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Instruction for use: Intal plus

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Active substance Cromoglicic acid + Salbutamol

ATX Code R01AC51 Cromoglicic acid in combination with other drugs

Pharmacotherapeutic group:

Beta-adrenergic agonist in combination

Mast cell stabilizers in combination

The nosological classification (ICD-10)

J45.0 Asthma with a predominance of allergic component

Asthma bakers, Allergic lung disease, Asthma professional, Aspirin asthma, atopic asthma, Atopic bronchial asthma, Atopic asthma, Atopic asthma, Persistent atopic asthma, Allergic respiratory diseases

J45.1 Non-allergic asthma

Asthma bronchial physical stress, Asthma physical effort

Structure and Composition

1 dose aerosol inhalation of sodium cromoglycate contains 1 mg of salbutamol sulphate and 120.5 g; in the cartridge 200 doses, in a cardboard box 1 cartridge.

pharmachologic effect

anti-inflammatory, bronchodilatory, antiallergic, antiasthmatic.

Promotes the expansion of the bronchi (salbutamol), inhibits mast cell degranulation and the release of histamine from them and other. Biologically active substances (cromolyn sodium).


After inhalation, about 10% of the administered dose absorbed into the body from the respiratory tract into the systemic circulation. The rest of the output from the light with a current of exhaled air and deposited on the walls of the oropharynx and then swallowed and excreted from the body through the digestive tract. From the digestive tract into the systemic circulation absorbed 1% of the administered dose. Cromolyn sodium is reversibly bound to plasma proteins (about 65%) is not subject to metabolic breakdown. Excreted unchanged in the urine and bile in approximately equal proportions. Much of the dose of salbutamol administered by inhalation, and swallowed. Salbutamol is well absorbed from the digestive tract, reaching peak plasma concentration after 3 hours from administration. To a large extent metabolized during the initial passage through the liver barrier; 50% is excreted in the urine as an inactive sulphate conjugate. The rest of the output unchanged. The rate of absorption of the light is significantly slower; Peak plasma concentration is achieved in 3-5 hours from the moment of introduction.

Indications of Intal® plus

Bronchial asthma (if necessary combined therapy stabilizers of membranes of mast cells and beta2-agonists).



Pregnancy and breast-feeding

Assign with caution.

Side effects

Sore throat, cough, bronchospasm, headache, transient muscle cramps, allergic reactions such as angioneurotic edema, urticaria, hypotension, collapse (in the event of receiving a cease and not resume).


It should not be combined with non-selective beta-blockers.

Dosing and Administration

Adults (including the elderly) and children 12 years of age - 2 inhalations 4 times a day. In more severe cases or intensive contact with the allergen dose may be increased up to 6-8 inhalations per day.


Symptoms: excessive stimulation of beta2-adrenergic receptors may experience a tremor of the hands, tachycardia, headache, dizziness, nausea, vomiting.

Treatment: cardioselective beta-blockers (to be used with caution in patients with bronchial asthma).

Precautionary measures

A possible consequence of the treatment of beta2-agonists may be the development of severe hypokalemia. Particular care should therefore be taken when severe asthma as hypokalemic effect of beta2-agonists can be potentiated concomitant therapy xanthine derivatives, corticosteroids, diuretics, and the presence of hypoxia. In such situations it is necessary to monitor the level of potassium in the blood serum. To relieve asthma attacks additionally be used drugs with a rapid bronchodilator effect. In the case of reducing the effectiveness of a bronchodilator with mild asthma patients should not increase the dose on their own (you must consult your doctor). We recommend caution when administered to patients with thyrotoxicosis.

Storage conditions

In the dark place at a temperature no higher than 25 ° C (do not freeze).

Keep out of the reach of children.


3 years.

Do not use beyond the expiration date printed on the package.

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