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Instruction for use: Immunoglobulin human normal + Histamine

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Trade name of the drug  Histaglobin, Histaglobin triplex, Histaglobulin siccum

The Latin name of the substance Immunoglobulin human normal + Histamine

Immunoglobulinum humanum normale + Histaminum (genus. Immunoglobulini humani normalis+ Histamini)

Pharmacological group:

Immunoglobulins in combinations

The nosological classification (ICD-10)

G43.9 Migraine, unspecified: Migraine; Acute migraine attack

J30 Vasomotor and allergic rhinitis: Allergic rhinopathy; Allergic rhinosinusopathy; Allergic diseases of the upper respiratory tract; Allergic rhinitis; Allergic rhinitis seasonal; Vasomotor runny nose; Prolonged allergic rhinitis; All-year-round allergic rhinitis; All-year allergic rhinitis; Year-round or seasonal allergic rhinitis; All-the-year-round rhinitis of an allergic nature; Rhinitis vasomotor allergic; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic rhinitis; Edema of the nasal mucosa; Edema of the nasal mucosa; Edema of the mucous membrane of the nasal cavity; Swelling of the nasal mucosa; Swelling of the nasal mucosa; Pollinosis; Permanent allergic rhinitis; Rhinoconjunctivitis; Rhinosinusitis; Rhinosinusopathy; Seasonal allergic rhinitis; Seasonal allergic rhinitis; Hay rhinitis; Chronic allergic rhinitis; Allergic diseases of the respiratory tract

J30.3 Other allergic rhinitis: Allergic rhinitis year-round; Allergic rhinoconjunctivitis

J45 Asthma: Asthma of physical effort; Asthmatic conditions; Bronchial asthma; Bronchial asthma of light course; Bronchial asthma with difficulty in sputum discharge; Bronchial asthma of severe course; Bronchial asthma physical effort; Hypersecretory asthma; The hormone-dependent form of bronchial asthma; Curbing asthma attacks with bronchial asthma; Non-allergic bronchial asthma; Night Asthma; Exacerbation of bronchial asthma; Attack of bronchial asthma; Endogenous forms of asthma; Night attacks of asthma; Cough with bronchial asthma

L30.9 Unspecified Dermatitis: Allergic dermatoses complicated by a secondary bacterial infection; Anal eczema; Bacterial maturation; Varicose Eczema; Venous dermatitis; Inflammation of the skin; Inflammation of the skin upon contact with plants; Inflammatory Skin Disease; Inflammatory Skin Diseases; Inflammatory Skin Diseases; Inflammatory skin reactions; Inflammatory processes of the skin; Hypostatic dermatitis; Fungal Eczema; Fungal dermatosis; Dermatitis; Dermatitis is stagnant; Dermatitis and eczema in the anal area; Dermatitis acute contact; Perianal dermatitis; Dermatosis; Dermatosis of the scalp; Dermatosis of psoriasis; Dermatosis with persistent itching; Dermatoses; Dermatoses itchy; Other itching dermatoses; Significant eczematous manifestations; Itching with dermatoses; Itching eczema; Itching dermatoses; Itching dermatitis; Itching dermatosis; True eczema; Skin reaction to insect bites; Skin itching with dermatosis; Constitutional eczema; Weeping eczema; Drowsing inflammatory skin disease; Dying Infectious-Inflammatory Skin Disease; Non-allergic dermatitis; Nummular eczema; Acute contact eczema; Acute inflammatory skin disease; Acute dermatosis; Acute severe dermatosis; Perianal dermatitis; Superficial dermatosis; Subacute Contact Eczema; Simple dermatitis; Occupational dermatitis; Psychogenic dermatosis; Bubble dermatitis of newborns; Pustular eruptions; Irritation and redness of the skin; Low-flammable eczema; Dry atrophic eczema; Dry eczema; Toxic dermatitis; Ear eczema like dermatitis; Chronic eczema; Chronic dermatosis; Chronic dermatosis; Chronic common dermatosis; Scaly papular dermatosis; Eczema; Eczema anal region; Eczema of the hands; Eczema Contact; Eczema lichenized; Eczema Nummular; Eczema acute; Eczema acute contact; Eczema subacute; Eczematous dermatitis; Eczema-like rashes; Ecome exogenous; Endogenous eczema; Gluteal dermatitis; Limited itching dermatitis

L50 Urticaria: Idiopathic chronic urticarial; Injury Urticaria; Chronic urticarial; Hives of the newborn

N94.3 Premenstrual tension syndrome: Pronounced premenstrual syndrome; Menstrual psychosomatic disorder; Menstrual syndrome; Premenstrual tension; Premenstrual status; Premenstrual period; Premenstrual syndrome; Menstruation syndrome

T78.4 Unspecified Allergy: Allergic reactions to insulin; Allergic reactions to insect stings; Allergic reactions similar to systemic lupus erythematosus; Allergic diseases; Allergic diseases of mucous membranes; Allergic diseases and conditions resulting from increased release of histamine; Allergic diseases of mucous membranes; Allergic symptoms; Allergic symptoms in the mucous membranes; Allergic reactions; Allergic reactions caused by insect bites; Allergic reactions; Allergic conditions; Allergic laryngeal edema; allergopathy; allergic conditions; Allergy; House dust allergy; Anaphylaxis; Cutaneous reactions to medications; Skin reaction to insect stings; Cosmetic allergy; Drug allergy; Acute allergic reaction; Laryngeal edema allergic genesis and background radiation; Food and drug allergy

Model clinical-pharmacological article 1

Pharmacotherapy. The human serum Ig complex and histamine dihydrochloride enhances the ability of blood serum to inactivate free histamine.

Indication. Allergic diseases in remission: incl. Urticaria, atopic dermatitis, eczema, migraine of allergic origin, atopic form of bronchial asthma (with the impossibility of using specific therapy with allergens), asthmatic bronchitis, rhinosinusopathy, conjunctivitis, pollinosis, recurrent angioedema.

Contraindications. Hypersensitivity (including immunoglobulins, human blood products), allergic diseases in the phase of exacerbation, hereditary angioedema, acute infectious diseases, exacerbation of chronic infectious diseases (including tonsillitis, sinusitis, bronchitis, cholecystitis, etc.). , Exacerbation of peptic ulcer of stomach and duodenum, glomerulonephritis, rheumatism; Severe diseases of the nervous, hematopoietic, endocrine systems, diffuse connective tissue diseases, arterial hypertension of the II century, pregnancy, menstruation period.

Dosing. SC, in the upper region of the outer surface of the shoulder, previously dissolved in 2 ml of the attached 0.9% NaCl solution (the prepared solution should be used within 30 minutes). Adults - 2 ml (1 dose), course - 4-10 injections with an interval of 3-4 days; Children - 4-6 injections with an interval of 4-7 days in increasing dosages, starting with 0.1 ml for children under 3 years, 0.3 ml - 3-5 years, 0.5 ml - over 5 years; For children of all age groups, the dose step is 0.1 ml.

Depending on the severity of the allergic process, the doctor can set an individual dosage of the drug, starting the course with reduced doses (0.1, 0.2 or 0.3 ml), the dose step is 0.1 ml.

If necessary, treatment courses can be repeated after 1-2 months for adults and not less than 2 months for children.

Side effect. Rarely - headache, malaise, mild dizziness (in the elderly), exacerbation of the underlying allergic disease.

Interaction. Incompatible with the conduct of specific hyposensitization, therapy with GCS, as well as with preventive vaccinations.

Special instructions. Treatment should be carried out during periods of remission. With pollinosis treatment should be carried out before the flowering season. In case of exacerbation of chronic infectious diseases, treatment is prescribed no earlier than 1 month after recovery; With exacerbation of peptic ulcer of stomach and duodenum, glomerulonephritis, rheumatism after reaching a stable remission.

In case of an acute allergic disease, the dose of the drug should be reduced or the intervals between injections should be increased and symptomatic treatment should be prescribed. With severe exacerbation the drug is canceled.

The drug is unsuitable for use in violation of the integrity of ampoules, the absence or violation of their labeling, the presence of foreign inclusions, expired shelf life.

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