Instruction for use: Mazipredonee (Mazipredoneum)
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Pharmacological group
Glucocorticosteroids
Nosological classification (ICD-10)
A48.3 Toxic shock syndrome
Bacteria-nomic shock, Infectious-toxic shock, intoxication syndrome, Toxic-infectious shock, Toxic shock, Chronic intoxication at diseases of the gastrointestinal tract, Chronic intoxication with gastrointestinal infections, endotoxin shock
E05.5 Thyroid crisis or coma
thyrotoxic crisis, hypothyroid coma, thyrotoxic crisis
E27.9 Adrenal disease, unspecified
Adrenal Dysfunction, Sympathic-adrenal crises
G93.6 Edema of the brain
Intraoperative cerebral edema, Cerebral edema, Post-traumatic swelling of the brain, Brain edema associated with radiation therapy, Brain edema associated with head trauma, Post-traumatic cerebral edema, Edema of the brain in poisoning
J45 Asthma
Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma
J46 Status asthmaticus
Asthmatic attack, status asthmaticus, Bronchospasm in bronchial asthma
K72.0 Acute and subacute liver failure
Lightning-fast hepatitis, Hepatitis acute, Hepatic failure acute and subacute
K72.9 Hepatic insufficiency, unspecified
Latent hepatic encephalopathy, Acute liver failure, Liver failure, Hepatic precoma, Acute hepatic-renal failure
M06.9 Other specified rheumatoid arthritis
Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism
M32 Systemic lupus erythematosus
Lupus erythematosus red disseminated, Disseminated lupus erythematosus, Chronic lupus erythematosus
R57.0 Cardiogenic shock
cardiogenic shock
R57.8 Other types of shock
Blood transfusion shock, Obstructive shock, Circulatory shock
R57.8.0 * Burn shock
Pain shock with burns, Burn shock
T49.8 Poisoning by other topical agents
T78.2 Anaphylactic shock, unspecified
Anaphylactic shock, Anaphylactoid reaction, Anaphylactic shock, Anaphylactic reactions, Anaphylactic shock to drugs
T78.4 Allergy, unspecified
Allergic reactions to insulin, Allergic reactions to insect stings, Allergic reactions similar to systemic lupus erythematosus, Allergic diseases, Allergic diseases of mucous membranes, Allergic diseases and conditions resulting from increased release of histamine, Allergic diseases of mucous membranes, Allergic symptoms, Allergic symptoms in the mucous membranes, Allergic reactions, Allergic reactions caused by insect bites, Allergic reactions, Allergic conditions, Allergic laryngeal edema, allergopathy, allergic conditions, Allergy, House dust allergy, Anaphylaxis, Cutaneous reactions to medications, Skin reaction to insect stings, Cosmetic allergy, Drug allergy, Acute allergic reaction, Laryngeal edema allergic genesis and background radiation, Food and drug allergy
T79.4 Traumatic shock
Hemorrhagic shock, Crush syndrome, hemorrhagic shock, postoperative shock, post-traumatic shock, traumatic shock, hemorrhagic shock and encephalopathy syndrome
T81.1 Shock during or after the procedure, not elsewhere classified
Operating shock, Postoperative shock, Operational shock
Code CAS13085-08-0
Characteristics
Hormonal remedy (glucocorticoid). Water-soluble synthetic derivative of prednisolone.
Pharmacology
Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive, anti-shock, glucocorticoid.
Interacts with specific cytoplasmic receptors, inhibits phospholipase A2, reduces the synthesis of leukotrienes and PG (prostaglandins). Promotes the involution of lymphoid tissue, reduces the production of antibodies. Stimulates cardiac activity, restores the sensitivity of adrenergic receptors to catecholamines, strengthens vasopressor effects, delays sodium and water.
When applied to the skin, it is slowly absorbed and has a local and systemic effect: it narrows the vessels of the skin, reduces the permeability of the capillaries, stabilizes the proliferation of epidermal cells and fibroblasts, depresses the chemotaxis of cells of the monocyte-macrophage system, reduces the number of basophils, disrupts the degranulation of mast cells.
With the / in the introduction is distributed in the body for 0.5 h, T1 / 2 - 3.3 h.
Application of Mazipredone
Shock (burn, traumatic, operational, toxic, cardiogenic) with ineffectiveness of other therapy; Allergic reactions (acute, severe forms), hemotransfusion shock, anaphylactic shock; Anaphylactoid reactions; Cerebral edema (including on the background of a brain tumor or associated with surgical intervention, radiation therapy or head trauma); Bronchial asthma (severe form), asthmatic status; Systemic connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis); Acute adrenal insufficiency; Thyrotoxic crisis; Acute hepatitis, hepatic coma; Poisoning with cauterizing fluids (reducing inflammation and preventing cicatricial narrowing).
Contraindications
Hypersensitivity (for short-term systemic use according to vital indications). With long-term treatment: peptic ulcer of the stomach or duodenal ulcer in the acute phase, Isenko-Cushing syndrome, diabetes mellitus at the stage of decompensation, severe osteoporosis, psychosis, severe arterial hypertension, acute infectious diseases, tuberculosis (without appropriate chemotherapy), vaccination period (increased risk The occurrence of infections, especially in children - including measles, herpes), an increased risk of thromboembolism, glaucoma, systemic mycoses, decompensated liver cirrhosis with portal hypertension syndrome And, decompensated heart failure, terminal renal failure with a syndrome of renal osteodystrophy, pregnancy, breast-feeding; The period of neonatal (due to the presence of benzyl alcohol).
pregnancy and lactation
Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.
Side effects
The frequency of development and the severity of side effects depend on the duration of the application, the amount of the dose used and the possibility of observing the circadian rhythm of the appointment.
On the part of the endocrine system and metabolism: Itenko-Cushing's syndrome, steroid diabetes, glucosuria, obesity, atrophy of the adrenal cortex, menstrual cycle disorders, negative nitrogen balance.
From the cardiovascular system and blood (hematopoiesis, hemostasis): arterial hypertension, vasculitis, leukocytosis.
From the nervous system and sensory organs: sleep disorders, psychosis, steroid cataract.
On the part of the digestive tract: erosive and ulcerative lesions of the gastrointestinal tract.
From the musculoskeletal system: osteoporosis, steroid myopathy, reduction of muscle mass.
On the part of the skin: slowing down the processes of wound healing, itching, rash, dryness and atrophy of the skin, hypopigmentation, hypertrichosis, ecchymosis.
Other: fluid retention, decreased resistance to infections, withdrawal syndrome, hypokalemia, hypocalcemia.
Interaction
Weaken the effect of antidiabetics, intensify - anticoagulants, cardiac glycosides (including toxic), ulcerogenicity of NSAIDs (nonsteroidal anti-inflammatory drugs), risk of hypokalemia in the treatment of amphotericin B, laxatives, diuretics. Etakrinovaya acid increases the likelihood of bleeding in the gastrointestinal tract, the induction of microsomal oxidation (phenobarbital, diphenhydramine, phenytoin, rifampicin, etc.) level glucocorticoid activity, some antimalarial drugs, estrogens, methandienone - strengthen it, the latter, in addition, Reduces the severity of certain complications (osteoporosis, negative nitrogen balance).
Routes of administration
In / in (intravenously) (struino slowly or drip), in / m (intramuscularly).
Precautions
Taking into account circadian rhythm of endogenous secretion of HA, the main dose of the drug should be administered in the morning hours. Discontinue treatment should be gradual, first reducing the dose taken in the evening and afternoon. Regular blood pressure control, cellular composition of peripheral blood, blood glucose level and electrolyte content are mandatory. Elderly and weakened patients with prolonged treatment showed an additional appointment of anabolic steroids.