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Instruction for use: Nefopam (Nefopamum)

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Pharmacological group

Other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Nosological classification (ICD-10)

R52 Pain, not elsewhere classified

Pain syndrome of radicular origin, Pain syndrome of small and medium intensity of different genesis, Pain syndrome after orthopedic surgery, Pain syndrome in superficial pathological processes, Radicular pain in the background of osteochondrosis of the spine, Radicular pain syndrome, Pleural pain, Chronic pain

R52.1 Constant unrestrained pain

Pain syndrome in oncology practice, Pain syndrome pronounced, Pain syndrome in malignant neoplasms, Pain syndrome in cancer, Pain syndrome with tumors, Pain syndrome in cancer patients, Pain in malignant neoplasms, Pain in malignant tumors, Pain in tumors, Pain in cancer patients, Pain in bone metastases, Pain in cancer, Malignant pain syndrome, Intensive chronic pain, Intensive pain syndrome, Intensive non-curable pain syndrome, Intensive chronic pain syndrome, Unrestrained pain, Unrestrained pain, Tumor pain, Post-traumatic pain syndrome, Severe pain, Chronic pain, Chronic Pain Syndrome

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

Code CAS



Pharmacological action - analgesic.

Affects dopamine, noradrenaline and serotonin receptors of the brain. Suppresses the nociceptive flexor reflex; relieves pain and chills in the postoperative period; hinders the development of chills as a side effect with the / in the introduction of amphotericin In patients with systemic fungal infections against the background of cancer pathology. With IV introduction, the effect begins within the first 30 seconds and reaches a maximum after 15-20 minutes; the duration of action depends on the dose.

Application of Nefopam

Pain syndrome of different etiology and intensity, incl. after trauma and surgical intervention, for analgesia of labor, generalized muscular tremor, prevention of chills as a side effect of other drugs (amphotericin B).


Hypersensitivity, epilepsy; diseases accompanied by increased convulsive readiness, simultaneous administration of MAO inhibitors, pregnancy, lactation.

Side effects of Nefopam

From the nervous system and sensory organs: dizziness, anxiety, increased excitability, drowsiness / insomnia, asthenia, blurred vision.

On the part of the intestine: nausea, vomiting, dryness of the oral mucosa.

From the cardiovascular system and blood (hematopoiesis, hemostasis): tachycardia.

Other: sweating during parenteral administration.

Routes of administration

Inside, in / m (intramuscularly), in / in (intravenously).

Precautions for Nefopam

It is not recommended to drive vehicles and engage in other potentially hazardous activities that require increased attention.

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