Instruction for use: Meclozine

The Latin name of the substance Meclozine

Meclozinum (genus. Meclozini)

Chemical name

1 - [(4-Chlorophenyl) phenylmethyl] -4 - [(3-methylphenyl) methyl] piperazine (and as dihydrochloride)

Gross formula

C₂₅H₂₇ClN₂

Pharmacological groups:

H1-Antihistamines

Antiemetic means

The nosological classification (ICD-10)

H81.0 Meniere's disease: Meniere's syndrome/ disease; Meniere's disease; Meniere's syndrome; Labyrinth dropsy; endolymphatic hydrops

H81.9 Violation of vestibular function, unspecified: Labyrinthine vestibular disorders; Labyrinthine disorders; Vestibular nystagmus; Cochleovestibular disorder; Cochleovestibular syndrome of vascular origin; Violation of microcirculation in the labyrinth; Ischemic impairment of hearing and balance

L20 Atopic dermatitis: Allergic diseases of the skin; Allergic skin disease noninfectious etiology; Allergic skin disease etiology nemikrobnoy; Allergic skin diseases; Allergic skin lesions; Allergic reactions on the skin; atopic dermatitis; Allergic dermatosis; Allergic diathesis; Allergic itching dermatosis; Allergic skin disease; Allergic skin irritation; allergic Dermatitis; atopic Dermatitis; allergic dermatoses; exudative diathesis; Itchy atopic eczema Itchy allergic dermatosis; Allergic skin disease; Cutaneous allergic reaction to drugs and chemicals; Cutaneous reactions to medications; Skin and allergic disease; Acute eczema; common neurodermatitis; Chronic atopic dermatitis; Exudative diathesis

R11 Nausea and vomiting: Postoperative vomiting; Nausea; Vomiting; Vomiting in the postoperative period; Vomiting medication; Vomiting in the background of radiation therapy; Vomiting uncontrollable; Vomiting in radiation therapy; Persistent vomiting; Indomitable vomiting; Postoperative nausea; Vomiting with chemotherapy; Vomiting of the central genesis; Vomiting with cytotoxic chemotherapy; Persistent hiccups; Repeated vomiting

T78.4 Unspecified Allergy: Allergic reactions to insulin; Allergic reactions to insect stings; Allergic reactions similar to systemic lupus erythematosus; Allergic diseases; Allergic diseases of mucous membranes; Allergic diseases and conditions resulting from increased release of histamine; Allergic diseases of mucous membranes; Allergic symptoms; Allergic symptoms in the mucous membranes; Allergic reactions; Allergic reactions caused by insect bites; Allergic reactions; Allergic conditions; Allergic laryngeal edema; allergopathy; allergic conditions; Allergy; House dust allergy; Anaphylaxis; Cutaneous reactions to medications; Skin reaction to insect stings; Cosmetic allergy; Drug allergy; Acute allergic reaction; Laryngeal edema allergic genesis and background radiation; Food and drug allergy

Y40-Y59 Drugs, medicines and biological substances that cause adverse reactions during therapeutic use

CAS Code

569-65-3

Characteristics of substance Meclozine

The powder is white-yellow, with a faint odor. Soluble in water (weakly), alcohol and dichloromethane, practically insoluble in ether.

Pharmacology

Pharmacological action - antiallergic, antihistamine, antiemetic.

It blocks H1-histamine receptors, reduces the vasodilator and spasmogenic effect of histamine. Has a weak cholinolytic activity. Efficacy at dizziness, nausea and vomiting, possibly, is caused by interaction with peripheral labyrinth structures.

After a single oral intake, the effect develops within 1 hour and lasts up to 24 hours (T1 / 2 - about 6 hours). Long-term experience with nausea and vomiting in pregnant women showed no signs of teratogenic effects. In studies on animals, the teratogenic effect was observed only in rats with high doses (25-50 mg / kg), in other experimental animals, including monkeys, it was absent.

Application of the substance Meclozine

Nausea, vomiting and dizziness (including with kinetosis, Meniere's syndrome, labyrinthine and vestibular disorders, vertigo); Allergic reactions of immediate type (including skin diseases accompanied by itching).

Contraindications

Hypersensitivity, children under 12 years of age (safety and efficacy in children are not defined).

Restrictions

Bronchial asthma, glaucoma, enlarged prostate, pregnancy.

Application in pregnancy and breastfeeding

Perhaps only if the expected effect of therapy exceeds the potential risk to the fetus.

The action category for fetus by FDA is B.

Side effects of Meclozine

From the nervous system: fatigue, drowsiness, in children - sometimes increased excitability, rarely - blurred vision.

On the part of the intestine: dry mouth, vomiting.

Interaction

Strengthens the action of deprimiruyuschih funds, including barbiturates, alcohol, tranquilizers and sedatives. MAO inhibitors prolong and intensify the cholinolytic effects of meclosin.

Overdose

Symptoms: in adults - CNS depression, drowsiness, coma, convulsions; In elderly patients - arterial hypotension; In children - cholinolytic effects and CNS excitement (hallucinations, sleep disorders, convulsions).

Treatment: induction of vomiting (if no more than 1 hour has elapsed since the intake), gastric lavage, the appointment of activated charcoal; Symptomatic and supportive therapy; When hypotension - the introduction of vasopressor drugs (except adrenaline), to reduce the anticholinergic effects - physostigmine, with the aim of arresting seizures of diazepam (IV).

Routes of administration

Inside.

Precautions for the substance Meclozine

With caution apply during work drivers of vehicles and people whose profession is associated with increased concentration of attention. It is necessary to avoid drinking alcohol during treatment.