibrosis of lungs progressive massive, Pneumofibrosis

K50 Crohn's disease [regional enteritis]

Crohn's disease, Crohn's disease with fistula, Granuloma of the intestine, Granulomatous enteritis, Crohn's disease, Regional ileitis, Terminal Ileitis, Enteritis regional

K51 Ulcerative colitis

Colitis acute ulcerative, Colitis ulcerative, Ulcerative-necrotic colitis, Colitis ulcerative-hemorrhagic nonspecific, Colitis ulcerative and trophic, Colitis ulcerative idiopathic, Colitis ulcerative nonspecific, Nonspecific ulcerative colitis, Proctocolitis ulcers, Hemorrhagic purulent rectoxitis, Rectoccolitis ulcerative-hemorrhagic

K72.0 Acute and subacute liver failure

Lightning-fast hepatitis, Hepatitis acute, Hepatic failure acute and subacute

K73.9 Chronic hepatitis, unspecified

Chronic hepatitis, Chronic hepatitis with signs of cholestasis, Inflammatory liver disease, Infection of the liver, Chronic reactive hepatitis, Chronic inflammatory liver disease, Hepatitis chronic

K74 Fibrosis and cirrhosis of the liver

Otecno-ascitic syndrome with cirrhosis of the liver, Inflammatory liver disease, Precircrotic condition, Cystic fibrosis of the liver, Cirrhotic and precircotic state, Cirrhosis with portal hypertension, Cirrhosis of the liver with portal hypertension and edematous-ascitic syndrome, Cirrhosis of the liver with portal hypertension, Cirrhosis of the liver with ascites and edema, Cirrhosis of the liver with ascites, Cirrhotic ascites

L10 Pemphigus [pemphigus]

Benign pemphigoid of mucous membranes, Bubble dermatosis, Pemphigus, Dermatitis, vesicular, Benign pemphigus, Ordinary pemphigus, Pemphigus, Bubble dermatitis, Family benign pemphigus Hailey-Hailey

L13.9 Bullous changes, unspecified

Bullous dermatitis

L20 Atopic dermatitis

Itchy atopic eczema, Common neurodermatitis, Allergic skin diseases, Allergic skin diseases of non-infectious etiology, Allergic skin diseases of non-microbial etiology, Allergic skin diseases, Allergic skin lesions, Allergic manifestations on the skin, Allergic dermatitis, Allergic diathesis, Allergic itching dermatosis, Allergic Skin Disease, Allergic skin irritation, Dermatitis allergic, Atopic dermatitis, Dermatosis allergic, Diathesis exudative, Skin Allergic Disease, Skin allergic reaction to medicinal and chemical preparations, Skin reaction to medication, Skin and allergic disease, Acute eczema, Chronic atopic dermatitis, Exudative diathesis, Itching allergic dermatosis

L20.8 Other atopic dermatitis

Constitutional neurodermatitis, Chronic neurodermatitis, Restricted neurodermatitis, Allergic eczema, Atopic eczema, Children's eczema, Diffuse neurodermatitis, Neurodermatitis, Neurodermatitis diffuse, Neurodermatitis limited, Neurodermatitis, Dermatosis of a neurogenic origin

L21 Seborrheic dermatitis

Dermatitis seborrheic, Increased sebum separation, Seborrheic Eczema, Seborrheic dermatitis of the scalp, Seborrheic pyodermatitis, Seborrhea, Eczema seborrheic

L25.9 Unspecified contact dermatitis, cause not specified

L26 Exfoliative dermatitis

Dermatitis exfoliative, Exfoliative dermatitis generalized

L21 Seborrheic dermatitis

Dermatitis seborrheic, Increased sebum separation, Seborrheic Eczema, Seborrheic dermatitis of the scalp, Seborrheic pyodermatitis, Seborrhea, Eczema seborrheic

L25.9 Unspecified contact dermatitis, cause not specified

L26 Exfoliative dermatitis

Dermatitis exfoliative, Exfoliative dermatitis generalized

L28.0 Simple chronic lichen

Common lichen, Chronic and simple lichen, Chronic lichen

L30.9 Dermatitis, unspecified

Allergic dermatoses complicated by a secondary bacterial infection, Anal eczema, Bacterial maturation, Varicose Eczema, Venous dermatitis, Inflammation of the skin, Inflammation of the skin upon contact with plants, Inflammatory Skin Diseases, Inflammatory skin reactions, Inflammatory processes of the skin, Hypostatic dermatitis, Fungal Eczema, Fungal dermatosis, Dermatitis, Dermatitis is stagnant, Dermatitis and eczema in the anal area, Dermatitis acute contact, Perianal dermatitis, Dermatosis, Dermatosis of the scalp, Dermatosis of psoriasis, Dermatosis with persistent itching, Dermatoses, Dermatoses itchy, Other itching dermatoses, Significant eczematous manifestations, Itching with, dermatoses, Itching eczema, True eczema, Skin reaction to insect bites,Skin itching with dermatosis, Constitutional eczema, Weeping eczema, Drowsing inflammatory skin disease, Dying Infectious-Inflammatory Skin Disease, Non-allergic dermatitis, Nummular eczema, Acute contact eczema, Acute inflammatory skin disease, Acute dermatosis, Acute severe dermatosis, Perianal dermatitis, Superficial dermatosis, Subacute Contact Eczema, Simple dermatitis, Occupational dermatitis, Psychogenic dermatosis, Bubble dermatitis of newborns, Pustular eruptions, Irritation and redness of the skin, Low-flammable eczema, Dry atrophic eczema, Dry eczema, Toxic dermatitis, Ear eczema like dermatitis, Chronic eczema, Chronic dermatosis, Chronic common dermatosis, Scaly papular dermatosis, Eczema, Eczema anal region, Eczema of the hands, Eczema Contact, Eczema lichenized, Eczema Nummular, Eczema acute, Eczema acute contact, Eczema subacute, Eczematous dermatitis, Eczema-like rashes, Ecome exogenous, Endogenous eczema, Gluteal dermatitis, Restricted itchy dermatitis

L40 Psoriasis

Chronic psoriasis with diffuse plaques, Generalized psoriasis, Psoriasis of the scalp, Psoriasis of the scalp, Generalized form of psoriasis, Psoriasis dermatitis, Psoriasis complicated by erythroderma, Invalidative psoriasis, Isolated psoriatic plaque, Exfoliative psoriasis, Psoriatic Erythroderma, Psoriasis with eczematosis, Hyperkeratosis in psoriasis,Inverse psoriasis,Psoriasis eczematous, Dermatosis of psoriasis, Psoriasis of the genitals, Psoriasis with lesions of hairy areas of skin, Erythrodermal psoriasis, Chronic psoriasis of the scalp, Chronic psoriasis, Ordinary psoriasis, Refractory psoriasis, Kebner phenomenon, Scaly lichen

L40.5 Arthropathy psoriasis (M07.0-M07.3 *, M09.0 *)

Arthritis psoriatic, Arthropathic form of psoriasis

L65.9 Non-scarring hair loss, unspecified

Degenerative changes in hair structure, Diffuse hair thinning, Baldness, Hair thinning

L91.0 Keloid cicatrix

Hyperlusculation, Keloid, Keloid cicatrix, Kelloid scars

L93.0 Discoid lupus erythematosus

Chronic discoid lupus erythematosus, Red discoid lupus, Discoid lupus, Discoid erythematosis

L98.8 Other specified diseases of skin and subcutaneous tissue

Favre-Canculo disease, Interdigital erosion, Ultrasonic cystic skin elastosis with comedones, Benign skin change

M06.1 Still's disease, developed in adults

Still's disease, Still's syndrome

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M08 Juvenile [juvenile] Arthritis

Juvenile arthritis, Juvenile chronic polyarthritis, Juvenile chronic arthritis, Juvenile rheumatoid arthritis, Arthritis juvenile chronic

M10.0 Idiopathic Gout

Primary gout

M13.0 Unspecified polyarthritis

Polyarthritis, Inflammatory diseases of joints, Nonspecific polyarthritis, Exchange polyarthritis, Polyarthritis, Polyarthropathy, Subchronic polyarthritis, Chronic polyarthritis, Pain with osteoarthritis, Polyarthritis of unclear etiology

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M30.0 Nodular polyarteritis

Periarteritis nodosa, Nodular periarteritis, Nodular polyarteritis (periarteritis)

M31.1 Thrombotic microangiopathy

Thrombotic thrombocytopenic purpura, Thrombocytopenic acroangiothrombosis, Moshkovich disease, Moshkovich-Singer-Simmers syndrome, Thrombotic microangiopathy, Purpura thrombotic, Purpura thrombocytopenic thrombohemolytic

M32 Systemic lupus erythematosus

Lupus erythematosus red disseminated, Disseminated lupus erythematosus, Chronic lupus erythematosus

M33.2 Poliomyositis

Muscle weakness in polymyositis, Polymyositis in children, Polyartralgia in polymyositis

M34 Systemic sclerosis

Scleroderma, Scleroderma generalized, Scleroderma diffuse, Scleroderma universal, Sclerosis systemic progressing, Buschke's disease, Sculpting adults, Sclera aponeurotic benign

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M47.9 Spondylosis, unspecified

Deforming spondylosis, Diseases of the spine, Spondyloarthritis, Seronegative spondylitis, Spondylarthrosis

M54.3 Sciatica

Ischialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M65.9 Synovitis and tendosynovitis, unspecified

Synovitis, Inflammation of the tendon sheath, Acute nonspecific tenosynovitis, Reactive synovitis

M71.9 Bursopathy, unspecified

Bursites, Alberta disease, Acute bursitis

M75.0 Adhesive shoulder capsulitis

Acute shoulder-scapular periarthritis, Duplay's disease, Duplay Syndrome, Frozen shoulder, Shoulder-shoulder periarthritis, Periarteritis humeroscapular, Shoulder periarthritis, Pleiraptocular periarthritis, Capsule, Frozen shoulder

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

M79.0 Other unspecified rheumatism

Degenerative rheumatic disease, Degenerative and rheumatic diseases of the tendons, Degenerative rheumatic diseases, Localized forms of rheumatism of soft tissues, Rheumatism, Rheumatism with a pronounced allergic component, Rheumatism of the articular and extraarticular, Rheumatic attack, Rheumatic complaints, Rheumatic diseases, Rheumatic disease of the spine, Relapses of rheumatism, Articular and extra-articular rheumatism, Articular and muscular rheumatism, Articular rheumatism, Articular syndrome with rheumatism, Chronic rheumatic pain, Chronic articular rheumatism, Rheumatoid diseases, Rheumatic diseases of the intervertebral disc

N00 Acute nephritic syndrome

Glomerulonephritis acute, Jade sharp, Disease with minimal changes, Disease of minimal changes, Rapidly progressive glomerulonephritis, Nephrotic syndrome with damage to small legs of podocytes, Acute nephritic syndrome,Acute glomerulonephritis

N04 Nephrotic syndrome

Nephrosis, Edema of the kidneys, Nephrotic syndrome, Lipoid nephrosis, Nephrotic syndrome without uremia, Acute nephrotic syndrome, Edematic syndrome of renal genesis, Renal form of diabetes insipidus, Segmental glomerulonephritis, Focal glomerulonephritis, Family Nephrotic Syndromes, Chronic nephrotic proteinuric syndrome, Lipiduria, Jade hereditary, Nephrotic-proteinuric syndrome

R11 Nausea and vomiting

Postoperative vomiting, Nausea, vomiting, Vomiting in the postoperative period, Vomiting drug, Vomiting on the background radiation therapy, Vomiting indomitable, Vomiting with radiation therapy, persistent vomiting, anacatharsis, Postoperative nausea, Vomiting during chemotherapy, Vomiting of central origin, Vomiting on the background of cytostatic chemotherapy, persistent hiccups, repeated vomiting

R21 Rashes and other nonspecific skin rashes

Skin rash, Skin and mucous eruptions, Skin rashes, Drug rash, Medicinal rash fixed, Dry skin rashes, Rash, Toxidermia, Toxicoderma, Toxic rash, Korepodobnye rashes from drugs, Maculo-papular rashes, Drug-induced rash

R57.9 Shock, unspecified

Pain shock, hemolytic shock, Neurogenic shock, Shock, state of shock

S05 Injury of the eye and orbit

Wounds of the eye penetrating, Non-penetrating wound of the eyeball, Superficial injury of the cornea, Post-traumatic keratopathy, Post-traumatic central retinal dystrophy, Penetrating wound of the cornea, Condition after eye injuries, Condition after eyeball injuries, Penetrating corneal wounds, Injuries to eye tissues, Injuries to the cornea, Injury of anterior part of eye

T49.8 Poisoning by other topical agents

T78.0 Anaphylactic shock caused by a pathological reaction to food

T78.1 Other manifestations of a pathological reaction to food

Allergic reactions to food, Allergy to cow's milk proteins, Allergy to proteins of mother's milk, Food Allergy, Artificial feeding of children from birth with intolerance to cow's milk proteins, Multiple food allergies, Disturbance of assimilation of milk food, Disturbance of food assimilation, Intolerance to cow's milk protein in infants, Intolerance to cow's milk proteins, Intolerance to cow milk, Intolerance to certain foods, Food allergy, Food and drug allergies, Food intolerance, Bowel irritation from food

T78.3 Angioedema

Edema Quincke, Laryngeal exacerbation with angioneurotic edema, Recurrent angioedema, Allergic edema, Recurrent swelling of Quincy

T78.4 Allergy, unspecified

Allergic reactions to insulin, Allergic reactions to insect stings, Allergic reactions similar to systemic lupus erythematosus, Allergic diseases, Allergic diseases of mucous membranes, Allergic diseases and conditions resulting from increased release of histamine, Allergic diseases of mucous membranes, Allergic symptoms, Allergic symptoms in the mucous membranes, Allergic reactions, Allergic reactions caused by insect bites, Allergic reactions, Allergic conditions, Allergic laryngeal edema, allergopathy, allergic conditions, Allergy, House dust allergy, Anaphylaxis, Cutaneous reactions to medications, Skin reaction to insect stings, Cosmetic allergy, Drug allergy, Acute allergic reaction, Laryngeal edema allergic genesis and background radiation, Food and drug allergy

T80.6 Other serum reactions

Serum sickness, Allergic reaction of the type of serum sickness, Serous disease accelerated

Y40-Y59 Drugs, medicines and biological substances that cause adverse reactions during therapeutic use

Z94 Presence of the transplanted organ and tissue

Allogeneic transplantation, Allotransplantation, Autotransplantation, Gomotransplant, Isotransplantation, Transplantation, Orthotopic transplantation

Code CAS 50-24-8

Characteristics

Hormonal (a glucocorticoid for systemic and topical application). It is a dehydrated analog of hydrocortisone.

In medical practice, prednisolone and prednisolone hemisuccinate are used (for intravenous (intravenous) or intravenous (intramuscular) administration).

Prednisolone - white or white with a slight yellowish tinge crystalline powder odorless. Virtually nerastvorim in water, Slightly soluble in alcohol, chloroform, dioxane, methanol. Molecular weight is 360.44.

Prednisolone hemisuccinate - white or white with a creamy tinge crystalline powder odorless. Soluble in water. Molecular weight 460.52.

Pharmacology

Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive, anti-shock, glucocorticoid.

Interacts with specific receptors in the cytoplasm of the cell and forms a complex that penetrates the cell nucleus, binds to DNA (deoxyribonucleic acid) and induces mRNA expression or depression, altering the formation of proteins on the ribosomes that mediate cellular effects. Increases the synthesis of lipocortin, which inhibits the phospholipase A2, blocks the liberation of arachidonic acid and the biosynthesis of endoperoxide, PG (prostaglandins), leukotrienes (contributing to the development of inflammation, allergies and other pathological processes). Stabilizes the membranes of lysosomes, inhibits the synthesis of hyaluronidase, reduces the production of lymphokines. Affects the alternative and exudative phases of inflammation, prevents the spread of the inflammatory process. Restriction of migration of monocytes to the focus of inflammation and inhibition of proliferation of fibroblasts cause antiproliferative action. Suppresses the formation of mucopolysaccharides, thereby limiting the binding of water and plasma proteins in the focus of rheumatic inflammation. Oppressing the activity of collagenase, preventing the destruction of cartilage and bones in rheumatoid arthritis.

The antiallergic effect is caused by a decrease in the number of basophils, direct inhibition of secretion and the synthesis of mediators of an immediate allergic reaction. It causes lymphopenia and involution of lymphoid tissue, what is responsible for immunosuppression. Reduces the level of T-lymphocytes in the blood, their effect on B-lymphocytes and the production of immunoglobulins. Reduces the formation and increases the disintegration of components of the complement system, blocks the Fc receptors of immunoglobulins, suppresses the functions of leukocytes and macrophages. Increases the number of receptors and restores / enhances their sensitivity to physiologically active substances, incl. To catecholamines.

Reduces the amount of protein in the plasma and the synthesis of the protein that binds calcium, increases protein catabolism in muscle tissue. Promotes the formation of enzyme proteins in the liver, fibrinogen, erythropoietin, surfactant, lipomodulin. Promotes the formation of higher fatty acids and triglycerides, the redistribution of fat (increases fat lipolysis on the limbs and its deposition on the face and upper half of the trunk). Increases the resorption of carbohydrates from the gastrointestinal tract, the activity of glucose-6-phosphatase and phosphoenolpyruvate kinase, which leads to the mobilization of glucose into the bloodstream and enhance gluconeogenesis. It retards sodium and water and promotes the excretion of potassium due to mineralocorticoid action (expressed in a lesser degree than in natural glucocorticoids, the ratio of gluco- and mineralocorticoid activity is 300: 1). Reduces absorption of calcium in the intestines, increases its leaching from the bones and excretion by the kidneys.

It has anti-shock effect, stimulates the formation of some cells in the bone marrow, increases the blood levels of erythrocytes and platelets, reduces - lymphocytes, eosinophils, monocytes, basophils.

After oral administration, it is quickly and well absorbed from the digestive tract. In plasma, 70-90% is in a bound form: with transcortin (corticosteroid-binding alpha1-globulin) and albumin. Tmax when ingested is 1-1.5 hours. Biotransformed by oxidation mainly in the liver, as well as in the kidneys, small intestine, bronchi. Oxidized forms are glucuronized or sulphated. T1 / 2 from the plasma - 2-4 h, from the tissues - 18-36 h. Passes through the placental barrier, less than 1% of the dose penetrates into breast milk. It is excreted by the kidneys, 20% - unchanged.

Use of Prednisolone

Parenteral administration. Acute allergic reactions; Bronchial asthma and asthmatic status; Prevention or treatment of thyrotoxic reaction and thyrotoxic crisis; Shock, incl. Resistant to other therapies; Myocardial infarction; Acute adrenal insufficiency; Cirrhosis of the liver, acute hepatitis, acute hepatic-renal failure; Poisoning with cauterizing fluids (to reduce inflammation and prevent cicatricial narrowing).

Intra-articular introduction: rheumatoid arthritis, spondyloarthritis, posttraumatic arthritis, osteoarthritis (in the presence of pronounced signs of inflammation of the joint, synovitis).

Pills. Systemic diseases of connective tissue (systemic lupus erythematosus, scleroderma, nodular periarteritis, dermatomyositis, rheumatoid arthritis); Acute and chronic inflammatory diseases of the joints: gouty and psoriatic arthritis, osteoarthritis (including posttraumatic), polyarthritis, humeropathy periarthritis, ankylosing spondylitis (Bechterew's disease), juvenile arthritis, Still's syndrome in adults, bursitis, nonspecific tenosynovitis, synovitis and epicondylitis ; Rheumatic fever, acute rheumatic heart disease; bronchial asthma; Acute and chronic allergic diseases: allergic reactions to drugs and food, whey, urticaria, allergic rhinitis, angioedema, drug exanthema, pollinosis; Diseases of the skin: pemphigus, psoriasis, eczema, atopic dermatitis, diffuse neurodermatitis, contact dermatitis (with damage to the large surface of the skin), toxicermy, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell syndrome), bullous herpetiform dermatitis, malignant exudative erythema Stevens-Johnson); Cerebral edema (including on the background of a brain tumor or associated with surgical intervention, radiation therapy or head trauma) after previous parenteral administration; Congenital adrenal hyperplasia; Primary or secondary adrenal insufficiency (including the condition after removal of the adrenal glands); Kidney disease of autoimmune genesis (including acute glomerulonephritis), nephrotic syndrome; Subacute thyroiditis; Diseases of the hematopoiesis: agranulocytosis, panmyelopathy, autoimmune hemolytic anemia, congenital (erythroid) hypoplastic anemia, acute lympho- and myeloid leukemia, lymphogranulomatosis, myeloma, thrombocytopenic purpura, secondary thrombocytopenia in adults, erythroblastopenia (erythrocyte anemia); Lung diseases: acute alveolitis, pulmonary fibrosis, sarcoidosis II-III; Tuberculosis meningitis, pulmonary tuberculosis, aspiration pneumonia (in combination with specific chemotherapy); Berylliosis, Leffler's syndrome (not amenable to other therapy); Lung cancer (in combination with cytostatics); multiple sclerosis; Diseases of the digestive tract (for removing the patient from a critical condition): ulcerative colitis, Crohn's disease, local enteritis; hepatitis; Prevention of graft rejection reaction; Hypercalcemia on the background of cancer; Nausea and vomiting during cytostatic therapy; Allergic eye diseases: allergic corneal ulcers, allergic forms of conjunctivitis; Inflammatory eye diseases: sympathetic ophthalmia, severe sluggish anterior and posterior uveitis, optic neuritis.

Ointment: urticaria, atopic dermatitis, diffuse neurodermatitis, simple chronic lichen (limited neurodermatitis), eczema, seborrheic dermatitis, discoid lupus erythematosus, simple and allergic dermatitis, toxicermy, erythroderma, psoriasis, alopecia; Epicondylitis, tendosynovitis, bursitis, humeroscapular periarthritis, keloid scars, ischialgia.

Eye drops: noninfectious inflammatory diseases of the anterior segment of the eye - iritis, iridocyclitis, uveitis, episcleritis, scleritis, conjunctivitis, parenchymal and discoid keratitis without damage to the corneal epithelium, allergic conjunctivitis, blepharoconjunctivitis, blepharitis, inflammatory processes after eye injuries and surgical interventions, sympathetic ophthalmia.

Contraindications

Hypersensitivity (for short-term systemic use according to vital indications is the only contraindication).

For systemic use: parasitic and infectious diseases of viral, fungal or bacterial nature (currently without appropriate chemotherapy or recently transferred, including recent contact with the patient): herpes simplex, herpes zoster (viremic phase), chicken pox, measles; Amebiasis, strongyloidiasis (established or suspected); Systemic mycosis; Active and latent tuberculosis. The use in severe infectious diseases is permissible only against the background of specific therapy. Immunodeficiency conditions (including AIDS or HIV infection), post-vaccination period (period of 8 weeks before and 2 weeks after vaccination), lymphadenitis after BCG vaccination; Gastrointestinal diseases (including peptic ulcer of stomach and duodenum, esophagitis, gastritis, acute or latent peptic ulcer, newly created intestinal anastomosis, ulcerative colitis with perforation or abscessing threat, diverticulitis); Diseases of the cardiovascular system, incl. Recently suffered myocardial infarction (in patients with acute and subacute myocardial infarction, the spread of the necrosis foci, slowing the formation of scar tissue and, as a result, rupture of the heart muscle), decompensated chronic heart failure, arterial hypertension, hyperlipidemia; Endocrine diseases: diabetes mellitus (including a violation of carbohydrate tolerance), thyrotoxicosis, hypothyroidism, Itenko-Cushing's disease; Severe chronic renal and / or hepatic insufficiency, nephrourolythiasis; Hypoalbuminemia and conditions predisposing to its occurrence; Systemic osteoporosis, myasthenia gravis, acute psychosis, obesity III-IV, poliomyelitis (except for the form of bulbar encephalitis), open and closed angle glaucoma, pregnancy, lactation.

For intraarticular administration: previous arthroplasty, pathological hemorrhage (endogenous or caused by anticoagulant use), transgressive bone fracture, infectious (septic) inflammatory process in the joint and periarticular infections (including in the anamnesis), general infectious disease, expressed near-joint osteoporosis, Absence of signs of inflammation in the joint (so-called "dry" joint, for example, with osteoarthritis without signs of synovitis), severe bone destruction and joint deformity (sharp contraction of su Stiff slit, ankylosis), joint instability as the outcome of arthritis, aseptic necrosis of the forming joint of the bones epiphyses, pregnancy.

When applied to the skin: bacterial, viral, fungal skin diseases, cutaneous manifestations of syphilis, skin tuberculosis, skin tumors, acne vulgaris, rosacea (possibly exacerbation of the disease), pregnancy.

Eye drops: viral and fungal eye diseases, acute purulent conjunctivitis, purulent infection of the mucous membrane of the eye and eyelids, purulent corneal ulcer, viral conjunctivitis, trachoma, glaucoma, violation of the integrity of the corneal epithelium; Tuberculosis of the eye; Condition after removal of the foreign body of the cornea.

pregnancy and breastfeeding

The use of corticosteroids during pregnancy is possible if the expected effect of therapy exceeds the potential risk for the fetus (adequate and strictly controlled safety studies have not been conducted). Women of childbearing age should be warned about the potential risk to the fetus (corticosteroids pass through the placenta). Care must be taken to monitor newborns whose mothers received corticosteroids during pregnancy (possibly developing adrenal insufficiency in the fetus and newborn).

Do not use often, in high doses, for a long period of time. It is recommended that breastfeeding women stop breastfeeding or using drugs, especially in high doses (corticosteroids penetrate breast milk and can inhibit growth, the production of endogenous corticosteroids and cause undesirable effects in the newborn).

It shows the teratogenicity of prednisolone in many animal species that received it at doses equivalent to human doses. In studies in pregnant mice, rats and rabbits, there was an increase in the frequency of development of the wolf mouth in offspring.

Side effects

The frequency of development and severity of side effects depend on the method, the duration of administration, the dose used, and the possibility of observing the circadian rhythm of prescribing drugs.

System Effects

On the part of metabolism: the delay of Na + and fluid in the body, hypokalemia, hypokalemic alkalosis, negative nitrogen balance due to protein catabolism, hyperglycemia, glucosuria, weight gain.

On the part of the endocrine system: secondary adrenal and hypothalamic-pituitary insufficiency (especially during stressful situations such as illness, trauma, surgery); Cushing's syndrome; Suppression of growth in children; Menstrual cycle disorders; Decreased tolerance to carbohydrates; Manifestation of latent diabetes mellitus, increased need for insulin or oral antidiabetic drugs in patients with diabetes mellitus.

From the side of the cardiovascular system and blood (blood, haemostasis): increased blood pressure, development (in predisposed patients) or increased severity of chronic heart failure, hypercoagulation, thrombosis, ECG (electrocardiogram, electrocardiography) changes characteristic of hypokalemia ; In patients with acute and subacute myocardial infarction - the spread of the focus of necrosis, slowing the formation of scar tissue with a possible rupture of the heart muscle, obliterating endarteritis.

From the musculoskeletal system: muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, compression fracture of the spine, aseptic necrosis of the head of the femoral and humerus bones, pathological fractures of long tubular bones.

On the part of the digestive tract (gastrointestinal tract): steroid ulcer with possible perforation and bleeding, pancreatitis, flatulence, ulcerative esophagitis, digestive disorders, nausea, vomiting, increased appetite.

On the part of the skin: hyper- or hypopigmentation, subcutaneous and cutaneous atrophy, abscess, atrophic bands, acne, delayed healing of wounds, thinning of the skin, petechiae and ecchymosis, erythema, excessive sweating.

From the nervous system and sensory organs: mental disorders such as delirium, disorientation, euphoria, hallucinations, depression; Increased intracranial pressure with the syndrome of the congestive nipple of the optic nerve (pseudotumor of the brain - more often in children, usually after too rapid reduction of the dose, symptoms - headache, deterioration of visual acuity or double vision); Sleep disturbance, dizziness, vertigo, headache; Sudden loss of vision (with parenteral administration in the head, neck, nasal concha, scalp), formation of posterior subcapsular cataract, increased intraocular pressure with possible damage to the optic nerve, glaucoma; Steroidal exophthalmos.

Allergic reactions: generalized (allergic dermatitis, hives, anaphylactic shock) and local.

Other: general weakness, disguise of symptoms of infectious diseases, fainting, withdrawal syndrome.

When applied to the skin: steroid acne, purpura, telangiectasia, burning and itching of the skin, irritation and dry skin; With long-term use and / or when applied to large surfaces, it is possible to display systemic side effects, the development of hypercorticism (in these cases, the ointment is canceled); With prolonged use of the ointment, it is also possible to develop secondary infectious skin lesions, atrophic changes, hypertrichosis.

Eye drops: with prolonged use - increased intraocular pressure, damage to the optic nerve, formation of posterior subcapsular cataract, impaired acuity and narrowing of the visual field (blurred vision or loss of vision, eye pain, nausea, dizziness), with thinning of the cornea - danger of perforation; Rarely - the spread of viral or fungal diseases of the eyes.

Interaction

With the simultaneous use of prednisolone and cardiac glycosides due to hypokalemia, the risk of cardiac arrhythmias increases. Barbiturates, antiepileptic drugs (phenytoin, carbamazepine), rifampicin accelerate the metabolism of glucocorticoids (by induction of microsomal enzymes), weaken their action. Antihistamines weaken the action of prednisolone. Thiazide diuretics, amphotericin B, inhibitors of carbonic anhydrase increase the risk of severe hypokalemia, Na + -containing drugs (drugs) - edema and increased blood pressure (arterial pressure). The use of prednisolone and paracetamol increases the risk of hepatotoxicity. Oral contraceptives containing estrogens can alter protein binding and prednisolone metabolism, reducing clearance and increasing T1 / 2, thereby enhancing the therapeutic and toxic effects of prednisolone. With the simultaneous administration of prednisolone and anticoagulants (coumarin derivatives, indanedione, heparin), the anticoagulant effect of the latter may be weakened; The dose should be specified on the basis of the definition of PT. Tricyclic antidepressants can enhanceTricyclic antidepressants can enhance mental disorders associated with the use of prednisolone, incl. Severity of depression (do not prescribe them to treat these disorders). Prednisolone weakens the hypoglycemic effect of oral antidiabetic drugs (drug), insulin. Immunosuppressants increase the risk of infection, lymphoma and other lymphoproliferative diseases. NSAIDs (non-steroidal anti-inflammatory drugs), acetylsalicylic acid, alcohol increase the risk of developing peptic ulcer and bleeding from the gastrointestinal tract. During the use of immunosuppressive doses of glucocorticoids and vaccines containing live viruses, virus replication and the development of viral diseases are possible, a decrease in the production of antibodies (simultaneous use is not recommended). When used with other vaccines, it is possible to increase the risk of neurological complications and decrease the production of antibodies. Increases (with prolonged use) the content of folic acid. Increases the likelihood of electrolyte metabolism disorders against the background of diuretics.

Overdose

The risk of overdose increases with prolonged use of prednisone, especially in high doses.

Symptoms: increased blood pressure, peripheral edema, increased side effects of the drug.

Treatment of acute overdose: immediate gastric lavage or induction of vomiting, no specific antidote was found.

Treatment of chronic overdose: should reduce the dose of the drug.

Routes of administration

Inside, parenterally (intravenously),, intraarticularly, externally.

PrecautionsAssign glucocorticoids in the smallest dosages and the minimum long time required to achieve the desired therapeutic effect. At appointment it is necessary to consider a daily circadian rhythm of endogenous secretion of glucocorticoids: at 6-8 o'clock in the morning appoint the greater (or all) part of a dose.

In case of stressful situations, patients who are on corticosteroid therapy show parenteral administration of corticosteroids before, during and after a stressful situation.

If there is an indication in the anamnesis of a psychosis, high doses are prescribed under the strict supervision of a physician.

During the treatment, especially with prolonged use, it is necessary to carefully monitor the dynamics of growth and development in children, observation of the oculist, control of blood pressure, water-electrolyte balance, blood glucose level, regular analysis of the cellular composition of peripheral blood are necessary.

A sudden cessation of treatment can cause the development of acute adrenocortical insufficiency; With prolonged use, you can not suddenly cancel the drug, the dose should decrease gradually. With a sudden cancellation after a long period of admission, it is possible to develop a withdrawal syndrome, manifested by an increase in body temperature, myalgia and arthralgia, and malaise. These symptoms can appear even in the case when there is no insufficiency of the adrenal cortex.

Prednisolone can mask the symptoms of infection, reduce resistance to infection.

During the treatment with eye drops, it is necessary to control the intraocular pressure and the condition of the cornea.

When using ointment in children from 1 year and older, the total duration of treatment should be limited and the measures leading to increased resorption and absorption (warming, fixing and occlusive dressings) should be excluded. To prevent infectious skin lesions prednisolone ointment is recommended to be prescribed in combination with antibacterial and antifungal agents.