Instruction for use: Mesodiethylethylendibenzosulfonate (Mesodiaethylaethylendibenzolsulfonas)

Pharmacological group

Other means regulating the function of the genitourinary system and reproduction

Nosological classification (ICD-10)

N95.1 menopausal and menopausal status of women

Atrophy of the mucosa of the lower genital tract, caused by estrogen deficiency; Vaginal dryness; Autonomic dysfunction in women; gipoestrogeniya state; Deficiency of estrogen in menopausal women; Degenerative changes of the mucous membrane in the menopause; Natural menopause; an intact uterus; climacteric; Menopause women; Menopause in women; menopausal depression; Climacteric ovarian dysfunction; Menopause; Climacteric neurosis; Menopause; Menopausal symptoms complicated psychovegetative; Climacteric syndrome; Climacteric vegetative disorders; Climacteric psychosomatic disorder; menopausal disorders; Menopausal disorders in women; menopausal condition; Climacteric vascular disorders; Menopause; Menopausal vasomotor symptoms; menopausal period; Lack of estrogen; Feeling the heat; Pathological menopause; perimenopause; menopause; postmenopausal; Premature menopause; premenopauznom period; tides; hot flashes; flushing in the Meno and postmenopausal; Hot flashes / hot flashes in menopause; Heart attack during menopause; Early menopause in women; Disorders of menopause; climacteric syndrome; Vascular complications of menopause; Physiological menopause; Estrogendefitsitnye state; premature Menopause

O48 Pregnant pregnancy

Pregnancy, Pregnancy prolonged, Prolonged pregnancy

O62.2 Other uterine inertia

metroparalysis; The weakness of labor activity; Decreased uterine tone; Induction of labor; Induction of labor at term; Induction of labor at term or near term; Activation of labor

P20.9 Intrauterine hypoxia, unspecified

Acute intrauterine asphyxia, Acute intrauterine fetal asphyxia

Code CAS60252-39-3

Characteristics of the substance Mesodiethylethylenedibenzenesulfonate

White crystalline powder odorless. It is soluble in water (1:50), easily soluble in hot water, practically insoluble in ethanol, ether and chloroform.

Pharmacology

The pharmacological action is uterotonizing, estrogen-like.

Affects the hypothalamic centers and gonadotropic function of the pituitary gland. Estrogenic activity does not possess, but takes part in the implementation of feedback (both positive and negative) in the hypothalamic-pituitary-ovary system, normalizing its functions. Increases the sensitivity of the myometrium to oxytocin and uterine contractions. Strengthens utero-placental circulation, transport function of the placenta and supply of the fetus with oxygen and nutrients. Has hypolipidemic effect, increases the blood levels of beta-lipoproteins, increases the sensitivity of tissues to insulin and the utilization of glucose.

Indications

Tablets: climacteric syndrome, manifested by hot flashes, sweating, sleep disturbances, irritability, depression, forgetfulness, degenerative changes in the skin and mucous membranes (fragility of the nails, thinning of the skin, wrinkles, dry mucous membranes of the urogenital tract).

Solution: weakness of labor (preferably in combination with other drugs that accelerate labor activity - oxytocin, Pituitrin, quinine), a pregnant pregnancy, intrauterine fetal asphyxia.

Contraindications

Hypersensitivity, massive blood loss in the parturient woman, premature detachment of the normally located placenta.

Restrictions on the use

Renal failure, impaired liver function, hyperlipoproteinemia.

Side effects of the substance Mesodiethylethylenedibenzenesulfonate

Nausea, vomiting, dizziness, rash, swelling of the eyelids; With prolonged use - metrorrhagia, cholestatic jaundice.

Interaction

Strengthens the effect of oxytocin, the action of diuretic, antiarrhythmic, antihypertensive drugs, anticoagulants; Weakens the effect of drugs male sexual hormones. Folic acid and thyroid hormone drugs increase effectiveness.

Overdose

Symptoms: metrorrhagia, hemorrhagic shock.

Treatment: withdrawal of the drug, blood transfusion, parenteral administration of blood substitutes.

Routes of administration

intravenously, intramuscularly, inside.