Instruction for use: Ibuprofen (Ibuprophenum)

Pharmacological group

NSAIDs - Propionic acid derivatives in combinations

Nosological classification (ICD-10)

G43 Migraine

The pain of migraine, Migraine, hemiplegic migraine, Migraine headache, A migraine attack, Continuous headache, hemicranias

G44.2 Headache of intense type

Tension headache, Tension headaches, Headache of neurogenic origin, The Barre-Liège syndrome, Cervical migraine, Psychogenic headache

G45.0 Syndrome of vertebrobasilar arterial system

Vertebral-basilar insufficiency, Syndrome of the vertebral artery, Benign positional dizziness, Benign positional dizziness after neurosurgical operations

G54.2 Disorders of the cervical roots, not elsewhere classified

Barre -Leu Syndrome, Neck migraine

G54.3 Lesions of thoracic roots, not elsewhere classified

Thoracic radicular syndrome

G54.5 Neuralgic amyotrophy

Personeness-Turner's disease, Neural amyotrophy

H92.0 Otalgia

Pain in the region of the external auditory canal, Ear pain, Ear pain with otitis

J01 Acute sinusitis

Inflammation of the sinuses, Inflammatory diseases of the paranasal sinuses, Purulent inflammation of the paranasal sinuses, Infectious-inflammatory diseases of ENT organs, Infection of the sinuses, Combined sinusitis, Exacerbation of sinusitis, Acute inflammation of the paranasal sinuses, Acute bacterial sinusitis, Acute sinusitis in adults, Subacute sinusitis, acute Sinusitis, sinusitis

J02.9 Acute pharyngitis, unspecified

purulent pharyngitis, Acute nasopharyngitis,Limfonodulyarny pharyngitis

J03.9 Acute tonsillitis, unspecified (angina agranulocytic)

Sore throat infections, Acute tonsillitis, Angina, Follicular tonsillitis, Angina alimentary-hemorrhagic, Secondary sore throat, Sore throat primary, Angina follicular, Angina, Inflammatory diseases of the tonsils, Catarrhal angina, Lacunar angina, Acute Sore Throat, Tonsillitis, Tonsillitis acute, Tonsillar angina, Follicular sore throat, Bacterial tonsillitis

J04.0 Acute laryngitis

Lektorsky laryngitis, Acute catarrhal Laryngitis,Laryngitis is an acute abscess

J06 Acute upper respiratory infections of multiple and unspecified

Frequent colds viral diseases, Infections of the upper respiratory tract, Acute respiratory disease influenza character, for colds Pain, Acute colds,Cold, respiratory infection,Seasonal colds, Pain in infectious and inflammatory diseases of the upper respiratory tract, Bacterial infections of the upper respiratory tract, Bacterial respiratory infections, Viral disease of the respiratory tract, Viral respiratory tract infections, Inflammatory disease of the upper respiratory tract, Inflammation of the upper respiratory tract disease, Inflammation of the upper respiratory tract illness with difficult sputum, Inflammatory airway disease, Secondary infections with colds, Shortness of sputum in acute and chronic respiratory diseases, Upper respiratory tract infection, Infections of the upper respiratory tract, Respiratory Tract Infections, Infections of the respiratory tract and lungs, Infectious-inflammatory diseases of the upper respiratory tract, Infectious-inflammatory diseases of the upper respiratory tract and ENT-organs, Infectious-inflammatory diseases of the upper respiratory tract in children and adults, Infectious-inflammatory diseases of the upper respiratory tract, Infectious inflammation of the airways,respiratory infection, Qatar upper respiratory tract, Catarrh of the upper respiratory tract, Catarrhal disease of the upper respiratory tract, Catarrhal symptoms of the upper respiratory tract, Coughing with a cold, SARS, ARI, ARI with rhinitis phenomena, Acute respiratory infection, Acute infectious and inflammatory disease of the upper respiratory tract, Acute respiratory disease, Sore throat or nose, Respiratory viral infections, Respiratory diseases, Respiratory infections, Recurrent respiratory infections, Secondary infection with influenza, cold in the chest, Feverish condition with flu usitis, acute sinusitis, genyantritis, purulent sinusitis

J11 Influenza, virus not identified

Flu, Influenza in the early stages of the disease, Flu in children, cold in the chest, Begins flu-like condition, Acute disease parainfluenza, parainfluenza, parainfluenza state, influenza epidemics, The pains of the flu, Influenza

J18 Pneumonia without specifying the pathogen

Alveolar pneumonia, Community-acquired pneumonia is atypical, Community-acquired pneumonia nepnevmokokkovaya, Pneumonia, Inflammation of the lower respiratory tract, Inflammatory disease of the lungs, lobar pneumonia, Infections of the respiratory tract and lungs, Infections of the lower respiratory tract, Cough in inflammatory diseases of the lung and bronchus, lobar pneumonia, nosocomial pneumonia, Exacerbation of chronic pneumonia, Acute community-acquired pneumonia, Acute pneumonia, lobular pneumonia, Pneumonia abscessed, bacterial Pneumonia, lobar pneumonia, Pneumonia alopecia, Pneumonia with obstruction of sputum discharge, Pneumonia in AIDS patients, Pneumonia in Children, Septic pneumonia, Chronic obstructive pneumonia, Chronic pneumonia, Lymphoid interstitial pneumonia

J30 Vasomotor and allergic rhinitis

Allergic rinopatiya, Allergic rhinosinusopathy, Allergic respiratory diseases, Allergic rhinitis, nasal allergy, Seasonal Allergic Rhinitis, Vasomotor rhinitis, Long-allergic rhinitis, Perennial allergic rhinitis, Perennial allergic rhinitis, Year-round or seasonal allergic rhinitis, Year-round allergic rhinitis nature, Rhinitis allergic vasomotor, Exacerbation of pollen allergy in the form of Syndrome rinokonyunktivalnogo, Acute allergic rhinitis, Edema of the nasal mucosa, Edema of the nasal mucosa, Swelling of the mucosa of the nasal cavity, Swelling of the nasal mucosa, Swelling of the nasal mucosa, pollen disease, Permanent allergic rhinitis, rhinoconjunctivitis, rhinosinusitis,rhinosinusopathy, Seasonal allergic rhinitis, Seasonal Allergic Rhinitis, Haymarket rhinitis, Chronic allergic rhinitis, Allergic respiratory diseases

J31.0 Chronic Rhinitis

Hyperplastic chronic Rhinitis, polypoid rhinosinusitis, Atrophic rhinitis with crusting, Hypertrophic rhinitis, Runny fetid, Rhinitis hyperplastic, chronic Rhinitis, Rhinitis chronic atrophic fetid, Rhinitis chronic atrophic simple, Rhinitis chronic hypertrophic, Exacerbation of chronic rhinitis, Chronic atrophic rhinitis, Dry rhinitis

J31.2 Chronic pharyngitis

Pharyngitis chronic, Exacerbation of inflammatory diseases of the pharynx and oral cavityHypertrophic pharyngitis, Inflammatory process of pharynx, Sore Throat Infection, Infectious-inflammatory diseases of the pharynx, Infectious-inflammatory diseases of the oral cavity and pharynx, Atrophic pharyngitis

J32 Chronic sinusitis

Allergic rhinosinusopathy, purulent sinusitis, Catarrh nasopharyngeal area, Catarrh of the sinuses, Exacerbation of sinusitis, chronic Sinusitis

J35.0 Chronic tonsillitis

Tonsillitis chronic, Inflammatory diseases of the tonsils, Angina chronic, Chronic hypertrophic tonsillitis, Tonsillar angina

J37.0 Chronic laryngitis

Chronic atrophic laryngitis

J40 Bronchitis, not specified as acute or chronic

wheeze bronchitis, Allergic bronchitis, Bronchitis asthma, Rinotraheobronhit, Asthmatic bronchitis, Bacterial bronchitis, Bronchitis, Bronchitis smoker, Inflammation of the lower respiratory tract, bronchi disease, Qatar smoker, smokers Cough, Cough in inflammatory diseases of the lung and bronchus, Violation of bronchial secretions, Violation of the functions of the bronchi, Acute bronchitis, Subacute bronchitis, tracheobronchitis, Chronic lung disease

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M07.3 Other psoriatic arthropathies (L40.5 +)

Arthritis psoriatic, The generalized form of psoriatic arthritis, Psoriatic arthritis

M10.9 Gout, unspecified

Arthritis Gouty, Acute gouty arthritis, Acute attack of gout, Gouty Arthritis, Articular syndrome with exacerbation of gout, Articular syndrome with gout, Urarturia, Chronic arthritic arthritis, Acute gout, Salt diathesis

M13.9 Arthritis, unspecified

Arthritis,Purulent arthritis (non-infectious), acute Arthritis,Pain in acute inflammatory diseases of the musculoskeletal system,Pain in chronic inflammatory diseases of the musculoskeletal system,The pain in osteoarthritis, Inflammation in osteoarthritis, Inflammatory arthropathy, Inflammatory and degenerative joint diseases, Inflammatory disease of the musculoskeletal system, Inflammatory joint disease, Inflammatory diseases of the musculoskeletal system, destructive arthritis, The disease of the musculoskeletal system, Diseases of the musculoskeletal system, Diseases of the musculoskeletal system and connective tissue, Infections musculoskeletal system, monoartrit, Non-infectious arthritis, rheumatic arthritis, Osteoarthritis, Acute inflammation of the musculoskeletal tissue, Acute inflammatory diseases of the musculoskeletal system, Acute inflammatory condition of the musculoskeletal system, Acute arthritis, Acute osteoarthritis, Post-traumatic osteoarthritis, Reactive arthritis, Chronic inflammatory diseases of the joints, Chronic arthritis, Chronic inflammatory arthritis, Chronic inflammation of the inner layer of the joint capsule, Chronic inflammation of the joint capsule,Chronic inflammatory disease of the joints, Exudative arthritis

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M42 Osteochondrosis

Pain in spinal osteochondrosis, Cervical osteochondrosis, Radicular syndrome in osteochondrosis, intervertebral osteochondrosis, osteochondrosis, Osteochondrosis with radicular syndrome, Osteocondritis of the spine

M47 Spondylosis

Spondyloarthrosis, spondylarthrosis, Diseases of the spinal column, spondylosis

M54.1 Radiculopathy

Acute sciatica, Radiculopathy, Radiculitis, Radiculitis with radicular syndrome, Acute radiculopathy, Pain syndrome with radiculitis, Subacute radiculitis, Radiculitis, Chronic radiculitis, Diseases of the spinal column

M54.3 Sciatica

Ishialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M54.5 Pain below the back

Pain in the lower back, Lumbar pain, Lumbalia, Painful conditions of the spinal column, Back pain, Lower Back Pain Syndrome

M65 Synovitis and tendosynovitis

Acute tenosynovitis, Tendovaginitis (tenovaginitis), Tendosinovit (tenosynovitis), Tendovaginitis, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Nonspecific tenosynovitis, Tendosinovit

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M75.0 Adhesive shoulder capsulitis

Acute shoulder-scapular periarthritis, Duplay's disease, Duplay Syndrome, Frozen shoulder, Shoulder-shoulder periarthritis, Periarteritis humeroscapular, Shoulder periarthritis, Pleiraptocular periarthritis, Capsule, Frozen shoulder

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

M79.0 Other unspecified rheumatism

Degenerative rheumatic disease, Degenerative and rheumatic diseases of the tendons, Degenerative rheumatic diseases, Localized forms of rheumatism of soft tissues, Rheumatism, Rheumatism with a pronounced allergic component, Rheumatism of the articular and extraarticular, Rheumatic attack, Rheumatic complaints, Rheumatic diseases, Rheumatic disease of the spine, Relapses of rheumatism, Articular and extra-articular rheumatism, Articular and muscular rheumatism, Articular rheumatism, Articular syndrome with rheumatism, Chronic rheumatic pain, Chronic articular rheumatism, Rheumatoid diseases, Rheumatic diseases of the intervertebral disc

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.3 Panniculitis, unspecified

Panniculitis

M89.9 Disease of bone, unspecified

Local osteopathy, Disturbance of bone mineralization processes, Osteopenia, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the musculoskeletal system, Infection of bones, Ossalgia, Pain in chronic degenerative bone diseases

N04 Nephrotic syndrome

Nephrosis, Edema of the kidneys, Nephrotic syndrome, Lipoid nephrosis, Nephrotic syndrome without uremia, Acute nephrotic syndrome, Edematic syndrome of renal genesis, Renal form of diabetes insipidus, Segmental glomerulonephritis, Focal glomerulonephritis, Family Nephrotic Syndromes, Chronic nephrotic proteinuric syndrome, Lipiduria, Jade hereditary, Nephrotic-proteinuric syndrome

N70 Salpingitis and oophoritis

Adnexitis, Inflammatory diseases of female genitalia, Inflammatory diseases of female genital organs, Infection of the genitals, Oophoritis, Acute adnexitis, Salpingitis, Salpingo-oophoritis, Chronic inflammatory diseases of the ovaries, Inflammation of the ovaries

N73.9 Inflammatory diseases of female pelvic organs, unspecified

Infections of the urogenital tract, Abscess of pelvic organs, Bacterial diseases of the urogenital tract, Bacterial infections of the genitourinary system, Bacterial infections of the pelvic organs, Intraluminal infections, Inflammation in the area of throat of the uterus, Inflammation of the pelvic organs, Inflammatory disease of the pelvic organs, Inflammatory gynecological diseases, Inflammatory diseases of female pelvic organs, Inflammatory diseases of the pelvic organs, Inflammatory diseases of pelvic organs, Inflammatory infections in the pelvis, Inflammatory processes in the pelvis, Gynecological infections,Gynecological infectious diseases, Pyoinflammatory diseases of the pelvic organs,Infections of female genital organs,Infections of the pelvic organs in women, Infections of the pelvic organs, Infectious diseases of the reproductive system, Infectious diseases of genital organs, Infection of female genital organs, Metritis, Acute infection of female genital organs, Acute pelvic inflammatory disease, Tubo-ovarian inflammation, Chlamydial gynecological infections, Chronic inflammatory diseases of the pelvic organs, Chronic inflammatory diseases of appendages, Chronic infections of female genital organsPelvic infection

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

Q25.0 Open ductus arteriosus

An open arterial duct in a premature baby

R07.0 Sore throat

A sharp pain in the throat, Sore throat

R50.0 Fever with chills

High fever, Heat, Chills, elevated temperature, hyperthermia, Prolonged fever, Feverish syndrome, Fervescence, Increased body temperature in infectious and inflammatory diseases, fever Symptoms, febrile syndrome, Febrile state, Fever, Fever in infectious and inflammatory diseases, Fever with SARS, Fever with cold, Fever for colds, febrility, Feverish condition with flu, Feverish state in infectious and inflammatory diseases , Feverish state of infectious diseases and in the postoperative period, Feverish condition for colds, Febrile of different genesis, Feverish syndrome on the background of infectious diseases, Feverish syndrome in infectious and inflammatory diseases, Feverish syndrome with colds, Feverish syndrome of different genesis, Increased temperature for colds, Increased temperature at catarrhal and infectious and inflammatory diseases, Increased body temperature in cold, etc., Increased body temperature in cold and other infectious and inflammatory diseases, Increased body temperature in cold and other infectious and inflammatory diseases, Fever during pregnancy, Fever with thrombocytopenia, Febrile reaction in blood transfusion

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

R52.9 Unspecified Pain

Pain after cholecystectomy, Pain shooting, Non-malignant pain, Obstetric and gynecological pain, Pain syndrome, Pain in the postoperative period, Pain in the postoperative period after orthopedic surgery, Pain of inflammatory genesis, Pain than cancer genesis, Pain syndrome after diagnostic procedures, Pain after surgery Diagnostic, Pain after surgery, Pain after orthopedic surgery, Pain after injuries, Pain after the removal of hemorrhoids, Pain at the non-rheumatic inflammation of nature, Pain in inflammatory lesions of the peripheral nervous system, Pain in diabetic neuropathy, Pain in acute inflammatory diseases of the musculoskeletal system, Pain when the tendon pathology, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs, Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Pain in trauma syndrome, Pain with injuries and after surgical interventions, Pain in chronic inflammatory diseases of the musculoskeletal system, Pain with duodenal ulcer, Pain syndrome in gastric ulcer, Pain syndrome in gastric ulcer and duodenal ulcer, pain, Pain during menstruation, pain syndromes, painful condition, Painful foot fatigue, Sore gums when wearing dentures, Soreness of the cranial nerves exit points, Painful menstrual irregularities, Painful dressings, Painful muscle spasm, Painful teeth growth, Melosalgia, Pain in the area of the surgical wound, Pain in the postoperative period, Pain in the body, Pain after diagnostic procedures, Pain after orthopedic surgery, Pain after surgery, The pains of the flu, Pain in diabetic polyneuropathy, Pain for burns, Pain during sexual intercourse, Pain during diagnostic procedures, Pain during therapeutic procedures, for colds Pain, Pain in sinusitis, Pain in trauma, Pain traumatic, The pain in the postoperative period, Pain after diagnostic procedures, The pain after sclerotherapy, Pain after surgery, postoperative Pain, Pain postoperative and posttraumatic, posttraumatic pain, Pain when swallowing, Pain in infectious and inflammatory diseases of the upper respiratory tract, The pain of burns, The pain in traumatic muscle injury, Pain in trauma, The pain of tooth extraction, The pain of traumatic origin, Pain caused by spasm of smooth muscles, Expressed pain syndrome, Expressed pain syndrome, traumatic origin, Postoperative pain, Post-traumatic pain, Post-traumatic pain syndrome, Torpid pain, Traumatic pain, Traumatic pain, Mild pain, Moderately severe pain, Moderate pain, Polyarthralgia with polymyositis

R60.0 Localized swelling

Allergic laryngeal edema, Local swelling, local edema, localized swelling, Swelling of the lower extremities, Swelling caused by inflammation of the tendon sheath, The swelling after dental surgery, Swelling of the mucosa of the nasopharynx, Swelling of traumatic origin, Traumatic edema, Swelling with injuries, Post-traumatic swelling, Post-traumatic edema, Post-traumatic soft tissue edema, Traumatic edema, Edema oral

R68.8.0 * Inflammatory syndrome

Painful syndrome of inflammatory genesis, Pain syndrome with inflammation of non-rheumatic nature, Pain syndrome with inflammatory lesions of the peripheral nervous system, Painful inflammation of the shoulder joint, Painful inflammation after trauma or surgery, Painful inflammation after surgery, Painful hemorrhoids, Inflammation of the tympanic membrane, Inflammation of the larynx, Inflammation of the gums, Inflammation of cellulose, Inflammation of lymph nodes, Tonsillitis, Inflammation of muscles, Inflammation of soft tissues, Inflammation of the mouth, Inflammation after surgery and trauma, Inflammation after orthopedic surgery, Inflammation after trauma, Inflammation in rheumatoid arthritis, Inflammation of the middle ear, Inflammatory gum disease, Inflammatory diseases of the eyelids, Inflammatory eye diseases, Inflammatory swelling of soft tissues, Inflammatory processes, Inflammatory processes after surgical interventions, Inflammatory process, Inflammatory Syndrome, Inflammatory syndrome of non-rheumatic origin, Inflammatory syndrome after surgery, Purulent infections, Infringements of function of a liver of an inflammatory etiology, Acute inflammation of the musculoskeletal tissue, Pre-inflammatory soft tissue inflammation

T03.9 Multiple dislocations, sprains and injuries of capsular-ligamentous apparatus of joints, unspecified

Dislocation, Dislocations, Distortion

T14.0 Surface injury of unspecified body region

Abrasions, Scratch, Skin Wounds, Wounds of soft tissues, Hematoma, Hematoma of traumatic origin, Hematomas, Hematomas of muscles, Hematomas of soft tissues, Healing of the skin, Bruise, Bruising due to sprains and bruises, Microtrauma, External bruises, Small combing, Superficial hematoma, Superficial damage to the skin and mucous membranes, Subcutaneous hematoma, Post-traumatic hematoma, Post-traumatic disturbance of microcirculation, Skinness of the skin, Traumatic plexus lesions, Injury, Contusion of soft tissues, Joint bruise, Traumatic bruises, Traumatic injury, Primary treatment of surface contaminated wounds, Abrasion, Bruise

T14.3 Dislocation, sprain and damage to the capsular-ligamentous apparatus of the joint of the unspecified area of the body

Painful stretching of muscles, Pain and inflammation in tension, Dislocation of dislocation, Degenerative changes in the ligamentous apparatus, Edema due to sprains and bruises, Edema after interventions for sprains, Damage and rupture of ligaments, The musculoskeletal system is damaged, Damage to ligaments, Damage to the joints, Ligament ruptures, Tendon tendons,Ruptures of the tendons of muscles,Stretching, Crick, Stretching of the muscle, Sprain, Tension of the tendons, Extensions,Stretch muscles, Sprains, Tension of the tendons, Injury of the musculoskeletal system, Injuries to the joints, Injuries of capsule-articular tissues, Injuries of the osteoarticular system, Injuries to ligamentsInjuries to the joints, Joint wounds, Stretching of the ligamentous apparatus, Habitual stretching and tearing

T14.9 Injury unspecified

Pain syndrome after trauma, Pain syndrome with injuries, Pain syndrome with trauma and after surgery, Pain in case of injury, Pain of a traumatic nature, Joint pain with injuries, Postoperative and post-traumatic pain, Pain in case of injury, Pain of a traumatic origin, Severe pain syndrome of traumatic origin, Deep tissue damage, Deep scratches on the trunk, Closed injury, Minor Household Injuries, Minor skin damage, Violations of the integrity of soft tissues, Uncomplicated trauma, Extensive traumatic injury, Acute pain syndrome of traumatic origin, Edema with trauma, Postponed sports injuries, Post-traumatic pain, Soft tissue injuries, Joint wounds, Sports injuries, Injury, Traumatic pain, Traumatic pains, Traumatic infiltrate,Injuries to sports

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Code CAS 15687-27-1

Characteristics of Ibuprofen

Ibuprofen is a racemic mixture of S- and R-enantiomers. White or off-white crystalline powder, practically insoluble in water, highly soluble in organic solvents (ethanol, acetone). Molecular weight 206.28.

Pharmacology

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Nekelectively inhibits COX-1 and COX-2, reduces the synthesis of PG. The anti-inflammatory effect is associated with a decrease in vascular permeability, an improvement in microcirculation, a decrease in the release of inflammatory mediators (PG, kinin, LT) from the cells and the suppression of energy supply of the inflammatory process. Analgesic effect is due to a decrease in the intensity of inflammation, a decrease in the production of bradykinin and its algogenicity. In rheumatoid arthritis it affects mainly the exudative and partly the proliferative components of the inflammatory reaction, has a quick and pronounced analgesic effect, reduces puffiness, morning stiffness and limited mobility in the joints. Reducing the excitability of the heat-regulating centers of the intermediate brain is resultant in antipyretic action. The severity of the antipyretic effect depends on the initial body temperature and dose. With a single admission, the effect lasts up to 8 hours. With primary dysmenorrhea reduces intrauterine pressure and the frequency of uterine contractions. Reversibly inhibits platelet aggregation.

Since GHGs delay the closure of the arterial duct after birth, it is believed that COX suppression is the main mechanism of action of ibuprofen for IV application in newborns with an open arterial duct.

When ingestion is well absorbed from the digestive tract. Cmax is created within 1 hour, after taking food after 1.5-2.5 hours. Binding to plasma proteins is 90%. Slowly penetrates into the joint cavity, but it lingers in the synovial tissue, creating in it greater concentrations than in the plasma. Biological activity is associated with the S-enantiomer. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into an active S-form. Undergoing biotransformation. There are 3 main metabolites excreted by the kidneys. Unchanged in the urine excreted not more than 1%. It has a two-phase elimination kinetics with T1 / 2 from plasma of 2-2.5 h (for retard forms - up to 12 h).

Application of Ibuprofen

For oral administration: inflammatory and degenerative diseases of the musculoskeletal system, incl. rheumatoid arthritis, osteoarthrosis, psoriatic arthritis, articular syndrome with exacerbation of gout, ankylosing spondylitis (Bechterew's disease), spondylosis, Barre-Lieu syndrome (cervical migraine, vertebral artery syndrome). Pain syndrome, incl. lumbar, sciatica, thoracic radicular syndrome, myalgia, neuralgic amyotrophy, neuralgia, arthralgia, ossalgia, bursitis, tendinitis, tenosynovitis, sprain of the ligamentous apparatus, hematomas, traumatic inflammation of the soft tissues and musculoskeletal system, postoperative pain syndrome accompanied by inflammation, migraine, headache and toothache, surgical operations in the oral cavity. Feverish conditions of various genesis (including after immunization), with influenza and ARVI. As an auxiliary: infectious and inflammatory diseases of the ENT organs (tonsillitis, pharyngitis, laryngitis, sinusitis, rhinitis), bronchitis, pneumonia, pelvic inflammatory processes, adnexitis, algodismenorea, panniculitis, nephrotic syndrome (to reduce the expression of proteinuria).

For external use: inflammatory and degenerative diseases of the musculoskeletal system: arthritis (rheumatoid, psoriatic), articular syndrome with rheumatism and exacerbation of gout, humerous periarthritis, ankylosing spondylitis, deforming osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, tendonitis, tendovaginitis, bursitis, lumbago, sciatica; muscle pain, trauma without compromising the integrity of soft tissues (including dislocation, stretching or rupture of muscles and ligaments, bruising, posttraumatic swelling of soft tissues).

For IV administration (only in newborns): treatment of a hemodynamically significant open arterial duct in premature newborns with a gestational age of less than 34 weeks.

For rectal use (for children from 3 months to 2 years): as an antipyretic agent - ARI, ARVI, influenza, other infectious and inflammatory diseases accompanied by fever; post-vaccination reactions. As an analgesic - pain syndrome of mild or moderate intensity (including headache and toothache, migraine, neuralgia, pain in the ears and throat, pain in the stretches).

Contraindications

Hypersensitivity. For oral administration: erosive and ulcerative diseases of the digestive tract in the phase of exacerbation (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis, peptic ulcer), aspirin bronchial asthma, urticaria, rhinitis, triggered by salicylates or other NSAIDs; disorders of blood clotting (including hemophilia, hypocoagulation, hemorrhagic diathesis), optic nerve disease, scotoma, amblyopia, color vision disorder, asthma, leukopenia, thrombocytopenia, hemorrhagic diathesis, confirmed hyperkalemia, severe hepatic impairment or active liver disease, severe renal failure (creatinine clearance <30 ml / min), progressive kidney disease, severe heart failure, children under 12 years (tablets, capsules, granules for solution), up to 6 years ( tablets effervescent), up to 3 months (suspension for ingestion for children, suppositories rectal for children).

For intravenous administration: life-threatening infection, clinically pronounced bleeding (especially intracranial or gastrointestinal), thrombocytopenia or blood clotting disorder, significant renal dysfunction, congenital heart disease in which the open arterial duct is a prerequisite for satisfactory pulmonary or systemic blood flow (eg pulmonary atresia, heavy tetralogy of Fallot, severe coarctation of the aorta); diagnosed or suspected necrotizing enterocolitis.

For external use: dermatitis, eczema, violation of the integrity of the skin (including infected abrasions and wounds).

Restrictions for use

Stomach ulcer and duodenal ulcer in history, arterial hypertension, hearing loss, vestibular apparatus pathology, elderly age, suspected infectious disease (for intravenous use).

pregnancy and lactation

Contraindicated in the III trimester of pregnancy, in the I and II trimester - with caution.

For the duration of treatment, breastfeeding should be discontinued.

Side effects of Ibuprofen

System Effects

On the part of the intestine: nausea, vomiting, NSAID-gastropathy (decreased appetite, pain and discomfort in the epigastric region, abdominal pain), irritation, dryness of the mucous membrane or pain in the oral cavity, ulceration of the gingival mucosa, aphthous stomatitis, pancreatitis, constipation / diarrhea, flatulence, digestive disorders, possibly - erosive-ulcerative lesion and bleeding from the digestive tract, impaired liver function.

From the nervous system and sensory organs: headache, drowsiness, anxiety, nervousness, irritability, psychomotor agitation, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases), hearing impairment, ringing in the ears, reversible toxic amblyopia, unclear vision or dilation, dryness and irritation of the eyes, edema of the conjunctiva and eyelids (allergic genesis), scotoma.

From the cardiovascular system and blood (hematopoiesis, hemostasis): heart failure, tachycardia, increased blood pressure, eosinophilia, anemia, incl. hemolytic, thrombocytopenic purpura, agranulocytosis, and leukopenia.

On the part of the respiratory system: dyspnea, bronchospasm.

From the genitourinary system: edematous syndrome, impaired renal function, acute renal failure, polyuria, cystitis.

Allergic reactions: skin rash (erythematous, urticaria), pruritus, hives, allergic rhinitis, allergic nephritis, Quincke's edema, anaphylactic reactions, incl. anaphylactic shock, multiforme exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis.

Other: increased sweating, fever.

For IV (intravenous) administration

On the part of the blood system: violations of blood clotting, leading to bleeding and hemorrhage, incl. intestinal and intracranial, respiratory disorders and pulmonary hemorrhage.

From the digestive tract: obstruction and perforation of the intestine.

On the part of the kidneys: a decrease in the volume of urine formed, the presence of blood in the urine.

At present, there are data on approximately 1,000 preterm infants found in the ibuprofen literature and obtained in clinical studies of ibuprofen with an iv administration. The causes of adverse events observed in preterm infants are difficult to estimate, they can be related both to the hemodynamic consequences of the open arterial duct, and to the direct effects of ibuprofen.

The following unfavorable events are listed below:

From the hematopoietic and lymphatic system:> 1/10 - thrombocytopenia, neutropenia.

From the nervous system:> 1/100, <1/10 - intraventricular hemorrhage, periventricular leukomalacia.

On the part of the respiratory system, chest and mediastinal organs:> 1/10 - bronchopulmonary dysplasia; > 1/100, <1/10 - pulmonary hemorrhage; > 1/1000, <1/100 - hypoxemia (occurred within 1 hour after the first infusion with normalization of the state within 30 min after inhalation of nitric oxide).

From the side of the kidneys and urinary tract:> 1/100, <1/10 - oliguria, fluid retention, hematuria; > 1/1000, <1/100 - acute renal failure.

Gastrointestinal disorders:> 1/100, <1/10 - necrotizing enterocolitis, perforation of the intestine; > 1/1000, <1/100 - gastrointestinal bleeding.

Other:> 1/10 - increase in the concentration of creatinine in the blood, a decrease in the concentration of sodium in the blood.

With external application

Irritation of skin in the form of redness, swelling, rashes or itching; with long-term use - systemic adverse reactions.

Interaction

It should avoid the simultaneous use of two or more NSAIDs due to an increased risk of side effects. With the simultaneous use of ibuprofen reduces the anti-inflammatory and antiaggregatory effect of acetylsalicylic acid (possibly increasing the incidence of acute coronary insufficiency in patients receiving low doses of acetylsalicylic acid as antiplatelet agent after taking ibuprofen). When used with thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases at the same time. Ibuprofen increases the effect of indirect anticoagulants, antiaggregants, fibrinolytic drugs.

Inductors of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions. Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action.

Antacids and colestyramine reduce the absorption of ibuprofen. Caffeine increases the analgesic effect of ibuprofen. Cefamandol, cefoperazone, cefotetan, valproic acid increase the frequency of hypoprothrombinemia.

Myelotoxic drugs increase the manifestation of hematotoxicity of ibuprofen. Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of PG in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects. LS, blocking tubular secretion, reduce excretion and increase the plasma concentration of ibuprofen.

Ibuprofen reduces the effect of antihypertensive drugs (including BCC and ACE inhibitors), natriuretic and diuretic activity of furosemide and hydrochlorothiazide, the effectiveness of uricosuric drugs. Increases the side effects of mineralocorticoids, glucocorticoids, estrogens, ethanol. Strengthens the effect of oral hypoglycemic drugs and insulin. Increases the concentration in the blood of digoxin, lithium and methotrexate. Ibuprofen may reduce the clearance of aminoglycosides (with the simultaneous appointment may increase the risk of nephrotoxicity and ototoxicity).

Ibuprofen for intravenous administration should not be confused with other drugs.

Overdose

Symptoms: abdominal pain, nausea, vomiting, retardation, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, hypotension, bradycardia, tachycardia, atrial fibrillation and respiratory arrest.

Treatment: gastric lavage (only for the first hour after ingestion), activated charcoal (to reduce absorption), alkaline drink, forced diuresis and symptomatic therapy (correction of KHS, AD, gastrointestinal bleeding).

Routes of administration

Inside, externally, rectally (children 3 months-2 years), in / in (newborn).

Precautions for Ibuprofen

Treatment with ibuprofen should be carried out at the lowest effective dose, with the minimum possible short course. During long-term treatment, control of the peripheral blood picture and the functional state of the liver and kidneys is necessary.

Given the possibility of developing NSAID-gastropathy, with caution appoint elderly people, in the presence of an anamnesis of stomach ulcers and other gastrointestinal diseases, gastrointestinal bleeding, with simultaneous therapy with glucocorticoids, other NSAIDs and for long-term therapy. When symptoms of gastropathy appear, careful monitoring (including esophagogastroduodenoscopy, a blood test with determination of hemoglobin, hematocrit, analysis of feces for latent blood) is shown. To prevent the development of NSAIDs, gastropathy is recommended to be combined with PGE (misoprostol) preparations.

With caution appoint patients with violations of the liver and kidneys (regular monitoring of bilirubin, transaminase, creatinine, concentration of kidneys), arterial hypertension and chronic heart failure (daily control of diuresis, body weight, blood pressure) is mandatory. If visual impairment occurs, reduce the dose or cancel the drug.

It is not recommended to drink alcoholic beverages during the treatment period.

Do not apply to an open wound surface, damaged skin; avoid getting cream, gel or ointment in the eyes and mucous membranes.