Instruction for use: Lysine acetylsalicylate (Lysini acetylsalicylas)

Pharmacological groups

NSAIDs - Salicylic acid derivatives in combinations

Nosological classification (ICD-10)

I25.2 Transferred last myocardial infarction

Cardiac syndrome, Myocardial infarction, post-MI, Rehabilitation after myocardial infarction, Reocclusion of the operated vessel, Angina postinfarctnaya, Status after myocardial infarction, Status after myocardial infarction, myocardial infarction

I74.9 Embolism and thrombosis of unspecified arteries

Arterial embolism, Arterial thrombosis, Acute arterial thromboembolism, Acute Vascular Occlusion, Acute occlusion of arteries, Acute arterial thrombosis, Acute thrombosis, Acute thrombosis of peripheral arteries, Thrombosis, Thrombosis in the extracorporeal circulation, Thrombosis of peripheral arteries, Peripheral vascular thrombosis, Shunttromboz, Embolism, Embolism of peripheral arteries, Occlusive Artery Disease

I82.9 Embolism and thrombosis of unspecified vein

Venous embolism, Venous thrombosis, Diseases caused by blood clots in the vessels, Acute Vascular Occlusion, Acute venous thrombosis, Acute thrombosis of veins, Thrombosis, Thromboembolism, Phlebothrombosis, Embolism

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

R50 Fever of unknown origin

Malignant hyperthermia, Hyperthermia malignant

R52.9 Unspecified Pain

Pain after cholecystectomy, Pain shooting, Non-malignant pain, Obstetric and gynecological pain, Pain syndrome, Pain in the postoperative period, Pain in the postoperative period after orthopedic surgery, Pain of inflammatory genesis, Pain than cancer genesis, Pain syndrome after diagnostic procedures, Pain after surgery Diagnostic, Pain after surgery, Pain after orthopedic surgery, Pain after injuries, Pain after the removal of hemorrhoids, Pain at the non-rheumatic inflammation of nature, Pain in inflammatory lesions of the peripheral nervous system, Pain in diabetic neuropathy, Pain in acute inflammatory diseases of the musculoskeletal system, Pain when the tendon pathology, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs, Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Pain in trauma syndrome, Pain with injuries and after surgical interventions, Pain in chronic inflammatory diseases of the musculoskeletal system, Pain with duodenal ulcer, Pain syndrome in gastric ulcer, Pain syndrome in gastric ulcer and duodenal ulcer, pain, Pain during menstruation, pain syndromes, painful condition, Painful foot fatigue, Sore gums when wearing dentures, Soreness of the cranial nerves exit points, Painful menstrual irregularities, Painful dressings, Painful muscle spasm, Painful teeth growth, Melosalgia, Pain in the area of the surgical wound, Pain in the postoperative period, Pain in the body, Pain after diagnostic procedures, Pain after orthopedic surgery, Pain after surgery, The pains of the flu, Pain in diabetic polyneuropathy, Pain for burns, Pain during sexual intercourse, Pain during diagnostic procedures, Pain during therapeutic procedures, for colds Pain, Pain in sinusitis, Pain in trauma, Pain traumatic, The pain in the postoperative period, Pain after diagnostic procedures, The pain after sclerotherapy, Pain after surgery, postoperative Pain, Pain postoperative and posttraumatic, posttraumatic pain, Pain when swallowing, Pain in infectious and inflammatory diseases of the upper respiratory tract, The pain of burns, The pain in traumatic muscle injury, Pain in trauma, The pain of tooth extraction, The pain of traumatic origin, Pain caused by spasm of smooth muscles, Expressed pain syndrome, Expressed pain syndrome, traumatic origin, Postoperative pain, Post-traumatic pain, Post-traumatic pain syndrome, Torpid pain, Traumatic pain, Traumatic pain, Mild pain, Moderately severe pain, Moderate pain, Polyarthralgia with polymyositis

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Code CAS34220-70-7

Characteristics of Lysine acetylsalicylate

White crystalline powder odorless or with a weak specific odor. Easily soluble in water.

Pharmacology

Pharmacological action - anti-inflammatory, antipyretic, antiaggregational, analgesic.

Inhibits cyclooxygenase (COX (cyclooxygenase) -1 and COX (cyclooxygenase) -2), inhibits the synthesis of PG (prostaglandins) and the formation of thromboxane A2 in platelets.

When taken orally quickly and fairly fully absorbed in the digestive tract. Binding to plasma proteins - 80-90%. Penetrates into most body tissues. In the blood it hydrolyzes, forming acetylsalicylic acid and lysine. Acetylsalicylic acid in the liver is converted to salicylic acid. T1 / 2 acetylsalicylic acid - 15-20 min, salicylic acid and its active metabolites from 3-6 h (small doses) to 15-30 h (high doses).

Application of Lysine Acetylsalicylate

Feverish syndrome with infectious and inflammatory diseases; pain syndrome of different genesis, incl. Rheumatic pains, toothache, neuralgia, myalgia, arthralgia, pain in the postoperative period; thrombosis and thromboembolism (prophylaxis), myocardial infarction (secondary prevention).

Contraindications

Hypersensitivity, erosive-ulcerative lesions of the digestive tract (gastrointestinal tract) (in the acute stage), gastrointestinal bleeding, aspirin asthma, hemophilia, hemorrhagic diathesis, hypoprothrombinemia, portal hypertension, avitaminosis K, renal failure, glucose-6- phosphate dehydrogenase, pregnancy (I and III trimester), childhood and adolescence up to 15 years when used as an antipyretic agent (risk of developing Reye syndrome in children with fever in the presence of viral diseases).

Restrictions for use

Gout, erosive-ulcerative diseases of the gastrointestinal tract in the anamnesis.

Side effects of Lysine Acetylsalicylate

On the part of the gastrointestinal tract: NSAIDs-gastropathy (dyspepsia, epigastric pain, nausea and vomiting, diarrhea, gastrointestinal bleeding), exacerbation of peptic ulcer of the stomach and duodenum, decreased appetite, hepatotoxicity.

From the cardiovascular system and blood (hematopoiesis, hemostasis): hemorrhagic syndrome.

From the nervous system and sensory organs: noise in the ears, hearing loss, headache (with prolonged use).

Allergic reactions: rash, bronchospasm, anaphylactic shock.

Other: exacerbation of bronchial asthma, nephrotoxicity, Reye syndrome in children.

Interaction

Strengthens the effect of methotrexate, oral hypoglycemic agents (derivatives of sulfonylureas), weakens - uricosuric agents. It potentiates the ulcerogenic effect of corticosteroids, other NSAIDs (non-steroidal anti-inflammatory drugs) and reserpine. The risk of developing bleeding increases with simultaneous use with direct and indirect anticoagulants.

Overdose

Symptoms: noise in the ears, hearing loss, severe headache.

Treatment: correction of KHS (acid-base state) (infusion of solutions of sodium bicarbonate, sodium citrate).

Routes of administration

Inside, intravenously, intravenously, intramuscularly, rectally.

Precautions for Lysine acetylsalicylate

Caution is prescribed for renal failure, menorrhagia, the presence of an intrauterine contraceptive.

When used in large doses close to the maximum, especially when IV is administered intravenously to people with a high risk of thrombosis, it is possible to increase the aggregation activity of platelets, therefore, it is more expedient to inject the drug intramuscularly.