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Instruction for use: Metrodin HP

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ATX Code G03GA04 Urofollitropin

Active substance: Urofollitropin

Pharmacological group

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Nosological classification (ICD-10)

N97 Female infertility

Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle

Composition and form of release

1 ampoule with a dry substance for the preparation of injections contains urofollitropina high purification 75 or 150 IU, complete with a solvent in ampoules of 1 ml; In the package 1 and 10 pcs.


Metrodine HF is manufactured using a technology that allows obtaining a preparation with a purification degree of more than 95%.

pharmachologic effect

Pharmacological action - follicle-stimulating.

Stimulates the growth and maturation of follicles, increases the level of estrogens, activates the proliferation of the endometrium.


Infertility (including unclear etiology): stimulation of one dominant follicle in patients with hypothalamic-pituitary-related disorders (including those with polycystic ovary syndrome), stimulation of multiple follicle growth during assisted reproduction methods.


Hypersensitivity to menotropins; Persistent ovarian enlargement or the occurrence of ovarian cysts (not caused by polycystosis syndrome); Abnormalities of genital organs (incompatible with pregnancy), uterine fibroids, gynecological bleeding of unexplained etiology, ovarian, uterine or breast cancer, primary ovarian failure.

pregnancy and lactation


Side effects

Possible in 3-5% of cases: dyspeptic disorders, pain in the epigastric region and lower abdomen, flatulence, fever, arthralgia, pain in the mammary glands and at the injection site, moderate increase and the formation of ovarian cysts. Ovarian hyperstimulation syndrome: early signs - severe pain in the abdomen, nausea, vomiting, weight gain, late (may lead to death) - hypovolemia, electrolyte imbalance, ascites, hemoperitoneum, pleural effusion, hydrothorax, thromboembolism.


Clomiphene citrate may increase the response of the follicle. The use of GnRH agonists requires, as a rule, an increase in the dose of metodine. Do not mix with other drugs in the same syringe.

Dosing and Administration

/ and / (the solution is prepared immediately before use). For 75-150 IU in the first 7 days of the cycle or every other day at 225-375 IU for a week. In the presence of ovulation and the absence of pregnancy, the course can be repeated at least twice (2 cycles).

storage Conditions

At a temperature not exceeding 25 C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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