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Instruction for use: Obsidan

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Trade name of the drug Obsidan

Dosage Form: tablets, injection

Active substance: Propranololum

ATX

C07AA05 Propranolol

Pharmacotherapeutic group: Beta-blockers

The nosological classification (ICD-10)

E05 Thyrotoxicosis [hyperthyroidism]: Von Basedow's disease; Basedow's disease; hyperthyroidism; Goitre diffuse toxic; Increased thyroid function; tireotoksicski reaction; Toxic diffuse goiter; Toxic goiter; Enlargement of the thyroid gland with symptoms of hyperthyroidism; The phenomenon of iodine Basedow

G43 Migraine: The pain of migraine; Migraine; hemiplegic migraine; Migraine headache; A migraine attack; Continuous headache; hemicranias

G90 Disorders of autonomic [autonomous] nervous system: angiodystonia; vasovegetative manifestations; vasomotor dystonia; vegetative dystonia; autonomic dysfunction; vegetative lability; Vegetative-vascular disorders; autonomic dysfunction; vasoneurosis; Vegetative-vascular dystonia; vegetative-vascular disorders; Vegetative-vascular disorders; Dystonia vegetovascular; Dystonia neurocirculatory; neuro disorder; Cardiopsychoneurosis; Neurocirculatory dystonia of hypertensive type; Primary neurovegetative syndrome; The syndrome of vegetative dystonia

I10 Essential (primary) hypertension: hypertension; Arterial hypertension; Arterial hypertension crisis course; Essential Hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Primary hypertension; Arterial hypertension, complications of diabetes; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; arterial Hypertension; malignant Hypertension; Hypertonic disease; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; Isolated systolic hypertension

I15 Secondary hypertension: Arterial hypertension, complications of diabetes; hypertension; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; hypertension; arterial Hypertension; malignant Hypertension; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; hypertension; Arterial hypertension; Arterial hypertension crisis course; renovascular hypertension; Hypertension symptomatic; Renal hypertension; Renovascular hypertension; renovascular hypertension; Symptomatic hypertension

I15.0 Renovascular hypertension: hypertensive crisis; renovascular disease; accelerated hypertension; Isolated systolic hypertension

I20 Angina [angina]: Heberden disease; Angina pectoris; The attack of angina pectoris; recurrent angina; Spontaneous angina; Stable angina pectoris; Angina rest; Angina progressing; Angina mixed; Angina spontaneous; stable angina; Chronic stable angina; Angina Syndrome X

I20.0 Unstable angina: heberden disease; Angina pectoris; The attack of angina pectoris; recurrent angina; Spontaneous angina; Stable angina pectoris; Angina rest; Angina progressing; Angina mixed; Angina spontaneous; stable angina; Chronic stable angina; Angina Syndrome X

I25 Chronic ischemic heart disease: Coronary heart disease on the background of hypercholesterolemia; Coronary heart disease is a chronic; Coronary heart disease; Stable coronary artery disease; Percutaneous transluminal angioplasty; Myocardial ischemia, arteriosclerosis; Recurrent myocardial ischemia

I42.1 Obstructive hypertrophic cardiomyopathy: Asymmetrical hypertrophy of the interventricular septum; Hypertrophic obstructive cardiomyopathy; Obliteriruschaya restrictive cardiomyopathy; Hypertrophic cardiomyopathy; Hypertrophic obstructive cardiomyopathy; Myocardial hypertrophy with obstruction

I49.9 Irregular heartbeat, unspecified: Paroxysmal supraventricular tachycardia; extrasystole arrhythmia; Atrial fibrillation tachysystolic; supraventricular tachyarrhythmia; supraventricular arrhythmias; AV reciprocating tachycardia; AV-nodal reciprocating tachycardia; ventricular fibrillation; Irregular heartbeat; Antidromic reciprocating tachycardia; Cardiac arrhythmias; Arrhythmias; Arrhythmia; Heart arythmy; Arrhythmia due to hypokalemia; ventricular tachyarrhythmias; The high frequency of ventricular contraction; Cardiac arrhythmias; Paroxysmal supraventricular arrhythmia; Paroxysmal supraventricular arrhythmia; Paroxysmal dysrhythmia; Paroxysmal atrial-ventricular rhythm; cardiac arrhythmias; supraventricular tachycardia; tachyarrhythmia; Precordial abnormal pulsation

R07.2 Pain in the heart: neuroses of the heart; Myocardial ischemic pain; Pain syndrome in myocardial infarction; cardialgia; cardioneurosis; Cardiac syndrome; Pain in cardiac patients; Cardialgia on background dyshormonal myocardial dystrophy; Functional cardialgia; Psevdostenokardiya; pericardial pain

R25.1 Tremor, unspecified: shake; senile tremor; Tremor; muscle tremors; Tremor when portal-systemic encephalopathy; Essential tremor family; Titubatsiya

T46.0 Poisoning by cardiac glycosides and drugs of similar action: Arrhythmia on the background of digitalis intoxication; digitalis intoxication; Intoxication with cardiac glycosides; digitalis arrhythmia; Intoxication with cardiac glycosides and diuretics; intoxication; Digitalis poisoning drugs; Overdose or poisoning of digitalis glycosides

Composition (per tablet):

1 tablet contains 40 mg of propranolol hydrochloride; 3 blisters in a box of 20 pieces.

1 ampoule of 5 ml of solution for injection - 5 mg; in a box of 10 pieces.

Pharmacological Properties of Obsidan

Pharmachologic effect - antianginal, hypotensive, anti-arrhythmic.

Beta-adrenoceptor blocking weakens the influence of the sympathetic impulses to the heart and reduces the frequency and force of heart contractions, the amount of cardiac output and myocardial oxygen demand.

Indications of Obsidan

Angina, progressive angina, silent myocardial ischemia, hypertension, arrhythmias, hypertrophic cardiomyopathy, cardiopsychoneurosis, digitalis intoxication, hyperthyroidism, migraine, essential tremor family.

Contraindications

Hypersensitivity, AV block II-III degree, bradycardia, hypotension, obstructive airway disease; relative contra-indications - diabetes in the stage of sub- and decompensation, psoriasis in the acute stage.

Side effect

Weakness, dizziness, headache, paresthesia, cold extremities, diarrhea disorders, conjunctivitis, skin rashes, itching.

Interaction

Barbiturates, nicotine increases the effect of cimetidine - weakens; It reinforces the negative inotropic effect of calcium antagonists, negative dromotropic - cardiac glycosides, hypotensive - antihypertensive agents, antiarrhythmic - lidocaine. It increases the likelihood of hypoglycemia in the background insulin.

Dosage and Administration

Hypertension - 40 mg 2 times a day. If necessary, the dose can be increased to 2-4 weeks to 80-160 mg 2 times a day. Angina, migraine, essential tremor - 20 mg 2-3 times a day. The dose may be increased within 1 week to 40 mg four times a day or up to 80 mg 2-3 times a day. The maximum daily dose - 240 mg with 480 mg of migraine and angina. Arrhythmia, hypertrophic cardiomyopathy, thyrotoxicosis - 10-40 mg 3-4 times a day (up to 240 mg / day).

Storage conditions of Obsidan

In a dry, dark place at room temperature.

Keep out of the reach of children.

Shelf life

5 years.

Do not use beyond the expiration date printed on the package.

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