Instruction for use: Humatropee
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ATX Code H01AC01 Somatropin
Active substance: Somatropin
Pharmacological group
Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists
Nosological classification (ICD-10)
E34.3 Low-growth [dwarfism], not elsewhere classified
Growth retardation, Growth retardation in children, Dwarfism, Nanism hypophyseal, Inadequate endogenous growth hormone, Growth Hormone Deficiency, Pituitary Nanism, Low height, Growth disorder, Disturbance of the growth process, Pituitary dwarfism, Disruption of endogenous hormone secretion with growth retardation, Growth disorders, Naniz disproportionate, Nanism associated with external factors
Q96 Turner Syndrome
Turner syndrome, Gonadal Dysgenesis, Mixed gonadal dysgenesis, Shereshevsky-Turner Syndrome
Composition and form of release
Lyophilized powder for the preparation of an injection solution in 4U bottles, complete with a solvent in 2 ml bottles or in cartridges for Humatropeen II syringes 18 and 36 IU / ml, complete with a solvent.
Characteristic
Biosynthetic recombinant human growth hormone, the polypeptide chain includes 191 amino acid residues (in a sequence identical to the human growth hormone).
pharmachologic effect
Pharmacological action - anabolic, hyperglycemic.
Stimulates the growth of the skeleton, increases the number and size of muscle cells, mobilizes fats, delays sodium, potassium, phosphorus.
Indications Growth disorder in the presence of growth hormone deficiency, Turner's syndrome.
Contraindications
Hypersensitivity (including m-cresol or glycerin), closed epiphyses, active tumor process, antitumor therapy, signs of tumor growth, acute period of intracranial injury.
Side effects
Hyperglycemia, a decrease in glucose tolerance, transient edematous syndrome, symptoms of hypothyroidism.
Interaction
Glucocorticoids weaken the effect.
Dosing and Administration
V / m, sc / k. The dose and intervals of administration are selected individually (up to 0.48 IU / kg per week). With a growth hormone deficiency - up to 0.48 IU / kg per week, with Turner's syndrome - 0.8-0.9 IU / kg, equivalent to 24-28 IU / m2 body surface per week. The weekly dose is divided into 6-7 injections and administered at night. When performing long-term therapy, it is necessary to control the concentration of glucose and thyroid hormones in the blood.
Storage conditions
At a temperature of 2-8 ° C. The prepared solution remains stable for 21 days at a temperature of 2-8 ° C. Do not freeze.
Keep out of the reach of children.
Shelf life
2 years.
Do not use after the expiry date printed on the package.