Instruction for use: Hemostabil

Dosage form: Solution for infusions

Active substance: Dextranum 30000-40000

ATX

B05AA05 Dextran

Pharmacological group

Substitutes for plasma and other blood components

Composition and release form

Solution for infusion - 1 container

10 g of dextran 40,000

7.5 g of sodium chloride

Water for injection to 100 ml

in polymeric containers 100, 250 or 500 ml; in one polymeric container packages.

Pharmacodynamics

Hemostabil - complex drug, which is a hypertonic solution. Under the effect of hypertonic component (high sodium chloride concentration, the osmolarity of 2567 mOsm) water, preferably from the interstitial space is moved quickly into the bloodstream, increasing fluid volume. Action hypertonic saline short-lived due to the elimination of sodium and chloride ions from the vessel. Dextran 40,000 for 3-4 hours keeps the fluid in the bloodstream, it supports BCC, providing, thus, hemodynamic effects. Maximum effect on BCC is the combined effect of hypertonic saline and dextran 40000. The drug has volemic action within 150-200% of the injected volume, which is maintained for 30-60 minutes. Infusion of 250 ml Hemostabil gives an increase intravascular volume to 1000 ml for 5 min.

Pharmacokinetics

The combination of sodium chloride and dextran 40000 does not alter the pharmacokinetic properties of each component. The sodium content of the blood plasma after administration Gemostabila increases to 9-12 mmol / l, returning to the normal values in less than 4 hours T1 / 2 Dextran 40000 -. 3-4 hours, excreted by the kidneys in the urine in unchanged form.

Indications of the drug Hemostabil

Initial volume replacement deficiency for the prevention and treatment of hypovolemia and shock with hypotension in acute blood loss, trauma, injuries, surgery, burns, infectious diseases.

Contraindications

known hypersensitivity / allergic to the drug or its components;

late pregnancy;

lactation;

severe cardio-pulmonary insufficiency;

impairment of renal function;

hyperhydration;

childhood.

Side effects

In individuals may experience intolerance reactions in exceptional cases, allergic reactions of various types, up to anaphylactic / anaphylactoid events. In this case, you should immediately discontinue administration of the drug and make the necessary urgent measures.

Interaction

Interactions with other drugs and medicines have been identified.

Dosing and Administration

IV, infusions as in peripheral or central vein. Introduction is performed once, bolus volume of 250 ml, during 2-4 minutes. 250 ml Gemostabil drug is optimal volume. Increasing BCC stabilizing hemodynamics and reduces the risk of irreversible pathological reactions in the body in response to acute hypovolemia. After transfusion Gemostabil drug infusion therapy continue with crystalloid and colloid solutions, blood products in required quantities. Preferably, following the introduction of Gemostabila use isotonic solutions.

Overdose

Symptoms of overdose are not established.

Special instructions

With caution appoint a drug for severe violations of blood coagulation (other than life-threatening conditions), dehydration. Since Hemostabil for a short time significantly increases the volume of intravascular fluid, attention should be paid to patients with heart failure. In patients with diabetes mellitus with severe hyperglycemia and hyperosmolarity, Hemostabil should be used with caution. In the process of treatment, it is necessary to monitor the ion composition of blood serum, fluid balance and kidney function. When the drug is injected into the peripheral veins, a burning sensation and tenderness may appear in the limb along the vein, into which the drug is infused.

Conditions of supply of pharmacies

On prescription.

Storage conditions of the drug Hemostabil

In a dry place at a temperature of 10-30 ° C. (Allowed to freeze).

Keep out of the reach of children.

The shelf life of the drug Hemostabil

2 years.

Do not use beyond the expiration date printed on the package.