Instruction for use: Hydrocortisone (Hydrocortisonum)

Pharmacological group

Glucocorticosteroids

Ophthalmic products

Nosological classification (ICD-10)

A16 Tuberculosis of respiratory organs, not confirmed bacteriologically or histologically

A17.0 Tuberculous meningitis (G01 *)

Tuberculosis of serous membranes, Tuberculous meningitis, Meningitis tuberculosis

B75 Trichinosis

Trichinosis with myocardial manifestations, Trichinosis with neurological manifestations, Trichinosis with myocardial infarction, Trichinosis with damage to the nervous system, Trichinosis with myocardial involvement, Trichinosis with CNS involvement, Multiple nematodes, Trichinosis

C34 Malignant neoplasm of bronchi and lung

Small cell anaplastic lung tumors, Small cell and non-small cell lung cancer, Small cell lung cancer, Locally-distributed small cell lung cancer, Locally advanced non-small cell lung cancer, Undifferentiated lung cancer, Non-small cell lung cancer, Bronchogenic Cancer, Non-small cell lung cancer, Inoperable locally advanced non-small cell lung cancer, Cancer of the bronchi, Lungs' cancer, Small cell lung cancer, Lung cancer, Small cell lung cancer, Non-small cell lung cancer, Lung cancer of squamous cell,Recurrent non-small cell non-small cell lung cancer, Small cell lung carcinoma, Inoperable metastatic non-small cell lung cancer, Lung carcinoma, Ovsyocellular carcinoma of the lung, Disseminated lung cancer, Tumors of the lungs

C81 Hodgkin's disease [lymphogranulomatosis]

Paltauf-Sternberg disease, The generalized form of Hodgkin's disease, Lymphogranulomatosis, Hodgkin's disease, Hodgkin's lymphoma, Hodgkin's malignant lymphoma, Hodgkin's lymphoma, Lymphoproliferative diseases, Reticulosis fibromyaloid, Pelya-Ebstein fever

C82 Follicular [nodular] non-Hodgkin's lymphoma

Brill-Simmers disease, Malignant lymphoma, Hepatic Lymphoma, Recurrent non-Hodgkin's lymphoma, Follicular B-cell non-Hodgkin's lymphoma, Follicular lymphoma, Lymphoma of the liver

C83 Diffuse non-Hodgkin's lymphoma

Diffuse B-Large-Cell Non-Hodgkin's Lymphoma, Malignant lymphoma, Malignant lymphoma, especially of the histiocytic type, Lymphoblastic non-Hodgkin's lymphoma, Lymphoma non-Hodgkin's diffuse, Hepatic Lymphoma, Recurrence of lymphoma, Recurrent non-Hodgkin's lymphoma, Lymphoma of the liver

C85 Other and unspecified types of non-Hodgkin's lymphoma

Lymphoma of mixed type, Lymphomas from cells of the mantle zone, Malignant lymphoma, Lymphoma non-Hodgkin's disease, Lymphocytic lymphoma

C91 Lymphoid leukemia [lymphatic leukemia]

Lymphocytic leukemia, Lymphoproliferative diseases, Neuroleukemia, Refractory acute lymphoblastic leukemia, Refractory lymphoblastic leukemia, Transformation of preleukemias, Chronic lymphatic leukemia, Lymphoproliferative disorders

C95.0 Acute leukemia of unspecified cell type

Leukemia acute, Acute leukemia, Acute leukemia in children, Acute leukemia in adults

C92 Myeloid leukemia [myeloid leukemia]

Ph-positive chronic myelogenous leukemia, Granulocytic leukemia, Myeloid leukemia, Myeloid leukemia, Myeloma disease, Neuroleukemia, Acute myeloblastic leukemia, Acute non-lymphoblastic leukemia, Acute non-lymphoblastic leukemia in adults, Refractory acute non-lymphoblastic leukemia, Induction of remission in PMLL, Transformation of preleukemias, Subleukemic myelosis, Myeloblastic leukemia, Myeloid leukemia

D59.1 Other autoimmune hemolytic anemia

Autoimmune hemolytic anemia, Immune hemolytic anemia, Autoimmune hemolytic anemia

D60.9 Acquired pure red cell aplasia, unspecified

Hematopoietic disorders, Partial red cell aplasia of hematopoiesis, Erythroid anemia

D61.0 Constitutional aplastic anemia

Anemia hypoplastic

D69.3 Idiopathic thrombocytopenic purpura

Werlhof's disease, Idiopathic autoimmune thrombocytopenia, Idiopathic thrombocytopenic purpura of adults, Idiopathic thrombocytopenic purpura in adults, Immune idiopathic thrombocytopenic purpura, Immune thrombocytopenia, Bleeding in patients with thrombocytopenic purpura, Evans Syndrome, Thrombocytopenic purpura, Thrombocytopenia of immune origin, Chronic idiopathic thrombocytopenic purpura, Essential thrombocytopenia, Autoimmune thrombocytopenic purpura in pregnancy, Posttransfusion purpura

D86 Sarcoidosis

Beca disease, Beka sarcoid, Bénie-Beca-Schaumann disease, Bénya-Beca-Schaumann syndrome, Granulomatosis benign, Lymphogranulomatosis benign, Reticuloendotheliosis epithelioid cell chronic, Shaumann benign lymphogranulomatosis, Shaumann syndrome, Symptomatic sarcoidosis

E05.0 Thyrotoxicosis with diffuse goiter

Goiter toxic diffuse, Toxic goiter, Diffuse thyrotoxic goiter, Graves disease, Diffuse toxic goiter, Goiter diffuse toxic, Parry's disease, Flanyani disease, Von Bazedova's disease, Toxic diffuse goiter

E06 Thyroiditis

Pulmonary thyroiditis

E25.9 Adrenergic disorder, unspecified

Feminic physique in boys at pubertal age, Vyrilization (masculinization), Masculinization

E27.1 Primary insufficiency of the adrenal cortex

Addison's Disease, Addisonism, Adrenocortical insufficiency, Hypofunction of the adrenal cortex, Collapse with Addison's Disease, Insufficiency of the adrenal cortex primary, Primary adrenocortical insufficiency, Primary adrenal insufficiency

E27.2 Addison's Crisis

Insufficiency of the adrenal cortex is acute, Adrenal crisis, Sympathic-adrenal crises, Acute adrenal insufficiency, Acute insufficiency of the adrenal cortex, Addisonism

E27.4 Other and unspecified adrenocortical insufficiency

Hypocorticism, Hypoaldosteronism, Adrenal insufficiency, Insufficiency of the adrenal cortex, Insufficiency of the adrenal cortex, Secondary adrenocortical insufficiency, Secondary adrenal insufficiency, Secondary insufficiency of the adrenal cortex, Temporary decrease in the function of the adrenal cortex, Dysfunction of the adrenal cortex

E83.5.0 * Hypercalcemia

Hypercalcemic crisis, Idiopathic hypercalcemia of newborns, Milk-alkaline syndrome

G35 Multiple sclerosis

Disseminated sclerosis, multiple sclerosis, Relapsing Multiple Sclerosis, Secondary progressive multiple sclerosis, Exacerbation of multiple sclerosis, Mixed forms of multiple sclerosis

G45 Transient transient cerebral ischemic attacks [attacks] and related syndromes

Ischemic neurological disorders, Acute cerebrovascular insufficiency, Recurrent transient ischemia of the brain, Transient ischemic attack, Transient ischemic disorder, Transient ischemic state, Transitory impairment of cerebral circulation, Transient ischemic attack, Transient ischemia, Transient cerebral ischemic attack, Transient cerebral ischemia, Transient attacks of ischemia, Transient ischemic attack, Chronic cerebral ischemia, Drop-attack, Transient ischemic attacks, Transient ischemic impairment of cerebral circulation, Ischemic brain damage, Syndrome of subclavian stealing

G56.0 Carpal tunnel syndrome

Carpal tunnel syndrome, Compression neuropathies

H01.0 Blepharitis

Blepharitis, Inflammation of the eyelids, Inflammatory diseases of the eyelids, Demodectic blepharitis, Superficial bacterial infection of the eyes, Superficial infection of the eye, Scaly blepharitis

H01.1 Non-infectious dermatoses of the eyelid

Eczematous lesion of the eyelids

H10.1 Acute atopic conjunctivitis

Allergic conjunctivitis, Allergic eye disease, Allergic conjunctivitis, Allergic conjunctivitis is caused by chemical and physical factors, Allergic rhinoconjunctivitis,Allergic inflammation of the eye, Spring catarrh, Spring keratitis, Spring conjunctivitis, allergic Conjunctivitis, Perennial allergic conjunctivitis,Exacerbation of pollen allergy in the form of Syndrome rinokonyunktivalnogo, Acute allergic keratoconjunctivitis, Acute allergic conjunctivitis,Superficial bacterial eye infections,rhinoconjunctivitis, Seasonal allergic conjunctivitis, Seasonal conjunctivitis, Sennoz, Chronic allergic keratoconjunctivitis, Chronic allergic conjunctivitis

H16.9 Other specified keratitis

Vesicular keratitis, Deep keratitis without epithelial damage, Fungal keratitis, Diskovidny keratitis without damage to the epithelium of the cornea, Keratitis without epithelial defects, Inflammation of the cornea

H20 Iridocyclitis

recurrent iritis, sympathetic iridocyclitis, Sluggish posterior uveitis, Sluggish posterior uveitis, Posterior uveitis, the posterior segment of the eye Iridocyclitis, Iridocyclitis and other uveitis, Irit, Keratoiridotsiklit, Acute iritis, uveitis, cycle of Acute iridocyclitis, Acute non-infectious uveitis

H30.9 chorioretinal inflammation, unspecified

Choroiditis, myopic chorioretinitis, Violation of choroidal circulation, Central retinitis

H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere

Eye infections, Bacterial infections of the epididymis, Infections of eye tissues, Bacterial eye infections

H44.1 Other endophthalmitis

Ophthalmic sympathetic, Egyptian ophthalmia,Endophthalmitis

I01 Rheumatic fever with involvement of the heart

Rheumatic carditis acute

I01 Rheumatic fever with involvement of the heart

Rheumatic carditis acute

I21 Acute myocardial infarction

Myocardial infarction in the acute phase, Acute Myocardial Infarction, Myocardial infarction with pathologic Q wave and without, Myocardial infarction complicated by cardiogenic shock, Infarction left ventricular, Transmural myocardial infarction, Myocardial infarction netransmuralny (subendocardial), Netransmuralny myocardial infarction, Subendocardial myocardial infarction, The acute phase of myocardial infarction, Acute myocardial infarction, Sub-acute phase of myocardial infarction, Subacute phase of myocardial infarction, Thrombosis of the coronary arteries (the arteries), Threatened myocardial infarction, Myocardial infarction without Q wave

I61 Intracerebral haemorrhage

Apoplexic shock, Apoplexy of the brain, Hematoma subduralnoy, Hematoma epidural, Hemorrhagic stroke, Stroke apoplexy, Hemorrhagic stroke, Hemorrhage in the brain, Intra cerebral hemorrhage, Postponed hemorrhagic stroke, Subdural hematoma chronic, Epidural hematomas

I63 Cerebral infarction

Stroke ischemic, Ischemic disease of the brain, Ischemic stroke, Ischemic stroke and its consequences, Ischemic cerebral stroke, Ischemic impairment of cerebral circulation, Ischemic damage of the brain, Ischemic brain damage, Ischemic state, Ischemia of the brain, Acute hypoxia of the brain, Acute cerebral ischemia, Acute ischemic impairment of cerebral circulation, Acute cerebral infarction, Acute ischemic stroke, Acute period of ischemic stroke, Focal cerebral ischemia, Postponed ischemic stroke, Repeated stroke, Morgagni-Adams-Stokes Syndrome, Chronic cerebral ischemia, Cerebrovascular stroke, Embolic Stroke, Ischemic brain damage

I95 Hypotension

hypotension, Age hypotension, arterial Hypertension, Hypotonic disease, hypotonic reaction, postural hypotension, Symptomatic hypotension, Essential hypotension

I95.1 Orthostatic hypotension

Idiopathic orthostatic hypotension, Orthostatic hypotension, Orthostatic syndrome, Response by type of asympathicotonia

J38.4 Laryngeal edema

Laryngeal edema of allergic genesis and on the background of irradiation, Acute non-infectious edema of the larynx

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

J46 Status asthmaticus

Asthmatic attack, status asthmaticus, Bronchospasm in bronchial asthma

J63.2 Berylliosis

J82 Pulmonary eosinophilia, not elsewhere classified

Pulmonary infiltrate, Eosinophilic pulmonary infiltrate, Leffler's syndrome, Leffler's disease

J69.0 Pneumonitis caused by food and vomit

Aspiration pneumonia, Pneumonia aspiration, Postoperative aspiration pneumonia in neurosurgical and thoracic operations

J95.4 Mendelssohn syndrome

Aspiration of gastric juice, Aspiration of acidic stomach contents

K50 Crohn's disease [regional enteritis]

Crohn's disease, Crohn's disease with fistula, Granuloma of the intestine, Granulomatous enteritis, Crohn's disease, Regional ileitis, Terminal Ileitis, Enteritis regional

K51 Ulcerative colitis

Colitis acute ulcerative, Colitis ulcerative, Ulcerative-necrotic colitis, Colitis ulcerative-hemorrhagic nonspecific, Colitis ulcerative and trophic, Colitis ulcerative idiopathic, Colitis ulcerative nonspecific, Nonspecific ulcerative colitis, Proctocolitis ulcers, Hemorrhagic purulent rectoxitis, Rectoccolitis ulcerative-hemorrhagic

K72.0 Acute and subacute liver failure

Lightning-fast hepatitis, Hepatitis acute, Hepatic failure acute and subacute

K72.9 Hepatic insufficiency, unspecified

Latent hepatic encephalopathy, Acute liver failure, Liver failure, Hepatic precoma, Acute hepatic-renal failure

L10 Pemphigus [pemphigus]

Benign pemphigoid of mucous membranes, Bubble dermatosis, Pemphigus, Dermatitis, vesicular, Benign pemphigus, Ordinary pemphigus, Pemphigus, Bubble dermatitis, Family benign pemphigus Hailey-Hailey

L13.9 Bullous changes, unspecified

Bullous dermatitis

L20 Atopic dermatitis

Itchy atopic eczema, Common neurodermatitis, Allergic skin diseases, Allergic skin diseases of non-infectious etiology, Allergic skin diseases of non-microbial etiology, Allergic skin diseases, Allergic skin lesions, Allergic manifestations on the skin, Allergic dermatitis, Allergic diathesis, Allergic itching dermatosis, Allergic Skin Disease, Allergic skin irritation, Dermatitis allergic, Atopic dermatitis, Dermatosis allergic, Diathesis exudative, Skin Allergic Disease, Skin allergic reaction to medicinal and chemical preparations, Skin reaction to medication, Skin and allergic disease, Acute eczema, Chronic atopic dermatitis, Exudative diathesis, Itching allergic dermatosis

L21 Seborrheic dermatitis

Dermatitis seborrheic, Increased sebum separation, Seborrheic Eczema, Seborrheic dermatitis of the scalp, Seborrheic pyodermatitis, Seborrhea, Eczema seborrheic

L23.9 Allergic contact dermatitis, cause not specified

Allergic skin diseases, Allergic contact reactions, Skin allergic, Contact hypersensitivity reactions

L25.9 Unspecified contact dermatitis, cause not specified

L26 Exfoliative dermatitis

Dermatitis exfoliative, Exfoliative dermatitis generalized

L29.3 Anogenital pruritus, unspecified

Itching in the genital and anus, Anal itching, Anogenital itching, Genital itching, Anogenital itching, Itching of the anorectal region, Itching of the vulva, Itching of the genitals, Perianal dermatitis

L30.9 Dermatitis, unspecified

Allergic dermatoses complicated by a secondary bacterial infection, Anal eczema, Bacterial maturation, Varicose Eczema, Venous dermatitis, Inflammation of the skin, Inflammation of the skin upon contact with plants, Inflammatory Skin Diseases, Inflammatory skin reactions, Inflammatory processes of the skin, Hypostatic dermatitis, Fungal Eczema, Fungal dermatosis, Dermatitis, Dermatitis is stagnant, Dermatitis and eczema in the anal area, Dermatitis acute contact, Perianal dermatitis, Dermatosis, Dermatosis of the scalp, Dermatosis of psoriasis, Dermatosis with persistent itching, Dermatoses, Dermatoses itchy, Other itching dermatoses, Significant eczematous manifestations, Itching with, dermatoses, Itching eczema, True eczema, Skin reaction to insect bites,Skin itching with dermatosis, Constitutional eczema, Weeping eczema, Drowsing inflammatory skin disease, Dying Infectious-Inflammatory Skin Disease, Non-allergic dermatitis, Nummular eczema, Acute contact eczema, Acute inflammatory skin disease, Acute dermatosis, Acute severe dermatosis, Perianal dermatitis, Superficial dermatosis, Subacute Contact Eczema, Simple dermatitis, Occupational dermatitis, Psychogenic dermatosis, Bubble dermatitis of newborns, Pustular eruptions, Irritation and redness of the skin, Low-flammable eczema, Dry atrophic eczema, Dry eczema, Toxic dermatitis, Ear eczema like dermatitis, Chronic eczema, Chronic dermatosis, Chronic common dermatosis, Scaly papular dermatosis, Eczema, Eczema anal region, Eczema of the hands, Eczema Contact, Eczema lichenized, Eczema Nummular, Eczema acute, Eczema acute contact, Eczema subacute, Eczematous dermatitis, Eczema-like rashes, Ecome exogenous, Endogenous eczema, Gluteal dermatitis, Restricted itchy dermatitis

L40 Psoriasis

Chronic psoriasis with diffuse plaques, Generalized psoriasis, Psoriasis of the scalp, Psoriasis of the scalp, Generalized form of psoriasis, Psoriasis dermatitis, Psoriasis complicated by erythroderma, Invalidative psoriasis, Isolated psoriatic plaque, Exfoliative psoriasis, Psoriatic Erythroderma, Psoriasis with eczematosis, Hyperkeratosis in psoriasis,Inverse psoriasis,Psoriasis eczematous, Dermatosis of psoriasis, Psoriasis of the genitals, Psoriasis with lesions of hairy areas of skin, Erythrodermal psoriasis, Chronic psoriasis of the scalp, Chronic psoriasis, Ordinary psoriasis, Refractory psoriasis, Kebner phenomenon, Scaly lichen

L40.5 Arthropathy psoriasis (M07.0-M07.3 *, M09.0 *)

Arthritis psoriatic, Arthropathic form of psoriasis

L43.9 Lichen red flat unspecified

Lishay Wilson, Red flat lichen, Red hair follicle, Red haired pityriasis, Red flat lichen of oral mucosa

L53 Other erythematous conditions

Variable erythrokeratodermia, Malignant exudative erythema, Erythema, Erythematous, Erythroderma, Erythema from diapers

L56 Other acute skin changes caused by ultraviolet radiation

Impact of UV rays, Acute skin changes caused by ultraviolet radiation, Sun Dermatitis, Photodermatitis, Photodermatosis, Dermatitis sunflower

L63 Alopecia areata

Lupecia nesting, Nesting baldness, Nesting alopecia, Alopecia marginal alopecia, Nesting baldness, Alopecia areata, Hair loss in the form of a circle, Circumferential baldness

L91.0 Keloid cicatrix

Hyperlusculation, Keloid, Keloid cicatrix, Kelloid scars

L92.0 Granuloma annular

Ring-shaped granuloma

L92.1 Necrobiosis lipoid, not elsewhere classified

Dyslipidosis of the skin, Diabetic lipoid necrobiosis

L93.0 Discoid lupus erythematosus

Chronic discoid lupus erythematosus, Red discoid lupus, Discoid lupus, Discoid erythematosis

L98.9 Lesion of skin and subcutaneous tissue, unspecified

Adiponecrosis, Atonic leather, Diseases of the skin, Blister, Inflammatory disease of soft tissues, Inflammatory processes of epithelial tissues, Degenerative changes in the skin and mucous membranes, Degenerative changes in the skin and mucous membranes, Excess granulation, Thinning of the skin, Skin diseases, Maceration of the skin, Minor skin lesions, Surface crack and skin abrasion, Increased skin peeling, Skin lesion, Erosion of the skin, Lipedema, Local non-infectious processes of skin and soft tissues, Disturbance of skin structure, Dysfunction of the skin, Skin disorders

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M08 Juvenile [juvenile] Arthritis

Juvenile arthritis, Juvenile chronic polyarthritis, Juvenile chronic arthritis, Juvenile rheumatoid arthritis, Arthritis juvenile chronic

M10.0 Idiopathic Gout

Primary gout

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M32 Systemic lupus erythematosus

Lupus erythematosus red disseminated, Disseminated lupus erythematosus, Chronic lupus erythematosus

M33.2 Poliomyositis

Muscle weakness in polymyositis, Polymyositis in children, Polyartralgia in polymyositis

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M65.9 Synovitis and tendosynovitis, unspecified

Synovitis, Inflammation of the tendon sheath, Acute nonspecific tenosynovitis, Reactive synovitis

M67.8 Other specified disorders of synovium and tendon

Cystic swelling of the tendons, Synovitis in osteoarthritis

M67.9 Lesion of synovium and tendon, unspecified

Inflammation of the tendons, Inflammation of ligaments, Inflammation of tendons with injuries, Inflammation of tendons

M71.9 Bursopathy, unspecified

Bursites, Alberta disease, Acute bursitis

M75.0 Adhesive shoulder capsulitis

Acute shoulder-scapular periarthritis, Duplay's disease, Duplay Syndrome, Frozen shoulder, Shoulder-shoulder periarthritis, Periarteritis humeroscapular, Shoulder periarthritis, Pleiraptocular periarthritis, Capsule, Frozen shoulder

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

N04 Nephrotic syndrome

Nephrosis, Edema of the kidneys, Nephrotic syndrome, Lipoid nephrosis, Nephrotic syndrome without uremia, Acute nephrotic syndrome, Edematic syndrome of renal genesis, Renal form of diabetes insipidus, Segmental glomerulonephritis, Focal glomerulonephritis, Family Nephrotic Syndromes, Chronic nephrotic proteinuric syndrome, Lipiduria, Jade hereditary, Nephrotic-proteinuric syndrome

R57.0 Cardiogenic shock

cardiogenic shock

R57.8 Other types of shock

Blood transfusion shock, Obstructive shock, Circulatory shock

R58 Bleeding, not elsewhere classified

Abdominal apoplexy, Hemorrhagia, Haemorrhage of the esophagus, Hemorrhage, Generalized bleeding, Diffuse bleeding, Diffuse bleeding, Prolonged bleeding, Blood loss, Blood loss during surgical interventions, Bleeding during surgery and in the postoperative period, Bleeding during labor, Bleeding and haemorrhage in hemophilia B, Bleeding from the gums, Bleeding intraoperative abdominal, Bleeding against a background of coumarin anticoagulants, Hepatic hepatitis, Bleeding at hemophilia A,Bleeding with inhibitory forms of hemophilia A and B, Bleeding due to leukemia, Bleeding in patients with leukemia,Bleeding,Bleeding due to portal hypertension, Bleeding due to hyperfibrinolysis, Drug bleeding, Local bleeding, Local bleeding due to activation of fibrinolysis, Massive blood loss, Acute blood loss, Parenchymal hemorrhage, Hepatic bleeding, Postoperative hemorrhage, Kidney bleeding,Vascular-platelet hemostasis, Traumatic bleeding, Threatening bleeding, Chronic blood loss

S05.0 Injury of the conjunctiva and corneal abrasion without mention of the foreign body

Superficial injury of the cornea, Corneal surface damage, Traumatic erosion of the cornea, Mechanical injuries of the cornea

S05.9 Injury of unspecified part of the eye and orbit

eye injury, Superficial corneal injury

T45.2 Poisoning with vitamins not elsewhere classified

Vitamin D poisoning, Overdose of pyridoxine

T65.9 Toxic effect of unspecified substance

idiosyncrasy toxic, Intoxication nitro compounds, Intoxication toxins, Professional intoxication, Poisoning nitrites, Poisoning toxins

T78.2 Anaphylactic shock, unspecified

Anaphylactic shock, Anaphylactoid reaction, Anaphylactic shock, Anaphylactic reactions, Anaphylactic shock to drugs

T78.4 Allergy, unspecified

Allergic reactions to insulin, Allergic reactions to insect stings, Allergic reactions similar to systemic lupus erythematosus, Allergic diseases, Allergic diseases of mucous membranes, Allergic diseases and conditions resulting from increased release of histamine, Allergic diseases of mucous membranes, Allergic symptoms, Allergic symptoms in the mucous membranes, Allergic reactions, Allergic reactions caused by insect bites, Allergic reactions, Allergic conditions, Allergic laryngeal edema, allergopathy, allergic conditions, Allergy, House dust allergy, Anaphylaxis, Cutaneous reactions to medications, Skin reaction to insect stings, Cosmetic allergy, Drug allergy, Acute allergic reaction, Laryngeal edema allergic genesis and background radiation, Food and drug allergy

T79.4 Traumatic shock

Hemorrhagic shock, Crush syndrome, hemorrhagic shock, postoperative shock, post-traumatic shock, traumatic shock, hemorrhagic shock and encephalopathy syndrome

T80.6 Other serum reactions

Serum sickness, Allergic reaction of the type of serum sickness, Serous disease accelerated

T81.1 Shock during or after the procedure, not elsewhere classified

Operating shock, Postoperative shock, Operational shock

W57 Bite or sting with non-toxic insect and other non-venous arthropods

Allergic reaction to insect bites, Skin reaction after insect bite, Reactions to insect bites, Mosquito bite, Bite of bloodsucking insects, A bite of an insect, The bite of the wasp

X20 Contact with poisonous snakes and lizards

Snake bite

X21 Contact with poisonous spiders

Y40-Y59 Drugs, medicines and biological substances that cause adverse reactions during therapeutic use

Y47.2 Adverse reactions in the therapeutic use of chlorine derivatives

Z13.0 Special screening examination for the detection of blood diseases and hemopoietic organs, as well as certain disorders involving the immune mechanism

Code CAS 50-23-7

Characteristics

Hydrocortisone is a hormone secreted by the adrenal cortex, a glucocorticoid. In medical practice, for natural and systemic use, natural hydrocortisone or its esters (hydrocortisone acetate and hydrocortisone sodium hemisuccinate) are used.

Hydrocortisone is a white or almost white powder without a smell, a bitter taste. Solubility (mg / ml) at 25 ° C: water 0.28; Ethanol 15.0; Methanol: 6.2; Acetone 9.3; Chloroform 1.6; Propylene glycol 12.7; Ether - about 0.35. Soluble in concentrated sulfuric acid to form a fluorescent solution of intense green color. Molecular weight 362.47.

Hydrocortisone acetate is a synthetic steroid, white or white with a slightly yellowish tinge, crystalline powder, odorless. Slightly hygroscopic. Solubility in water: 1 mg / 100 ml, in ethanol: 0.45 g / 100 ml, in methanol: 3.9 mg / ml, in acetone: 1.1 mg / g, in ether: 0.15 mg / ml , In chloroform: 1 g / 200 ml, readily soluble in dimethylformamide, soluble in dioxane. Molecular weight 404.50.

Hydrocortisone sodium hemisuccinate is a synthetic steroid, white or white with a slightly yellowish tint porous mass or amorphous hygroscopic white powder; Solubility in water of approximately 500 mg / ml. Easily soluble in methanol, ethanol, hardly soluble in chloroform. Molecular weight 484.51.

Hydrocortisone 17-butyrate is a molecular weight of 432.55.

Pharmacology

Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive, antipruritic, anti-shock, antiexudative, glucocorticoid.

It inhibits hypersensitivity reactions, proliferative and exudative processes in connective tissue, in the inflammatory focus. Reduces local hyperemia and skin hyperthermia. The action is mediated through specific intracellular receptors. Prevents the activation of phospholipase A2, stimulating the formation of its inhibitor - lipomodulin and due to direct effects on cell membranes, disrupts the synthesis of PG and the release of macrophage chemotactic factor, inhibits the activation of tissue kinin. Reduces the migration of macrophages and lymphocytes to the focus of inflammation. It blocks Fc receptors on macrophage surfaces for IgG and C3 complement components. Stabilizes the membranes of lysosomes, preventing the release of lysosomal enzymes. Suppresses alteration, exudation and proliferation. In large doses inhibits the development of lymphoid and connective tissue, inhibits the activity of hyaluronidase, reduces the permeability of capillaries. It inhibits the production of collagenase and activates the synthesis of protease inhibitors. It blocks synthesis and release from sensitized mast cells and basophils of histamine and other biologically active substances, suppresses various stages of immunogenesis, without having a mitostatic effect. Increases the level of glycogen in the liver, inhibits the release of sodium and water, increases - potassium. Affects protein (causes a negative nitrogen balance due to increased catabolism) and lipid metabolism. Increases BCC, hydrophilicity of tissues, increases blood pressure, has anti-shock effect. The threshold dose, which leads to the development of Cushing's syndrome with prolonged use, is about 30 mg. With prolonged use, atrophy of the adrenal cortex develops, the formation of ACTH and the thyroid-stimulating hormone of the pituitary gland is inhibited.

Hydrocortisone acetate is characterized by slowly developing, but longer, than in water-soluble drugs, the effect. It is used to insert into the injury sites, joints and soft tissues, where it has a local anti-inflammatory effect, although it is possible to develop systemic hormonal effects. The therapeutic effect with intra-articular injection occurs within 6-24 hours and lasts from several days to several weeks. Hydrocortisone sodium succinate has both metabolic and anti-inflammatory activity. After iv introduction, the effect manifests itself after 1 hour, the duration of it varies. Excretion of the administered dose is carried out for 12 hours. If it is necessary to maintain high plasma concentrations, administration is recommended every 4-6 hours. This hydrocortisone salt is rapidly absorbed and when excreted in the same way it is excreted as well as with IV application.

Well absorbed after ingestion. Cmax is achieved after 1 h. After the / m administration, the absorption is slow (24-48 h). It binds to plasma transcortin by 70-80%, with albumin - 10%, about 10% is in the form of a free fraction. It penetrates well through the mucous membranes and the histohematic barriers. Metabolised in the liver. It is excreted primarily through the kidneys in the form of inactive metabolites. In the placenta, about 70% of hydrocortisone is metabolized with the formation of an inactive 11-keto form.

When applying ophthalmic ointment (in the form of hydrocortisone acetate) poorly penetrates through the cornea into the intraocular liquid, but penetrates the epidermis and epithelium of the mucous membrane. After application to the skin (in the form of hydrocortisone acetate and hydrocortisone 17-butyrate) accumulates in the epidermis. In a small degree, it can be absorbed through the skin and have a systemic effect. The absorbed part is metabolized in the epidermis and then in the liver. Metabolites and an insignificant part of hydrocortisone is excreted in urine or bile.

Indication

For systemic use: acute allergic reactions, severe attack of bronchial asthma, asthmatic condition, serum sickness, hypersensitivity reactions to the administration of drugs; emergency conditions - hypotension, including Orthostatic, collapse in Addison's disease, myocardial infarction, hemorrhagic stroke, Morgagni-Adams-Stokes syndrome, coma with cerebral circulation and inflammatory brain diseases, hypothyroid and hepatic coma, multiple bleeding, acute liver failure in poisoning, laryngeal edema in allergic and inflammatory Lesions, burns and injuries, poisoning with vitamin D, strong acids, organophosphorus substances, quinine, chlorine, posttransfusion complications, Mendels syndrome on the bites of snakes and scorpions; Anaphylactic, hemorrhagic, cardiogenic and traumatic shock; Endocrine diseases - Waterhouse-Frideriksen syndrome, primary or secondary adrenocortical insufficiency (preferably natural cortisone and hydrocortisone, synthetic analogues should be used in combination with mineralocorticoids), adrenogenital syndrome with loss of sodium, thyroiditis; Hypercalcemia associated with cancer; Rheumatic diseases - psoriatic, rheumatoid, juvenile and acute gouty arthritis, ankylosing spondylitis, acute and subacute bursitis, humerus periarthritis, systemic lupus erythematosus, acute rheumatic carditis, dermatomyositis; Sarcoidosis, Leffler's syndrome, berylliosis, fulminant or disseminated pulmonary tuberculosis, aspiration pneumonitis (in combination with specific chemotherapy); Idiopathic thrombocytopenic purpura in adults, autoimmune hemolytic and congenital hypoplastic anemia, erythroblastopenia, palliative therapy of leukemia and lymphoma in adults, acute leukemia in children; Nephrotic syndrome without signs of uremia (to reduce proteinuria and induction of diuresis), severe exacerbations of ulcerative colitis and Crohn's disease, tuberculous meningitis with a subarachnoid block, trichinosis with neurological and myocardial manifestations, acute manifestations of multiple sclerosis, disseminated lung cancer (complementary therapy), differential Diagnosis of idiopathic and drug-induced leukopenia.

Intraarticular and periarticular administration (hydrocortisone acetate): reactive synovitis (including deforming osteoarthritis), rheumatoid arthritis, acute and subacute bursitis, acute gouty arthritis, epicondylitis, acute nonspecific tendosynovitis, carpal tunnel syndrome, posttraumatic osteoarthritis.

When applied to the skin: inflammatory and allergic skin diseases of non-microbial etiology, incl. Eczema, dermatitis (allergic, atopic, bullous herpetiform, exfoliative, seborrheic, contact); Itching dermatoses, photodermatosis, anogenital itching, insect bites, pemphigus, erythroderma, psoriasis.

In ophthalmology (hydrocortisone acetate in the form of ophthalmic ointment): allergic conjunctivitis, blepharitis, dermatitis of the eyelids, keratitis, restoration of the transparency of the cornea and suppression of neovascularization after the transferred keratitis, chemical and thermal burns (after complete corneal epithelialization); Iritis, iridocyclitis, anterior segment inflammation, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, condition after surgery.

V / k for keloids, localized hypertrophic, infiltrative, inflammatory lesions, flat lichen, psoriatic plaques, annular granuloma, neurodermatitis, discoid lupus erythematosus, diabetic lipoid necrobiosis, alopecia areata, cystic tumors of the aponeurosis and tendons.

Contraindications

Hypersensitivity (for short-term systemic use according to vital indications is the only contraindication).

For systemic use. Systemic mycoses, parasitic and infectious diseases of a viral or bacterial nature (currently without appropriate chemotherapy or recently transferred, including recent contact with the patient), incl. Herpes simplex, herpes zoster (viremic form), chickenpox, measles, amebiasis, strongyloidiasis (established or suspected), active and latent tuberculosis; Immunodeficiency states (including AIDS (acquired immunodeficiency syndrome) or HIV (human immunodeficiency virus) -infection), post-vaccination period, acute psychosis, severe forms of arterial hypertension, decompensated diabetes mellitus of severe course; Peptic ulcer of the stomach and duodenum in the stage of exacerbation, diverticulitis; Recent application of intestinal anastomoses; Peptic ulcer; Osteoporosis, myastenia gravis, Ithenko-Cushing's disease, thrombophilic conditions, renal failure, pregnancy, lactation.

For intraarticular and periarticular application: previous arthroplasty, conditions after intestinal anastomosis, intestinal anastomosis, pregnancy, breastfeeding.

When applied to the skin: bacterial, viral and fungal skin diseases, skin manifestations of syphilis, skin tuberculosis, skin tumors, breach of the integrity of the skin (ulcers, wounds), rosacea, vulgar acne, perioral dermatitis, post-vaccination period, pregnancy, breastfeeding.

For ophthalmic ointment: purulent, viral, tuberculosis and fungal diseases of the eye, trachoma, primary glaucoma, violation of the integrity of the corneal epithelium; The period of vaccination, pregnancy, breastfeeding.

pregnancy and lactation

The use of corticosteroids during pregnancy is possible if the expected effect of therapy exceeds the potential risk to the fetus (adequate and strictly controlled safety studies have not been conducted). Women of childbearing age should be warned about the potential risk to the fetus (corticosteroids pass through the placenta). Care must be taken to monitor newborns whose mothers received corticosteroids during pregnancy (possibly developing adrenal insufficiency in the fetus and newborn). Do not use often, in high doses, for a long period of time.

The action category for fetus by FDA is C.

It is recommended that breastfeeding women stop breastfeeding or using drugs, especially in high doses (corticosteroids penetrate breast milk and can suppress growth, the production of endogenous corticosteroids and cause undesirable effects in the newborn). When using external forms of hydrocortisone, do not apply the drug to the skin of the breast.

Side effects

The frequency of development and severity of side effects depend on the method, the duration of administration, the dose used, and the possibility of observing the circadian rhythm of the drug (drug) appointment.

System Effects

From the metabolism: the delay of Na + and fluid in the body, hypokalemia, hypokalemic alkalosis, negative nitrogen balance, hyperglycemia, glucosuria, weight gain.

On the part of the endocrine system: secondary adrenal and hypothalamic-pituitary insufficiency (especially during stressful situations such as illness, trauma, surgery); Cushing's syndrome; Suppression of growth in children; Disorders of the menstrual cycle; Decreased tolerance to carbohydrates; Manifestation of latent diabetes mellitus, increased need for insulin or oral antidiabetic drugs in patients with diabetes mellitus.

From the cardiovascular system and blood (hematopoiesis, hemostasis): increased blood pressure, development (in predisposed patients) or increased severity of chronic heart failure, hypercoagulation, thromboembolism, ECG changes characteristic of hypokalemia; In patients with acute and subacute myocardial infarction - the spread of the focus of necrosis, slowing the formation of scar tissue with a possible rupture of the heart muscle, obliterating endarteritis, hematological changes.

From the musculoskeletal system: muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, compression fracture of the spine, aseptic necrosis of the head of the femoral and humerus bones, pathological fractures of long tubular bones, ruptures of tendons, primarily Achilles.

On the part of the intestine (gastrointestinal tract): steroid ulcer with possible perforation and bleeding, pancreatitis, flatulence, ulcerative esophagitis, digestive disorders, nausea, vomiting, increase / decrease in appetite; After treatment with corticosteroids, ALT (alanine aminotransferase), AST (aspartate aminotransferase) and alkaline phosphatase (alkaline phosphatase) in the blood serum increased; Usually these changes are insignificant, not associated with any clinical syndromes and are reversible after discontinuation of treatment.

On the part of the skin: atrophic bands, acne, delayed healing of wounds, thinning of the skin, petechia and ecchymosis, erythema, excessive sweating.

From the side of the nervous system and sensory organs: convulsions, increased intracranial pressure with the syndrome of the congestive nipple of the optic nerve (pseudotumor of the brain - more often in children, usually after too rapid dose reduction, symptoms - headache, deterioration of visual acuity or double vision); Vertigo, headache, malaise, mental disorders; Formation of posterior subcapsular cataract, increased intraocular pressure, glaucoma; Steroidal exophthalmos.

Allergic reactions: generalized (allergic dermatitis, urticaria, anaphylactic shock) and local.

Other: masking of symptoms of infectious diseases, withdrawal syndrome; Reactions at the injection site - burning, numbness, pain, paresthesia and infection, hyper or hypopigmentation, scarring; Atrophy of the skin and subcutaneous tissue, sterile abscess.

When applied to the skin: irritation, burning, dry skin, local allergic reactions, incl. Hyperemia, puffiness, itching; With prolonged use, especially under impermeable dressings or on large areas of the skin - systemic side effects; Steroid acne, purpura, telangiectasia; Development of hypercorticism as a manifestation of resorptive action (in these cases, the drug is canceled); With prolonged use, it is also possible to develop secondary infectious skin lesions, atrophic changes, hypertrichosis.

Eye ointment: allergic reactions, burning, injected sclera, increased intraocular pressure, exophthalmos; If the integrity of the corneal epithelium is compromised, the healing and perforation of the cornea may be delayed; At long application - development of a steroid glaucoma is possible; Frequent repeated courses of treatment can lead to the formation of posterior subcapsular cataract; Secondary infection joining.

Interaction

Barbiturates, antiepileptic and antihistamines reduce effectiveness. NSAIDs increase the risk of ulceration in the digestive tract, paracetamol - hepatotoxicity. Hydrocortisone reduces the level in the blood of salicylates (increases clearance) and the activity of antidiabetics, changes the effectiveness of anticoagulants. Cardiac glycosides and non-potassium-sparing diuretics potentiate hypokalemia, anabolic steroids increase the hydrophilicity of tissues. When combined with amphotericin B, the development of dilated myocardial damage and heart failure is possible.

Routes of administration

In / in (intravenously), in / m (intramuscularly), inside, intraarticularly and periarticularly, v / c (intradermally), topically.

Precautions for the substance Hydrocortisone

During the period of treatment, vaccination is not recommended (due to the immunosuppressive effect of hydrocortisone). Intra-articular administration should be performed in conditions of strict aseptic and antiseptic activity and only after the exclusion of the infectious process in the joint. In / m (intramuscular) injection is performed as deep as possible in the gluteus muscle to prevent the development of muscle atrophy. With long-term therapy, it is recommended to monitor the potassium content in the blood (and its purpose) and regular ECG (electrocardiogram, electrocardiography) -research. To prevent the development of secondary hypokorticism caused by cancellation of treatment, the dose should decrease gradually. Glucocorticoids can mask some manifestations of the infectious process, it is possible to join new infections due to a decrease in resistance. In the treatment of corticosteroids or their combination with other drugs that suppress cellular, humoral immunity, or the function of neutrophils, various viral, bacterial, fungal, protozoal infections and helminthic infestations that have previously occurred latent can manifest themselves. The risk of infection and its more severe course increases in proportion to the increase in the dose of the drug.

A sudden cessation of treatment can cause the development of acute adrenocortical insufficiency; With prolonged use, you can not suddenly cancel the drug, the dose should decrease gradually. With a sudden cancellation after a long period of admission, it is possible to develop a withdrawal syndrome, manifested by a rise in body temperature, myalgia and arthralgia, and malaise. These symptoms can appear even in the case when there is no insufficiency of the adrenal cortex.

Eye ointment. In the event that after the application of the ophthalmic ointment visual clarity is temporarily lost, it is not recommended to drive the machine immediately after application or to work with complex mechanisms. During treatment, you should refrain from wearing contact lenses. With excessive and frequent application of ophthalmic ointment during the day or its use in children, the systemic effect of hydrocortisone is possible (with the withdrawal of the drug the symptoms pass by themselves). When using other medicines (medicinal product) in the form of eye drops, the time interval between their application and application of the ointment should be at least 15 minutes. When using ointments more than 2 weeks and the presence of an open or closed angle glaucoma in the anamnesis, control of intraocular pressure is necessary. Children are more likely to develop systemic effects of hydrocortisone than adults. In this regard, ointment should be used in children, if possible, in short courses (5-7 days).

Forms for external use. Children under 12 years of age, the drug is prescribed only under strict medical supervision. When using ointment in children older than 1 year should limit the total duration of treatment and exclude conditions that lead to increased resorption of the drug (warming, fixing and occlusive dressings). Avoid getting ointment in the eyes. With extreme caution, the drug should be applied to the skin of the face due to the possibility of side effects (telangiectasia, atrophy, dermatitis perioralis), even after a short-term use. To prevent infectious skin lesions, hydrocortisone ointment is recommended to be prescribed in combination with antibacterial and antifungal agents.