Instruction for use: Heparin calcium

Trade name of the drug – Calciparine

The Latin name of the substance Heparin calcium

Heparinum calcium (genus. Heparini calcii)

Chemical name

Mucopolysaccharide ester of polysulfuric acid

Pharmacological group:

Anticoagulants

The nosological classification (ICD-10)

I74 Embolism and arterial thrombosis: Thrombosis of effort (stress); Arterial thrombosis; Arteriothrombosis; Subacute and chronic arterial thrombosis; Subacute thrombosis of peripheral arteries; Postoperative thrombosis; Vascular thrombosis; Vascular embolism; Thrombosis of aortocoronary shunt; Arterial thrombosis; Thrombosis of arteries; Coronary artery thrombosis; Coronary thrombosis; Thrombosis of blood vessels; Thrombosis with ischemic stroke; Thrombosis with general surgical operations; Thrombosis in Oncology Operations; Vascular thrombosis; Thrombus formation in the postoperative period; Thrombotic complications; Thromboembolic diseases; Thromboembolic syndrome; Thromboembolic complication in the postoperative period; Thromboembolism of arteries; Partial vascular thrombosis; Embolism; Embolism of arteries

I80 Phlebitis and thrombophlebitis: Diseases of peripheral vessels; Inflammation of superficial veins; Inflammatory diseases of veins; Deep venous thrombophlebitis; The disease of veins; Disease of the veins of the lower extremities; Diseases of peripheral vessels; Migrating phlebitis; Insufficiency of veins of lower extremities; Exacerbation of chronic thrombophlebitis; Acute thrombophlebitis; Acute thrombophlebitis of superficial veins; Periphlebitis; Periflebit surface; Superficial inflammation of veins; Surface thrombophlebitis; Surface phlebitis; Thrombophlebitis; Deep vein thrombophlebitis; Thrombophlebitis superficial; Phlebitis; Phlebitis of deep veins; Phlebitis of superficial veins; Phlebopathy; Chronic thrombophlebitis; Endophlebitis

CAS Code

37270-89-6

Pharmacology

Mode of action - anticoagulant.

Forms a complex with the molecule of antithrombin III (cofactor of heparin) and potentiates the ability of the latter to inhibit the activation of IX, X, XI and XII factors of blood coagulation. Reducing the content of factor Xa inhibits the formation of thrombin and blood clotting. Accelerates the formation of the ligament thrombin - antithrombin III, prevents the conversion of fibrinogen into fibrin and the appearance of fibrin clots. Increases pulmonary ventilation and coronary blood flow, inhibits inflammation, activates lipoprotein lipase. After sc injection, Cmax is determined after 30-60 minutes. T1 / 2 - 60-90 min. It does not penetrate through the histogematic and placental barriers. Partially destroyed by heparinase. It is excreted unchanged in urine.

Application of substance Heparin calcium

Thrombosis, thromboembolism.

Contraindications

Hypersensitivity, bleeding or tendency to bleeding (thrombocytopenia, hypofibrinogenemia, hemophilia, impaired vascular permeability), gastric and duodenal ulcer, acute bacterial endocarditis, cerebral hemorrhage, postoperative period with interventions on the brain and spinal cord.

Side effects of the substance Heparin calcium

Hemorrhagic phenomena, osteoporosis (with prolonged treatment), an increase in the level of transaminases in the blood, eosinophilia, thrombocytopenia, reactions at the injection site: hematomas, nodules, cutaneous necrosis.

Interaction

The anticoagulant effect strengthens NSAID, incl. Salicylic acid, ticlopidine.

Overdose

Symptoms: hypocoagulation.

Treatment: slow IV injection of protamine (antagonist).

Routes of administration

SC (hypodermic).

Precautions for the substance Heparin calcium

Caution is prescribed for renal and hepatic insufficiency, hypertension, gastrointestinal ulcers (in the anamnesis), vascular chorioretinopathy, in combination with indirect anticoagulants, glucocorticoids, dextran, during labor due to the risk of bleeding.